CRSP CRISPR Therapeutics AG - Common Shares

NASDAQ · Biotechnology · Visualizza su SEC EDGAR ↗
$52,78
Prezzo · Ago 18, 2026
Fondamentali al Ago 3, 2026

Informazioni su CRISPR Therapeutics AG - Common Shares Panoramica della società da Wikipedia

CRISPR Therapeutics AG is a Swiss–American biotechnology company headquartered in Zug, Switzerland. The company does business as CRISPR Therapeutics, Inc. in the United States. It was one of the first companies formed to utilize the CRISPR gene editing platform to develop medicines for the treatment of various rare and common diseases. The company has approximately 500 employees and has offices in Zug, Switzerland; Boston, Massachusetts; San Francisco, California; and London, United Kingdom. Its manufacturing facility in Framingham, Massachusetts, won the Facilities of the Year Award (FOYA) award in 2022. The company’s lead program, exagamglogene autotemcel, or exa-cel, was granted regulatory approval by the US Food and Drug Administration (FDA) in December 2023.

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CRISPR Therapeutics AG is a Swiss–American biotechnology company headquartered in Zug, Switzerland. The company does business as CRISPR Therapeutics, Inc. in the United States. It was one of the first companies formed to utilize the CRISPR gene editing platform to develop medicines for the treatment of various rare and common diseases. The company has approximately 500 employees and has offices in Zug, Switzerland; Boston, Massachusetts; San Francisco, California; and London, United Kingdom. Its manufacturing facility in Framingham, Massachusetts, won the Facilities of the Year Award (FOYA) award in 2022. The company’s lead program, exagamglogene autotemcel, or exa-cel (formerly CTX001), was granted regulatory approval by the US Food and Drug Administration (FDA) in December 2023.

History

CRISPR Therapeutics was founded in 2013 by Emmanuelle Charpentier, Shaun Foy and Rodger Novak. Charpentier later shared the Nobel Prize in Chemistry in 2020 with Jennifer Doudna. As part of a working group, she provided the first scientific documentation on the development and use of CRISPR gene editing. This allows DNA to be specifically modified and edited, which can be used to ameliorate diseases. CRISPR Therapeutics is applying this technology platform to research, develop and commercialize medicines for various diseases including sickle cell disease, beta thalassemia, various cancers, type 1 diabetes, and cardiovascular diseases. The CEO is Samarth Kulkarni, PhD, who joined the company in 2015 as chief business officer. Kulkarni became CEO in 2017.

CRISPR Therapeutics has formed collaborations in support of its mission of developing medicines. Vertex Pharmaceuticals and CRISPR Therapeutics entered into a strategic research collaboration in 2015 focused on the use of CRISPR/Cas9 to discover and develop potential new treatments aimed at the underlying genetic causes of human disease. One of the first treatments to emerge from the joint research program was CTX001 or exagamglogene autotemcel (commonly known as Exa-cel). Subsequently, CRISPR Therapeutics and Vertex expanded their collaboration to include diseases like Duchenne muscular dystrophy and type 1 diabetes. In 2016, the company signed an agreement with Bayer AG to operate Casebia Therapeutics as a joint venture with Bayer under the management of CRISPR Therapeutics. The company went public on the NASDAQ exchange in October 2016.

CRISPR Therapeutics has established partnerships with additional companies such as Viacyte (part of Vertex), Nkarta, Capsida, Curevac, and others.

Products

CRISPR Therapeutics has drugs approved and in development for blood diseases, cancer, diabetes, and other severe diseases.

Exa-cel

Exa-cel is a drug therapy for the treatment of the rare blood disorders beta thalassemia and sickle cell disease developed jointly with Vertex Pharmaceuticals, that received FDA approval for clinical use in December 2023. In May 2020, exa-cel had received orphan drug designation from the US Food and Drug Administration (FDA) for transfusion-dependent beta thalassemia and from the European Medicines Agency for sickle cell disease and transfusion-dependent beta thalassemia. As of 2022 Phase 3 clinical trial results supported the safety and efficacy of this treatment. The rolling Biologics License Applications (BLAs) were submitted to the FDA for exa-cel for sickle cell disease and transfusion-dependent beta thalassemia. EU and UK filings were completed in 2022, and the submissions were validated by European Medicines Agency and The Medicines and Healthcare products Regulatory Agency as of April 2023.

Fonte: Wikipedia (Inglese), CC BY-SA 4.0 · Vedi su Wikipedia ↗

Wikidata ↗

CRSP Snapshot del titolo Prezzo, capitalizzazione di mercato, P/E, EPS, ROE, debito/capitale proprio, intervallo 52 settimane

Prezzo
$52.77
Capitalizzazione di Mercato
$5.06B
P/E (TTM)
-8.2
EPS (TTM)
$-6.47
Ricavi (TTM)
$4M
Rendimento div.
ROE
-32.0%
D/E Debito/Patrimonio
Intervallo 52 sett.
$44 – $78

CRSP Grafico del prezzo delle azioni OHLCV giornaliero con indicatori tecnici — panoramica, zoom e personalizza la tua visualizzazione

Performance decennale Andamento di ricavi, utile netto, margini e EPS

Ricavi e Utile Netto $4M
10-point trend, -32.0%
2016-12-31 2025-12-31
EPS $-6.47
9-point trend, -278.4%
2017-12-31 2025-12-31
Flusso di cassa libero $-346M
10-point trend, -493.1%
2016-12-31 2025-12-31
Margini -16569.8%

Valutazione Rapporti P/E, P/S, P/B, EV/EBITDA — il titolo è costoso o economico?

