PTCT PTC Therapeutics, Inc. - Common Stock

NASDAQ · Biotechnology · Visualizza su SEC EDGAR ↗
$72,62
Prezzo · Ago 19, 2026
Fondamentali al Lug 30, 2026

Informazioni su PTC Therapeutics, Inc. - Common Stock Panoramica della società da Wikipedia

PTC Therapeutics, Inc. is a US pharmaceutical company focused on the development of orally administered small molecule drugs and gene therapy which regulate gene expression by targeting post-transcriptional control (PTC) mechanisms in orphan diseases.

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PTC Therapeutics, Inc. is a US pharmaceutical company focused on the development of orally administered small molecule drugs and gene therapy which regulate gene expression by targeting post-transcriptional control (PTC) mechanisms in orphan diseases.

In September 2009, PTC entered into an agreement with Roche for the development of orally bioavailable small molecules for central nervous system diseases. PTC acquired the Bio-e platform in 2019.

Products

In 2017, PTC acquired Emflaza (deflazacort) from Marathon Pharmaceuticals. PTC also owns Translarna, (Ataluren) marketed for nonsense mutation Duchenne muscular dystrophy. Together, the two products generated revenues of 174 million dollars and 260 million dollars in 2017 and 2018 respectively.

PTC has the commercialization rights for WAYLIVRA (volanesorsen) in Latin America.

In 2018, PTC acquired Agilis Biotherapeutics and a gene therapy candidate, GT-AADC, with its compelling clinical data in treating aromatic L-amino acid decarboxylase (AADC) deficiency. AADC deficiency is a rare CNS disorder arising from reductions in the enzyme AADC that result from mutations in the dopa decarboxylase (DDC) gene. As of 2024, the AAV based treatment for AADC deficiency has been approved by the FDA and commercialized in the United States as Kebilidi. It is the first FDA-approved gene therapy treatment for AADC deficiency. This same product was granted EMA approval for use in the European Union under the name Upstaza.

Pipeline

In 2020, PTC acquired Censa Pharmaceuticals, Inc., a biopharmaceutical company focused on the development of CNSA-001 (sepiapterin), a clinical-stage investigational therapy for orphan metabolic diseases, including phenylketonuria (PKU) and other diseases associated with defects in the tetrahydrobiopterin (BH4) biochemical pathways diagnosed at birth.

In 2020, PTC announced the FDA approval of Evrysdi (risdiplam) for the treatment of spinal muscular atrophy (SMA) in adults and children 2 months and older.

In 2024, Novartis has committed $1 billion upfront in a licensing deal with PTC Therapeutics for an experimental treatment for Huntington’s disease, with the potential for an additional $1.9 billion tied to achieving specific development, regulatory, and commercial milestones. PTC Therapeutics’ therapy, known as PTC518, is an oral medication designed to reduce the production of the mutant protein linked to the genetic mutation responsible for the disease. This mutant protein is believed to contribute to neuronal death, driving disease progression. In June, interim data from a Phase 2 trial indicated that PTC518 successfully lowered levels of the mutant protein in both blood and cerebrospinal fluid.

Fonte: Wikipedia (Inglese), CC BY-SA 4.0 · Vedi su Wikipedia ↗

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PTCT Snapshot del titolo Prezzo, capitalizzazione di mercato, P/E, EPS, ROE, debito/capitale proprio, intervallo 52 settimane

Prezzo
$72.62
Capitalizzazione di Mercato
$5.92B
P/E (TTM)
9.3
EPS (TTM)
$7.78
Ricavi (TTM)
$1.73B
Rendimento div.
ROE
-331.5%
D/E Debito/Patrimonio
-1.4
Intervallo 52 sett.
$48 – $91

PTCT Grafico del prezzo delle azioni OHLCV giornaliero con indicatori tecnici — panoramica, zoom e personalizza la tua visualizzazione

Performance decennale Andamento di ricavi, utile netto, margini e EPS

Ricavi e Utile Netto $1.73B
10-point trend, +1992.6%
2016-12-31 2025-12-31
EPS $7.78
7-point trend, +282.2%
2019-12-31 2025-12-31
Flusso di cassa libero $702M
9-point trend, +766.7%
2016-12-31 2025-12-31
Margini 39.4%

Valutazione Rapporti P/E, P/S, P/B, EV/EBITDA — il titolo è costoso o economico?

Metrica
Tendenza 5 anni
PTCT
Mediana dei peer
P/E (TTM)
5-point trend, +282.1%
9.3
37.2
P/S (TTM)
5-point trend, -68.0%
3.4
9.9
P/B
5-point trend, -441.5%
-28.8
8.3
EV / EBITDA
5-point trend, +156.1%
4.7
Price / FCF (Prezzo / FCF)
5-point trend, +143.9%
8.4

Redditività Margini lordi, operativi e netti; ROE, ROA, ROIC

Metrica
Tendenza 5 anni
PTCT
Mediana dei peer
Operating Margin (Margine Operativo)
5-point trend, +144.2%
50.1%
Net Profit Margin (Margine di Profitto Netto)
5-point trend, +134.3%
39.4%
-15.1%
ROA
5-point trend, +229.7%
29.7%
-23.3%
ROE
5-point trend, -275.6%
-331.5%
-30.6%
ROIC
5-point trend, +1860.3%
1044.7%

Salute finanziaria Debito, liquidità, solvibilità — solidità del bilancio

Metrica
Tendenza 5 anni
PTCT
Mediana dei peer
Debt / Equity (Debito / Patrimonio Netto)
5-point trend, -317.7%
-1.4
Current Ratio (Rapporto corrente)
5-point trend, -47.1%
2.3
6.3
Quick Ratio
5-point trend, -48.1%
2.2

