CRNX Crinetics Pharmaceuticals, Inc. - Common Stock

NASDAQ · Pharmaceuticals · SEC EDGAR'da Görüntüle ↗
$84,77
Fiyat · Ağu 19, 2026
Temel veriler itibarıyla Ağu 3, 2026

Crinetics Pharmaceuticals, Inc. - Common Stock Hakkında Wikipedia'dan şirket genel bakışı

Crinetics Pharmaceuticals is a global pharmaceutical company known for developing drugs for the treatment of endocrine-related diseases. It was founded by Scott Struthers, Frank Zhu, Ana Kusnetzow, and Stephen F. Betz in 2008 and is headquartered in San Diego, California. It went public on NASDAQ in 2018.

Devamını oku

Crinetics Pharmaceuticals is a global pharmaceutical company known for developing drugs for the treatment of endocrine-related diseases. It was founded by Scott Struthers, Frank Zhu, Ana Kusnetzow, and Stephen F. Betz in 2008 and is headquartered in San Diego, California. It went public on NASDAQ in 2018.

In July 2026, Vertex Pharmaceuticals agreed to acquire the company for $10 billion.

History

Struthers, Zhu, Kusnetzow, and Betz founded Crinetics in 2008 after previously working together on a small molecule drug for the treatment of endometriosis at Neurocrine Biosciences.

Crinetics expanded into a larger laboratory in 2010. After receiving NIH grant funding, Crinetics moved into its second laboratory.

In 2011, Crinetics Pharmaceuticals competed for the Michelson Prize, a competition sponsored by the Found Animals Foundation to develop a low-cost, non-surgical method for sterilizing dogs and cats, which would later lead to the licensing of a molecule for the treatment of acromegaly in large breed dogs.

Crinetics first synthesized its lead drug candidate to treat acromegaly. The drug was named paltusotine, in 2016. Crinetics Pharmaceuticals went public with an IPO in 2018. It conducted Phase II trials for paltusotine from 2019 to 2020. It conducted Phase III trials for paltusotine from 2021 to 2024. After the drug succeeded in a second Phase III study, the FDA accepted the company's new drug application for paltusotine and the company announced it was planning for a 2025 launch for the drug. The FDA set a Prescription Drug User Fee Act for the drug on September 25, 2025.

In 2021, Crinetics, together with 5AM Ventures and Frazier Healthcare Partners, formed an independently operated new company, Radionetics Oncology, aimed to develop a deep pipeline of novel, targeted, nonpeptide radiopharmaceuticals for the treatment of a broad range of oncology indications.

Crinetics partnered with the veterinary medicine company Loyal to develop a pill to extend the lifespans of large dogs in 2023.

In 2024, Scott Struthers received the Ernst & Young Entrepreneur of the Year Award for his work with Crinetics. In 2024, Crinetics was reported to have patent activity in rare diseases, health technology, and addiction therapies.

In 2024, Radionetics formed a strategic relationship with Eli Lilly and Company to take forward Radionetics’ proprietary GPCR targeting small molecule radiopharmaceuticals. Under the terms of the agreement, Radionetics received a $140 million upfront cash payment. As part of the strategic agreement, Lilly obtained the exclusive right to acquire Radionetics upon conclusion of an exercise period for $1 billion.

Crinetics also established its first office outside the United States in Zug, Switzerland in 2024.

In 2025, Crinetics Pharmaceuticals plans to file an Investigational New Drug for an oral thyroid stimulating hormone receptor antagonist and its nonpeptide drug conjugate (CRN09682). A total of four development candidates are currently in IND-enabling studies, including a PTH antagonist (Hyperparathyrodism), non-peptide drug conjugate (NETs and SST2-expressing solid tumors), TSH antagonist (Graves’ disease & TED) and SST3 agonist (ADPKD).

In July 2026, Vertex Pharmaceuticals agreed to acquire Crinetics for $10 billion.

Treatments

Crinetics’ pipeline focuses on synthesizing novel molecules for rare endocrine diseases. It is most known for developing paltusotine, a drug designed to treat the hormonal disorder acromegaly. Paltusotine works by helping moderate elevated IGF-1 levels, which is the main symptom of acromegaly. Paltusotine has also been tested as a treatment for carcinoid syndrome.