Metrica
Tendenza 5 anni
CRSP
Mediana dei peer
P/E (TTM)
5-point trend, -150.3%
-8.2
P/S (TTM)
5-point trend, +22368.1%
1441.8
56.3
P/B
5-point trend, +7.6%
2.6
3.0
Price / FCF (Prezzo / FCF)
5-point trend, -213.9%
-14.6

Redditività Margini lordi, operativi e netti; ROE, ROA, ROIC

Metrica
Tendenza 5 anni
CRSP
Mediana dei peer
Operating Margin (Margine Operativo)
5-point trend, -46483.3%
-18933.7%
Net Profit Margin (Margine di Profitto Netto)
5-point trend, -40239.9%
-16569.8%
-1643.9%
ROA
5-point trend, -256.5%
-25.8%
-40.2%
ROE
5-point trend, -308.2%
-32.0%
-75.3%
ROIC
5-point trend, -324.7%
-34.8%

Salute finanziaria Debito, liquidità, solvibilità — solidità del bilancio

Metrica
Tendenza 5 anni
CRSP
Mediana dei peer
Current Ratio (Rapporto corrente)
5-point trend, -34.0%
13.3
6.7
Quick Ratio
5-point trend, -33.2%
13.2

Crescita Crescita di ricavi, EPS e utile netto: YoY, CAGR 3Y, CAGR 5Y

Metrica
Tendenza 5 anni
CRSP
Mediana dei peer
Revenue YoY (Ricavi YoY)
5-point trend, -99.6%
-90.6%
Revenue CAGR 3Y (CAGR Ricavi 3Y)
5-point trend, -99.6%
43.1%
Revenue CAGR 5Y (CAGR Ricavi 5Y)
5-point trend, -99.6%
37.3%

Metriche per Azione EPS, valore contabile per azione, flusso di cassa per azione, dividendo per azione

Metrica
Tendenza 5 anni
CRSP
Mediana dei peer
EPS (Diluted) (EPS (Diluito))
5-point trend, -237.7%
$-6.47

Efficienza del Capitale Rotazione delle attività, rotazione delle scorte, rotazione dei crediti

Metrica
Tendenza 5 anni
CRSP
Mediana dei peer

CRSP Consenso degli analisti Opinioni degli analisti, sia rialziste che ribassiste, target price a 12 mesi, potenziale di rialzo

COMPRA 29 analisti
  • Acquisto forte 6 20,7%
  • Compra 11 37,9%
  • Mantieni 12 41,4%
  • Vendi 0 0,0%
  • Vendita forte 0 0,0%

Target Price a 12 Mesi

18 analisti · 2026-08-15
Target mediano $80.00 +51,6%
Target medio $87.56 +65,9%

Cronologia utili EPS effettivo vs stima, surprise %, tasso di superamento, data prossimi utili

Sorpresa media
0.01%
Periodo EPS Actual EPS Stimato Sorpresa
30 Giugno 2026 $-0.94 $-1.22 0.28%
31 Marzo 2026 $-1.28 $-1.25 -0.03%
31 Dicembre 2025 $-1.37 $-1.18 -0.19%
30 Settembre 2025 $-1.17 $-1.29 0.12%
30 Giugno 2025 $-1.29 $-1.45 0.16%
31 Marzo 2025 $-1.58 $-1.28 -0.30%

Confronto Peer (GICS sub-settore industriale) Metriche chiave rispetto ai pari del settore

Ticker Capitalizzazione di Mercato P/E Rev YoY Margine Netto ROE Margine lordo
CRSP $5.03B -8.1 -90.6% -16569.8% -32.0%
MLTX -3.7 -60.5%
ACIU
ADCT $444M -3.2 14.8% -175.3% 74.1%

Fondamentali Completi Tutte le metriche per anno — conto economico, stato patrimoniale, rendiconto finanziario

