INSM Instantâneo da Ação Preço, capitalização de mercado, P/E, EPS, ROE, dívida/patrimônio, intervalo de 52 semanas

03

Preço $111.12

Capitalização de Mercado (MRQ) $24.26B

P/E (TTM) -27.0

EPS (TTM) $-4.12

Receita (TTM) $1.14B

ROE (TTM) -87.2%

Dívida/Capital (MRQ) 0.7

Intervalo 52 Semanas $90–$213

INSM Gráfico de Preço da Ação OHLCV diário com indicadores técnicos — panorâmica, zoom e personalize sua visualização

04

intervalo

barras

A granularidade da barra se adapta ao período selecionado — passe o mouse sobre o gráfico para ver a abertura/máxima/mínima/fechamento de uma barra.

Divisões de Ações 2

Data ex	Desdobramento	Tipo
3 de Março de 2011	1-for-10	Reverso
31 de Julho de 2000	1-for-4	Reverso

Desempenho de 10 Anos Tendências de receita, lucro líquido, margens e EPS

06

Receita$606M

2016-12-31 → 2025-12-31

EPS$-6.42

2019-12-31 → 2025-12-31

Fluxo de caixa livre$-968M

2016-12-31 → 2025-12-31

Margem líquida-76.9%

2018-12-31 → 2025-12-31

Avaliação e Proporções 07–12

Avaliação Rácios P/E, P/S, P/B, EV/EBITDA — a ação está cara ou barata?

Métrica	INSM	média 5A	Mediana de Pares	Veredito
P/E (TTM)	-27.0média 5A ≈-11.5	≈-11.5	·	·
P/S (TTM)	21.3média 5A ≈27.8	≈27.8	7.3	Sobreavaliado
P/B (MRQ)	32.0média 5A ≈23.7	≈23.7	6.1	Sobreavaliado
EV / EBITDA	-18.6média 5A ≈-12.9	≈-12.9	·	·
Preço / FCF (TTM)	-30.0média 5A ≈-16.0	≈-16.0	·	·
Preço / Fluxo de Caixa (TTM)	-31.1média 5A ≈-16.4	≈-16.4	·	·
EV / Receita (TTM)	20.8média 5A ≈27.3	≈27.3	·	·
EV / FCF (TTM)	-29.3média 5A ≈-15.7	≈-15.7	·	·
Preço / Valor Patrimonial Tangível (MRQ)	36.5média 5A ≈75.5	≈75.5	·	·

A mediana dos pares é calculada em uma base padronizada por métrica e pode não corresponder sempre à base TTM/MRQ mostrada para esta ação.

Lucratividade Margens bruta, operacional e líquida; ROE, ROA, ROIC

Métrica	INSM	média 5A	Mediana de Pares	Veredito
Margem Operacional (TTM)	-73.9%média 5A ≈-213.0%	≈-213.0%	16.9%	Fraco
EBITDA Margin (Margem EBITDA)	-205.6%média 5A ≈-211.2%	≈-211.2%	15.8%	Fraco
Margem de Impostos Pré-Tributação (TTM)	-76.4%média 5A ≈-226.4%	≈-226.4%	9.3%	Fraco
Margem de Lucro Líquido (TTM)	-76.9%média 5A ≈-226.9%	≈-226.9%	12.7%	Fraco
ROA (TTM)	-38.2%média 5A ≈-48.0%	≈-48.0%	6.8%	Fraco
ROE (TTM)	-87.2%média 5A ≈-376.1%	≈-376.1%	18.7%	Fraco
ROIC	-97.8%média 5A ≈-64.8%	≈-64.8%	16.4%	Fraco

Saúde financeira Dívida, liquidez, solvência — força do balanço patrimonial

Métrica	INSM	média 5A	Mediana de Pares	Veredito
Dívida / Patrimônio Líquido (MRQ)	0.7média 5A ≈3.1	≈3.1	0.0	Dívida alta
Índice de liquidez corrente (MRQ)	3.7média 5A ≈5.3	≈5.3	3.1	Liquidez forte
Índice de Liquidez Seca (MRQ)	3.1média 5A ≈4.7	≈4.7	1.7	Liquidez forte
Dívida de Longo Prazo / Patrimônio Líquido (MRQ)	0.7média 5A ≈3.1	≈3.1	·	·
Interest Coverage (Cobertura de Juros)	-14.9média 5A ≈-12.1	≈-12.1	-2.3	Baixa liquidez

Crescimento Crescimento da receita, EPS e lucro líquido: YoY, CAGR 3 anos, CAGR 5 anos

Métrica	INSM	média 5A	Mediana de Pares	Veredito
Revenue YoY (Receita Ano a Ano)	66.7%média 5A ≈31.0%	≈31.0%	·	·
Revenue CAGR 3Y (CAGR Receita 3A)	35.2%média 5A ≈27.5%	≈27.5%	·	·
Revenue CAGR 5Y (CAGR Receita 5A)	29.8%	·	·	·

Métricas por Ação EPS, valor patrimonial por ação, fluxo de caixa por ação, dividendo por ação

Métrica	INSM	média 5A	Mediana de Pares	Veredito
EPS (Diluted) (EPS (Diluído))	$-6.42média 5A ≈$-5.02	≈$-5.02	·	·
Revenue / Share (Receita / Ação)	$3.05média 5A ≈$2.22	≈$2.22	·	·
Cash Flow / Share (Fluxo de Caixa / Ação)	$-4.70média 5A ≈$-3.84	≈$-3.84	·	·
Cash / Share (Caixa / Ação)	$2.38média 5A ≈$4.54	≈$4.54	·	·

Eficiência de Capital Giro de ativos, giro de estoques, giro de contas a receber

Métrica	INSM	média 5A	Mediana de Pares	Veredito
Asset Turnover (Giro do Ativo)	0.3média 5A ≈0.2	≈0.2	0.7	Fraco
Inventory Turnover (Giro de Estoque)	1.1média 5A ≈0.9	≈0.9	1.9	Fraco
Receivables Turnover (Giro de Contas a Receber)	6.3média 5A ≈8.2	≈8.2	7.1	Fraco
Revenue / Employee (Receita anual ÷ funcionários (número de funcionários reportado, yfinance). Derivado — não é um conceito SEC-XBRL armazenado.)	≈$364.4K	·	·	·

valor · ≈ média 5A · mediana do setor · veredicto relativo à mediana

Histórico de Lucros EPS real vs. estimativa, surpresa %, taxa de acerto, próxima data de resultados

14

Surpresa Média 6.1%

Próximo relatório Out 28, 2026

Período	Relatório	EPS Actual	EPS est.	Surpresa
30 de Junho de 2026	Ago 5, 2026	$-0.06	$-0.80	92.5%
31 de Março de 2026	Mai 6, 2026	$-0.76	$-0.98	22.3%
31 de Dezembro de 2025		$-1.54	$-1.32	-17.0%
30 de Setembro de 2025		$-1.75	$-1.37	-28.1%
30 de Junho de 2025		$-1.70	$-1.32	-28.9%
31 de Março de 2025		$-1.42	$-1.36	-4.5%

Fundamentos Completos Todas as métricas por ano — demonstração de resultados, balanço patrimonial, fluxo de caixa