Crescita Crescita di ricavi, EPS e utile netto: YoY, CAGR 3Y, CAGR 5Y

Metrica
Tendenza 5 anni
PTCT
Mediana dei peer
Revenue YoY (Ricavi YoY)
5-point trend, +221.3%
114.5%
Revenue CAGR 3Y (CAGR Ricavi 3Y)
5-point trend, +221.3%
35.3%
Revenue CAGR 5Y (CAGR Ricavi 5Y)
5-point trend, +221.3%
35.4%

Metriche per Azione EPS, valore contabile per azione, flusso di cassa per azione, dividendo per azione

Metrica
Tendenza 5 anni
PTCT
Mediana dei peer
EPS (Diluted) (EPS (Diluito))
5-point trend, +204.7%
$7.78

Efficienza del Capitale Rotazione delle attività, rotazione delle scorte, rotazione dei crediti

Metrica
Tendenza 5 anni
PTCT
Mediana dei peer

PTCT Consenso degli analisti Opinioni degli analisti, sia rialziste che ribassiste, target price a 12 mesi, potenziale di rialzo

COMPRA 21 analisti
  • Acquisto forte 6 28,6%
  • Compra 11 52,4%
  • Mantieni 3 14,3%
  • Vendi 1 4,8%
  • Vendita forte 0 0,0%

Target Price a 12 Mesi

14 analisti · 2026-08-13
Target mediano $98.00 +34,9%
Target medio $97.86 +34,8%

Cronologia utili EPS effettivo vs stima, surprise %, tasso di superamento, data prossimi utili

Sorpresa media
1.9%
Periodo EPS Actual EPS Stimato Sorpresa
30 Giugno 2026 $0.92 $0.43 0.49%
31 Marzo 2026 $-0.03 $-0.48 0.45%
31 Dicembre 2025 $-1.67 $0.04 -1.7%
30 Settembre 2025 $0.20 $-1.40 1.6%
30 Giugno 2025 $-0.83 $-1.08 0.25%
31 Marzo 2025 $10.04 $-0.22 10.3%

Confronto Peer (GICS sub-settore industriale) Metriche chiave rispetto ai pari del settore

Ticker Capitalizzazione di Mercato P/E Rev YoY Margine Netto ROE Margine lordo
PTCT $6.19B 9.8 114.5% 39.4% -331.5%
MIRM $4.10B -168.1 54.7% -4.5% -8.2%
COGT $5.72B -16.4 -83.1%
DNTH $1.78B -9.8 -67.3% -7973.3% -40.8%
ERAS $1.06B -8.5 -35.7%
CAI $7.62B -8.4 97.0% -8.4% -13.2%
TVTX $3.47B -131.8 110.5% -5.2% -34.6%
ACAD $4.55B 11.6 11.9% 36.5% 38.1%
DYN $3.23B -5.6 -57.8%
PBLS
CELC $4.81B -26.3 -244.3%

Fondamentali Completi Tutte le metriche per anno — conto economico, stato patrimoniale, rendiconto finanziario

