CYTK Cytokinetics, Incorporated - Common Stock

NASDAQ · Biotechnology · Visualizza su SEC EDGAR ↗
$76,48
Prezzo · Ago 18, 2026
Fondamentali al Ago 6, 2026

Informazioni su Cytokinetics, Incorporated - Common Stock Panoramica della società da Wikipedia

Cytokinetics, Incorporated, is a biopharmaceutical company based in South San Francisco, California, that develops muscle activators and muscle inhibitors as potential treatments for people with diseases characterized by impaired or declining muscle function.

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Cytokinetics, Incorporated, is a biopharmaceutical company based in South San Francisco, California, that develops muscle activators and muscle inhibitors as potential treatments for people with diseases characterized by impaired or declining muscle function.

History

Cytokinetics was founded in 1997 by James Spudich, Ronald Vale, James Sabry and Lawrence S.B. Goldstein, four scientists at Stanford, UCSD, and UCSF. Operations began in 1998.

Initially, Cytokinetics focused on the possible pharmacological targets and areas of application of drugs based on cytoskeletal proteins. Eventually, the company narrowed its focus to the mechanics of muscle biology. Cytokinetics develops muscle activators and muscle inhibitors to improve muscle function in patients with cardiovascular and neuromuscular diseases.

In 2004 the company completed its initial public offering (IPO).

In January 2007, Cytokinetics named Robert I. Blum as president and CEO. Prior to this, Blum has been involved in the company since its founding, with roles in business development, corporate development and R&D.

In 2013, Cytokinetics finalized a licensing and discovery deal with Astellas to research treatment for muscle weakness and fatigue.

In July 2020, Ji Xing Pharmaceuticals signed a financing deal with Cytokinetics, which included the rights to commercialize the drug designed to treat hypertrophic cardiomyopathies, aficamten, in China and certain neighboring regions.

Products

Omecamtiv mecarbil is a cardiac muscle activator for the potential treatment of heart failure. In May 2020, omecamtiv mecarbil was granted fast track designation by the FDA for the treatment of chronic HF with reduced ejection fraction. Amgen purchased an option on omecamtiv mecarbil in 2006, and the two companies extended their partnership several times. In June 2013, Cytokinetics and Amgen expanded their licensing deal for omecamtiv mecarbil to include Japan. In November 2020 Amgen elected to terminate the collaboration, effective May 20, 2021, and Cytokinetics regained worldwide rights to develop and commercialize omecamtiv mecarbil.

Reldesemtiv (previously known as CK-2127107) is a next-generation fast skeletal muscle troponin activator (FSTA) that has undergone clinical trials for ALS.

Aficamten (previously known as CK-3773274) is an oral, small-molecule myosin inhibitor, to treat hypertrophic cardiomyopathy (HCM).

Fonte: Wikipedia (Inglese), CC BY-SA 4.0 · Vedi su Wikipedia ↗

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CYTK Snapshot del titolo Prezzo, capitalizzazione di mercato, P/E, EPS, ROE, debito/capitale proprio, intervallo 52 settimane

Prezzo
$76.48
Capitalizzazione di Mercato
$9.40B
P/E (TTM)
-11.7
EPS (TTM)
$-6.54
Ricavi (TTM)
$88M
Rendimento div.
ROE
152.7%
D/E Debito/Patrimonio
-0.4
Intervallo 52 sett.
$35 – $88

CYTK Grafico del prezzo delle azioni OHLCV giornaliero con indicatori tecnici — panoramica, zoom e personalizza la tua visualizzazione

Performance decennale Andamento di ricavi, utile netto, margini e EPS

Ricavi e Utile Netto $88M
10-point trend, -17.3%
2016-12-31 2025-12-31
EPS $-6.54
8-point trend, -1776.9%
2016-12-31 2025-12-31
Flusso di cassa libero $-535M
10-point trend, -1611.4%
2016-12-31 2025-12-31
Margini -891.6%

Valutazione Rapporti P/E, P/S, P/B, EV/EBITDA — il titolo è costoso o economico?

Metrica
Tendenza 5 anni
CYTK
Mediana dei peer
P/E (TTM)
5-point trend, +40.3%
-11.7
28.5
P/S (TTM)
5-point trend, +61.7%
106.8
20.1
P/B
5-point trend, -174.7%
-14.3
12.9
EV / EBITDA
5-point trend, +35.8%
-15.9
Price / FCF (Prezzo / FCF)
5-point trend, +27.7%
-17.6

Redditività Margini lordi, operativi e netti; ROE, ROA, ROIC

Metrica
Tendenza 5 anni
CYTK
Mediana dei peer
Operating Margin (Margine Operativo)
5-point trend, -162.9%
-695.4%
Net Profit Margin (Margine di Profitto Netto)
5-point trend, -191.6%
-891.6%
-48.4%
ROA
5-point trend, -77.4%
-55.5%
-28.4%
ROE
5-point trend, +274.7%
152.7%
-49.2%

Salute finanziaria Debito, liquidità, solvibilità — solidità del bilancio

Metrica
Tendenza 5 anni
CYTK
Mediana dei peer
Debt / Equity (Debito / Patrimonio Netto)
5-point trend, -324.5%
-0.4
Current Ratio (Rapporto corrente)
5-point trend, -39.2%
4.5
5.0
Quick Ratio
5-point trend, -69.7%
0.7

Crescita Crescita di ricavi, EPS e utile netto: YoY, CAGR 3Y, CAGR 5Y

Metrica
Tendenza 5 anni
CYTK
Mediana dei peer
Revenue YoY (Ricavi YoY)
5-point trend, +25.0%
376.6%
Revenue CAGR 3Y (CAGR Ricavi 3Y)
5-point trend, +25.0%
-2.4%
Revenue CAGR 5Y (CAGR Ricavi 5Y)
5-point trend, +25.0%
9.5%