15

Demonstração de Resultados 17

Métrica	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Revenue	$606M	$364M	$305M	$245M	$188M	$164M	$136M	$10M	$0	$0	$0	·
Cost of Revenue	$123M	$86M	$66M	$55M	$44M	$40M	$24M	$2M	$0	$0	·	·
Gross Profit	·	·	·	·	·	·	$112M	$7M	$0	·	·	·
R&D Expense	$771M	$598M	$571M	$398M	$273M	$181M	$132M	$145M	$110M	$123M	$74M	$56M
SG&A Expense	$701M	$461M	$345M	$266M	$234M	$204M	$211M	$168M	$79M	$51M	$43M	$31M
Operating Expenses	$1.85B	$1.24B	$1.01B	$703M	$564M	$430M	$372M	$317M	$189M	$173M	$117M	$87M
Operating Income	$-1.25B	$-878M	$-710M	$-457M	$-375M	$-265M	$-235M	$-307M	$-189M	$-173M	$-117M	$-87M
Interest Expense	$84M	$85M	$82M	$26M	$40M	$30M	$28M	$25M	$6M	$3M	$3M	$2M
Other Non-op	$-2M	$29.0K	$2M	$-6M	$-3M	$405.0K	$-531.0K	$602.0K	$300.0K	$119.0K	$-33.0K	$141.0K
Pretax Income	$-1.27B	$-910M	$-747M	$-480M	$-436M	$-293M	$-254M	$-324M	$-193M	$-176M	$-120M	$-90M
Income Tax	$5M	$4M	$3M	$1M	$-2M	$1M	$777.0K	$201.0K	$-272.0K	$98.0K	$-2M	$-10M
Net Income	$-1.28B	$-914M	$-750M	$-482M	$-435M	$-294M	$-254M	$-324M	$-193M	$-176M	$-118M	$-79M
EPS (Basic)	$-6.42	$-5.57	$-5.34	$-3.91	$-3.88	$-3.01	$-3.01	·	·	·	·	·
EPS (Diluted)	$-6.42	$-5.57	$-5.34	$-3.91	$-3.88	$-3.01	$-3.01	·	·	·	·	·
Shares (Basic)	199,014,000	164,043,000	140,433,000	123,035,000	112,111,000	97,605,000	84,560,000	76,889,000	66,576,000	61,892,000	58,633,000	43,095,000
Shares (Diluted)	199,014,000	164,043,000	140,433,000	123,035,000	112,111,000	97,605,000	84,560,000	76,889,000	66,576,000	61,892,000	58,633,000	43,095,000
EBITDA	$-1.25B	$-878M	$-704M	$-452M	$-366M	$-256M	$-230M	$-304M	$-186M	$-171M	$-116M	·

Balanço Patrimonial 27

Métrica	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Cash & Equivalents	$510M	$555M	$482M	$1.07B	$717M	$533M	$487M	$495M	$381M	$163M	$283M	$159M
Short-term Investments	$920M	$879M	$298M	$74M	$0	·	·	·	·	·	·	·
Receivables	$141M	$52M	$41M	$30M	$24M	$17M	$19M	$6M	$0	·	·	·
Inventory	$132M	$99M	$83M	$70M	$67M	$50M	$28M	$7M	$0	·	·	·
Prepaid Expense	$91M	$37M	$24M	$25M	$29M	$24M	$20M	$11M	$8M	$6M	$5M	$5M
Current Assets	$1.79B	$1.62B	$929M	$1.27B	$837M	$623M	$555M	$519M	$389M	$168M	$288M	$165M
PP&E (Net)	$103M	$80M	$65M	$56M	$53M	$54M	$60M	$23M	$12M	$10M	$8M	$8M
PP&E (Gross)	$164M	$130M	$110M	$96M	$90M	$82M	$79M	$37M	$23M	$18M	$13M	$11M
Accum. Depreciation	$61M	$50M	$45M	$39M	$37M	$28M	$19M	$14M	$11M	$8M	$5M	$3M
Goodwill	$136M	$136M	$136M	$136M	$136M	$0	·	·	·	·	·	·
Intangibles	$98M	$59M	$64M	$69M	$74M	$49M	$54M	$59M	$58M	·	·	·
Total Assets	$2.26B	$2.03B	$1.33B	$1.66B	$1.24B	$796M	$742M	$605M	$462M	$238M	$357M	$231M
Accounts Payable	$80M	$73M	$65M	$50M	$36M	$43M	$13M	$18M	$15M	$10M	$7M	$9M
Accrued Liabilities	·	·	·	·	$61M	$38M	$40M	$38M	$17M	$17M	$11M	$10M
Current Liabilities	$469M	$298M	$226M	$190M	$135M	$119M	$85M	$80M	$45M	$28M	$22M	$20M
Capital Leases	$12M	$9M	$11M	$15M	$21M	$21M	$29M	·	·	·	·	·
Other Non-current Liabilities	$6M	$499.0K	$3M	$9M	$20M	$9M	$11M	$0	$765.0K	$693.0K	$572.0K	$23.0K
Total Liabilities	$1.53B	$1.74B	$1.66B	$1.57B	$833M	$520M	$481M	$396M	$101M	$83M	$45M	$45M
Long-term Debt	$547M	$1.12B	$1.18B	$1.15B	$800M	$450M	$450M	$450M	$55M	$55M	$25M	$25M
Total Debt	$541M	$1.10B	$1.16B	$1.13B	$567M	$356M	$336M	$317M	$56M	$55M	$25M	·
Common Stock	$2M	$2M	$1M	$1M	$1M	$1M	$897.0K	$773.0K	$766.0K	$620.0K	$618.0K	$498.0K
Paid-in Capital	$6.37B	$4.65B	$3.11B	$2.78B	$2.67B	$2.11B	$1.80B	$1.49B	$1.32B	$919M	$900M	$657M
Retained Earnings	$-5.64B	$-4.36B	$-3.45B	$-2.70B	$-2.27B	$-1.83B	$-1.54B	$-1.28B	$-958M	$-765M	$-589M	$-471M
AOCI	$1M	$-2M	$-745.0K	$756.0K	$968.0K	$193.0K	$-10.0K	$-9.0K	$-3.0K	$-65.0K	·	·
Stockholders' Equity	$739M	$285M	$-332M	$88M	$410M	$276M	$262M	$208M	$361M	$154M	$312M	$186M
Liabilities + Equity	$2.26B	$2.03B	$1.33B	$1.66B	$1.24B	$796M	$742M	$605M	$462M	$238M	$357M	$231M
Shares Outstanding	214,255,853	179,383,000	147,978,000	135,654,000	118,738,000	102,763,060	89,682,387	77,307,521	76,610,508	62,019,889	61,813,995	49,806,131

Fluxo de Caixa 15

Métrica	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
D&A	·	·	$6M	$5M	$9M	$9M	$5M	$4M	$3M	$2M	$2M	$1M
Stock-based Comp	$153M	$97M	$75M	$58M	$46M	$36M	$27M	$26M	$18M	$18M	$16M	$11M
Deferred Tax	$-27.0K	$-29.0K	$-54.0K	$-231.0K	$-3M	$0	$0	$0	$-417.0K	$0	$0	·
Amort. of Intangibles	$6M	$5M	$5M	$5M	$5M	$5M	$5M	$1M	$0	$0	·	·
Other Non-cash	·	·	$133M	$18M	$20M	$29M	$-28M	$36M	$12M	$9M	$-89.0K	·
Operating Cash Flow	$-935M	$-684M	$-536M	$-400M	$-363M	$-219M	$-251M	$-258M	$-160M	$-147M	$-101M	$-64M
CapEx	$33M	$22M	$13M	$10M	$7M	$6M	$42M	$13M	$3M	$4M	$3M	$5M
Investing Cash Flow	$-65M	$-583M	$-224M	$-35M	$-64M	$-7M	$-42M	$-15M	$-3M	$-4M	$-3M	·
Stock Issued	$823M	$1.08B	$152M	$292M	$270M	$246M	$261M	$0	$378M	$0	$223M	$109M
Net Stock Activity	$823M	$1.08B	$152M	$292M	$270M	$246M	$261M	$0	$378M	·	$223M	·
Financing Cash Flow	$954M	$1.34B	$168M	$793M	$613M	$271M	$285M	$387M	$381M	$31M	$228M	·
Net Change in Cash	$-45M	$73M	$-592M	$357M	$184M	$45M	$-8M	$114M	$219M	$-120M	$124M	$45M
Taxes Paid	$4M	$2M	$2M	$2M	$2M	$814.0K	$339.0K	$154.0K	$166.0K	$85.0K	$-3M	$9M
Free Cash Flow	$-968M	$-706M	$-550M	$-410M	$-371M	$-226M	$-293M	$-271M	$-163M	$-151M	$-104M	·
Levered FCF	$-1.05B	$-791M	$-632M	$-437M	$-411M	$-255M	$-321M	$-297M	$-169M	$-154M	$-107M	·