Conto Economico 15
Dati annuali Conto Economico per PTCT
Metrica Tendenza 202520242023202220212020201920182017201620152014
Revenue 12-point trend, +6755.4% $1.73B $807M $938M $699M $539M $381M $307M $265M $194M $83M $37M $25M
Cost of Revenue 5-point trend, +12135000.00 · · · · · · $12M $13M $5M $0 $0 ·
R&D Expense 12-point trend, +470.2% $455M $534M $667M $651M $541M $478M $257M $172M $117M $118M $122M $80M
SG&A Expense 12-point trend, +674.5% $347M $301M $333M $326M $286M $245M $203M $154M $121M $97M $82M $45M
Operating Expenses 12-point trend, +592.9% $864M $1.11B $1.38B $1.15B $913M $813M $548M $380M $259M $215M $204M $125M
Operating Income 12-point trend, +972.1% $867M $-303M $-440M $-447M $-374M $-432M $-241M $-116M $-64M $-132M $-167M $-99M
Other Non-op 12-point trend, -8391.1% $-18M $7M $10M $-49M $-58M $85M $14M $129.0K $-1M $-1M $-465.0K $-213.0K
Pretax Income 12-point trend, +807.6% $697M $-363M $-696M $-587M $-518M $-403M $-240M $-128M $-78M $-142M $-170M $-98M
Income Tax 12-point trend, +397.8% $14M $176.0K $-70M $-28M $6M $35M $12M $-29.0K $1M $569.0K $485.0K $-5M
Net Income 12-point trend, +828.1% $683M $-363M $-627M $-559M $-524M $-438M $-252M $-128M $-79M $-142M $-170M $-94M
EPS (Basic) 10-point trend, +388.9% $8.58 $-4.73 $-8.37 $-7.79 $-7.43 $-6.64 $-4.27 $-2.75 $-2.02 · · $-2.97
EPS (Diluted) 8-point trend, +362.0% $7.78 $-4.73 $-8.37 $-7.79 $-7.43 $-6.64 $-4.27 · · · · $-2.97
Shares (Basic) 8-point trend, +152.0% 79,534,290 76,845,055 74,838,292 71,728,634 70,466,393 66,027,908 58,863,185 · · · · 31,565,310
Shares (Diluted) 8-point trend, +179.8% 88,311,494 76,845,055 74,838,292 71,728,634 70,466,393 66,027,908 58,863,185 · · · · 31,565,310
EBITDA 11-point trend, +1011.1% $906M $-227M $-203M · $-310M $-388M $-209M $-90M $-47M $-132M $-167M $-99M
Stato Patrimoniale 27
Dati annuali Stato Patrimoniale per PTCT
Metrica Tendenza 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, +1879.3% $985M $780M $594M $280M $190M $209M $288M $169M $112M $58M $58M $50M
Short-term Investments 12-point trend, +261.9% $961M $360M $283M $131M $584M $895M $399M $58M $79M $173M $281M $265M
Receivables 12-point trend, +3986.0% $182M $159M $161M $156M $110M $70M $56M $68M $40M $25M $11M $4M
Inventory 10-point trend, +79647000.00 $80M $23M $31M $22M $16M $19M $19M $16M $11M $0 · ·
Prepaid Expense 12-point trend, +1632.5% $67M $44M $150M $106M $55M $39M $18M $9M $7M $5M $6M $4M
Current Assets 12-point trend, +602.8% $2.27B $1.37B $1.22B $694M $954M $1.23B $779M $321M $249M $261M $356M $324M
PP&E (Net) 12-point trend, +504.6% $55M $61M $87M $73M $53M $34M $22M $13M $8M $7M $9M $9M
PP&E (Gross) 12-point trend, +200.4% $102M $94M $138M $110M $80M $52M $33M $20M $41M $38M $37M $34M
Accum. Depreciation 12-point trend, +88.6% $47M $33M $51M $37M $27M $18M $12M $7M $33M $31M $28M $25M
Goodwill 9-point trend, +82341000.00 $82M $82M $82M $82M $82M $82M $82M $82M $0 · · ·
Intangibles 10-point trend, +388753000.00 $389M $119M $379M $706M $725M $715M $710M $701M $133M $0 · ·
Total Assets 12-point trend, +769.9% $2.90B $1.71B $1.90B $1.71B $1.94B $2.21B $1.62B $1.12B $392M $269M $365M $333M
Accounts Payable 12-point trend, +1001.9% $45M $17M $6M $27M $23M $19M $10M $6M $15M $6M $6M $4M
Current Liabilities 12-point trend, +2882.1% $968M $581M $603M $406M $509M $277M $236M $167M $82M $50M $45M $32M
Capital Leases 7-point trend, +937.7% $94M $75M $98M $101M $74M $79M $9M · · · · ·
Deferred Tax 7-point trend, +55905000.00 · · $56M $103M $137M $137M $131M $122M $0 · · ·
Other Non-current Liabilities 11-point trend, +501.8% $14M $21M $141.0K $3M · $1M $141.0K $58.0K $243.0K $335.0K $2M $2M
Total Liabilities 12-point trend, +8832.1% $3.10B $2.80B $2.71B $2.05B $1.94B $1.73B $1.03B $768M $235M $150M $139M $35M
Long-term Debt 4-point trend, +197.6% · · · · $431M · $314M $153M $145M · · ·
Total Debt 10-point trend, +203.0% $287M $285M $284M · $431M $309M $314M $153M $145M $98M $95M ·
Common Stock 12-point trend, +142.4% $80.0K $77.0K $75.0K $72.0K $71.0K $70.0K $62.0K $51.0K $42.0K $34.0K $34.0K $33.0K
Paid-in Capital 12-point trend, +280.8% $2.75B $2.57B $2.47B $2.31B $2.12B $2.17B $1.80B $1.29B $967M $856M $820M $722M
Retained Earnings 12-point trend, -601.5% $-2.96B $-3.65B $-3.28B $-2.66B $-2.10B $-1.63B $-1.19B $-939M $-814M $-735M $-593M $-423M
AOCI 12-point trend, +1524.8% $11M $-26M $-1M $5M $-24M $-61M $-11M $1M $4M $-1M $-1M $-737.0K
Stockholders' Equity 12-point trend, -168.8% $-205M $-1.10B $-819M $-347M $1M $482M $594M $351M $156M $120M $226M $298M
Liabilities + Equity 12-point trend, +769.9% $2.90B $1.71B $1.90B $1.71B $1.94B $2.21B $1.62B $1.12B $392M $269M $365M $333M
Shares Outstanding 12-point trend, +147.7% 81,474,366 77,704,188 75,708,889 73,104,692 70,828,226 69,718,096 61,935,870 50,606,147 41,612,395 34,169,410 33,916,559 32,898,392
Flusso di cassa 16
Dati annuali Flusso di cassa per PTCT
Metrica Tendenza 202520242023202220212020201920182017201620152014
D&A 11-point trend, +1249.6% $39M $76M $237M $129M $64M $43M $32M $26M $18M $3M $3M ·
Stock-based Comp 12-point trend, +286.1% $75M $75M $102M $110M $104M $70M $42M $33M $31M $35M $34M $19M
Deferred Tax 12-point trend, -3000.00 $-3.0K $-56M $-47M $-34M $377.0K $6M $9M $0 $199.0K $-199.0K $0 $0