Metriche per Azione EPS, valore contabile per azione, flusso di cassa per azione, dividendo per azione

Metrica
Tendenza 5 anni
CYTK
Mediana dei peer
EPS (Diluted) (EPS (Diluito))
5-point trend, -133.6%
$-6.54

Efficienza del Capitale Rotazione delle attività, rotazione delle scorte, rotazione dei crediti

Metrica
Tendenza 5 anni
CYTK
Mediana dei peer

CYTK Consenso degli analisti Opinioni degli analisti, sia rialziste che ribassiste, target price a 12 mesi, potenziale di rialzo

COMPRA 28 analisti
  • Acquisto forte 6 21,4%
  • Compra 19 67,9%
  • Mantieni 3 10,7%
  • Vendi 0 0,0%
  • Vendita forte 0 0,0%

Target Price a 12 Mesi

20 analisti · 2026-08-18
Target mediano $107.50 +40,6%
Target medio $109.90 +43,7%

Cronologia utili EPS effettivo vs stima, surprise %, tasso di superamento, data prossimi utili

Sorpresa media
-0.08%
Periodo EPS Actual EPS Stimato Sorpresa
30 Giugno 2026 $-1.50 $-1.67 0.17%
31 Marzo 2026 $-1.67 $-1.69 0.02%
31 Dicembre 2025 $-1.50 $-1.49 -0.01%
30 Settembre 2025 $-2.55 $-1.61 -0.94%
30 Giugno 2025 $-1.12 $-1.41 0.28%
31 Marzo 2025 $-1.39 $-1.41 0.02%

Confronto Peer (GICS sub-settore industriale) Metriche chiave rispetto ai pari del settore

Ticker Capitalizzazione di Mercato P/E Rev YoY Margine Netto ROE Margine lordo
CYTK $7.81B -9.7 376.6% -891.6% 152.7%
ARWR $4.68B -3449.0 23258.2% -0.20% -0.50%
MDGL $13.30B -45.3 432.1% -30.1% -44.4%
HALO $7.93B 26.3 37.5% 22.7% 166.1%
PRAX $7.43B -21.9 249.5% -47.3%
APGE $5.16B -17.9
PTGX $5.47B -42.6 -89.4% -282.8% -20.3%
KRYS $7.20B 36.0 33.9% 52.6% 18.1%
KYMR $6.33B -21.1 -16.7% -794.0% -24.4%
SMMT $13.56B -12.1 -235.1%

Fondamentali Completi Tutte le metriche per anno — conto economico, stato patrimoniale, rendiconto finanziario