Lucratividade 8

Métrica	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Gross Margin	·	·	·	·	·	·	82.3%	·	·	·	·	·
Operating Margin	-205.6%	-241.5%	-232.5%	-186.4%	-199.0%	-161.3%	-172.4%	-3124.9%	·	·	·	·
Net Margin	-210.5%	-251.2%	-245.6%	-196.3%	-230.6%	-178.9%	-186.4%	-3297.2%	·	·	·	·
Pretax Margin	-209.7%	-250.2%	-244.8%	-195.7%	-231.6%	-178.0%	-185.8%	-3295.1%	·	·	·	·
EBITDA Margin	-205.6%	-241.5%	-230.7%	-184.2%	-194.2%	-155.8%	-168.6%	-3088.3%	·	·	·	·
ROA	-59.5%	-54.5%	-50.2%	-33.2%	-42.6%	-38.2%	-37.8%	-60.8%	-55.0%	-59.3%	-40.2%	·
ROE	-128.4%	-237.7%	241.3%	-1660.7%	-95.0%	-92.9%	-89.9%	-129.8%	-74.7%	-75.6%	-47.5%	·
ROIC	-97.8%	-63.5%	-86.5%	-37.8%	-38.2%	-42.1%	-39.5%	-58.6%	-45.3%	-82.9%	-34.3%	·

Liquidez e Solvência 5

Métrica	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Current Ratio	3.8	5.5	4.1	6.7	6.2	5.2	6.5	6.5	8.7	6.0	12.9	·
Quick Ratio	3.4	5.0	3.6	6.2	5.5	4.6	5.9	6.3	8.5	5.8	12.7	·
Debt / Equity	0.7	3.9	-3.5	12.8	1.4	1.3	1.3	1.5	0.2	0.4	0.1	·
LT Debt / Equity	0.7	3.9	-3.5	12.8	1.4	1.3	1.3	1.5	0.2	0.4	0.1	·
Interest Coverage	-14.9	-10.3	-8.7	-17.3	-9.3	-9.0	-8.5	-12.1	-31.9	-49.6	-40.7	·

Eficiência 3

Métrica	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Asset Turnover	0.3	0.2	0.2	0.2	0.2	0.2	0.2	0.0	0.0	·	·	·
Inventory Turnover	1.1	0.9	0.9	0.8	0.8	1.0	1.4	0.7	·	·	·	·
Receivables Turnover	6.3	7.8	8.6	9.1	9.2	9.2	11.0	3.6	·	·	·	·

Por Ação 5

Métrica	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Book Value / Share	$3.45	$1.59	$-2.24	$0.65	$3.46	$2.68	$2.92	$2.69	$4.71	$2.49	$5.04	·
Revenue / Share	$3.05	$2.22	$2.17	$1.99	$1.68	$1.68	$1.61	$0.13	$0.00	·	·	·
Cash Flow / Share	$-4.70	$-4.17	$-3.82	$-3.25	$-3.24	$-2.25	$-2.96	$-3.36	$-2.40	$-2.37	$-1.72	·
Cash / Share	$2.38	$3.09	$3.26	$7.92	$6.04	$5.18	$5.44	$6.40	$4.98	$2.62	$4.58	·
EPS (TTM)	$-6.42	$-5.57	$-5.34	$-3.91	$-3.88	$-3.01	$-3.01	·	·	·	·	·

Taxas de Crescimento 3

Métrica	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Revenue YoY	66.7%	19.2%	24.4%	30.2%	14.6%	·	·	·	·	·	·	·
Revenue CAGR 3Y	35.2%	24.5%	22.9%	·	·	·	·	·	·	·	·	·
Revenue CAGR 5Y	29.8%	·	·	·	·	·	·	·	·	·	·	·

Avaliação (TTM) 14

Métrica	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Revenue TTM	$606M	$364M	$305M	$245M	$188M	$164M	$136M	$10M	$0	$0	$0	$12M
Net Income TTM	$-1.28B	$-914M	$-750M	$-482M	$-435M	$-294M	$-254M	$-324M	$-193M	$-176M	$-118M	$-79M
Market Cap	$37.29B	$12.38B	$4.59B	$2.71B	$3.23B	$3.42B	$2.14B	$1.01B	$2.39B	$821M	$1.12B	·
Enterprise Value	$36.40B	$12.05B	$4.96B	$2.69B	$3.08B	$3.24B	$1.99B	$836M	$2.06B	$713M	$864M	·
P/E	-27.1	-12.4	-5.8	-5.1	-7.0	-11.1	-7.9	·	·	·	·	·
P/S	61.5	34.1	15.0	11.0	17.2	20.8	15.7	103.1	·	·	·	·
P/B	50.5	43.4	-13.8	30.8	7.9	12.4	8.2	4.9	6.6	5.3	3.6	·
P / Tangible Book	73.8	136.7	·	·	16.1	15.1	·	·	·	·	·	·
P / Cash Flow	-39.9	-18.1	-8.6	-6.8	-8.9	-15.6	-8.5	-3.9	-15.0	-5.6	-11.1	·
P / FCF	-38.5	-17.5	-8.3	-6.6	-8.7	-15.2	-7.3	-3.7	-14.7	-5.4	-10.8	·
EV / EBITDA	-29.2	-13.7	-7.0	-5.9	-8.4	-12.7	-8.7	-2.8	-11.1	-4.2	-7.5	·
EV / FCF	-37.6	-17.1	-9.0	-6.5	-8.3	-14.4	-6.8	-3.1	-12.7	-4.7	-8.3	·
EV / Revenue	60.0	33.1	16.3	11.0	16.4	19.7	14.6	85.0	·	·	·	·
Earnings Yield	-3.7%	-8.1%	-17.2%	-19.6%	-14.2%	-9.0%	-12.6%	·	·	·	·	·