Amort. of Intangibles 11-point trend, +24742000.00 $25M $61M $223M $117M $55M $37M $28M $23M $15M $0 $0 ·
Restructuring · · · · · · · · $0 · · ·
Other Non-cash 8-point trend, -513.8% $-85M $161M $177M · $105M $124M $70M $41M $20M · · ·
Operating Cash Flow 12-point trend, +1341.7% $711M $-108M $-158M $-357M $-251M $-194M $-99M $-28M $-10M $-104M $-124M $-57M
CapEx 12-point trend, +90.0% $9M $7M $28M $32M $28M $18M $14M $7M $3M $2M $3M $5M
Investing Cash Flow 12-point trend, -493.8% $-862M $44M $-177M $290M $219M $-562M $-387M $-43M $13M $104M $-21M $-145M
Net Debt Issued 2-point trend, +100.0% · · · · · · · · · $0 · $-49.0K
Stock Issued 7-point trend, -88.1% · · · · · $28M $324M $118M $0 $0 $0 $236M
Net Stock Activity 5-point trend, -88.1% · · · · · $28M $324M $118M · $0 · $236M
Financing Cash Flow 12-point trend, +39.6% $331M $256M $646M $168M $21M $669M $613M $132M $44M $968.0K $154M $237M
Net Change in Cash 12-point trend, +491.3% $203M $185M $314M $99M $-19M $-79M $126M $58M $53M $299.0K $8M $34M
Taxes Paid 12-point trend, +36854000.00 $37M $18M $14M $5M $8M $26M $2M $2M $1M $943.0K $111.0K $0
Free Cash Flow 11-point trend, +1233.9% $702M $-114M $-187M · $-280M $-212M $-112M $-35M $-13M $-105M $-127M $-62M
Redditività 7
Dati annuali Redditività per PTCT
Metrica Tendenza 202520242023202220212020201920182017201620152014
Operating Margin 11-point trend, +112.7% 50.1% -37.5% -46.9% · -69.5% -113.4% -78.6% -43.7% -33.1% -159.7% -454.6% -393.8%
Net Margin 11-point trend, +110.6% 39.4% -45.0% -66.8% · -97.3% -115.1% -82.0% -48.4% -40.6% -171.8% -463.6% -371.4%
Pretax Margin 11-point trend, +110.3% 40.2% -45.0% -74.2% · -96.2% -105.8% -78.2% -48.4% -40.0% -171.1% -462.3% -390.0%
EBITDA Margin 11-point trend, +113.3% 52.3% -28.1% -21.6% · -57.6% -102.0% -68.1% -33.8% -24.0% -159.7% -454.6% -393.8%
ROA 11-point trend, +176.7% 29.7% -20.2% -34.8% · -25.3% -22.9% -18.3% -17.0% -23.9% -44.8% -48.6% -38.6%
ROE 11-point trend, -669.1% -331.5% 33.8% 84.1% · -985.1% -88.3% -40.0% -34.8% -57.2% -82.2% -65.0% -43.1%
ROIC 11-point trend, +3393.6% 1044.7% 37.2% 74.0% · -87.4% -59.4% -27.8% -23.0% -21.7% -60.9% -52.3% -31.7%
Liquidità e Solvibilità 4
Dati annuali Liquidità e Solvibilità per PTCT
Metrica Tendenza 202520242023202220212020201920182017201620152014
Current Ratio 11-point trend, -76.4% 2.3 2.4 2.0 · 1.9 4.4 3.3 1.9 3.0 5.3 7.8 10.0
Quick Ratio 11-point trend, -77.7% 2.2 2.2 1.7 · 1.7 4.2 3.1 1.8 2.8 5.2 7.7 9.8
Debt / Equity 10-point trend, -433.5% -1.4 -0.3 -0.3 · 300.0 0.6 0.5 0.4 0.9 0.8 0.4 ·
LT Debt / Equity 9-point trend, -162.1% · -0.3 -0.3 · 196.0 0.6 0.5 0.4 0.9 0.8 0.4 ·
Efficienza 3
Dati annuali Efficienza per PTCT
Metrica Tendenza 202520242023202220212020201920182017201620152014
Asset Turnover 11-point trend, +622.2% 0.8 0.4 0.5 · 0.3 0.2 0.2 0.4 0.6 0.3 0.1 0.1
Inventory Turnover 2-point trend, -19.5% · · · · · · 0.7 · 0.9 · · ·
Receivables Turnover 11-point trend, +8.9% 10.2 5.1 5.9 · 6.0 6.1 5.0 4.9 6.0 4.6 4.7 9.3
Per Azione 5
Dati annuali Per Azione per PTCT
Metrica Tendenza 202520242023202220212020201920182017201620152014
Book Value / Share 11-point trend, -127.8% $-2.52 $-14.13 $-10.81 · $0.02 $6.91 $9.60 $6.93 $3.76 $3.50 $6.66 $9.07
Revenue / Share 5-point trend, +2350.3% $19.60 $10.50 $12.53 · $7.64 · · · · · · $0.80
Cash Flow / Share 5-point trend, +543.8% $8.05 $-1.40 $-2.12 · $-3.57 · · · · · · $-1.81
Cash / Share 11-point trend, +699.2% $12.09 $10.03 $7.85 · $2.68 $3.00 $4.65 $3.35 $2.69 $1.71 $1.71 $1.51
EPS (TTM) 12-point trend, +362.0% $7.78 $-4.73 $-8.37 $-7.79 $-7.43 $-6.64 $-4.27 $-3.21 $-3.21 $-3.21 $-3.21 $-2.97
Tassi di Crescita 3
Dati annuali Tassi di Crescita per PTCT
Metrica Tendenza 202520242023202220212020201920182017201620152014
Revenue YoY 5-point trend, +176.3% 114.5% -14.0% 34.2% 29.8% 41.4% · · · · · · ·
Revenue CAGR 3Y 3-point trend, +0.7% 35.3% 14.4% 35.0% · · · · · · · · ·
Revenue CAGR 5Y 35.4% · · · · · · · · · · ·
Valutazione (TTM) 13
Dati annuali Valutazione (TTM) per PTCT
Metrica Tendenza 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +6755.4% $1.73B $807M $938M $699M $539M $381M $307M $265M $194M $83M $37M $25M
Net Income TTM 12-point trend, +828.1% $683M $-363M $-627M $-559M $-524M $-438M $-252M $-128M $-79M $-142M $-170M $-94M
Market Cap 11-point trend, +263.4% $6.19B $3.51B $2.09B · $2.82B $4.25B $2.97B $1.74B $694M $373M $1.10B $1.70B
Enterprise Value 10-point trend, +430.1% $4.53B $2.65B $1.49B · $2.48B $3.46B $2.60B $1.66B $648M $239M $855M ·
P/E 12-point trend, +156.0% 9.8 -9.5 -3.3 -4.9 -5.4 -9.2 -11.2 -10.7 -5.2 -3.4 -10.1 -17.4
P/S 11-point trend, -94.7% 3.6 4.3 2.2 · 5.2 11.2 9.7 6.6 3.6 4.5 29.9 67.5
P/B 11-point trend, -628.2% -30.1 -3.2 -2.5 · 1961.8 8.8 5.0 5.0 4.4 3.1 4.9 5.7
P / Cash Flow 11-point trend, +129.3% 8.7 -32.6 -13.2 · -11.2 -21.9 -30.2 -62.8 -69.0 -3.6 -8.8 -29.7
P / FCF 11-point trend, +132.0% 8.8 -30.7 -11.2 · -10.1 -20.1 -26.5 -50.0 -52.7 -3.5 -8.6 -27.5
EV / EBITDA 10-point trend, +197.8% 5.0 -11.7 -7.4 · -8.0 -8.9 -12.5 -18.6 -13.9 -1.8 -5.1 ·
EV / FCF 10-point trend, +195.9% 6.5 -23.2 -8.0 · -8.9 -16.3 -23.2 -47.9 -49.2 -2.3 -6.7 ·
EV / Revenue 10-point trend, -88.7% 2.6 3.3 1.6 · 4.6 9.1 8.5 6.3 3.3 2.9 23.2 ·
Earnings Yield 12-point trend, +278.4% 10.2% -10.5% -30.4% -20.4% -18.6% -10.9% -8.9% -9.3% -19.2% -29.4% -9.9% -5.7%