Crinetics has also developed oral treatments for neuroendocrine tumors, hyperinsulism, and Cushing's disease. The company's drug for treating Cushing's disease, Atumeltnant (also known as CRN049894), works by reducing levels of ACTH.

The company's pipeline also includes an oral parathyroid hormone inhibitor program for hyperparathyroidism and treatments for thyroid eye disease, Graves' disease, and obesity. Additionally, Crinetics nonpeptide drug conjugates (NDCs) include CRN09682, which is a somatostatin receptor 2 (SST2) targeted drug. NDCs are a new technology developed in-house by Crinetics.

== References ==

Kaynak: Wikipedia (İngilizce), CC BY-SA 4.0 · Wikipedia'da Görüntüle ↗

Wikidata ↗

CRNX Hisse Senedi Özeti Fiyat, piyasa değeri, P/E, EPS, ROE, borç/öz sermaye, 52 haftalık aralık

Fiyat
$84.77
Piyasa Değeri
$8.10B
P/E (TTM)
-17.1
EPS (TTM)
$-4.95
Gelir (TTM)
$8M
Temettü Verimi
ROE
-43.0%
D/E Borç/Özsermaye
52 Haftlık Aralık
$29 – $85

CRNX Hisse Senedi Fiyat Grafiği Teknik göstergeler ile günlük OHLCV — kaydır, yakınlaştır ve görünümünüzü özelleştirin

10 Yıllık Performans Gelir, net kar, marjlar ve EPS trendleri

Gelir ve Net Gelir $8M
10-point trend, +1206.6%
2016-12-31 2025-12-31
Hisse Başına Kâr $-4.95
6-point trend, -104.5%
2020-12-31 2025-12-31
Serbest Nakit Akışı $-384M
8-point trend, -1770.0%
2018-12-31 2025-12-31
Marjlar -6046.2%

Değerleme P/E, P/S, P/B, EV/EBITDA oranları — hisse senedi pahalı mı ucuz mu?

Metrik
5 Yıllık trend
CRNX
Akran Ortalaması
P/E (TTM)
5-point trend, +7.3%
-17.1
47.9
P/S (TTM) (F/S (TTM))
5-point trend, -53.9%
1052.7
16.2
P/B (F/D)
5-point trend, +10.1%
8.2
9.3
Price / FCF (Fiyat / Serbest Nakit Akışı)
5-point trend, +23.7%
-21.1

Kârlılık Brüt, faaliyet ve net kâr marjları; ROE, ROA, ROIC

Metrik
5 Yıllık trend
CRNX
Akran Ortalaması
Operating Margin (Faaliyet Kâr Marjı)
5-point trend, +32.8%
-6714.8%
Net Profit Margin (Net Kâr Marjı)
5-point trend, +39.4%
-6046.2%
5.1%
ROA
5-point trend, +9.8%
-36.3%
0.81%
ROE
5-point trend, -5.0%
-43.0%
-15.3%
ROIC
5-point trend, -60.6%
-52.1%

Finansal Sağlık Borç, likidite, solventlik — bilanço gücü

Metrik
5 Yıllık trend
CRNX
Akran Ortalaması
Current Ratio (Cari Oran)
5-point trend, -42.8%
12.3
2.7
Quick Ratio (Cari Oran)
5-point trend, -42.1%
12.1

Büyüme Gelir, EPS ve net gelir büyümesi: YOY, 3 Yıllık CAGR, 5 Yıllık CAGR

Metrik
5 Yıllık trend
CRNX
Akran Ortalaması
Revenue YoY (Gelir Yıllık Bazda)
5-point trend, +613.9%
640.7%
Revenue CAGR 3Y (Gelir 3 Yıllık Bileşik Büyüme Oranı)
5-point trend, +613.9%
17.6%
Revenue CAGR 5Y (Gelir 5 Yıllık Bileşik Büyüme Oranı)
5-point trend, +613.9%
155.3%

Hisse Başı Metrikler Hisse Başı Kâr, hisse başına defter değeri, hisse başına nakit akışı, hisse başına temettü