Conto Economico 16
Dati annuali Conto Economico per CYTK
Metrica Tendenza 202520242023202220212020201920182017201620152014
Revenue 12-point trend, +87.6% $88M $18M $8M $95M $70M $56M $27M $32M $13M $106M $29M $47M
R&D Expense 12-point trend, +836.4% $416M $339M $330M $241M $160M $97M $86M $89M $90M $60M $46M $44M
SG&A Expense 12-point trend, +1546.2% $284M $215M $174M $178M $97M $53M $40M $31M $36M $28M $20M $17M
Operating Expenses 12-point trend, +1035.1% $700M $555M $504M $419M $257M $150M $126M $120M $127M $88M $66M $62M
Operating Income 12-point trend, -4049.8% $-612M $-536M $-496M $-324M $-186M $-94M $-99M $-89M $-113M $19M $-37M $-15M
Interest Expense 12-point trend, +45579000.00 $46M $38M $28M $19M $16M $16M $7M $4M $3M $3M $268.0K $0
Interest Income 8-point trend, +11187.1% · · · $11M $1M $5M $4M $4M · $449.0K $156.0K $101.0K
Other Non-op 12-point trend, +44733.3% $48M $52M $28M $11M $331.0K $5M $5M $4M $3M $464.0K $174.0K $108.0K
Pretax Income 5-point trend, -625.7% · · · · · · · $-106M $-128M $16M $-38M $-15M
Income Tax Flat — no change across 12 periods $0 $0 $0 $0 $0 $0 $0 $0 $0 $0 $0 $0
Net Income 12-point trend, -5259.5% $-785M $-590M $-526M $-389M $-215M $-127M $-122M $-106M $-128M $16M $-38M $-15M
EPS (Basic) 10-point trend, -1495.1% $-6.54 $-5.26 $-5.45 $-4.33 $-2.80 $-1.97 · · $-2.59 $0.41 $-0.97 $-0.41
EPS (Diluted) 10-point trend, -1495.1% $-6.54 $-5.26 $-5.45 $-4.33 $-2.80 $-1.97 · · $-2.59 $0.39 $-0.97 $-0.41
Shares (Basic) 10-point trend, -99.7% 120,103 111,979 96,524 89,825 76,886 64,524 · · 49,404,000 39,943,000 38,814,000 35,709,000
Shares (Diluted) 10-point trend, -99.7% 120,103 111,979 96,524 89,825 76,886 64,524 · · 49,404,000 42,561,000 38,814,000 35,709,000
EBITDA 12-point trend, -4121.3% $-602M $-527M $-484M $-318M $-184M $-92M $-98M $-88M $-111M $19M $-37M $-14M
Stato Patrimoniale 26
Dati annuali Stato Patrimoniale per CYTK
Metrica Tendenza 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +506.1% $123M $95M $113M $66M $113M $83M $36M $42M $125M $67M $65M $20M
Receivables 10-point trend, +73916.7% $18M $17M $1M $147.0K $52M $4M $5M $2M $1M $24.0K · ·
Inventory $0 · · · · · · · · · · ·
Prepaid Expense 12-point trend, +1251.6% $17M $15M $12M $12M $12M $6M $3M $2M $4M $2M $2M $1M
Other Current Assets · · · · · · · · · · · $1M
Current Assets 12-point trend, +599.3% $917M $1.11B $628M $795M $536M $474M $234M $208M $274M $159M $113M $131M
PP&E (Net) 12-point trend, +4737.8% $79M $66M $69M $80M $73M $13M $5M $3M $4M $4M $2M $2M
PP&E (Gross) 12-point trend, +475.9% $126M $103M $97M $98M $89M $38M $29M $27M $26M $25M $23M $22M
Accum. Depreciation 12-point trend, +132.7% $47M $37M $28M $17M $16M $25M $24M $24M $23M $21M $21M $20M
Other Non-current Assets 11-point trend, +8570.5% $17M $8M $8M $10M $7M $6M · $300.0K $429.0K $200.0K $200.0K $200.0K
Total Assets 12-point trend, +971.3% $1.42B $1.40B $824M $1.01B $841M $534M $290M $211M $295M $170M $115M $133M
Accounts Payable 12-point trend, +1541.2% $22M $20M $22M $26M $21M $8M $8M $4M $5M $4M $2M $1M
Accrued Liabilities 12-point trend, +1442.2% $83M $55M $43M $44M $34M $19M $12M $16M $17M $18M $8M $5M
Current Liabilities 12-point trend, +748.7% $202M $180M $103M $85M $72M $31M $26M $22M $32M $33M $32M $24M
Capital Leases 8-point trend, +13903.9% $108M $113M $120M $127M $112M $440.0K $2M $771.0K · · · ·
Other Non-current Liabilities 8-point trend, -100.0% · $0 $186.0K $1M $4M $0 · $771.0K $1M $142.0K · ·
Total Liabilities 12-point trend, +4995.3% $2.08B $1.54B $1.21B $1.12B $597M $420M $301M $185M $185M $76M $47M $41M
Long-term Debt 10-point trend, +1864.4% $288M $620M $639M $650M · $46M $45M $42M $32M $30M $15M ·
Total Debt 11-point trend, +1864.4% $288M $105M $68M $64M $47M $46M $45M $42M $32M $30M $15M ·
Common Stock 12-point trend, +215.4% $123.0K $118.0K $102.0K $94.0K $84.0K $70.0K $59.0K $55.0K $54.0K $41.0K $40.0K $39.0K
Paid-in Capital 2-point trend, +146.5% · · · · $1.45B · · · · · · $589M
Retained Earnings 12-point trend, -601.2% $-3.49B $-2.70B $-2.11B $-1.59B $-1.21B $-992M $-865M $-743M $-646M $-518M $-535M $-497M
AOCI 12-point trend, +15850.0% $630.0K $2M $-10.0K $-4M $-869.0K $149.0K $679.0K $500.0K $343.0K $137.0K $149.0K $-4.0K
Stockholders' Equity 12-point trend, -816.5% $-660M $-135M $-386M $-108M $244M $113M $-11M $26M $110M $94M $69M $92M
Liabilities + Equity 12-point trend, +971.3% $1.42B $1.40B $824M $1.01B $841M $534M $290M $211M $295M $170M $115M $133M
Shares Outstanding 12-point trend, +218.0% 122,943,172 118,209,139 101,637,922 94,833,975 84,799,542 71,015,183 59,172,124 54,717,906 53,960,832 40,646,595 39,581,692 38,659,738
Flusso di cassa 16
Dati annuali Flusso di cassa per CYTK
Metrica Tendenza 202520242023202220212020201920182017201620152014
D&A 12-point trend, +1966.3% $10M $10M $12M $6M $2M $2M $1M $1M $2M $741.0K $589.0K $490.0K
Stock-based Comp 12-point trend, +3272.0% $112M $98M $72M $48M $27M $18M $11M $10M $9M $7M $5M $3M
Deferred Tax Flat — no change across 3 periods · · · · · · · · · $0 $0 $0
Restructuring · · · · · · · · · · · $0
Other Non-cash 12-point trend, +548.4% $153M $86M $28M $36M $44M $117M $19M $-6M $15M $13M $37M $-34M
Operating Cash Flow 12-point trend, -1037.3% $-510M $-396M $-414M $-300M $-143M $9M $-91M $-101M $-102M $37M $5M $-45M