Demonstração de Resultados 16

Métrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Revenue	$425M	$306M	$264M	$142M	$107M	$93M	$104M	$93M	$90M	$76M	$84M	$79M	$77M	$65M	$59M	$68M
Cost of Revenue	$67M	$47M	$44M	$29M	$28M	$21M	$26M	$21M	$21M	$17M	$18M	$17M	$17M	$14M	$13M	$13M
R&D Expense	$210M	$209M	$255M	$186M	$177M	$153M	$180M	$151M	$147M	$121M	$137M	$109M	$197M	$128M	$125M	$100M
SG&A Expense	$247M	$247M	$212M	$186M	$155M	$148M	$143M	$119M	$107M	$93M	$90M	$91M	$84M	$80M	$73M	$76M
Operating Expenses	$427M	$459M	$584M	$508M	$420M	$341M	$335M	$307M	$379M	$221M	$262M	$227M	$313M	$213M	$211M	$195M
Operating Income	$-2M	$-153M	$-320M	$-366M	$-313M	$-248M	$-230M	$-213M	$-289M	$-146M	$-178M	$-148M	$-236M	$-148M	$-151M	$-128M
Interest Expense	·	·	·	·	$21M	$22M	$22M	$21M	$21M	$21M	$21M	$20M	$21M	$20M	$16M	$3M
Other Non-op	$-531.0K	$-736.0K	$-2M	$-603.0K	$453.0K	$132.0K	$-445.0K	$2M	$-269.0K	$-1M	$2M	$285.0K	$-488.0K	$-111.0K	$1M	$-2M
Pretax Income	$-11M	$-162M	$-327M	$-369M	$-320M	$-256M	$-234M	$-220M	$-300M	$-157M	$-185M	$-158M	$-244M	$-159M	$-160M	$-131M
Income Tax	$2M	$1M	$2M	$1M	$1M	$912.0K	$1M	$1M	$838.0K	$589.0K	$998.0K	$544.0K	$530.0K	$483.0K	$125.0K	$372.0K
Net Income	$-13M	$-164M	$-328M	$-370M	$-322M	$-257M	$-236M	$-221M	$-301M	$-157M	$-186M	$-159M	$-245M	$-160M	$-160M	$-131M
EPS (Basic)	$-0.06	$-0.76	$-1.55	$-1.75	$-1.70	$-1.42	$-1.30	$-1.27	$-1.94	$-1.06	$-1.28	$-1.11	$-1.78	$-1.17	$-1.22	$-1.09
EPS (Diluted)	$-0.06	$-0.76	$-1.55	$-1.75	$-1.70	$-1.42	$-1.30	$-1.27	$-1.94	$-1.06	$-1.28	$-1.11	$-1.78	$-1.17	$-1.22	$-1.09
Shares (Basic)	217,352,000	215,468,000	·	211,759,000	189,302,000	180,860,000	·	173,721,000	154,702,000	148,456,000	·	142,899,000	137,553,000	136,355,000	·	120,789,000
Shares (Diluted)	217,352,000	215,468,000	·	211,759,000	189,302,000	180,860,000	·	173,721,000	154,702,000	148,456,000	·	142,899,000	137,553,000	136,355,000	·	120,789,000
EBITDA	$-2M	$-153M	·	$-366M	$-313M	$-248M	·	$-213M	$-289M	$-146M	·	$-148M	$-236M	$-148M	·	$-128M

Balanço Patrimonial 26

Métrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Cash & Equivalents	$545M	$582M	$510M	$335M	$1.28B	$403M	$555M	$461M	$1.25B	$596M	·	$487M	$613M	$969M	·	$415M
Short-term Investments	$616M	$641M	$920M	$1.35B	$572M	$796M	$879M	$1.01B	$0	$0	·	$299M	$305M	$30M	·	$99M
Receivables	$215M	$179M	$141M	$65M	$55M	$48M	$52M	$42M	$40M	$37M	·	$36M	$31M	$31M	·	$27M
Inventory	$142M	$133M	$132M	$121M	$108M	$101M	$99M	$98M	$90M	$83M	·	$78M	$77M	$71M	·	$66M
Prepaid Expense	$116M	$78M	$91M	$66M	$62M	$55M	$37M	$41M	$41M	$43M	·	$27M	$26M	$29M	·	$25M
Current Assets	$1.63B	$1.61B	$1.79B	$1.93B	$2.08B	$1.40B	$1.62B	$1.65B	$1.42B	$759M	·	$927M	$1.05B	$1.13B	·	$632M
PP&E (Net)	$107M	$103M	$103M	$90M	$90M	$88M	$80M	$75M	$73M	$69M	·	$65M	$62M	$60M	·	$54M
PP&E (Gross)	$174M	$166M	$164M	$147M	$145M	$141M	$130M	$124M	$120M	$115M	·	$108M	$104M	$100M	·	$92M
Accum. Depreciation	$67M	$64M	$61M	$57M	$55M	$52M	$50M	$49M	$47M	$46M	·	$43M	$42M	$41M	·	$38M
Goodwill	$136M	$136M	$136M	$136M	$136M	$136M	$136M	$136M	$136M	$136M	·	$136M	$136M	$136M	·	$136M
Intangibles	$93M	$96M	$98M	$85M	$56M	$57M	$59M	$60M	$61M	$62M	$64M	$65M	$66M	$67M	·	$70M
Total Assets	$2.10B	$2.08B	$2.26B	$2.36B	$2.48B	$1.80B	$2.03B	$2.05B	$1.81B	$1.16B	·	$1.32B	$1.44B	$1.52B	·	$995M
Accounts Payable	$75M	$73M	$80M	$80M	$74M	$58M	$73M	$65M	$51M	$44M	·	$65M	$56M	$57M	·	$12M
Current Liabilities	$439M	$361M	$469M	$417M	$312M	$239M	$298M	$259M	$524M	$421M	·	$197M	$204M	$188M	·	$138M
Capital Leases	$8M	$10M	$12M	$8M	$8M	$8M	$9M	$10M	$12M	$14M	·	$13M	$13M	$15M	·	$17M
Other Non-current Liabilities	$6M	$6M	$6M	$6M	$6M	$5M	$499.0K	$3M	$3M	$3M	·	$6M	$11M	$10M	·	$11M
Total Liabilities	$1.35B	$1.37B	$1.53B	$1.42B	$1.23B	$1.70B	$1.74B	$1.57B	$1.77B	$1.62B	·	$1.61B	$1.59B	$1.56B	·	$1.02B
Long-term Debt	$547M	$547M	$547M	$547M	$547M	$1.12B	·	$972M	$1.19B	$1.18B	·	$1.17B	$1.17B	$1.16B	·	$800M
Total Debt	$544M	$542M	·	$540M	$539M	$1.11B	·	$955M	$1.17B	$1.16B	·	$1.15B	$1.14B	$1.13B	·	$785M
Common Stock	$2M	$2M	$2M	$2M	$2M	$2M	$2M	$2M	$2M	$1M	·	$1M	$1M	$1M	·	$1M
Paid-in Capital	$6.57B	$6.50B	$6.37B	$6.25B	$6.18B	$4.71B	$4.65B	$4.61B	$3.94B	$3.14B	·	$2.97B	$2.95B	$2.81B	·	$2.51B
Retained Earnings	$-5.81B	$-5.80B	$-5.64B	$-5.31B	$-4.94B	$-4.62B	$-4.36B	$-4.12B	$-3.90B	$-3.60B	·	$-3.26B	$-3.10B	$-2.86B	·	$-2.54B
AOCI	$-3M	$4.0K	$1M	$2M	$2M	$-902.0K	$-2M	$547.0K	$-3M	$-2M	·	$-2M	$-1M	$1M	·	$-1M
Stockholders' Equity	$757M	$705M	$739M	$946M	$1.25B	$99M	$285M	$483M	$39M	$-465M	$-332M	$-289M	$-156M	$-45M	$88M	$-30M
Liabilities + Equity	$2.10B	$2.08B	$2.26B	$2.36B	$2.48B	$1.80B	$2.03B	$2.05B	$1.81B	$1.16B	·	$1.32B	$1.44B	$1.52B	·	$995M
Shares Outstanding	218,281,059	216,521,841	214,255,853	212,583,015	211,110,658	181,900,074	179,382,635	178,846,991	166,666,599	148,560,882	147,978,000	143,049,197	142,750,463	136,429,216	135,654,000	121,726,199