Conto Economico 15
Dati annuali Conto Economico per CRSP
Metrica Tendenza 20252024202320222021202020192018201720162015
Revenue 11-point trend, +1321.1% $4M $37M $371M $1M $915M $719.0K $290M $3M $41M $5M $247.0K
R&D Expense 11-point trend, +2165.2% $285M $310M $387M $462M $341M $221M $179M $114M $70M $42M $13M
SG&A Expense 11-point trend, +448.7% $74M $73M $76M $102M $100M $86M $63M $48M $36M $31M $13M
Operating Expenses 11-point trend, +2471.9% $668M $504M $594M $674M $541M $355M $243M $162M $106M $73M $26M
Operating Income 11-point trend, -2483.0% $-665M $-467M $-223M $-673M $374M $-354M $47M $-159M $-65M $-68M $-26M
Interest Income 3-point trend, +347.6% · $104M $76M $23M · · · · · · ·
Other Non-op 11-point trend, +541187.5% $87M $104M $72M $23M $6M $6M $26M $-1M $-197.0K $79M $16.0K
Pretax Income 11-point trend, -2138.4% $-578M $-363M $-151M $-650M $380M $-348M $67M $-164M $-67M $-23M $-26M
Income Tax 11-point trend, +51814.3% $4M $4M $3M $-325.0K $2M $809.0K $448.0K $553.0K $2M $484.0K $7.0K
Net Income 11-point trend, -2180.5% $-582M $-366M $-154M $-650M $378M $-349M $67M $-165M $-68M $-23M $-26M
EPS (Basic) 9-point trend, -278.4% $-6.47 $-4.34 $-1.94 $-8.36 $4.97 $-5.29 $1.23 $-3.44 $-1.71 · ·
EPS (Diluted) 9-point trend, -278.4% $-6.47 $-4.34 $-1.94 $-8.36 $4.70 $-5.29 $1.17 $-3.44 $-1.71 · ·
Shares (Basic) 9-point trend, +124.5% 89,925,109 84,359,126 79,220,930 77,746,575 75,948,686 65,949,672 54,392,304 47,964,368 40,057,365 · ·
Shares (Diluted) 9-point trend, +124.5% 89,925,109 84,359,126 79,220,930 77,746,575 80,393,496 65,949,672 56,932,798 47,964,368 40,057,365 · ·
EBITDA 10-point trend, -859.9% $-645M $-447M $-203M $-649M $391M $-345M $51M $-155M $-62M $-67M ·
Stato Patrimoniale 25
Dati annuali Stato Patrimoniale per CRSP
Metrica Tendenza 20252024202320222021202020192018201720162015
Cash & Equivalents 11-point trend, +122.8% $348M $298M $389M $212M $923M $1.17B $944M $457M $240M $316M $156M
Short-term Investments 7-point trend, +1628269000.00 $1.63B $1.61B $1.30B $1.60B $1.46B $522M $0 · · · ·
Receivables 11-point trend, -100.0% $0 $25M $200M $0 $305.0K $144.0K $99.0K $88.0K $3M $3M $339.0K
Prepaid Expense 11-point trend, +1722.8% $10M $8M $14M $38M $38M $26M $44M $10M $6M $2M $540.0K
Current Assets 11-point trend, +1166.0% $1.99B $1.94B $1.91B $1.85B $2.42B $1.72B $988M $466M $248M $320M $157M
PP&E (Net) 11-point trend, +8623.7% $116M $134M $152M $164M $138M $42M $31M $18M $19M $21M $1M
PP&E (Gross) 11-point trend, +14678.8% $207M $206M $205M $197M $175M $63M $43M $26M $23M $22M $1M
Accum. Depreciation 11-point trend, +126361.1% $91M $72M $53M $34M $38M $21M $12M $7M $4M $942.0K $72.0K
Intangibles 10-point trend, -100.0% · $0 $16.0K $71.0K $125.0K $180.0K $235.0K $289.0K $344.0K $399.0K $454.0K
Other Non-current Assets 11-point trend, +24026.7% $24M $16M $2M $5M $5M $1M $1M $669.0K $606.0K $198.0K $101.0K
Total Assets 11-point trend, +1320.9% $2.27B $2.24B $2.23B $2.24B $2.75B $1.83B $1.07B $489M $271M $345M $159M
Accounts Payable 11-point trend, +603.2% $11M $15M $38M $27M $15M $9M $6M $5M $2M $5M $2M
Accrued Liabilities 11-point trend, +960.6% $89M $41M $45M $78M $91M $54M $30M $21M $11M $16M $8M
Current Liabilities 11-point trend, +1368.4% $149M $88M $109M $121M $120M $94M $57M $28M $15M $22M $10M
Capital Leases 7-point trend, +327.2% $188M $206M $223M $228M $213M $50M $44M · · · ·
Other Non-current Liabilities 11-point trend, +2085.8% $6M $3M $958.0K $6M $7M $8M $14M $243.0K $314.0K $189.0K $281.0K
Total Liabilities 11-point trend, +176.9% $343M $310M $347M $368M $352M $164M $127M $97M $84M $112M $124M
Long-term Debt $0 · · · · · · · · · ·
Common Stock 11-point trend, +1605.5% $3M $3M $2M $2M $2M $2M $2M $2M $1M $1M $181.0K
Retained Earnings 11-point trend, -5644.0% $-1.95B $-1.37B $-1000M $-846M $-196M $-574M $-225M $-292M $-125M $-57M $-34M
Treasury Stock 11-point trend, +60000.00 $60.0K $62.0K $62.0K $63.0K $63.0K $63.0K $63.0K $57.0K $0 $0 $0
AOCI 11-point trend, +60362.5% $5M $2M $2M $-16M $-5M $-83.0K $7.0K $-8.0K $14.0K $-26.0K $-8.0K
Stockholders' Equity 11-point trend, +6704.8% $1.92B $1.93B $1.88B $1.88B $2.40B $1.66B $939M $392M $188M $233M $-29M
Liabilities + Equity 11-point trend, +1320.9% $2.27B $2.24B $2.23B $2.24B $2.75B $1.83B $1.07B $489M $271M $345M $159M
Shares Outstanding 11-point trend, +1634.7% 95,894,341 85,741,981 80,044,378 78,512,450 76,990,066 73,914,844 60,783,799 51,852,862 40,592,248 39,719,434 5,528,079
Flusso di cassa 14
Dati annuali Flusso di cassa per CRSP
Metrica Tendenza 20252024202320222021202020192018201720162015
D&A 11-point trend, +15237.8% $19M $19M $20M $24M $18M $9M $5M $4M $3M $925.0K $127.0K