Metrik
5 Yıllık trend
CRNX
Akran Ortalaması
EPS (Diluted) (Hisse Başına Kar (Seyreltilmiş))
5-point trend, -76.8%
$-4.95

Sermaye Verimliliği Aktif devir hızı, stok devir hızı, alacak devir hızı

Metrik
5 Yıllık trend
CRNX
Akran Ortalaması

CRNX Analist Uzlaşması Boğa ve ayı analist görüşleri, 12 aylık fiyat hedefi, yukarı yönlü potansiyel

TUT 21 analist
  • Güçlü Al 3 14,3%
  • Al 4 19,0%
  • Tut 14 66,7%
  • Sat 0 0,0%
  • Güçlü Sat 0 0,0%

12 Aylık Fiyat Hedefi

10 analist · 2026-08-20
Medyan hedef $85.00 +0,3%
Ortalama hedef $85.50 +0,9%

Kazanç Geçmişi EPS gerçekleşen vs tahmin, sürpriz %, kazanma oranı, bir sonraki kazanç tarihi

Ort. Sürpriz
-0.01%
Dönem EPS Gerçek EPS Tahmin Sürpriz
30 Haziran 2026 $-1.14 $-1.23 0.09%
31 Mart 2026 $-1.23 $-1.26 0.03%
31 Aralık 2025 $-1.29 $-1.39 0.10%
30 Eylül 2025 $-1.38 $-1.28 -0.10%
30 Haziran 2025 $-1.23 $-1.12 -0.11%
31 Mart 2025 $-1.04 $-0.96 -0.08%

Akran karşılaştırması (GICS alt sektörü) Anahtar metrikler sektördeki benzerlerine karşı

Hisse Sembolü Piyasa Değeri P/E Gelir YoY Net Kar Marjı ROE Brüt Kar Marjı
CRNX $4.45B -9.4 640.7% -6046.2% -43.0%
CORT $3.69B 42.4 12.8% 13.1% 15.5%
ELAN $11.25B -48.1 6.2% -4.9% -3.5% 55.0%
AXSM $9.29B -49.6 65.5% -28.7% -227.0%
LQDA $3.01B -43.1 1031.2% -43.5% -230.0%
BLTE
DFTX $1.32B -6.5 212.0% -71.0%
AMRX 57.3 8.1% 2.4% -80.0% 36.9%
LGND $3.74B 30.8 60.4% 46.4% 13.5%
LLY 46.8 44.7% 31.7% 101.2%