CapEx 12-point trend, +2147.0% $25M $4M $1M $11M $49M $11M $3M $889.0K $3M $2M $562.0K $1M
Investing Cash Flow 9-point trend, +125.3% $17M $-553M $239M $-262M $-148M $-197M $-75M $5M $-66M · · ·
Net Debt Issued 3-point trend, +77.3% $-11M $-9M · $-48M · · · · · · · ·
Stock Issued 9-point trend, +235.4% · · $164M · $0 $0 $36M $0 $112M $0 $9M $49M
Net Stock Activity 9-point trend, +235.4% · · $164M · $0 $0 $36M $0 $112M $0 $9M $49M
Financing Cash Flow 9-point trend, +132.1% $524M $931M $221M $516M $320M $234M $160M $13M $226M · · ·
Net Change in Cash 12-point trend, +53233.3% $30M $-18M $46M $-45M $30M $47M $-6M $-83M $58M $2M $45M $57.0K
Taxes Paid 8-point trend, -100.0% $0 $0 $0 · · · · $1.0K $1.0K $1.0K $1.0K $1.0K
Free Cash Flow 12-point trend, -1064.0% $-535M $-400M $-416M $-311M $-191M $-2M $-94M $-102M $-105M $35M $4M $-46M
Levered FCF 4-point trend, -130.5% · · · · · · · $-106M $-108M $33M · $-46M
Redditività 7
Dati annuali Redditività per CYTK
Metrica Tendenza 202520242023202220212020201920182017201620152014
Operating Margin 12-point trend, -2112.7% -695.4% -2902.7% -6589.7% -342.8% -264.5% -168.3% -368.0% -282.3% -848.3% 17.6% -130.5% -31.4%
Net Margin 12-point trend, -2757.7% -891.6% -3191.1% -6988.6% -411.2% -305.7% -228.0% -452.9% -337.4% -955.9% 15.5% -130.9% -31.2%
Pretax Margin 5-point trend, -981.4% · · · · · · · -337.4% -955.9% 15.5% -130.9% -31.2%
EBITDA Margin 12-point trend, -2150.5% -683.9% -2851.1% -6431.8% -336.6% -261.3% -165.0% -363.2% -278.3% -833.9% 18.3% -128.5% -30.4%
ROA 12-point trend, -310.0% -55.5% -53.0% -57.2% -41.9% -31.3% -30.9% -48.6% -42.0% -55.0% 11.5% -30.2% -13.6%
ROE 12-point trend, +863.7% 152.7% 789.8% 127.6% 628.0% -87.4% -96.8% 790.0% -272.5% -125.2% 20.2% -46.7% -20.0%
ROIC 5-point trend, -711.5% · · · · · · · -130.1% -80.1% 15.0% -44.9% -16.0%
Liquidità e Solvibilità 5
Dati annuali Liquidità e Solvibilità per CYTK
Metrica Tendenza 202520242023202220212020201920182017201620152014
Current Ratio 12-point trend, -17.6% 4.5 6.2 6.1 9.4 7.5 15.2 9.0 9.4 8.5 4.8 3.6 5.5
Quick Ratio 12-point trend, -18.2% 0.7 0.6 1.1 0.8 2.3 2.8 1.6 2.0 3.9 2.0 2.1 0.8
Debt / Equity 11-point trend, -304.3% -0.4 -0.8 -0.2 -0.6 0.2 0.4 -4.1 1.6 0.3 0.3 0.2 ·
LT Debt / Equity 11-point trend, -275.0% -0.4 -0.7 -0.2 -0.6 0.2 0.4 -4.1 1.5 0.3 0.3 0.2 ·
Interest Coverage 10-point trend, -293.9% -13.4 -14.2 -17.5 -16.7 -11.3 -5.9 -14.9 -23.4 -37.6 6.9 · ·
Efficienza 2
Dati annuali Efficienza per CYTK
Metrica Tendenza 202520242023202220212020201920182017201620152014
Asset Turnover 12-point trend, -85.7% 0.1 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.7 0.2 0.4
Receivables Turnover 9-point trend, -78.3% 5.1 2.1 10.5 3.6 2.5 11.7 7.3 18.8 23.5 · · ·
Per Azione 5
Dati annuali Per Azione per CYTK
Metrica Tendenza 202520242023202220212020201920182017201620152014
Book Value / Share 12-point trend, -325.3% $-5.37 $-1.15 $-3.80 $-1.14 $2.88 $1.60 $-0.18 $0.47 $2.04 $2.32 $1.73 $2.38
Revenue / Share 6-point trend, +29220.0% $733.03 $164.98 $78.01 $1053.03 · · · · $0.27 $2.50 · ·
Cash Flow / Share 6-point trend, -488813.3% $-4246.43 $-3535.39 $-4292.54 $-3334.44 · · · · $-2.06 $0.87 · ·
Cash / Share 12-point trend, +90.6% $1.00 $0.80 $1.11 $0.69 $1.33 $1.17 $0.62 $0.77 $2.32 $1.65 $1.64 $0.52
EPS (TTM) 10-point trend, -1495.1% $-6.54 $-5.26 $-5.45 $-4.33 $-2.80 $-1.97 · · $-2.59 $0.39 $-0.97 $-0.41
Tassi di Crescita 3
Dati annuali Tassi di Crescita per CYTK
Metrica Tendenza 202520242023202220212020201920182017201620152014
Revenue YoY 5-point trend, +1340.0% 376.6% 145.3% -92.0% 34.3% 26.2% · · · · · · ·
Revenue CAGR 3Y 3-point trend, +95.2% -2.4% -36.0% -48.7% · · · · · · · · ·
Revenue CAGR 5Y 9.5% · · · · · · · · · · ·
Valutazione (TTM) 14
Dati annuali Valutazione (TTM) per CYTK
Metrica Tendenza 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +87.6% $88M $18M $8M $95M $70M $56M $27M $32M $13M $106M $29M $47M
Net Income TTM 12-point trend, -5259.5% $-785M $-590M $-526M $-389M $-215M $-127M $-122M $-106M $-128M $16M $-38M $-15M
Market Cap 12-point trend, +2422.7% $7.81B $5.56B $8.49B $4.35B $3.87B $1.48B $628M $346M $440M $494M $414M $310M
Enterprise Value 11-point trend, +2093.9% $7.98B $5.57B $8.44B $4.34B $3.80B $1.44B $636M $346M $346M $457M $364M ·
P/E 10-point trend, +50.3% -9.7 -8.9 -15.3 -10.6 -16.3 -10.5 · · -3.1 31.2 -10.8 -19.5
P/S 12-point trend, +1245.0% 88.7 301.0 1126.9 45.9 54.9 26.4 23.4 11.0 32.9 4.6 14.4 6.6
P/B 12-point trend, -452.1% -11.8 -41.1 -22.0 -40.3 15.8 13.0 -57.4 13.3 4.0 5.2 6.0 3.4
P / Tangible Book 2-point trend, +21.8% · · · · 15.8 13.0 · · · · · ·
P / Cash Flow 12-point trend, -121.8% -15.3 -14.0 -20.5 -14.5 -27.1 165.0 -6.9 -3.4 -4.3 13.4 84.8 -6.9
P / FCF 12-point trend, -116.7% -14.6 -13.9 -20.4 -14.0 -20.2 -699.7 -6.7 -3.4 -4.2 14.0 95.8 -6.7
EV / EBITDA 11-point trend, -34.1% -13.2 -10.6 -17.4 -13.6 -20.6 -15.6 -6.5 -3.9 -3.1 23.5 -9.9 ·
EV / FCF 11-point trend, -117.7% -14.9 -13.9 -20.3 -14.0 -19.9 -682.3 -6.8 -3.4 -3.3 12.9 84.1 ·
EV / Revenue 11-point trend, +614.2% 90.6 301.5 1121.0 45.9 54.0 25.8 23.7 11.0 25.9 4.3 12.7 ·
Earnings Yield 10-point trend, -101.0% -10.3% -11.2% -6.5% -9.4% -6.1% -9.5% · · -31.8% 3.2% -9.3% -5.1%