Stock-based Comp 11-point trend, +1867.9% $72M $87M $81M $98M $102M $66M $44M $35M $19M $11M $4M
Deferred Tax 11-point trend, +1794.4% $915.0K $-484.0K $-424.0K $-1M $2M $409.0K $-34.0K $6.0K $180.0K $-137.0K $-54.0K
Other Non-cash 10-point trend, +428.3% $144M $118M $-207M $33M $39M $35M $-59M $30M $-24M $-44M ·
Operating Cash Flow 11-point trend, -680.6% $-345M $-143M $-260M $-496M $539M $-238M $57M $-96M $-70M $-53M $59M
CapEx 11-point trend, -20.8% $914.0K $2M $9M $37M $82M $18M $7M $3M $8M $3M $1M
Investing Cash Flow 10-point trend, -199.8% $-32M $-280M $375M $-259M $-1.04B $-541M $1M $-3M $-8M $32M ·
Stock Issued 10-point trend, +347.0% $398M $301M $33M $970.0K $213M $982M $415M $307M $0 $89M ·
Stock Repurchased · · · · · · · $57.0K · · ·
Net Stock Activity 8-point trend, +29.7% $398M $301M $33M $970.0K $213M $982M $415M $307M · · ·
Financing Cash Flow 10-point trend, +132.5% $426M $332M $63M $39M $251M $1.02B $431M $316M $3M $183M ·
Net Change in Cash 11-point trend, -68.2% $49M $-91M $177M $-716M $-246M $237M $489M $217M $-76M $162M $155M
Taxes Paid $3M · · · · · · · · · ·
Free Cash Flow 10-point trend, -493.1% $-346M $-145M $-270M $-533M $457M $-257M $50M $-99M $-78M $-58M ·
Redditività 7
Dati annuali Redditività per CRSP
Metrica Tendenza 20252024202320222021202020192018201720162015
Operating Margin 10-point trend, -1335.1% -18933.7% -1250.4% -60.0% -56190.4% 40.8% -49295.5% 16.1% -5087.8% -157.7% -1319.3% ·
Net Margin 10-point trend, -3591.9% -16569.8% -981.5% -41.4% -54271.7% 41.3% -48520.9% 23.1% -5281.1% -166.7% -448.8% ·
Pretax Margin 10-point trend, -3642.9% -16466.2% -971.9% -40.6% -54298.8% 41.5% -48408.3% 23.2% -5263.4% -162.5% -439.9% ·
EBITDA Margin 10-point trend, -1312.2% -18378.7% -1198.8% -54.6% -54172.7% 42.8% -48018.2% 17.8% -4975.2% -150.3% -1301.4% ·
ROA 10-point trend, -180.8% -25.8% -16.4% -6.9% -26.0% 16.5% -24.1% 8.6% -43.4% -22.2% -9.2% ·
ROE 10-point trend, -40.7% -32.0% -18.9% -8.5% -34.0% 15.4% -23.2% 8.7% -40.8% -32.5% -22.8% ·
ROIC 10-point trend, -16.5% -34.8% -24.4% -12.0% -35.9% 15.5% -21.3% 4.9% -40.7% -35.3% -29.9% ·
Liquidità e Solvibilità 2
Dati annuali Liquidità e Solvibilità per CRSP
Metrica Tendenza 20252024202320222021202020192018201720162015
Current Ratio 10-point trend, -8.5% 13.3 22.1 17.5 15.3 20.2 18.2 17.3 16.8 17.1 14.6 ·
Quick Ratio 10-point trend, -8.5% 13.2 22.0 17.4 15.0 19.8 17.9 16.5 16.5 16.7 14.5 ·
Efficienza 2
Dati annuali Efficienza per CRSP
Metrica Tendenza 20252024202320222021202020192018201720162015
Asset Turnover 10-point trend, -92.2% 0.0 0.0 0.2 0.0 0.4 0.0 0.4 0.0 0.1 0.0 ·
Receivables Turnover 10-point trend, -90.5% 0.3 0.3 3.7 7.9 4075.6 5.9 3097.2 2.3 14.2 3.0 ·
Per Azione 5
Dati annuali Per Azione per CRSP
Metrica Tendenza 20252024202320222021202020192018201720162015
Book Value / Share 10-point trend, +241.9% $20.04 $22.53 $23.52 $23.89 $31.17 $22.52 $15.46 $7.56 $4.63 $5.86 ·
Revenue / Share 7-point trend, -99.2% $0.04 $0.44 $4.69 $0.02 $11.38 $0.01 $5.09 · · · ·
Cash Flow / Share 7-point trend, -485.4% $-3.84 $-1.69 $-3.29 $-6.38 $6.70 $-3.61 $1.00 · · · ·
Cash / Share 10-point trend, -54.4% $3.62 $3.48 $4.87 $2.70 $11.99 $15.81 $15.53 $8.81 $5.91 $7.94 ·
EPS (TTM) 10-point trend, +8.2% $-6.47 $-4.34 $-1.94 $-8.36 $4.70 $-5.29 $1.17 $-3.44 $-1.71 $-7.05 ·
Tassi di Crescita 3
Dati annuali Tassi di Crescita per CRSP
Metrica Tendenza 20252024202320222021202020192018201720162015
Revenue YoY 5-point trend, -100.1% -90.6% -90.0% 30885.5% -99.9% 127154.9% · · · · · ·
Revenue CAGR 3Y 3-point trend, -93.9% 43.1% -65.6% 702.2% · · · · · · · ·
Revenue CAGR 5Y 37.3% · · · · · · · · · ·
Valutazione (TTM) 10
Dati annuali Valutazione (TTM) per CRSP
Metrica Tendenza 20252024202320222021202020192018201720162015
Revenue TTM 10-point trend, -32.0% $4M $37M $371M $1M $915M $719.0K $290M $3M $41M $5M ·
Net Income TTM 10-point trend, -2409.4% $-582M $-366M $-154M $-650M $378M $-349M $67M $-165M $-68M $-23M ·
Market Cap 10-point trend, +524.9% $5.03B $3.37B $5.01B $3.19B $5.83B $11.32B $3.70B $1.48B $953M $805M ·
P/E 10-point trend, -182.0% -8.1 -9.1 -32.3 -4.9 16.1 -28.9 52.1 -8.3 -13.7 -2.9 ·
P/S 10-point trend, +819.4% 1432.7 90.4 13.5 2664.0 6.4 15740.1 12.8 474.2 23.2 155.8 ·
P/B 10-point trend, -24.3% 2.6 1.7 2.7 1.7 2.4 6.8 3.9 3.8 5.1 3.5 ·
P / Tangible Book 6-point trend, -61.5% 2.6 1.7 2.7 1.7 2.4 6.8 · · · · ·
P / Cash Flow 10-point trend, -0.2% -14.6 -23.6 -19.2 -6.4 10.8 -47.5 65.3 -15.4 -13.6 -14.5 ·
P / FCF 10-point trend, -5.4% -14.5 -23.3 -18.6 -6.0 12.8 -44.1 74.1 -15.0 -12.2 -13.8 ·
Earnings Yield 10-point trend, +64.5% -12.3% -11.0% -3.1% -20.6% 6.2% -3.5% 1.9% -12.0% -7.3% -34.8% ·