Tüm Temeller Tüm metrikler yıla göre — gelir tablosu, bilanço, nakit akışı

Gelir Tablosu 17
CRNX için Yıllık Gelir Tablosu verileri
Metrik Eğilim 202520242023202220212020201920182017
Revenue 9-point trend, +276.3% $8M $1M $4M $5M $1M $71.0K $1M $2M $2M
Cost of Revenue 3-point trend, +1076000.00 $1M $0 $0 · · · · · ·
R&D Expense 9-point trend, +3496.4% $332M $240M $169M $130M $84M $57M $42M $24M $9M
SG&A Expense 9-point trend, +9767.5% $191M $100M $58M $42M $25M $18M $14M $7M $2M
Operating Expenses 9-point trend, +4594.5% $524M $340M $227M $173M $109M $75M $55M $31M $11M
Operating Income 9-point trend, -5562.0% $-517M $-339M $-223M $-168M $-108M $-75M $-54M $-29M $-9M
Interest Expense · · · · · · · · $8.0K
Interest Income 9-point trend, +199857.7% $52M $41M $13M $4M $157.0K $991.0K $3M $2M $26.0K
Other Non-op 9-point trend, -1090.0% $-357.0K $-519.0K $-159.0K $5M $61.0K $1M $3M $2M $-30.0K
Pretax Income 9-point trend, -4979.6% $-465M $-298M $-209M $-164M $-108M $-74M $-50M $-27M $-9M
Income Tax 9-point trend, +180000.00 $180.0K $0 $0 $0 $0 $0 $0 $0 $0
Net Income 9-point trend, -4981.5% $-465M $-298M $-215M $-164M $-108M $-74M $-50M $-27M $-9M
EPS (Basic) 6-point trend, -104.5% $-4.95 $-3.69 $-3.69 $-3.15 $-2.80 $-2.42 · · ·
EPS (Diluted) 6-point trend, -104.5% $-4.95 $-3.69 $-3.69 $-3.15 $-2.80 $-2.42 · · ·
Shares (Basic) 6-point trend, +208.9% 94,057,000 80,783,000 58,071,000 51,982,000 38,436,000 30,448,000 · · ·
Shares (Diluted) 6-point trend, +208.9% 94,057,000 80,783,000 58,071,000 51,982,000 38,436,000 30,448,000 · · ·
EBITDA 8-point trend, -1686.4% $-513M $-339M $-223M $-168M $-108M $-75M $-54M $-29M ·
Bilanço 24
CRNX için Yıllık Bilanço verileri
Metrik Eğilim 202520242023202220212020201920182017
Cash & Equivalents 9-point trend, +615.4% $102M $265M $55M $33M $201M $93M $40M $45M $14M
Short-term Investments 8-point trend, +679.1% $926M $1.09B $504M $302M $133M $78M $78M $119M ·
Receivables 2-point trend, +592000.00 $592.0K $0 · · · · · · ·
Inventory 2-point trend, +2022000.00 $2M $0 · · · · · · ·
Prepaid Expense 9-point trend, +1733.4% $18M $21M $16M $11M $11M $7M $5M $3M $973.0K
Other Current Assets 9-point trend, +1346.0% $3M $2M $448.0K $2M $912.0K $1M $668.0K $876.0K $239.0K
Current Assets 9-point trend, +6812.9% $1.05B $1.38B $574M $345M $345M $177M $123M $167M $15M
PP&E (Net) 9-point trend, +3474.0% $14M $12M $11M $4M $3M $3M $4M $4M $400.0K
PP&E (Gross) 9-point trend, +3060.2% $22M $20M $16M $8M $6M $6M $6M $5M $704.0K
Accum. Depreciation 9-point trend, +2515.8% $8M $8M $5M $4M $3M $3M $2M $741.0K $304.0K
Other Non-current Assets 7-point trend, +8472.7% · $3M $2M $37.0K $0 $40.0K $82.0K · $33.0K
Total Assets 9-point trend, +7120.5% $1.13B $1.43B $635M $352M $351M $183M $130M $171M $16M
Accounts Payable 9-point trend, +5510.7% $23M $6M $7M $7M $3M $6M $5M $5M $403.0K
Accrued Liabilities 2-point trend, +2240.8% · · · · · · · $4M $179.0K
Current Liabilities 9-point trend, +9384.1% $85M $60M $44M $28M $16M $10M $8M $8M $897.0K
Capital Leases 7-point trend, +767.2% $42M $45M $48M $2M $3M $4M $5M · ·
Other Non-current Liabilities 3-point trend, +3240000.00 $3M $829.0K $0 · · · · · ·
Total Liabilities 9-point trend, +14484.1% $134M $110M $96M $36M $19M $15M $13M $11M $920.0K
Common Stock 4-point trend, +25200.0% · · $253.0K $0 · · · $24.0K $1.0K
Retained Earnings 9-point trend, -8614.6% $-1.42B $-952M $-654M $-439M $-275M $-168M $-94M $-43M $-16M
AOCI 8-point trend, +2957.4% $2M $963.0K $977.0K $-4M $-382.0K $25.0K $148.0K $61.0K ·
Stockholders' Equity 9-point trend, +6704.2% $992M $1.32B $539M $316M $332M $169M $117M $160M $-15M
Liabilities + Equity 9-point trend, +7120.5% $1.13B $1.43B $635M $352M $351M $183M $130M $171M $16M
Shares Outstanding 9-point trend, +6067.8% 95,575,000 92,926,000 68,175,000 53,877,000 47,597,000 33,001,000 24,263,000 24,061 1,549,575
Nakit Akışı 13
CRNX için Yıllık Nakit Akışı verileri
Metrik Eğilim 202520242023202220212020201920182017
D&A 9-point trend, +2946.9% $4M $3M $1M $983.0K $922.0K $948.0K $887.0K $471.0K $128.0K