Bilanci Conto economico, stato patrimoniale, flusso di cassa — annuale, ultimi 5 anni

Conto Economico
2025-12-312024-12-312023-12-312022-12-312021-12-31
Ricavi $88M$18M$8M$95M$70M
Margine Operativo % -695.4%-2902.7%-6589.7%-342.8%-264.5%
Utile netto $-785M$-590M$-526M$-389M$-215M
EPS Diluito $-6.54$-5.26$-5.45$-4.33$-2.80
Stato Patrimoniale
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debito / Patrimonio Netto -0.4-0.8-0.2-0.60.2
Rapporto corrente 4.56.26.19.47.5
Quick Ratio 0.70.61.10.82.3
Flusso di cassa
2025-12-312024-12-312023-12-312022-12-312021-12-31
Flusso di cassa libero $-535M$-400M$-416M$-311M$-191M

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Proprietari istituzionali (13F) 539 filer · $9.0B totale · Aggiornato al 30 Giugno 2026

Istituzioni che segnalano il possesso di questo titolo nel loro Modulo SEC 13F trimestrale. Solo posizioni lunghe; un singolo depositante può apparire due volte per diverse gambe di opzioni. Grandi posizioni put/call contrapposte riflettono tipicamente market-making o inventario coperto, non convinzione direzionale.

Attività istituzionale — Q2 2026 vs trimestre precedente
Nuove posizioni Posizioni chiuse Aumentato Diminuito Variazione netta delle azioni
104 (+7 vs trimestre precedente) 49 (-8 vs trimestre precedente) 222 (+45 vs trimestre precedente) 112 (-32 vs trimestre precedente) +17.8M

Confrontato con Q1 2026. Le dichiarazioni SEC Form 13F sono dovute entro 45 giorni dalla fine del trimestre più un breve margine per i dichiaranti in ritardo — i trimestri ancora all'interno di questa finestra vengono saltati a favore della coppia più recente completamente riportata.