Bilanci Conto economico, stato patrimoniale, flusso di cassa — annuale, ultimi 5 anni

Conto Economico
2025-12-312024-12-312023-12-312022-12-312021-12-31
Ricavi $4M$37M$371M$1M$915M
Margine Operativo % -18933.7%-1250.4%-60.0%-56190.4%40.8%
Utile netto $-582M$-366M$-154M$-650M$378M
EPS Diluito $-6.47$-4.34$-1.94$-8.36$4.70
Stato Patrimoniale
2025-12-312024-12-312023-12-312022-12-312021-12-31
Rapporto corrente 13.322.117.515.320.2
Quick Ratio 13.222.017.415.019.8
Flusso di cassa
2025-12-312024-12-312023-12-312022-12-312021-12-31
Flusso di cassa libero $-346M$-145M$-270M$-533M$457M

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Proprietari istituzionali (13F) 573 filer · $3.3B totale · Aggiornato al 30 Giugno 2026

Istituzioni che segnalano il possesso di questo titolo nel loro Modulo SEC 13F trimestrale. Solo posizioni lunghe; un singolo depositante può apparire due volte per diverse gambe di opzioni. Grandi posizioni put/call contrapposte riflettono tipicamente market-making o inventario coperto, non convinzione direzionale.

Attività istituzionale — Q2 2026 vs trimestre precedente
Nuove posizioni Posizioni chiuse Aumentato Diminuito Variazione netta delle azioni
89 (0 vs trimestre precedente) 47 (-13 vs trimestre precedente) 148 (-24 vs trimestre precedente) 145 (+21 vs trimestre precedente) +5.4M

Confrontato con Q1 2026. Le dichiarazioni SEC Form 13F sono dovute entro 45 giorni dalla fine del trimestre più un breve margine per i dichiaranti in ritardo — i trimestri ancora all'interno di questa finestra vengono saltati a favore della coppia più recente completamente riportata.