Bilanci Conto economico, stato patrimoniale, flusso di cassa — annuale, ultimi 5 anni

Conto Economico
2025-12-312024-12-312023-12-312022-12-312021-12-31
Ricavi $1.73B$807M$938M$699M$539M
Margine Operativo % 50.1%-37.5%-46.9%-69.5%
Utile netto $683M$-363M$-627M$-559M$-524M
EPS Diluito $7.78$-4.73$-8.37$-7.79$-7.43
Stato Patrimoniale
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debito / Patrimonio Netto -1.4-0.3-0.3300.0
Rapporto corrente 2.32.42.01.9
Quick Ratio 2.22.21.71.7
Flusso di cassa
2025-12-312024-12-312023-12-312022-12-312021-12-31
Flusso di cassa libero $702M$-114M$-187M$-280M

Segnali di trading Segnali recenti di acquisto/vendita con prezzo di entrata e rapporto rischio/rendimento

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Proprietari istituzionali (13F) 403 filer · $5.4B totale · Aggiornato al 30 Giugno 2026

Istituzioni che segnalano il possesso di questo titolo nel loro Modulo SEC 13F trimestrale. Solo posizioni lunghe; un singolo depositante può apparire due volte per diverse gambe di opzioni. Grandi posizioni put/call contrapposte riflettono tipicamente market-making o inventario coperto, non convinzione direzionale.

Attività istituzionale — Q2 2026 vs trimestre precedente
Nuove posizioni Posizioni chiuse Aumentato Diminuito Variazione netta delle azioni
83 (+22 vs trimestre precedente) 43 (-9 vs trimestre precedente) 133 (-4 vs trimestre precedente) 109 (+6 vs trimestre precedente) +2.1M

Confrontato con Q1 2026. Le dichiarazioni SEC Form 13F sono dovute entro 45 giorni dalla fine del trimestre più un breve margine per i dichiaranti in ritardo — i trimestri ancora all'interno di questa finestra vengono saltati a favore della coppia più recente completamente riportata.