Stock-based Comp 9-point trend, +33488.2% $91M $69M $41M $28M $17M $10M $6M $2M $271.0K
Deferred Tax Flat — no change across 3 periods $0 $0 $0 · · · · · ·
Other Non-cash $-8M · · · · · · · ·
Operating Cash Flow 9-point trend, -3886.9% $-378M $-230M $-169M $-115M $-89M $-62M $-46M $-19M $-9M
CapEx 9-point trend, +1795.4% $6M $4M $5M $2M $436.0K $186.0K $492.0K $1M $304.0K
Investing Cash Flow 9-point trend, +57306.6% $174M $-575M $-200M $-174M $-56M $217.0K $42M $-119M $-304.0K
Stock Issued 7-point trend, -100.0% $0 $985M $370M $117M $250M $114M · $106M ·
Net Stock Activity 6-point trend, -100.0% $0 $970M $369M $117M $250M $114M · · ·
Financing Cash Flow 9-point trend, +243.5% $41M $1.01B $391M $122M $253M $115M $67.0K $170M $12M
Net Change in Cash 8-point trend, +10176.9% · $210M $22M $-167M $108M $53M $-5M $31M $2M
Taxes Paid 3-point trend, +89000.00 $89.0K $0 $0 · · · · · ·
Free Cash Flow 8-point trend, -1770.0% $-384M $-230M $-171M $-117M $-89M $-62M $-47M $-21M ·
Kârlılık 7
CRNX için Yıllık Kârlılık verileri
Metrik Eğilim 202520242023202220212020201920182017
Operating Margin 8-point trend, -467.9% -6714.8% -32613.5% -5547.2% -3544.1% -9990.9% -105567.6% -4512.3% -1182.5% ·
Net Margin 8-point trend, -441.4% -6046.2% -28720.7% -5345.9% -3460.4% -9985.2% -103960.6% -4226.5% -1116.8% ·
Pretax Margin 8-point trend, -441.2% -6043.9% -28720.7% -5345.9% -3460.4% -9985.2% -103960.6% -4226.5% -1116.8% ·
EBITDA Margin 8-point trend, -463.6% -6664.1% -32613.5% -5547.2% -3544.1% -9990.9% -105567.6% -4512.3% -1182.5% ·
ROA 8-point trend, -25.3% -36.3% -28.8% -43.5% -46.6% -40.3% -47.0% -33.4% -29.0% ·
ROE 8-point trend, -159.9% -43.0% -27.7% -39.5% -49.1% -41.0% -41.4% -40.9% -16.6% ·
ROIC 8-point trend, -190.8% -52.1% -25.6% -41.3% -53.1% -32.5% -44.4% -46.0% -17.9% ·
Likidite ve Solventlik 2
CRNX için Yıllık Likidite ve Solventlik verileri
Metrik Eğilim 202520242023202220212020201920182017
Current Ratio 8-point trend, -41.4% 12.3 23.0 13.1 12.5 21.6 16.9 14.8 21.0 ·
Quick Ratio 8-point trend, -41.5% 12.1 22.7 12.7 12.1 20.9 16.3 14.2 20.7 ·
Verimlilik 3
CRNX için Yıllık Verimlilik verileri
Metrik Eğilim 202520242023202220212020201920182017
Asset Turnover 8-point trend, -76.9% 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ·
Inventory Turnover 1.1 · · · · · · · ·
Receivables Turnover 26.0 · · · · · · · ·
Hisse Başına 5
CRNX için Yıllık Hisse Başına verileri
Metrik Eğilim 202520242023202220212020201920182017
Book Value / Share 8-point trend, +55.9% $10.38 $14.26 $7.91 $5.87 $6.97 $5.12 $4827.89 $6.66 ·
Revenue / Share 4-point trend, -10.2% $0.08 $0.01 $0.07 $0.09 · · · · ·
Cash Flow / Share 4-point trend, -81.3% $-4.02 $-2.80 $-2.86 $-2.22 · · · · ·
Cash / Share 8-point trend, -43.2% $1.06 $2.85 $0.81 $0.61 $4.22 $2.82 $1662.04 $1.87 ·
EPS (TTM) 6-point trend, -104.5% $-4.95 $-3.69 $-3.69 $-3.15 $-2.80 $-2.42 · · ·
Büyüme Oranları 3
CRNX için Yıllık Büyüme Oranları verileri
Metrik Eğilim 202520242023202220212020201920182017
Revenue YoY 5-point trend, -54.8% 640.7% -74.1% -15.3% 339.4% 1418.3% · · · ·
Revenue CAGR 3Y 3-point trend, -93.8% 17.6% -1.2% 283.8% · · · · · ·
Revenue CAGR 5Y 155.3% · · · · · · · ·
Değerleme (TTM) 10
CRNX için Yıllık Değerleme (TTM) verileri
Metrik Eğilim 202520242023202220212020201920182017
Revenue TTM 8-point trend, +217.0% $8M $1M $4M $5M $1M $71.0K $1M $2M ·
Net Income TTM 8-point trend, -1616.1% $-465M $-298M $-215M $-164M $-108M $-74M $-50M $-27M ·
Market Cap 8-point trend, +516.6% $4.45B $4.75B $2.43B $986M $1.35B $466M $608.8K $722M ·
P/E 6-point trend, -61.3% -9.4 -13.9 -9.6 -5.8 -10.1 -5.8 · · ·
P/S 8-point trend, +94.5% 578.1 4573.0 604.5 208.1 1254.4 6558.4 0.5 297.2 ·
P/B 8-point trend, -0.4% 4.5 3.6 4.5 3.1 4.1 2.8 0.0 4.5 ·
P / Tangible Book 6-point trend, +62.7% 4.5 3.6 4.5 3.1 4.1 2.8 · · ·
P / Cash Flow 8-point trend, +68.3% -11.8 -21.0 -14.6 -8.6 -15.3 -7.5 -0.0 -37.1 ·
P / FCF 8-point trend, +67.0% -11.6 -20.7 -14.2 -8.4 -15.2 -7.5 -0.0 -35.2 ·
Earnings Yield 6-point trend, +38.0% -10.6% -7.2% -10.4% -17.2% -9.9% -17.2% · · ·