Istituzione Valore Azioni % di 13F tracciati Tipo
ARK Investment Management LLC $515.999.631 9.460.939 15,58% Azioni
Orbis Allan Gray Ltd $296.334.582 5.433.344 8,95% Azioni
Capital World Investors $259.039.094 4.749.525 7,82% Azioni
STATE STREET CORP $235.703.664 4.321.666 7,12% Azioni
GSK plc $175.652.997 3.220.627 5,30% Azioni
GEODE CAPITAL MANAGEMENT, LLC $117.453.717 2.153.015 3,55% Azioni
SR One Capital Management, LP $111.194.134 2.038.763 3,36% Azioni
TWO SIGMA INVESTMENTS, LP $108.459.389 1.988.621 3,27% Azioni
Sumitomo Mitsui Trust Group, Inc. $93.848.832 1.720.734 2,83% Azioni
Amova Asset Management Americas, Inc. $93.762.487 1.720.097 2,83% Azioni
EcoR1 Capital, LLC $75.771.113 1.389.276 2,29% Azioni
Capital International Investors $69.178.918 1.268.407 2,09% Azioni
VANGUARD CAPITAL MANAGEMENT LLC $64.457.935 1.181.847 1,95% Azioni
NEA Management Company, LLC $57.734.408 1.058.570 1,74% Azioni
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $57.694.430 1.057.837 1,74% Azioni
FMR LLC $53.577.751 982.357 1,62% Azioni
D. E. Shaw & Co., Inc. $48.748.506 893.812 1,47% Azioni
VANGUARD PORTFOLIO MANAGEMENT LLC $35.380.807 648.713 1,07% Azioni
UBS Group AG $32.419.612 594.419 0,98% Azioni
VANGUARD FIDUCIARY TRUST CO $31.089.982 570.040 0,94% Azioni
VANGUARD GROUP INC $27.714.225 528.494 0,84% Azioni
CITADEL ADVISORS LLC $25.404.514 465.796 0,77% Azioni
BANK OF AMERICA CORP /DE/ $23.509.740 431.055 0,71% Azioni
SUSQUEHANNA INTERNATIONAL GROUP, LLP $23.298.288 427.178 0,70% Azioni
MILLENNIUM MANAGEMENT LLC $20.836.025 382.032 0,63% Azioni
IQ EQ FUND MANAGEMENT (IRELAND) Ltd $20.833.789 381.991 0,63% Azioni
SUSQUEHANNA INTERNATIONAL GROUP, LLP $18.456.336 338.400 0,56% Opzione Put
SUSQUEHANNA INTERNATIONAL GROUP, LLP $17.763.678 325.700 0,54% Opzione Call
Logos Global Management LP $16.362.000 300.000 0,49% Azioni
CITADEL ADVISORS LLC $15.822.054 290.100 0,48% Opzione Put
Squarepoint Ops LLC $15.641.472 286.789 0,47% Azioni
NORGES BANK $14.767.032 270.756 0,45% Azioni
CITADEL ADVISORS LLC $13.973.148 256.200 0,42% Opzione Call
GOLDMAN SACHS GROUP INC $12.748.193 233.740 0,38% Azioni
JANE STREET GROUP, LLC $12.566.016 230.400 0,38% Opzione Call
PEAK6 LLC $11.633.382 213.300 0,35% Opzione Put
Swiss National Bank $9.228.168 169.200 0,28% Azioni
Susquehanna Portfolio Strategies, LLC $8.945.978 164.026 0,27% Azioni
TWO SIGMA ADVISERS, LP $8.516.256 162.400 0,26% Azioni
LPL Financial LLC $8.376.280 153.581 0,25% Azioni
Bank of New York Mellon Corp $8.337.366 152.867 0,25% Azioni
DIMENSIONAL FUND ADVISORS LP $8.301.261 152.205 0,25% Azioni
Versant Venture Management, LLC $8.117.243 148.831 0,25% Azioni
Pictet Asset Management Holding SA $7.989.776 142.213 0,24% Azioni
Life Cycle Investment Partners Ltd $7.836.962 143.692 0,24% Azioni
TD Asset Management Inc $7.777.513 142.602 0,23% Azioni
AMERICAN CENTURY COMPANIES INC $7.606.257 139.462 0,23% Azioni
RAYMOND JAMES FINANCIAL INC $7.230.750 132.577 0,22% Azioni
RHUMBLINE ADVISERS $6.627.197 121.511 0,20% Azioni
SFE Investment Counsel $6.229.434 16.700 0,19% Opzione Put
Private Advisor Group, LLC $6.060.980 111.129 0,18% Azioni
EverSource Wealth Advisors, LLC $6.032.669 110.610 0,18% Azioni
CONGRESS ASSET MANAGEMENT CO $5.969.567 109.453 0,18% Azioni
BlackRock, Inc. $5.937.061 108.857 0,18% Azioni
D. E. Shaw & Co., Inc. $5.901.228 108.200 0,18% Opzione Call
Campbell & CO Investment Adviser LLC $5.864.632 107.529 0,18% Azioni
JANE STREET GROUP, LLC $5.852.142 107.300 0,18% Opzione Put
California Public Employees Retirement System $5.599.567 102.669 0,17% Azioni
CAPITAL INTERNATIONAL SARL $5.521.521 101.238 0,17% Azioni
Affinity Asset Advisors, LLC $5.454.000 100.000 0,16% Azioni
ALLIANCEBERNSTEIN L.P. $5.439.011 114.337 0,16% Azioni
CLOUGH CAPITAL PARTNERS L P $5.363.300 98.337 0,16% Azioni
Zurcher Kantonalbank (Zurich Cantonalbank) $5.172.465 94.838 0,16% Azioni
Slow Capital, Inc. $5.066.439 92.894 0,15% Azioni
CAPITAL FUND MANAGEMENT S.A. $4.867.258 89.242 0,15% Azioni
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $4.815.606 101.232 0,15% Azioni
VANGUARD ASSET MANAGEMENT, Ltd $4.720.437 86.550 0,14% Azioni
GROUP ONE TRADING LLC $4.638.082 85.040 0,14% Azioni
HIMENSION CAPITAL (SINGAPORE) PTE. LTD. $4.575.742 83.897 0,14% Azioni
STATE OF MICHIGAN RETIREMENT SYSTEM $4.502.113 82.547 0,14% Azioni
Concurrent Investment Advisors, LLC $4.497.728 82.467 0,14% Azioni
WELLS FARGO & COMPANY/MN $4.309.151 79.009 0,13% Azioni
Fisher Asset Management, LLC $4.251.957 77.960 0,13% Azioni
Trexquant Investment LP $4.225.268 77.471 0,13% Azioni
COMMONWEALTH EQUITY SERVICES, LLC $4.194.122 76.900 0,13% Azioni
JONES FINANCIAL COMPANIES LLLP $4.055.652 73.847 0,12% Azioni
Man Group plc $3.992.001 73.194 0,12% Azioni
PEAK6 LLC $3.834.162 70.300 0,12% Opzione Call
ENVESTNET ASSET MANAGEMENT INC $3.822.196 70.081 0,12% Azioni
ALGERT GLOBAL LLC $3.593.095 65.880 0,11% Azioni
Walleye Trading LLC $3.528.738 64.700 0,11% Opzione Put
MILLENNIUM MANAGEMENT LLC $3.146.958 57.700 0,10% Opzione Call
CAPITAL INTERNATIONAL LTD /CA/ $3.057.840 56.066 0,09% Azioni
NOMURA HOLDINGS INC $3.055.713 56.027 0,09% Azioni
Rafferty Asset Management, LLC $3.045.132 55.833 0,09% Azioni
Green Alpha Advisors, LLC $3.043.550 55.804 0,09% Azioni
Walleye Trading LLC $3.005.154 55.100 0,09% Opzione Call
Caption Management, LLC $2.999.700 55.000 0,09% Opzione Call
MetLife Investment Management, LLC $2.958.413 54.243 0,09% Azioni
BENJAMIN EDWARDS INC $2.956.845 54.216 0,09% Azioni
Quantinno Capital Management LP $2.869.349 52.610 0,09% Azioni
Cetera Investment Advisers $2.856.133 52.368 0,09% Azioni
STATE OF WISCONSIN INVESTMENT BOARD $2.788.521 51.128 0,08% Azioni
CITIGROUP INC $2.781.540 51.000 0,08% Opzione Call
CITIGROUP INC $2.781.540 51.000 0,08% Opzione Put
WOLVERINE ASSET MANAGEMENT LLC $2.727.000 50.000 0,08% Opzione Put
OSAIC HOLDINGS, INC. $2.693.150 49.381 0,08% Azioni
Privium Fund Management B.V. $2.452.882 44.974 0,07% Azioni
CANADA PENSION PLAN INVESTMENT BOARD $2.394.306 43.900 0,07% Azioni
TUDOR INVESTMENT CORP ET AL $2.318.604 42.512 0,07% Azioni