Fluxo de Caixa 12

Métrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Stock-based Comp	$41M	$46M	$39M	$31M	$43M	$39M	$27M	$26M	$23M	$21M	$20M	$20M	$18M	$16M	$15M	$16M
Deferred Tax	$0	$0	$-27.0K	$0	$0	$0	$-29.0K	$0	$0	$0	$-54.0K	$0	$0	$0	$-231.0K	$0
Amort. of Intangibles	$2M	$2M	$2M	$2M	$1M	$1M	$1M	$1M	$1M	$1M	$1M	$1M	$1M	$1M	$1M	$1M
Operating Cash Flow	$-89M	$-223M	$-248M	$-220M	$-206M	$-262M	$-196M	$-181M	$-123M	$-184M	$-131M	$-136M	$-123M	$-146M	$-103M	$-90M
CapEx	$6M	$3M	$17M	$2M	$3M	$10M	$7M	$4M	$7M	$5M	$2M	$3M	$5M	$3M	$5M	$582.0K
Investing Cash Flow	$25M	$266M	$389M	$-762M	$228M	$80M	$132M	$-1.00B	$-7M	$295M	$2M	$7M	$-274M	$42M	$20M	$49M
Stock Issued	·	·	$0	$-256.0K	·	·	$-12.0K	$371M	·	·	$114M	$0	·	·	$259M	$33M
Financing Cash Flow	$27M	$30M	$34M	$33M	$858M	$29M	$159M	$397M	$781M	$3M	$123M	$1M	$44M	$-399.0K	$743M	$37M
Net Change in Cash	$-37M	$72M	$176M	$-950M	$881M	$-152M	$94M	$-785M	$651M	$113M	$-5M	$-126M	$-356M	$-105M	$659M	$-1M
Taxes Paid	$696.0K	$3M	$111.0K	$1M	$677.0K	$2M	$248.0K	$689.0K	$354.0K	$1M	$75.0K	$518.0K	$358.0K	$1M	$91.0K	$432.0K
Free Cash Flow	·	$-226M	·	·	·	$-272M	·	·	·	$-189M	·	·	·	$-150M	·	·
Levered FCF	·	·	·	·	·	$-294M	·	·	·	$-210M	·	·	·	$-170M	·	·

Lucratividade 7

Métrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Operating Margin	-0.36%	-50.1%	·	-257.1%	-291.3%	-267.3%	·	-228.4%	-319.8%	-192.7%	·	-186.8%	-305.0%	-227.2%	·	-188.5%
Net Margin	-3.1%	-53.5%	·	-259.9%	-299.5%	-276.4%	·	-236.0%	-332.8%	-208.1%	·	-201.0%	-317.0%	-245.0%	·	-193.6%
Pretax Margin	-2.7%	-53.0%	·	-259.0%	-298.3%	-275.4%	·	-235.0%	-331.8%	-207.3%	·	-200.3%	-316.3%	-244.2%	·	-193.1%
EBITDA Margin	-0.36%	-50.1%	·	-257.1%	-291.3%	-267.3%	·	-228.4%	-319.8%	-192.7%	·	-186.8%	-305.0%	-227.2%	·	-188.5%
ROA	-0.58%	-8.4%	·	-16.8%	-15.0%	-17.3%	·	-13.1%	-18.5%	-11.7%	·	-13.7%	-19.6%	-12.0%	·	-11.4%
ROE	-1.3%	-40.7%	·	-51.8%	-49.9%	140.3%	·	-227.3%	514.2%	61.7%	·	99.6%	439.1%	-424.7%	·	-55.2%
ROIC	-0.14%	-12.4%	·	-24.7%	-17.6%	-20.7%	·	-14.9%	-23.9%	-20.9%	·	-17.3%	-24.0%	-13.7%	·	-17.0%

Liquidez e Solvência 5

Métrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Current Ratio	3.7	4.5	·	4.6	6.7	5.9	·	6.4	2.7	1.8	·	4.7	5.2	6.0	·	4.6
Quick Ratio	3.1	3.9	·	4.2	6.1	5.2	·	5.8	2.5	1.5	·	4.2	4.6	5.5	·	3.9
Debt / Equity	0.7	0.8	·	0.6	0.4	11.1	·	2.0	30.2	-2.5	·	-4.0	-7.3	-25.4	·	-26.2
LT Debt / Equity	0.7	0.8	·	0.6	0.4	11.1	·	2.0	24.4	-2.0	·	-4.0	-7.3	-25.4	·	-26.2
Interest Coverage	·	·	·	·	-14.7	-11.5	·	-10.1	-13.6	-6.9	·	-7.3	-11.4	-7.4	·	-38.1

Eficiência 3

Métrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Asset Turnover	0.2	0.2	·	0.1	0.1	0.1	·	0.1	0.1	0.1	·	0.1	0.1	0.0	·	0.1
Inventory Turnover	0.5	0.4	·	0.3	0.3	0.2	·	0.2	0.3	0.2	·	0.2	0.2	0.2	·	0.2
Receivables Turnover	3.1	2.7	·	2.6	2.3	2.2	·	2.4	2.5	2.2	·	2.5	2.6	2.3	·	2.9

Por Ação 5

Métrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Book Value / Share	$3.47	$3.26	·	$4.45	$5.92	$0.55	·	$2.70	$0.23	$-3.13	·	$-2.02	$-1.09	$-0.33	·	$-0.25
Revenue / Share	$1.96	$1.42	·	$0.67	$0.57	$0.51	·	$0.54	$0.58	$0.51	·	$0.55	$0.56	$0.48	·	$0.56
Cash Flow / Share	·	$-1.03	·	·	·	$-1.45	·	·	·	$-1.24	·	·	·	$-1.07	·	·
Cash / Share	$2.50	$2.69	·	$1.57	$6.08	$2.22	·	$2.58	$7.48	$4.01	·	$3.41	$4.29	$7.10	·	$3.41
EPS (TTM)	$-4.12	$-5.76	·	$-6.17	$-5.69	$-5.93	·	$-5.55	$-5.39	$-5.23	·	$-5.28	$-5.26	$-4.28	·	$-3.65

Avaliação (TTM) 11

Métrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Revenue TTM	$1.14B	$820M	·	$447M	$398M	$381M	·	$343M	$329M	$315M	·	$281M	$269M	$257M	·	$242M
Net Income TTM	$-875M	$-1.18B	·	$-1.18B	$-1.03B	$-1.01B	·	$-864M	$-803M	$-747M	·	$-724M	$-696M	$-547M	·	$-434M
Market Cap	$23.27B	$35.41B	·	$30.61B	$21.25B	$13.88B	·	$13.06B	$11.17B	$4.03B	·	$3.61B	$3.01B	$2.33B	·	$2.62B
Enterprise Value	$22.66B	$34.72B	·	$29.47B	$19.93B	$13.78B	·	$12.54B	$11.09B	$4.60B	·	$3.97B	$3.23B	$2.46B	·	$2.89B
P/E	-25.9	-28.4	·	-23.3	-17.7	-12.9	·	-13.2	-12.4	-5.2	·	-4.8	-4.0	-4.0	·	-5.9
P/S	20.5	43.2	·	68.5	53.4	36.4	·	38.1	34.0	12.8	·	12.9	11.2	9.0	·	10.8
P/B	30.7	50.2	·	32.4	17.0	139.9	·	27.0	287.7	-8.7	·	-12.5	-19.3	-52.1	·	-87.5
P / Tangible Book	44.1	74.8	·	42.2	20.1	·	·	45.4	·	·	·	·	·	·	·	·
P / Cash Flow	·	-159.0	·	·	·	-52.9	·	·	·	-21.9	·	·	·	-15.9	·	·
EV / Revenue	19.9	42.4	·	65.9	50.1	36.2	·	36.6	33.8	14.6	·	14.2	12.0	9.6	·	11.9
Earnings Yield	-3.9%	-3.5%	·	-4.3%	-5.7%	-7.8%	·	-7.6%	-8.0%	-19.3%	·	-20.9%	-24.9%	-25.1%	·	-17.0%

Período mais recente à esquerda · valores nulos mostrados como ·

Demonstrações Financeiras Demonstração de resultados, balanço patrimonial, fluxo de caixa — anual, últimos 5 anos