Finansal Tablolar Gelir tablosu, bilanço, nakit akışı — yıllık, son 5 yıl

Gelir Tablosu
2025-12-312024-12-312023-12-312022-12-312021-12-31
Gelir $8M$1M$4M$5M$1M
Faaliyet Kâr Marjı % -6714.8%-32613.5%-5547.2%-3544.1%-9990.9%
Net Gelir $-465M$-298M$-215M$-164M$-108M
Seyreltilmiş Hisse Başı Kâr $-4.95$-3.69$-3.69$-3.15$-2.80
Bilanço
2025-12-312024-12-312023-12-312022-12-312021-12-31
Cari Oran 12.323.013.112.521.6
Cari Oran 12.122.712.712.120.9
Nakit Akışı
2025-12-312024-12-312023-12-312022-12-312021-12-31
Serbest Nakit Akışı $-384M$-230M$-171M$-117M$-89M

Son Haberler Bu şirketten bahseden son manşetler

Metriklerim Kişisel izleme listeniz — Tam Temeller'den seçilen satırlar

📊

Sizin için önemli olan metrikleri seçin — yukarıdaki Tam Temeller'deki herhangi bir satırın yanındaki ➕ düğmesine tıklayın.

Seçiminiz kaydedildi ve tüm hisse senetlerinde sizinle birlikte gelir.

Kurumsal Sahipler (13F) 287 dosya · $3.2B toplam · Tarih itibarıyla 30 Haziran 2026

Çeyreklik SEC Form 13F'lerinde bu hisse senedini tuttuklarını bildiren kurumlar. Yalnızca uzun pozisyonlar; tek bir başvuru sahibi, ayrı opsiyon bacakları için iki kez görünebilir. Büyük dengeleyici alım/satım bacakları genellikle piyasa yapımını veya korunmuş envanteri yansıtır, yönlü bir inancı değil.