Insider aziendali 32 insider · 12 dirigenti · 16 direttori

Insider Ruolo Ultima attività Azioni possedute Acquisti 12m Vendite 12m Netto 12m
Samarth Kulkarni Chief Executive Officer 20 Marzo 2026 M 255.501 0 9 $-10.756.932
Brendan Smith Chief Financial Officer 18 Febbraio 2023 M 5.072 0 0 $0
Michael John Tomsicek Chief Financial Officer 11 Marzo 2021 M 1.891 0 0 $0
Julianne Bruno Chief Operating Officer 20 Marzo 2025 M 10.544 0 0 $0
Lawrence Otto Klein CBO & COO 16 Agosto 2022 A 26.797 0 0 $0
Naimish Patel Chief Medical Officer 29 Maggio 2026 A 19.357 1 2 $-312.892
James R. Kasinger General Counsel and Secretary 29 Maggio 2026 A 94.308 0 5 $-645.902
Phuong Khanh Morrow Chief Medical Officer 13 Ottobre 2023 A 4.411 0 0 $0
Tony W Ho Executive VP, Head of R&D 03 Dicembre 2021 M 52.364 0 0 $0
Tyler Dylan-Hyde Chief Legal Officer 16 Gennaio 2018 M 25.204 0 0 $0
Kala Subramanian Senior Vice President, Strategic Development and Operations 15 Giugno 2017 A 0 0 $0
Sven Ante Lundberg Chief Scientific Officer 24 Ottobre 2016 C 505.617 0 0 $0
Christian Rommel Direttore 05 Giugno 2026 A 0 0 $0
Harold Edward Fleming Direttore 05 Giugno 2026 A 0 0 $0
Douglas A Treco Direttore 05 Giugno 2026 A 0 0 $0
Briggs Morrison Direttore 05 Giugno 2026 A 0 0 $0
Katherine A High Direttore 05 Giugno 2026 A 0 0 $0
Ali Behbahani Direttore 05 Giugno 2026 A 14 0 0 $0
John Greene Direttore 05 Giugno 2026 A 7.000 0 0 $0
Simeon George Direttore 05 Giugno 2026 A 1.730.179 0 0 $0
Maria Fardis Direttore 05 Giugno 2026 A 0 0 $0
Sandesh Mahatme Direttore 05 Giugno 2026 A 0 0 $0
Bradley J Bolzon PhD Direttore 09 Giugno 2022 A 148.831 0 0 $0
Pablo J Cagnoni Direttore 19 Novembre 2019 M 0 0 0 $0
Kurt Von Emster Direttore 18 Dicembre 2018 S 1.171.268 0 0 $0
Thomas Woiwode Direttore 15 Giugno 2018 A 640.014 0 0 $0
Anthony N Coles Direttore 31 Maggio 2017 A 70.000 0 0 $0
CELGENE CORP /DE/ Proprietario del 10% 04 Dicembre 2017 S 3.722.534 0 0 $0
Hadley Harbor Master Investors (Cayman) L.P. Proprietario del 10% 24 Ottobre 2016 C 744.380 0 0 $0
GSK plc Proprietario del 10% 24 Ottobre 2016 C 3.220.627 0 0 $0
Raju Prasad 07 Agosto 2026 G 14.815 0 10 $-5.100.841
Rodger Novak 30 Giugno 2021 S 573.007 0 0 $0

Insider dai depositi SEC Modulo 3/4/5; netto = solo acquisti/vendite di mercato

Attivisti e proprietari del 5%+ 6 partecipazioni

Investitori che hanno depositato SEC Schedule 13D — proprietà effettiva superiore al 5% con l'intento di influenzare l'emittente (partecipazioni attiviste, campagne per il consiglio di amministrazione, M&A). Ogni riga mostra lo stato più recente noto della posizione di quel depositante.