Istituzione Valore Azioni % di 13F tracciati Tipo
RTW INVESTMENTS, LP $631.875.072 7.746.415 11,70% Azioni
JANUS HENDERSON GROUP PLC $479.178.655 7.034.622 8,87% Azioni
VANGUARD PORTFOLIO MANAGEMENT LLC $401.986.014 4.928.111 7,45% Azioni
STATE STREET CORP $375.136.515 4.598.952 6,95% Azioni
VANGUARD CAPITAL MANAGEMENT LLC $305.000.589 3.739.127 5,65% Azioni
WELLINGTON MANAGEMENT GROUP LLP $292.435.873 3.585.091 5,42% Azioni
WESTFIELD CAPITAL MANAGEMENT CO LP $159.563.645 1.956.156 2,96% Azioni
GEODE CAPITAL MANAGEMENT, LLC $155.132.041 1.901.417 2,87% Azioni
Hood River Capital Management LLC $141.818.662 1.738.613 2,63% Azioni
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC $140.519.660 1.722.688 2,60% Azioni
TANG CAPITAL MANAGEMENT LLC $122.355.000 1.500.000 2,27% Azioni
Driehaus Capital Management LLC $117.469.528 1.440.107 2,18% Azioni
Jefferies Financial Group Inc. $110.693.916 1.357.042 2,05% Azioni
FULLER & THALER ASSET MANAGEMENT, INC. $94.361.749 1.156.819 1,75% Azioni
Pictet Asset Management Holding SA $93.629.635 1.147.844 1,73% Azioni
ARMISTICE CAPITAL, LLC $87.393.690 1.071.395 1,62% Azioni
Blue Sparrow, LLC /DE $85.705.599 1.050.700 1,59% Azioni
D. E. Shaw & Co., Inc. $77.478.857 949.845 1,44% Azioni
Palo Alto Investors LP $74.950.268 918.846 1,39% Azioni
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $64.449.436 790.112 1,19% Azioni
RENAISSANCE TECHNOLOGIES LLC $59.015.895 723.500 1,09% Azioni
Boston Partners $57.080.953 699.871 1,06% Azioni
FMR LLC $56.956.987 698.259 1,05% Azioni
BANK OF AMERICA CORP /DE/ $56.350.840 690.828 1,04% Azioni
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP $53.377.940 654.382 0,99% Azioni
DIMENSIONAL FUND ADVISORS LP $51.486.821 631.199 0,95% Azioni
VANGUARD FIDUCIARY TRUST CO $47.953.943 587.887 0,89% Azioni
Ensign Peak Advisors, Inc $41.442.128 508.056 0,77% Azioni
AMERICAN CENTURY COMPANIES INC $40.866.277 500.995 0,76% Azioni
MANUFACTURERS LIFE INSURANCE COMPANY, THE $36.050.432 441.957 0,67% Azioni
Parkman Healthcare Partners LLC $35.539.315 435.691 0,66% Azioni
LOOMIS SAYLES & CO L P $35.387.921 433.835 0,66% Azioni
Defilade Capital Management, L.P. $35.376.827 433.699 0,66% Azioni
GOLDMAN SACHS GROUP INC $34.153.522 418.702 0,63% Azioni
SUSQUEHANNA INTERNATIONAL GROUP, LLP $32.274.149 395.662 0,60% Azioni
BNP PARIBAS FINANCIAL MARKETS $30.892.190 378.720 0,57% Azioni
Qube Research & Technologies Ltd $25.398.777 311.374 0,47% Azioni
ARMISTICE CAPITAL, LLC $24.471.000 300.000 0,45% Opzione Call
Public Sector Pension Investment Board $23.249.326 285.023 0,43% Azioni
SEGALL BRYANT & HAMILL, LLC $22.165.424 271.735 0,41% Azioni
CITADEL ADVISORS LLC $20.338.011 249.332 0,38% Azioni
MORGAN STANLEY $18.990.210 232.808 0,35% Azioni
Boxer Capital Management, LLC $16.314.000 200.000 0,30% Azioni
RHUMBLINE ADVISERS $15.718.994 192.706 0,29% Azioni
AMERIPRISE FINANCIAL INC $13.904.178 170.457 0,26% Azioni
PRUDENTIAL FINANCIAL INC $13.746.176 168.520 0,25% Azioni
BlackRock, Inc. $13.589.562 166.600 0,25% Azioni
Rock Springs Capital Management LP $13.238.648 162.298 0,25% Azioni
Hudson Bay Capital Management LP $13.033.091 159.778 0,24% Azioni
Russell Investments Group, Ltd. $12.687.724 155.544 0,23% Azioni
Schonfeld Strategic Advisors LLC $12.025.457 147.425 0,22% Azioni
MARSHALL WACE, LLP $11.724.301 143.733 0,22% Azioni
Swiss National Bank $11.539.300 141.465 0,21% Azioni
Universal- Beteiligungs- und Servicegesellschaft mbH $11.063.583 135.633 0,20% Azioni
Legal & General Group Plc $10.362.979 127.044 0,19% Azioni
CITIGROUP INC $9.272.143 113.671 0,17% Azioni
FIRST TRUST ADVISORS LP $9.246.285 113.354 0,17% Azioni
Longaeva Partners L.P. $9.119.771 111.803 0,17% Azioni
JUPITER ASSET MANAGEMENT LTD $8.927.184 109.442 0,17% Azioni
SCHRODER INVESTMENT MANAGEMENT GROUP $8.215.404 100.716 0,15% Azioni
SECTOR GAMMA AS $8.157.000 100.000 0,15% Azioni
WCM INVESTMENT MANAGEMENT, LLC $7.651.184 93.799 0,14% Azioni
PANAGORA ASSET MANAGEMENT INC $7.256.141 88.956 0,13% Azioni
VOYA INVESTMENT MANAGEMENT LLC $7.239.501 88.752 0,13% Azioni
ALLIANCEBERNSTEIN L.P. $7.217.488 105.937 0,13% Azioni
Aquatic Capital Management LLC $6.808.648 83.470 0,13% Azioni
XTX Topco Ltd $6.682.459 81.923 0,12% Azioni
MOORE CAPITAL MANAGEMENT, LP $6.165.713 75.588 0,11% Azioni
PINNACLE ASSOCIATES LTD $5.745.383 70.435 0,11% Azioni
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $5.744.722 84.320 0,11% Azioni
VANGUARD ASSET MANAGEMENT, Ltd $5.614.300 68.828 0,10% Azioni
Capricorn Fund Managers Ltd $5.212.323 63.900 0,10% Azioni
SUSQUEHANNA INTERNATIONAL GROUP, LLP $5.000.241 61.300 0,09% Opzione Call
INTECH INVESTMENT MANAGEMENT LLC $4.696.882 57.581 0,09% Azioni
ExodusPoint Capital Management, LP $4.672.166 57.278 0,09% Azioni
LOS ANGELES CAPITAL MANAGEMENT LLC $4.561.884 55.926 0,08% Azioni
BARCLAYS PLC $4.169.858 51.120 0,08% Azioni
ORBIMED ADVISORS LLC $4.005.087 49.100 0,07% Azioni
MetLife Investment Management, LLC $3.932.653 48.212 0,07% Azioni
Point72 Europe (London) LLP $3.829.919 62.407 0,07% Azioni
MILLENNIUM MANAGEMENT LLC $3.792.516 46.494 0,07% Azioni
Phocas Financial Corp. $3.766.087 46.170 0,07% Azioni
MARTINGALE ASSET MANAGEMENT L P $3.627.826 44.475 0,07% Azioni
Quadrature Capital Ltd $3.589.488 44.005 0,07% Azioni
SUSQUEHANNA INTERNATIONAL GROUP, LLP $3.531.981 43.300 0,07% Opzione Put
STATE OF WISCONSIN INVESTMENT BOARD $3.436.299 42.127 0,06% Azioni
CREDIT AGRICOLE S A $3.344.370 41.000 0,06% Azioni
Fisher Asset Management, LLC $3.322.345 40.730 0,06% Azioni
HSBC HOLDINGS PLC $3.200.425 38.732 0,06% Azioni
NEW YORK STATE COMMON RETIREMENT FUND $3.134.490 38.427 0,06% Azioni
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $3.114.179 38.178 0,06% Azioni
CenterBook Partners LP $3.082.938 37.795 0,06% Azioni
Rafferty Asset Management, LLC $3.069.805 37.634 0,06% Azioni
FIFTH THIRD BANCORP $3.044.843 37.328 0,06% Azioni
BURNEY CO/ $3.044.192 37.320 0,06% Azioni
Vanguard Global Advisers, LLC $3.033.180 37.185 0,06% Azioni
Arrowpoint Investment Partners (Singapore) Pte. Ltd. $3.007.731 36.873 0,06% Azioni
Louisiana State Employees Retirement System $2.969.148 36.400 0,05% Azioni
JANE STREET GROUP, LLC $2.854.950 35.000 0,05% Opzione Put
CASTLEARK MANAGEMENT LLC $2.765.223 33.900 0,05% Azioni