Kurumsal faaliyet — Q2 2026 ve önceki çeyrek
Yeni pozisyonlar Çıkan pozisyonlar Artırıldı Azaldı Net hisse senedi değişimi
63 (+11 önceki Ç'ye göre) 30 (-13 önceki Ç'ye göre) 95 (-17 önceki Ç'ye göre) 63 (+3 önceki Ç'ye göre) +11.4M

Q1 2026 ile karşılaştırıldı. SEC Form 13F başvuruları, çeyrek sonundan itibaren 45 gün içinde ve geç başvuranlar için kısa bir ek süre içinde tamamlanmalıdır — bu pencere içindeki çeyrekler, en son tam olarak raporlanan çifte tercih edilerek atlanır.

Kurum Değer Hisse senetleri % izlenen 13F'nin Tür
FMR LLC $486.250.673 12.994.406 15,13% Hisse senetleri
FARALLON CAPITAL MANAGEMENT, L.L.C. $336.372.047 8.989.098 10,46% Hisse senetleri
Driehaus Capital Management LLC $241.866.078 6.463.551 7,52% Hisse senetleri
WELLINGTON MANAGEMENT GROUP LLP $237.002.526 6.333.579 7,37% Hisse senetleri
VANGUARD PORTFOLIO MANAGEMENT LLC $180.836.416 4.832.614 5,63% Hisse senetleri
VANGUARD CAPITAL MANAGEMENT LLC $177.567.704 4.745.262 5,52% Hisse senetleri
STATE STREET CORP $100.635.477 2.689.350 3,13% Hisse senetleri
Bellevue Group AG $98.040.400 2.620.000 3,05% Hisse senetleri
BAKER BROS. ADVISORS LP $87.991.820 2.351.465 2,74% Hisse senetleri
GEODE CAPITAL MANAGEMENT, LLC $87.542.675 2.338.905 2,72% Hisse senetleri
Polar Capital Holdings Plc $85.108.460 2.274.411 2,65% Hisse senetleri
Pictet Asset Management Holding SA $77.572.984 2.075.375 2,41% Hisse senetleri
Siren, L.L.C. $53.165.887 1.420.788 1,65% Hisse senetleri
First Light Asset Management, LLC $50.923.606 1.360.866 1,58% Hisse senetleri
NOVO HOLDINGS A/S $49.394.400 1.320.000 1,54% Hisse senetleri
AMERICAN CENTURY COMPANIES INC $47.245.129 1.262.562 1,47% Hisse senetleri
ADAR1 Capital Management, LLC $45.730.234 1.222.080 1,42% Hisse senetleri
DIMENSIONAL FUND ADVISORS LP $44.555.208 1.190.679 1,39% Hisse senetleri
MONTANOVA CAPITAL, LLC $44.390.560 1.186.279 1,38% Hisse senetleri
ORBIMED ADVISORS LLC $37.382.580 999.000 1,16% Hisse senetleri
Hood River Capital Management LLC $36.259.830 968.996 1,13% Hisse senetleri
GOLDMAN SACHS GROUP INC $34.657.132 926.166 1,08% Hisse senetleri
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $32.841.401 877.643 1,02% Hisse senetleri
Aberdeen Group plc $30.699.181 820.395 0,95% Hisse senetleri
Candriam S.C.A. $30.618.690 819.032 0,95% Hisse senetleri
VANGUARD FIDUCIARY TRUST CO $28.230.995 754.436 0,88% Hisse senetleri
Fisher Asset Management, LLC $27.748.912 741.553 0,86% Hisse senetleri
SCHRODER INVESTMENT MANAGEMENT GROUP $17.709.036 479.400 0,55% Hisse senetleri
AMERIPRISE FINANCIAL INC $17.451.149 466.356 0,54% Hisse senetleri
Impax Asset Management Group plc $16.277.700 435.000 0,51% Hisse senetleri
Prosight Management, LP $14.020.002 374.666 0,44% Hisse senetleri
Universal- Beteiligungs- und Servicegesellschaft mbH $13.991.714 373.910 0,44% Hisse senetleri
KENNEDY CAPITAL MANAGEMENT LLC $13.685.018 365.714 0,43% Hisse senetleri
BRAUN STACEY ASSOCIATES INC $13.027.511 348.143 0,41% Hisse senetleri