Istituzione Valore Azioni % di 13F tracciati Tipo
VANGUARD PORTFOLIO MANAGEMENT LLC $571.778.157 6.711.799 6,37% Azioni
STATE STREET CORP $553.243.709 6.494.233 6,16% Azioni
VANGUARD CAPITAL MANAGEMENT LLC $521.151.103 6.117.515 5,80% Azioni
WELLINGTON MANAGEMENT GROUP LLP $509.521.049 5.980.996 5,68% Azioni
Avoro Capital Advisors LLC $425.949.915 4.999.999 4,74% Azioni
FMR LLC $375.035.430 4.402.341 4,18% Azioni
GEODE CAPITAL MANAGEMENT, LLC $259.207.450 3.042.018 2,89% Azioni
BANK OF AMERICA CORP /DE/ $251.706.463 2.954.648 2,80% Azioni
RTW INVESTMENTS, LP $243.814.036 2.862.003 2,72% Azioni
Polar Capital Holdings Plc $191.988.358 2.253.649 2,14% Azioni
SUSQUEHANNA INTERNATIONAL GROUP, LLP $161.060.214 1.890.600 1,79% Opzione Call
Capital Research Global Investors $143.683.584 1.686.625 1,60% Azioni
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC $136.597.224 1.603.442 1,52% Azioni
Integral Health Asset Management, LLC $136.304.000 1.600.000 1,52% Azioni
Point72 Asset Management, L.P. $135.257.185 1.587.712 1,51% Azioni
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $133.386.924 1.565.758 1,49% Azioni
SUSQUEHANNA INTERNATIONAL GROUP, LLP $131.998.327 1.549.458 1,47% Azioni
PRINCIPAL FINANCIAL GROUP INC $111.435.932 1.308.087 1,24% Azioni
Capital International Investors $111.245.191 1.305.848 1,24% Azioni
ARMISTICE CAPITAL, LLC $106.487.500 1.250.000 1,19% Opzione Call
ARMISTICE CAPITAL, LLC $102.342.325 1.201.342 1,14% Azioni
Pictet Asset Management Holding SA $99.038.455 1.160.463 1,10% Azioni
Frazier Life Sciences Management, L.P. $98.810.092 1.159.879 1,10% Azioni
Holocene Advisors, LP $97.506.685 1.144.579 1,09% Azioni
Woodline Partners LP $93.769.315 1.100.708 1,04% Azioni
NORGES BANK $86.512.319 1.015.522 0,96% Azioni
Royalty Pharma Sub-Manager, LLC $83.519.594 980.392 0,93% Azioni
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $81.937.000 961.815 0,91% Azioni
VANGUARD FIDUCIARY TRUST CO $77.218.175 906.423 0,86% Azioni
CITADEL ADVISORS LLC $77.062.874 904.600 0,86% Opzione Call
Melqart Asset Management (UK) Ltd $65.385.455 767.525 0,73% Azioni
Siren, L.L.C. $64.655.121 758.952 0,72% Azioni
Fisher Asset Management, LLC $63.355.547 743.697 0,71% Azioni
Foresite Capital Management IV, LLC $60.884.867 714.695 0,68% Azioni
Balyasny Asset Management L.P. $60.599.821 711.349 0,67% Azioni
Deep Track Capital, LP $59.633.000 700.000 0,66% Azioni
JANE STREET GROUP, LLC $59.633.000 700.000 0,66% Opzione Call
BNP PARIBAS FINANCIAL MARKETS $58.702.470 689.077 0,65% Azioni
Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. $56.251.809 660.310 0,63% Azioni
CITADEL ADVISORS LLC $54.601.338 640.936 0,61% Azioni
GOLDMAN SACHS GROUP INC $54.053.311 634.503 0,60% Azioni
Qube Research & Technologies Ltd $48.774.257 572.535 0,54% Azioni
EVENTIDE ASSET MANAGEMENT, LLC $48.081.832 564.398 0,54% Azioni
Affinity Asset Advisors, LLC $46.854.500 550.000 0,52% Azioni
First Turn Management, LLC $44.930.228 527.412 0,50% Azioni
AMERICAN CENTURY COMPANIES INC $44.162.525 518.398 0,49% Azioni
Caption Management, LLC $43.651.356 512.400 0,49% Opzione Call
D. E. Shaw & Co., Inc. $40.874.247 479.801 0,46% Azioni
Checkpoint Capital L.P. $40.465.250 475.000 0,45% Azioni
Hood River Capital Management LLC $39.977.367 469.273 0,45% Azioni
RP Management, LLC $39.401.954 980.392 0,44% Azioni
EMERALD ADVISERS, LLC $39.013.272 457.956 0,43% Azioni
ADAR1 Capital Management, LLC $39.009.097 457.907 0,43% Azioni
AMERIPRISE FINANCIAL INC $38.010.006 446.179 0,42% Azioni
Candriam S.C.A. $37.708.477 443.066 0,42% Azioni
MARSHALL WACE, LLP $36.259.335 425.629 0,40% Azioni
RHUMBLINE ADVISERS $35.933.015 421.799 0,40% Azioni
CITADEL ADVISORS LLC $35.882.028 421.200 0,40% Opzione Put
ALLIANCEBERNSTEIN L.P. $35.327.299 535.993 0,39% Azioni
GILDER GAGNON HOWE & CO LLC $34.096.829 400.245 0,38% Azioni
TD Asset Management Inc $32.809.225 385.130 0,37% Azioni
BlackRock, Inc. $29.124.928 341.882 0,32% Azioni
GSK plc $29.001.573 340.434 0,32% Azioni
TWO SIGMA INVESTMENTS, LP $27.040.243 317.411 0,30% Azioni
CITIGROUP INC $26.852.314 315.205 0,30% Azioni
SUSQUEHANNA INTERNATIONAL GROUP, LLP $24.671.024 289.600 0,27% Opzione Put
Trails Edge Capital Partners, LP $24.542.302 288.089 0,27% Azioni
EMERALD MUTUAL FUND ADVISERS TRUST $23.833.521 279.769 0,27% Azioni
Polaris Capital Management, LLC $22.737.211 266.900 0,25% Azioni
SEGALL BRYANT & HAMILL, LLC $21.899.197 257.063 0,24% Azioni
Alyeska Investment Group, L.P. $21.297.500 250.000 0,24% Azioni
ExodusPoint Capital Management, LP $21.234.374 249.259 0,24% Azioni
Capital World Investors $21.196.550 248.815 0,24% Azioni
Walleye Capital LLC $20.422.428 239.728 0,23% Azioni
E. Ohman J:or Asset Management AB $19.823.223 300.762 0,22% Azioni
Sarissa Capital Management LP $19.476.393 228.623 0,22% Azioni
Swiss National Bank $18.946.256 222.400 0,21% Azioni
SPHERA FUNDS MANAGEMENT LTD. $18.740.693 219.987 0,21% Azioni
BAKER BROS. ADVISORS LP $17.997.836 211.267 0,20% Azioni
California Public Employees Retirement System $17.979.520 211.052 0,20% Azioni
Nicholas Investment Partners, LP $17.810.758 209.071 0,20% Azioni
PINNACLE ASSOCIATES LTD $17.245.864 202.440 0,19% Azioni
Mirador Capital Partners LP $17.239.900 202.370 0,19% Azioni
Tri Locum Partners LP $16.526.860 194.000 0,18% Azioni
PFM Health Sciences, LP $16.329.730 191.686 0,18% Azioni
Rock Springs Capital Management LP $16.014.016 187.980 0,18% Azioni
PRUDENTIAL FINANCIAL INC $15.933.512 187.035 0,18% Azioni
DAFNA Capital Management LLC $14.652.510 171.998 0,16% Azioni
Ghisallo Capital Management LLC $14.482.300 170.000 0,16% Azioni
Impax Asset Management Group plc $14.056.350 165.000 0,16% Azioni
Lombard Odier Asset Management (Europe) Ltd $13.494.096 158.400 0,15% Opzione Call
KINGDON CAPITAL MANAGEMENT, L.L.C. $13.383.349 157.100 0,15% Azioni
MANUFACTURERS LIFE INSURANCE COMPANY, THE $13.330.276 156.477 0,15% Azioni
JANE STREET GROUP, LLC $12.735.905 149.500 0,14% Opzione Put
SCHRODER INVESTMENT MANAGEMENT GROUP $12.145.719 139.190 0,14% Azioni
Retirement Systems of Alabama $11.962.891 140.426 0,13% Azioni
MetLife Investment Management, LLC $11.930.519 140.046 0,13% Azioni
Polymer Capital Management (HK) LTD $11.777.943 138.255 0,13% Azioni
Cinctive Capital Management LP $11.742.419 137.838 0,13% Azioni
TUDOR INVESTMENT CORP ET AL $11.279.156 132.400 0,13% Opzione Call