Depositante Depositato Partecipazione Stato Scopo Deposito
Versant Venture Capital IV, L.P., Versant Side Fund IV, L.P., Versant Ventures IV, LLC, Versant Venture Capital V, L.P., Versant Affiliates Fund V, L.P., Versant Ophthalmic Affiliates Fund I, L.P., Versant Ventures V, LLC, Versant Venture Capital V (Canada) LP, Versant Ventures V GP-GP (Canada), Inc., Versant Ventures V (Canada), L.P., Versant Venture Management, LLC ×5 depositi 16 Febbraio 2021 Deposito iniziale SEC
GlaxoSmithKline plc ×5 depositi 10 Luglio 2020 Deposito iniziale SEC
Bayer Global Investments B.V., Bayer AG ×4 depositi 04 Febbraio 2020 Deposito iniziale SEC
Vertex Pharmaceuticals Incorporated (“Vertex US”), Vertex Pharmaceuticals (Europe) Limited (“Vertex Europe”) ×4 depositi 07 Giugno 2019 Deposito iniziale SEC
CELGENE ALPINE INVESTMENT CO. III, LLC, CELGENE CORPORATION ×4 depositi 08 Febbraio 2018 Deposito iniziale SEC
Abingworth LLP 98-051-8585, Abingworth Bioventures VI, LP ×3 depositi 16 Gennaio 2018 Deposito iniziale SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Proprietà ETF Posseduti da 32 ETF

Il peso riflette solo le partecipazioni azionarie dirette (N-PORT); fondi a leva o basati su derivati possono detenere ulteriore esposizione swap non mostrata.

Fondo Peso Unità Aggiornato al Fonte
GNOM · Global X Funds 3,85% 38.191 NS 31 Maggio 2026 N-PORT
IDNA · iShares Trust 1,63% 62.247 SH 08 Agosto 2026 Giornaliero
LABU · Direxion Shares ETF Trust 0,98% 97.235 NS 30 Aprile 2026 N-PORT
IBB · iShares Trust 0,36% 658.537 SH 08 Agosto 2026 Giornaliero
IBBQ · Invesco Exchange-Traded Fund Trust … 0,35% 5.248 SH 08 Agosto 2026 Giornaliero
VTWV · VANGUARD SCOTTSDALE FUNDS 0,28% 70.696 SH 08 Agosto 2026 Giornaliero
IWN · iShares Trust 0,27% 752.223 SH 08 Agosto 2026 Giornaliero
AVSC · AMERICAN CENTURY ETF TRUST 0,21% 104.016 NS 31 Maggio 2026 N-PORT
ISCV · iShares Trust 0,15% 20.568 SH 08 Agosto 2026 Giornaliero
IWM · iShares Trust 0,15% 2.353.025 SH 08 Agosto 2026 Giornaliero
VTWO · VANGUARD SCOTTSDALE FUNDS 0,15% 536.446 SH 08 Agosto 2026 Giornaliero
RSSL · Global X Funds 0,15% 39.589 NS 30 Aprile 2026 N-PORT
PDN · Invesco Exchange-Traded Fund Trust … 0,10% 6.636 SH 08 Agosto 2026 Giornaliero
ISCB · iShares Trust 0,07% 4.136 SH 08 Agosto 2026 Giornaliero
SMLF · iShares Trust 0,07% 57.970 SH 08 Agosto 2026 Giornaliero
VXF · VANGUARD INDEX FUNDS 0,06% 1.106.455 SH 08 Agosto 2026 Giornaliero
ESML · iShares Trust 0,06% 33.283 SH 08 Agosto 2026 Giornaliero
AVIE · AMERICAN CENTURY ETF TRUST 0,06% 108 NS 31 Maggio 2026 N-PORT
WSML · iShares Trust 0,04% 5.486 SH 08 Agosto 2026 Giornaliero
VTWG · VANGUARD SCOTTSDALE FUNDS 0,04% 13.170 SH 08 Agosto 2026 Giornaliero
IWO · iShares Trust 0,04% 109.974 SH 08 Agosto 2026 Giornaliero
OMFS · Invesco Exchange-Traded Self-Indexe… 0,03% 1.736 SH 08 Agosto 2026 Giornaliero
XT · iShares Trust 0,03% 21.837 SH 08 Agosto 2026 Giornaliero
MSSM · MORGAN STANLEY PATHWAY FUNDS 0,03% 3.509 NS 31 Maggio 2026 N-PORT
VTHR · VANGUARD SCOTTSDALE FUNDS 0,01% 7.774 SH 08 Agosto 2026 Giornaliero
ESGV · VANGUARD WORLD FUND 0,01% 20.627 SH 08 Agosto 2026 Giornaliero
IYY · iShares Trust 0,01% 4.231 SH 08 Agosto 2026 Giornaliero
ITOT · iShares Trust 0,01% 128.511 SH 08 Agosto 2026 Giornaliero
AVUS · AMERICAN CENTURY ETF TRUST 0,01% 15.609 NS 31 Maggio 2026 N-PORT
IWV · iShares Trust 0,01% 25.457 SH 08 Agosto 2026 Giornaliero
AVSU · AMERICAN CENTURY ETF TRUST 0,00% 289 NS 31 Maggio 2026 N-PORT
VT · VANGUARD INTERNATIONAL EQUITY INDEX… 0,00% 75.392 SH 08 Agosto 2026 Giornaliero