16

Métrica	2025-12-31	2024-12-31	2023-12-31	2022-12-31	2021-12-31
Receita	$606M	$364M	$305M	$245M	$188M
Margem Operacional %	-205.6%	-241.5%	-232.5%	-186.4%	-199.0%
Lucro líquido	$-1.28B	$-914M	$-750M	$-482M	$-435M
EPS Diluído	$-6.42	$-5.57	$-5.34	$-3.91	$-3.88

Métrica	2025-12-31	2024-12-31	2023-12-31	2022-12-31	2021-12-31
Dívida / Patrimônio Líquido	0.7	3.9	-3.5	12.8	1.4
Índice de liquidez corrente	3.8	5.5	4.1	6.7	6.2
Índice de Liquidez Seca	3.4	5.0	3.6	6.2	5.5

Métrica	2025-12-31	2024-12-31	2023-12-31	2022-12-31	2021-12-31
Fluxo de caixa livre	$-968M	$-706M	$-550M	$-410M	$-371M

Investidores institucionais (13F) 745 declarantes · $27.2B total · Em 30 de Setembro de 2026

17

Instituições que relatam a posse desta ação em seu Formulário 13F trimestral da SEC. Apenas posições compradas; um único declarante pode aparecer duas vezes para opções separadas. Grandes posições de compra/venda compensatórias geralmente refletem market-making ou inventário protegido, não convicção direcional.

Detentores 745

Valor detido $27.2B

Novas posições 129

Posições encerradas 115

Atividade institucional — Q2 2026 vs trimestre anterior

Novas posições	Posições encerradas	Aumentou	Diminuído	Variação líquida de ações
129 (+11 vs trimestre anterior)	115 (+23 vs trimestre anterior)	256 (-28 vs trimestre anterior)	241 (+13 vs trimestre anterior)	+7.8M

Comparado a Q1 2026. Os registros do Formulário 13F da SEC devem ser feitos em até 45 dias após o final do trimestre, mais um pequeno período de tolerância para registrantes atrasados — trimestres ainda dentro desse período são ignorados em favor do par mais recente totalmente reportado.

Instituição	Valor	Ações	% de 13F rastreado	Tipo
VANGUARD GROUP INC	$3.668.126.910	21.076.344	13,48%	Ações
FMR LLC	$1.721.228.828	16.143.583	6,33%	Ações
BlackRock, Inc.	$1.685.447.191	15.807.984	6,19%	Ações
VANGUARD PORTFOLIO MANAGEMENT LLC	$1.109.696.908	10.407.962	4,08%	Ações
JPMORGAN CHASE & CO	$1.092.246.620	10.428.170	4,01%	Ações
VANGUARD CAPITAL MANAGEMENT LLC	$1.043.902.026	9.790.865	3,84%	Ações
BAKER BROS. ADVISORS LP	$937.841.355	8.796.111	3,45%	Ações
Capital International Investors	$878.338.960	8.238.124	3,23%	Ações
Darwin Global Management, Ltd.	$673.600.013	6.431.163	2,48%	Ações
AMERIPRISE FINANCIAL INC	$658.878.001	6.179.571	2,42%	Ações
Orbis Allan Gray Ltd	$647.875.044	6.076.487	2,38%	Ações
STATE STREET CORP	$645.282.792	6.052.174	2,37%	Ações
D. E. Shaw & Co., Inc.	$626.707.989	5.877.959	2,30%	Ações
Artisan Partners Limited Partnership	$580.195.955	5.441.718	2,13%	Ações
RTW INVESTMENTS, LP	$516.347.866	4.842.880	1,90%	Ações
GEODE CAPITAL MANAGEMENT, LLC	$448.763.113	4.220.155	1,65%	Ações
NORGES BANK	$360.124.083	3.377.641	1,32%	Ações
UBS Group AG	$275.553.633	2.584.446	1,01%	Ações
CITADEL ADVISORS LLC	$272.624.461	2.556.973	1,00%	Ações
FRANKLIN RESOURCES INC	$242.371.000	2.273.222	0,89%	Ações
MAVERICK CAPITAL LTD	$229.314.244	2.150.762	0,84%	Ações
MILLENNIUM MANAGEMENT LLC	$218.358.293	2.048.005	0,80%	Ações
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	$198.680.888	1.215.025	0,73%	Ações
Qube Research & Technologies Ltd	$179.370.451	1.682.334	0,66%	Ações
WESTFIELD CAPITAL MANAGEMENT CO LP	$173.743.795	1.629.561	0,64%	Ações
Integral Health Asset Management, LLC	$170.592.000	1.600.000	0,63%	Ações
GOLDMAN SACHS GROUP INC	$150.322.007	1.409.885	0,55%	Ações
VANGUARD FIDUCIARY TRUST CO	$149.433.474	1.401.552	0,55%	Ações
Bellevue Group AG	$148.566.227	1.393.418	0,55%	Ações
Balyasny Asset Management L.P.	$141.423.967	1.326.430	0,52%	Ações
Paradigm Biocapital Advisors LP	$141.375.668	1.325.977	0,52%	Ações
NORTHERN TRUST CORP	$140.239.951	1.315.325	0,52%	Ações
Bank of New York Mellon Corp	$139.965.961	1.312.756	0,51%	Ações
TWO SIGMA INVESTMENTS, LP	$132.445.710	1.242.222	0,49%	Ações
MORGAN STANLEY	$131.515.791	1.233.498	0,48%	Ações
Pictet Asset Management Holding SA	$129.804.038	1.220.353	0,48%	Ações
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	$129.432.735	1.213.963	0,48%	Ações
Hood River Capital Management LLC	$112.683.586	1.056.871	0,41%	Ações
BANK OF AMERICA CORP /DE/	$109.084.466	1.023.114	0,40%	Ações
SEI INVESTMENTS CO	$108.312.723	1.015.870	0,40%	Ações
Castle Hook Partners LP	$105.906.712	993.310	0,39%	Ações
JENNISON ASSOCIATES LLC	$96.501.143	905.094	0,35%	Ações
TimesSquare Capital Management, LLC	$95.626.169	584.798	0,35%	Ações
Polar Capital Holdings Plc	$94.984.773	890.872	0,35%	Ações
MILLENNIUM MANAGEMENT LLC	$92.119.680	864.000	0,34%	Opção de compra
FIL Ltd	$91.289.537	856.214	0,34%	Ações
PRINCIPAL FINANCIAL GROUP INC	$91.280.154	856.126	0,34%	Ações
ADAGE CAPITAL PARTNERS GP, L.L.C.	$90.627.000	850.000	0,33%	Ações
Fiera Capital Corp	$89.885.138	843.042	0,33%	Ações
Legal & General Group Plc	$88.114.072	826.431	0,32%	Ações