Insider aziendali 33 insider · 13 dirigenti · 14 direttori

Insider Ruolo Ultima attività Azioni possedute Acquisti 12m Vendite 12m Netto 12m
Stuart Walter Peltz Chief Executive Officer 01 Febbraio 2022 S 38.728 0 0 $0
Pierre Gravier CHIEF FINANCIAL OFFICER 14 Luglio 2026 S 83.986 0 1 $-280.743
Emily Luisa Hill Chief Financial Officer 01 Febbraio 2022 S 37.169 0 0 $0
Shane William Charles Kovacs Chief Financial Officer 09 Maggio 2017 M 37.850 0 0 $0
Claudia De Oliveira Ribeiro Hirawat President 15 Gennaio 2015 M 39.247 0 0 $0
Marcio Souza Chief Operating Officer 10 Febbraio 2020 M 6.744 0 0 $0
Neil Gregory Almstead CHIEF TECHNICAL OPS OFFICER 09 Luglio 2026 M 60.299 0 20 $-9.184.852
Mark Elliott Boulding EXEC. VP AND CLO 06 Luglio 2026 M 105.272 0 12 $-1.254.986
Christine Marie Utter SVP, CHIEF ACCOUNTING OFFICER 17 Giugno 2026 M 70.199 0 1 $-1.487.474
Eric Pauwels CHIEF BUSINESS OFFICER 10 Giugno 2026 S 73.411 0 28 $-7.477.160
Mark Rothera Chief Commercial Officer 24 Maggio 2017 M 33.739 0 0 $0
Tuyen Ong Chief Medical Officer 03 Gennaio 2017 A 6.000 0 0 $0
Robert J. Spiegel Chief Medical Officer 04 Gennaio 2016 A 3.239 0 0 $0
Hege Elisabeth Sollie-Zetlmayer Direttore 28 Luglio 2026 A 52.526 0 0 $0
Mary L. Smith Direttore 09 Luglio 2026 M 21.813 0 2 $-1.425.060
Stephanie Okey Direttore 07 Gennaio 2022 A 4.163 0 0 $0
Emma Reeve Direttore 07 Gennaio 2022 A 7.528 0 0 $0
Allan Steven Jacobson Direttore 07 Gennaio 2022 A 8.348 0 0 $0
Dawn Svoronos Direttore 07 Gennaio 2022 A 29.755 0 0 $0
Jerome B Zeldis Direttore 07 Gennaio 2022 A 6.500 0 0 $0
Cameron Geoffrey Mcdonough Direttore 03 Gennaio 2017 A 0 0 $0
Adam Koppel Direttore 03 Gennaio 2017 A 2.333.333 0 0 $0
Ronald C Renaud JR Direttore 03 Gennaio 2017 A 0 0 $0
Richard Aldrich Direttore 08 Giugno 2015 M 0 0 0 $0
Michael L Kranda Direttore 16 Marzo 2015 S 2.242 0 0 $0
Axel Bolte Direttore 25 Giugno 2013 P 20.000 0 0 $0
HBM Healthcare Investments (Cayman) Ltd. Proprietario del 10% 17 Dicembre 2013 S 2.441.504 0 0 $0
Matthew B. Klein 04 Agosto 2026 S 383.868 0 1 $-705.722
Michael Schmertzler 02 Gennaio 2026 A 163.266 0 0 $0
Glenn Steele JR MD PHD 02 Gennaio 2026 A 22.500 0 1 $-916.200
David P Southwell 02 Gennaio 2026 A 20.850 0 0 $0
Complete Pharma Holdings II, LLC 28 Aprile 2017 J 0 0 0 $0
CREDIT SUISSE/ 25 Giugno 2013 C 2.256.882 0 0 $0

Insider dai depositi SEC Modulo 3/4/5; netto = solo acquisti/vendite di mercato

Attivisti e proprietari del 5%+ 3 partecipazioni

Investitori che hanno depositato SEC Schedule 13D — proprietà effettiva superiore al 5% con l'intento di influenzare l'emittente (partecipazioni attiviste, campagne per il consiglio di amministrazione, M&A). Ogni riga mostra lo stato più recente noto della posizione di quel depositante.

Depositante Depositato Partecipazione Stato Scopo Deposito
Brookside Capital Partners Fund, L.P., Brookside Capital Trading Fund, L.P. ×5 depositi 30 Gennaio 2015 Deposito iniziale SEC
HBM Healthcare Investments (Cayman) Ltd. (“HBM”) ×2 depositi 12 Novembre 2014 Deposito iniziale SEC
HBM Healthcare Investments (Cayman) Ltd. 05 Luglio 2013 Deposito iniziale SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Proprietà ETF Posseduti da 87 ETF

Il peso riflette solo le partecipazioni azionarie dirette (N-PORT); fondi a leva o basati su derivati possono detenere ulteriore esposizione swap non mostrata.