Insider aziendali 52 insider · 18 dirigenti · 22 direttori

Insider Ruolo Ultima attività Azioni possedute Acquisti 12m Vendite 12m Netto 12m
Sung Lee EVP, Chief Financial Officer 01 Luglio 2026 M 63.221 0 5 $-5.695.855
Ching Jaw SVP Finance & CFO 06 Marzo 2023 A 87.346 0 0 $0
Sharon Surrey Barbari EVP, Finance & CFO 28 Febbraio 2017 F 40.323 0 0 $0
Fady Ibraham Malik EVP Research & Development 18 Agosto 2026 M 153.902 0 22 $-4.429.370
Andrew Callos EVP, Chief Commercial Officer 30 Luglio 2026 M 58.555 0 24 $-15.318.893
Jeffrey Hessekiel Chief Legal & Admin Officer 15 Marzo 2026 A 107.943 0 0 $0
Robert Wong VP, Chief Accounting Officer 03 Dicembre 2024 A 18.655 0 0 $0
Brett A Pletcher EVP, Chief Legal Officer 30 Agosto 2024 A 33.140 0 0 $0
Mark A Schlossberg SVP - Legal & General Counsel 15 Marzo 2022 M 103.408 0 0 $0
David Cragg Chief HR & Admin Officer 07 Marzo 2022 F 153.233 0 0 $0
Caryn Gordon Mcdowell GC & Chief Compliance Officer 27 Febbraio 2018 A 32.548 0 0 $0
Peter S Roddy SVP Finance & CAO 27 Febbraio 2018 A 21.520 0 0 $0
Bradley Paul Morgan SVP Drug Discovery & Early Dev 31 Agosto 2017 M 46.441 0 0 $0
Bonnie Charpentier SVP Regulatory & Compliance 28 Febbraio 2017 A 29.004 0 0 $0
Andrew A Wolff SVP & CMO 28 Febbraio 2017 A 47.255 0 0 $0
David J Morgans JR EVP-Preclinical R&D 28 Febbraio 2011 A 42.000 0 0 $0
Michael Rabson SVP Business Dev/Legal & GC 18 Dicembre 2009 M 20.043 0 0 $0
Jay K Trautman VP, Discovery Research 29 Febbraio 2008 A 47.896 0 0 $0
Robert Arthur Harrington Direttore 15 Luglio 2026 A 21.932 0 2 $-248.260
James M Daly Direttore 15 Luglio 2026 A 3.390 0 0 $0
Edward M. Kaye MD Direttore 15 Luglio 2026 A 10.434 0 6 $-3.544.372
Nancy Wysenski Direttore 15 Luglio 2026 A 33.992 0 0 $0
Wendell Wierenga Direttore 15 Luglio 2026 A 35.563 0 3 $-1.881.925
John T Henderson Direttore 15 Luglio 2026 A 78.360 0 2 $-2.078.525
Lynne B Parshall Direttore 01 Giugno 2026 S 15.784 0 3 $-1.000.100
Muna Bhanji Direttore 27 Maggio 2026 A 26.361 0 0 $0
Robert E Landry Direttore 27 Maggio 2026 A 10.184 0 0 $0
Wendall Wierenga Direttore 15 Luglio 2025 A 32.345 0 0 $0
COSTA SANTO J Direttore 15 Maggio 2024 A 20.600 0 0 $0
Sandford D Smith Direttore 02 Gennaio 2024 A 18.801 0 0 $0
Robert Califf Direttore 03 Gennaio 2022 A 6.003 0 0 $0
GAGE L PATRICK Direttore 08 Novembre 2021 M 28.932 0 0 $0
Denise Gilbert Direttore 20 Maggio 2015 J 0 0 $0
Stephen M Dow Direttore 02 Gennaio 2013 A 1.421.052 0 0 $0
James A Spudich Direttore 18 Maggio 2011 A 180.600 0 0 $0
Grant A Heidrich III Direttore 03 Gennaio 2011 A 93.755 0 0 $0
Michael Schmertzler Direttore 03 Giugno 2010 S 4.340.923 0 0 $0
Mark Mcdade Direttore 21 Maggio 2009 A 0 0 $0
Charles J Homcy Direttore 22 Maggio 2008 A 0 0 $0
William J Rutter Direttore 29 Aprile 2004 C 172.413 0 0 $0
SEVIN ROSEN FUND VI LP Proprietario del 10% 29 Aprile 2004 C 1.615.716 0 0 $0
SRB ASSOCIATES VIII LP Proprietario del 10% 29 Aprile 2004 C 771.052 0 0 $0
SRB ASSOCIATES VII LP Proprietario del 10% 29 Aprile 2004 C 650.000 0 0 $0
SEVIN ROSEN FUND VIII LP Proprietario del 10% 29 Aprile 2004 C 755.631 0 0 $0
Robert I Blum 10 Agosto 2026 M 377.820 0 19 $-9.702.097
Elisabeth Schnieders 28 Febbraio 2017 A 43.919 0 0 $0
James H Sabry 03 Giugno 2010 M 0 0 0 $0
SEVIN ROSEN VII AFFILIATES FUND LP 29 Aprile 2004 C 24.050 0 0 $0
SEVIN ROSEN FUND VII LP 29 Aprile 2004 C 625.950 0 0 $0
SRB ASSOCIATES VI LP 29 Aprile 2004 C 1.742.951 0 0 $0

Insider dai depositi SEC Modulo 3/4/5; netto = solo acquisti/vendite di mercato

Proprietà ETF Posseduti da 84 ETF

Il peso riflette solo le partecipazioni azionarie dirette (N-PORT); fondi a leva o basati su derivati possono detenere ulteriore esposizione swap non mostrata.