Mostrar todos os 745 proprietários institucionais →

Executivos da empresa 48 insiders · 31 diretores · 18 conselheiros

19

Investidor com informação privilegiada	Função	Última atividade	Ações detidas	Vendas 12m	Líquido 12m
William Lewis	Chair and CEO	23 de Julho de 2026 M	259.058	74	$-32.791.057
Timothy Whitten	President & CEO	1 de Junho de 2012 P	10.000	0	$0
Geoffrey Allan	President, CEO and Chairman	31 de Março de 2009 M	1.715.557	0	$0
Sara Bonstein	Chief Financial Officer	3 de Junho de 2026 S	69.082	6	$-2.132.573
Paolo Tombesi	Chief Financial Officer	3 de Janeiro de 2019 A	10.669	0	$0
Andrew T Drechsler	Chief Financial Officer	1 de Março de 2017 M	15.000	0	$0
Kevin P Tully	Executive VP & CFO	21 de Dezembro de 2011 A	377.344	0	$0
Steve C Glover	President Follow-on Biologics	31 de Março de 2009 M	372.113	0	$0
Roger Adsett	Chief Operating Officer	10 de Agosto de 2026 M	98.744	10	$-48.253.225
Ronald D Gunn	Executive Vice President & COO	8 de Dezembro de 2005 A	40.074	0	$0
Martina Flammer M.D.	Chief Medical Officer	6 de Agosto de 2026 M	60.486	40	$-23.323.179
Samuele Butera	SVP, GM, Global Respiratory	23 de Junho de 2026 A	7.342	0	$0
Michael Alexander Smith	Chief Legal Officer	22 de Junho de 2026 S	37.648	20	$-13.997.738
Orlov S Nicole Schaeffer	Chief People Strategy Officer	2 de Janeiro de 2026 M	41.754	9	$-21.113.483
John Drayton Wise	Chief Commercial Officer	7 de Fevereiro de 2025 S	133.015	0	$0
John Soriano	Chief Compliance Officer	7 de Setembro de 2021 M	35.204	0	$0
Christine A Pellizzari	Chief Legal Officer	15 de Maio de 2021 F	149.985	0	$0
John Goll	Chief Accounting Officer	3 de Janeiro de 2020 A	14.166	0	$0
Paul Streck	Chief Medical Officer	8 de Agosto de 2018 A	15.996	0	$0
Eugene Jeffrey Sullivan	Chief Med. & Scientific Ofc.	17 de Maio de 2017 A	·	0	$0
Mark Quigley	Vice President, Quality	12 de Maio de 2015 M	0	0	$0
Peggy Berry	Vice President, Regulatory	26 de Fevereiro de 2015 A	·	0	$0
Matthew Pauls	Chief Commercial Officer	2 de Junho de 2014 A	·	0	$0
Renu Gupta	Executive Vice President & CMO	31 de Janeiro de 2014 M	37.014	0	$0
Andrea Holtzman Drucker	SVP, Gen. Counsel & Corp Sec.	3 de Junho de 2013 M	45.000	0	$0
Nicholas A. Labella Jr.	Chief Scientific Officer	21 de Dezembro de 2011 A	·	0	$0
Nicholas Lee Gurreri	Senior VP, Commercial Ops	31 de Janeiro de 2011 A	·	0	$0
Doug Farrar	Vice President, ITP	31 de Março de 2009 M	292.055	0	$0
Michael Duncan	Principal Financial Officer	8 de Dezembro de 2005 A	·	0	$0
Philip J Young	Chief Business Officer and EVP	8 de Dezembro de 2005 A	·	0	$0
Thomas A Keuer	Sr VP, ITP (Subsidiary)	8 de Dezembro de 2005 A	·	0	$0
David R Brennan	Conselheiro	9 de Setembro de 2026 S	39.238	1	$-3.100.000
Melvin Sharoky MD	Conselheiro	17 de Agosto de 2026 S	0	2	$-4.737.850
Clarissa Desjardins	Conselheiro	13 de Maio de 2026 A	70.312	0	$0
Elizabeth M Anderson	Conselheiro	13 de Maio de 2026 A	62.034	2	$-2.981.600
Leo Lee	Conselheiro	13 de Maio de 2026 A	57.971	5	$-14.692.249
David W J Mcgirr	Conselheiro	9 de Fevereiro de 2026 G	53.400	0	$0
Alfred Altomari	Conselheiro	13 de Maio de 2024 A	69.495	0	$0
Steinar J Engelsen	Conselheiro	1 de Novembro de 2021 P	320.802	0	$0
Donald J Hayden JR	Conselheiro	9 de Abril de 2019 M	62.197	0	$0
Myrtle S Potter	Conselheiro	15 de Maio de 2018 A	25.510	0	$0
Randall W Whitcomb	Conselheiro	10 de Março de 2015 M	69.188	0	$0
Richard S Kollender	Conselheiro	31 de Outubro de 2013 M	24.598	0	$0
Dennis M Lanfear	Conselheiro	9 de Junho de 2010 A	168.404	0	$0
Graham K Crooke	Conselheiro	9 de Junho de 2010 A	228.404	0	$0
Kenneth G Condon	Conselheiro	9 de Junho de 2010 A	168.504	0	$0
FMR LLC	Detentor de 10%	22 de Julho de 2013 S	2.221	0	$0
Carol Schafer	·	13 de Maio de 2026 A	66.622	0	$0

Executivos de declarações SEC Formulário 3/4/5; líquido = apenas P/V de mercado aberto

Participação em ETFs Detido por 73 ETFs

20

O peso reflete apenas participações diretas em ações (N-PORT); fundos alavancados ou baseados em derivativos podem deter exposição adicional a swaps não mostrada.