Fondo Peso Unità Aggiornato al Fonte
IBRN · iShares Trust 3,81% 4.145 SH 08 Agosto 2026 Giornaliero
PSCH · Invesco Exchange-Traded Fund Trust … 3,08% 71.992 SH 08 Agosto 2026 Giornaliero
PBE · Invesco Exchange-Traded Fund Trust 2,59% 128.216 SH 08 Agosto 2026 Giornaliero
XSMO · Invesco Exchange-Traded Fund Trust 1,52% 642.023 SH 08 Agosto 2026 Giornaliero
BBP · ETFis Series Trust I 1,37% 12.510 NS 30 Aprile 2026 N-PORT
SIXS · EXCHANGE TRADED CONCEPTS TRUST 1,30% 22.380 NS 31 Maggio 2026 N-PORT
RZG · Invesco Exchange-Traded Fund Trust 1,25% 23.662 SH 08 Agosto 2026 Giornaliero
GURU · Global X Funds 1,03% 9.268 NS 30 Aprile 2026 N-PORT
LABU · Direxion Shares ETF Trust 0,93% 73.928 NS 30 Aprile 2026 N-PORT
VAMO · Cambria ETF Trust 0,83% 10.625 NS 30 Aprile 2026 N-PORT
VIOG · VANGUARD ADMIRAL FUNDS 0,74% 98.733 SH 08 Agosto 2026 Giornaliero
VMAX · Lattice Strategies Trust 0,72% 5.120 NS 30 Aprile 2026 N-PORT
IJT · iShares Trust 0,66% 770.376 SH 08 Agosto 2026 Giornaliero
FNY · First Trust Exchange-Traded AlphaDE… 0,51% 40.257 NS 30 Aprile 2026 N-PORT
MMSC · First Trust Exchange-Traded Fund VI… 0,49% 3.490 NS 31 Maggio 2026 N-PORT
CLSE · Trust for Professional Managers 0,49% 40.488 NS 31 Maggio 2026 N-PORT
IBB · iShares Trust 0,44% 588.017 SH 08 Agosto 2026 Giornaliero
HQGO · Lattice Strategies Trust 0,43% 3.203 NS 30 Aprile 2026 N-PORT
IBBQ · Invesco Exchange-Traded Fund Trust … 0,41% 4.514 SH 08 Agosto 2026 Giornaliero
OASC · Unified Series Trust 0,40% 4.569 NS 31 Maggio 2026 N-PORT
BRNY · EA Series Trust 0,40% 34.057 NS 30 Aprile 2026 N-PORT
VIOO · VANGUARD ADMIRAL FUNDS 0,37% 290.018 SH 08 Agosto 2026 Giornaliero
XJR · iShares Trust 0,37% 9.802 SH 08 Agosto 2026 Giornaliero
MSSM · MORGAN STANLEY PATHWAY FUNDS 0,34% 35.034 NS 31 Maggio 2026 N-PORT
VTWG · VANGUARD SCOTTSDALE FUNDS 0,34% 75.795 SH 08 Agosto 2026 Giornaliero
ESSC · Strategy Shares 0,34% 1.335 NS 30 Aprile 2026 N-PORT
IJR · iShares Trust 0,32% 5.058.562 SH 08 Agosto 2026 Giornaliero
IWO · iShares Trust 0,31% 641.280 SH 08 Agosto 2026 Giornaliero
BIB · ProShares Trust 0,31% 3.062 NS 31 Maggio 2026 N-PORT
FSCC · Federated Hermes ETF Trust 0,31% 11.451 NS 31 Maggio 2026 N-PORT
GSSC · Goldman Sachs ETF Trust 0,30% 39.411 NS 31 Maggio 2026 N-PORT
SAA · ProShares Trust 0,26% 961 NS 31 Maggio 2026 N-PORT
ROUS · Lattice Strategies Trust 0,25% 22.443 NS 30 Aprile 2026 N-PORT
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0,24% 27.276 NS 30 Aprile 2026 N-PORT
BKSE · BNY Mellon ETF Trust 0,23% 2.877 NS 30 Aprile 2026 N-PORT
AFSM · First Trust Exchange-Traded Fund VI… 0,23% 3.003 NS 31 Maggio 2026 N-PORT
VTWO · VANGUARD SCOTTSDALE FUNDS 0,20% 477.030 SH 08 Agosto 2026 Giornaliero
FNX · First Trust Exchange-Traded AlphaDE… 0,20% 39.967 NS 30 Aprile 2026 N-PORT
VBK · VANGUARD INDEX FUNDS 0,19% 1.099.640 SH 08 Agosto 2026 Giornaliero
PRFZ · Invesco Exchange-Traded Fund Trust 0,18% 72.691 SH 08 Agosto 2026 Giornaliero
IWM · iShares Trust 0,18% 2.102.256 SH 08 Agosto 2026 Giornaliero
LRGF · iShares Trust 0,16% 84.151 SH 08 Agosto 2026 Giornaliero
ISCG · iShares Trust 0,16% 22.792 SH 08 Agosto 2026 Giornaliero
RSSL · Global X Funds 0,16% 34.125 NS 30 Aprile 2026 N-PORT
FAD · First Trust Exchange-Traded AlphaDE… 0,15% 11.071 NS 30 Aprile 2026 N-PORT
ITWO · ProShares Trust 0,15% 3.710 NS 31 Maggio 2026 N-PORT
VFMO · VANGUARD WELLINGTON FUND 0,14% 35.428 SH 08 Agosto 2026 Giornaliero
FSMD · FIDELITY COVINGTON TRUST 0,14% 49.932 NS 30 Aprile 2026 N-PORT
OMFS · Invesco Exchange-Traded Self-Indexe… 0,14% 5.350 SH 08 Agosto 2026 Giornaliero
SMDX · Tidal Trust III 0,13% 2.579 NS 30 Aprile 2026 N-PORT