Fondo Peso Unità Aggiornato al Fonte
LFSC · RBB Fund, Inc. 3,16% 43.268 NS 31 Maggio 2026 N-PORT
HRTS · Tema ETF Trust 2,52% 17.069 NS 31 Maggio 2026 N-PORT
PTH · Invesco Exchange-Traded Fund Trust 1,81% 58.136 SH 08 Agosto 2026 Giornaliero
FMED · Fidelity Covington Trust 1,55% 8.262 NS 31 Maggio 2026 N-PORT
GDOC · Goldman Sachs ETF Trust 1,40% 3.663 NS 31 Maggio 2026 N-PORT
JSMD · Janus Detroit Street Trust 1,24% 189.801 NS 30 Aprile 2026 N-PORT
JSML · Janus Detroit Street Trust 0,98% 48.338 NS 30 Aprile 2026 N-PORT
LABU · Direxion Shares ETF Trust 0,94% 76.297 NS 30 Aprile 2026 N-PORT
IBB · iShares Trust 0,75% 874.995 SH 08 Agosto 2026 Giornaliero
BBC · ETFis Series Trust I 0,75% 4.355 NS 30 Aprile 2026 N-PORT
IBBQ · Invesco Exchange-Traded Fund Trust … 0,71% 7.377 SH 08 Agosto 2026 Giornaliero
VTWV · VANGUARD SCOTTSDALE FUNDS 0,64% 102.933 SH 08 Agosto 2026 Giornaliero
IWN · iShares Trust 0,62% 1.099.434 SH 08 Agosto 2026 Giornaliero
FNY · First Trust Exchange-Traded AlphaDE… 0,51% 41.612 NS 30 Aprile 2026 N-PORT
BIB · ProShares Trust 0,47% 4.553 NS 31 Maggio 2026 N-PORT
NUSC · Nushares ETF Trust 0,47% 94.565 NS 30 Aprile 2026 N-PORT
MIDE · DBX ETF Trust 0,41% 178 NS 29 Maggio 2026 N-PORT
DWAS · Invesco Exchange-Traded Fund Trust … 0,37% 21.543 SH 08 Agosto 2026 Giornaliero
XJH · iShares Trust 0,35% 18.349 SH 08 Agosto 2026 Giornaliero
IQSM · New York Life Investments ETF Trust 0,34% 16.959 NS 30 Aprile 2026 N-PORT
VTWO · VANGUARD SCOTTSDALE FUNDS 0,34% 761.130 SH 08 Agosto 2026 Giornaliero
IWM · iShares Trust 0,34% 3.349.200 SH 08 Agosto 2026 Giornaliero
IVOG · VANGUARD ADMIRAL FUNDS 0,33% 72.343 SH 08 Agosto 2026 Giornaliero
VBK · VANGUARD INDEX FUNDS 0,32% 1.797.986 SH 08 Agosto 2026 Giornaliero
IVOO · VANGUARD ADMIRAL FUNDS 0,32% 219.413 SH 08 Agosto 2026 Giornaliero
IJK · iShares Trust 0,32% 429.311 SH 08 Agosto 2026 Giornaliero
ISCG · iShares Trust 0,32% 38.968 SH 08 Agosto 2026 Giornaliero
IVOV · VANGUARD ADMIRAL FUNDS 0,31% 53.623 SH 08 Agosto 2026 Giornaliero
IJH · iShares Trust 0,30% 4.684.495 SH 08 Agosto 2026 Giornaliero
IJJ · iShares Trust 0,29% 317.724 SH 08 Agosto 2026 Giornaliero
FNX · First Trust Exchange-Traded AlphaDE… 0,26% 55.086 NS 30 Aprile 2026 N-PORT
ITWO · ProShares Trust 0,25% 6.062 NS 31 Maggio 2026 N-PORT
RSSL · Global X Funds 0,23% 51.834 NS 30 Aprile 2026 N-PORT
PTMC · Pacer Funds Trust 0,23% 14.028 NS 30 Aprile 2026 N-PORT
MVV · ProShares Trust 0,22% 4.565 NS 31 Maggio 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0,21% 635.330 NS 31 Maggio 2026 N-PORT
BKMC · BNY Mellon ETF Trust 0,20% 19.862 NS 30 Aprile 2026 N-PORT
ESML · iShares Trust 0,20% 72.711 SH 08 Agosto 2026 Giornaliero
SCHM · SCHWAB STRATEGIC TRUST 0,19% 356.940 NS 31 Maggio 2026 N-PORT
FFSM · FIDELITY COVINGTON TRUST 0,19% 37.821 NS 30 Aprile 2026 N-PORT
VFMO · VANGUARD WELLINGTON FUND 0,17% 40.586 SH 08 Agosto 2026 Giornaliero
ISCB · iShares Trust 0,16% 5.525 SH 08 Agosto 2026 Giornaliero
MIDU · Direxion Shares ETF Trust 0,15% 2.025 NS 30 Aprile 2026 N-PORT
UMDD · ProShares Trust 0,15% 638 NS 31 Maggio 2026 N-PORT
FAD · First Trust Exchange-Traded AlphaDE… 0,15% 11.444 NS 30 Aprile 2026 N-PORT
BBMC · J.P. Morgan Exchange-Traded Fund Tr… 0,15% 47.609 NS 30 Aprile 2026 N-PORT
UWM · ProShares Trust 0,15% 4.765 NS 31 Maggio 2026 N-PORT
SMDX · Tidal Trust III 0,15% 2.868 NS 30 Aprile 2026 N-PORT
VB · VANGUARD INDEX FUNDS 0,14% 3.113.794 SH 08 Agosto 2026 Giornaliero
VHT · VANGUARD WORLD FUND 0,14% 333.056 SH 08 Agosto 2026 Giornaliero