Fundo	Peso	Unidades	Em	Fonte
MEDI · Harbor ETF Trust	2,52%	10.513 NS	31 de Julho de 2026	N-PORT
IBB · iShares Trust	2,02%	1.640.771 SH	11 de Setembro de 2026	Diário
IBBQ · Invesco Exchange-Traded Fund Trust …	1,63%	15.452 SH	1 de Outubro de 2026	Diário
SPIT · RBB Fund, Inc.	1,60%	5.414 NS	31 de Julho de 2026	N-PORT
BBP · ETFis Series Trust I	1,39%	13.870 NS	31 de Julho de 2026	N-PORT
JDOC · J.P. Morgan Exchange-Traded Fund Tr…	0,97%	894 NS	31 de Julho de 2026	N-PORT
IWP · iShares Trust	0,80%	1.209.253 SH	11 de Setembro de 2026	Diário
LABU · Direxion Shares ETF Trust	0,73%	36.726 NS	31 de Julho de 2026	N-PORT
IYH · iShares Trust	0,44%	125.597 SH	11 de Setembro de 2026	Diário
IMCG · iShares Trust	0,38%	118.553 SH	11 de Setembro de 2026	Diário
WINN · Harbor ETF Trust	0,36%	40.917 NS	31 de Julho de 2026	N-PORT
VHT · VANGUARD WORLD FUND	0,33%	632.581 SH	19 de Agosto de 2026	Diário
VBK · VANGUARD INDEX FUNDS	0,32%	1.435.651 SH	19 de Agosto de 2026	Diário
FHLC · FIDELITY COVINGTON TRUST	0,30%	100.200 NS	31 de Julho de 2026	N-PORT
FFLG · FIDELITY COVINGTON TRUST	0,26%	15.672 NS	31 de Julho de 2026	N-PORT
VXF · VANGUARD INDEX FUNDS	0,26%	2.487.127 SH	19 de Agosto de 2026	Diário
VOT · VANGUARD INDEX FUNDS	0,25%	830.249 SH	19 de Agosto de 2026	Diário
SIZE · iShares Trust	0,23%	7.660 SH	11 de Setembro de 2026	Diário
PWS · Pacer Funds Trust	0,21%	502 NS	31 de Julho de 2026	N-PORT
IWR · iShares Trust	0,20%	879.778 SH	11 de Setembro de 2026	Diário
EUSA · iShares, Inc.	0,20%	29.864 SH	11 de Setembro de 2026	Diário
HEQQ · J.P. Morgan Exchange-Traded Fund Tr…	0,19%	587 NS	31 de Julho de 2026	N-PORT
IMCB · iShares Trust	0,19%	25.151 SH	11 de Setembro de 2026	Diário
FFSM · FIDELITY COVINGTON TRUST	0,19%	28.857 NS	31 de Julho de 2026	N-PORT
JMOM · J.P. Morgan Exchange-Traded Fund Tr…	0,15%	38.663 NS	31 de Julho de 2026	N-PORT
VB · VANGUARD INDEX FUNDS	0,14%	2.485.842 SH	19 de Agosto de 2026	Diário
ESLG · Strategy Shares	0,13%	313 NS	31 de Julho de 2026	N-PORT
ESUM · Strategy Shares	0,13%	2.410 NS	31 de Julho de 2026	N-PORT
LRND · New York Life Investments ETF Trust	0,12%	4.894 NS	31 de Julho de 2026	N-PORT
PRFZ · Invesco Exchange-Traded Fund Trust	0,12%	27.929 SH	1 de Outubro de 2026	Diário
ESLV · Strategy Shares	0,12%	171 NS	31 de Julho de 2026	N-PORT
SUSA · iShares Trust	0,11%	35.904 SH	11 de Setembro de 2026	Diário
VO · VANGUARD INDEX FUNDS	0,11%	2.348.570 SH	19 de Agosto de 2026	Diário
USXF · iShares Trust	0,11%	12.482 SH	11 de Setembro de 2026	Diário
SDG · iShares Trust	0,10%	1.340 SH	11 de Setembro de 2026	Diário
ESSC · Strategy Shares	0,10%	368 NS	31 de Julho de 2026	N-PORT
ILCG · iShares Trust	0,09%	20.984 SH	10 de Setembro de 2026	Diário
EQAL · Invesco Exchange-Traded Fund Trust …	0,09%	5.928 SH	1 de Outubro de 2026	Diário
IWF · iShares Trust	0,08%	806.337 SH	11 de Setembro de 2026	Diário
FBCG · FIDELITY COVINGTON TRUST	0,08%	53.285 NS	31 de Julho de 2026	N-PORT
VONG · VANGUARD SCOTTSDALE FUNDS	0,07%	339.999 SH	19 de Agosto de 2026	Diário
VUG · VANGUARD INDEX FUNDS	0,05%	1.801.856 SH	19 de Agosto de 2026	Diário
DYNF · BlackRock ETF Trust	0,05%	147.228 SH	11 de Setembro de 2026	Diário
ILCB · iShares Trust	0,04%	4.085 SH	11 de Setembro de 2026	Diário
VFMO · VANGUARD WELLINGTON FUND	0,04%	7.753 SH	19 de Agosto de 2026	Diário
ESGV · VANGUARD WORLD FUND	0,04%	48.501 SH	19 de Agosto de 2026	Diário
IWB · iShares Trust	0,04%	148.337 SH	11 de Setembro de 2026	Diário
IYY · iShares Trust	0,04%	9.185 SH	11 de Setembro de 2026	Diário
ITOT · iShares Trust	0,04%	283.947 SH	11 de Setembro de 2026	Diário
IWV · iShares Trust	0,04%	59.481 SH	11 de Setembro de 2026	Diário
PBUS · Invesco Exchange-Traded Fund Trust …	0,04%	36.517 SH	1 de Outubro de 2026	Diário
BBUS · J.P. Morgan Exchange-Traded Fund Tr…	0,03%	29.520 NS	31 de Julho de 2026	N-PORT
VOTE · TCW ETF Trust	0,03%	3.623 NS	31 de Julho de 2026	N-PORT
BKLC · BNY Mellon ETF Trust	0,03%	17.548 NS	31 de Julho de 2026	N-PORT
DFUS · Dimensional ETF Trust	0,03%	66.777 NS	31 de Julho de 2026	N-PORT
TOK · iShares Trust	0,03%	583 SH	11 de Setembro de 2026	Diário
VTI · VANGUARD INDEX FUNDS	0,03%	6.885.800 SH	19 de Agosto de 2026	Diário
VONE · VANGUARD SCOTTSDALE FUNDS	0,03%	35.614 SH	19 de Agosto de 2026	Diário
VTHR · VANGUARD SCOTTSDALE FUNDS	0,03%	18.072 SH	19 de Agosto de 2026	Diário
TOV · EA Series Trust	0,03%	751 NS	31 de Julho de 2026	N-PORT
URTH · iShares, Inc.	0,03%	18.868 SH	11 de Setembro de 2026	Diário
RECS · Columbia ETF Trust I	0,03%	17.415 NS	31 de Julho de 2026	N-PORT
ACWI · iShares Trust	0,03%	67.041 SH	11 de Setembro de 2026	Diário
CRBN · iShares Trust	0,02%	2.066 SH	11 de Setembro de 2026	Diário
VV · VANGUARD INDEX FUNDS	0,02%	126.924 SH	19 de Agosto de 2026	Diário
VT · VANGUARD INTERNATIONAL EQUITY INDEX…	0,02%	178.900 SH	19 de Agosto de 2026	Diário
TILT · FlexShares Trust	0,02%	4.108 NS	31 de Julho de 2026	N-PORT
DFSU · Dimensional ETF Trust	0,02%	4.167 NS	31 de Julho de 2026	N-PORT
DCOR · Dimensional ETF Trust	0,02%	5.993 NS	31 de Julho de 2026	N-PORT
DFAU · Dimensional ETF Trust	0,01%	18.487 NS	31 de Julho de 2026	N-PORT
HDUS · Lattice Strategies Trust	0,01%	250 NS	31 de Julho de 2026	N-PORT
DFAC · Dimensional ETF Trust	0,01%	48.566 NS	31 de Julho de 2026	N-PORT
SMLF · iShares Trust	·	124.879 SH	11 de Setembro de 2026	Diário

INSM Consenso dos analistas Opiniões de analistas otimistas e pessimistas, preço-alvo de 12 meses, potencial de alta

21

classificação · 30 analistas COMPRA

Alvo mediano $195.00 +75,5%

9 30,0% Compra forte

20 66,7% Compra

1 3,3% Manter

0 0,0% Venda

0 0,0% Venda forte

Preço-alvo de 12 meses

23 analistas · 2026-09-29

Alvo médio $199.04 +79,1%

← Abaixo de todos os alvos Preço atual $111.12

Mín$169.00 Média$199.04 Máx$243.00

Comparação de pares (subindústria GICS) Métricas chave vs pares do setor

22

Base do ano fiscal, preços no fechamento do último ano fiscal de cada empresa.

Ticker	Capitalização de Mercado	P/E	Receita YoY	Margem Líquida	ROE	Margem Bruta
INSM	$37.29B	-27.1	66.7%	-210.5%	-128.4%	·
NTRA	$32.00B	-150.7	35.9%	-9.0%	-14.1%	·
RVMD	·	·	·	·	·	·
BIIB	$25.84B	20.0	2.2%	13.1%	7.2%	·
ALNY	$52.64B	170.7	65.2%	8.5%	60.4%	·
UTHR	$21.27B	17.5	10.6%	41.9%	18.7%	87.9%
INCY	$19.60B	15.4	21.2%	25.0%	27.6%	·
NBIX	$14.20B	30.4	21.4%	16.7%	16.1%	·
EXEL	$11.44B	15.7	7.0%	33.7%	37.3%	·
SMMT	$13.56B	-12.1	·	·	-235.1%	·

Últimas notícias Notícias recentes mencionando esta empresa

23

Is Insmed (INSM) One of the Most Promising Healthcare Stocks After Cantor Fitzgerald’s Target Raise? Yahoo Finance · 3 meses, 1 semana atrás Pressões Competitivas Levam Truist a Cortar Alvo da Insmed (INSM) Yahoo Finance · 4 meses, 1 semana atrás Insmed CEO revela população de pacientes japoneses excede a população dos EUA para doenças pulmonares Yahoo Finance · 6 meses, 1 semana atrás Artisan Small Cap Fund Vendeu Insmed (INSM) em Consideração de Avaliação Yahoo Finance · 6 meses, 2 semanas atrás

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INSM Insmed Incorporated - Common Stock