Fiera Capital Corp $12.395.263 331.247 0,39% Hisse senetleri
BANK OF AMERICA CORP /DE/ $11.271.877 301.226 0,35% Hisse senetleri
Defilade Capital Management, L.P. $8.959.845 239.440 0,28% Hisse senetleri
SEB Asset Management AB $8.003.786 213.891 0,25% Hisse senetleri
Foresite Capital Management VI LLC $7.933.414 212.010 0,25% Hisse senetleri
RICE HALL JAMES & ASSOCIATES, LLC $7.346.220 196.318 0,23% Hisse senetleri
TD Asset Management Inc $7.152.534 191.142 0,22% Hisse senetleri
Swiss National Bank $6.877.796 183.800 0,21% Hisse senetleri
SEGALL BRYANT & HAMILL, LLC $6.855.307 183.199 0,21% Hisse senetleri
BlackRock, Inc. $6.781.290 181.221 0,21% Hisse senetleri
JENNISON ASSOCIATES LLC $6.056.839 161.861 0,19% Hisse senetleri
New Leaf Venture Partners, L.L.C. $5.872.650 141.000 0,18% Hisse senetleri
SILVERCREST ASSET MANAGEMENT GROUP LLC $5.865.136 156.738 0,18% Hisse senetleri
Foresite Capital Management IV, LLC $5.613.000 150.000 0,17% Hisse senetleri
Bank of New York Mellon Corp $5.581.754 149.165 0,17% Hisse senetleri
NEW YORK STATE COMMON RETIREMENT FUND $5.508.898 147.218 0,17% Hisse senetleri
ENVESTNET ASSET MANAGEMENT INC $5.471.384 146.216 0,17% Hisse senetleri
Moody Aldrich Partners LLC $5.466.201 146.077 0,17% Hisse senetleri
Ishara Investments LP $5.369.770 143.500 0,17% Hisse senetleri
CITADEL ADVISORS LLC $5.176.271 138.329 0,16% Hisse senetleri
RHUMBLINE ADVISERS $4.861.141 129.908 0,15% Hisse senetleri
ALLIANCEBERNSTEIN L.P. $4.782.618 131.680 0,15% Hisse senetleri
GordonMD Global Investments LP $4.751.779 126.985 0,15% Hisse senetleri
MANUFACTURERS LIFE INSURANCE COMPANY, THE $4.712.974 125.948 0,15% Hisse senetleri
JANUS HENDERSON GROUP PLC $4.700.428 129.392 0,15% Hisse senetleri
Cormorant Asset Management, LP $4.677.500 125.000 0,15% Hisse senetleri
SECTOR GAMMA AS $4.289.380 114.628 0,13% Hisse senetleri
XTX Topco Ltd $4.164.547 111.292 0,13% Hisse senetleri
ALPS ADVISORS INC $3.981.825 106.409 0,12% Hisse senetleri
FEDERATED HERMES, INC. $3.957.390 105.756 0,12% Hisse senetleri
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $3.834.048 105.563 0,12% Hisse senetleri
Nuveen Asset Management, LLC $3.760.151 73.541 0,12% Hisse senetleri
Burkehill Global Management, LP $3.742.000 100.000 0,12% Hisse senetleri
Nuveen, LLC $3.619.262 96.720 0,11% Hisse senetleri
VICTORY CAPITAL MANAGEMENT INC $3.484.251 93.112 0,11% Hisse senetleri
MORGAN STANLEY $3.320.829 88.744 0,10% Hisse senetleri
TWO SIGMA INVESTMENTS, LP $3.266.729 87.299 0,10% Hisse senetleri
VANGUARD ASSET MANAGEMENT, Ltd $3.254.754 86.979 0,10% Hisse senetleri
AWM Investment Company, Inc. $3.180.700 85.000 0,10% Hisse senetleri
Odyssean, LLC $3.160.344 84.456 0,10% Hisse senetleri
Affinity Asset Advisors, LLC $2.806.500 75.000 0,09% Hisse senetleri
ALGERT GLOBAL LLC $2.714.147 72.532 0,08% Hisse senetleri
ExodusPoint Capital Management, LP $2.652.404 70.882 0,08% Hisse senetleri
Ensign Peak Advisors, Inc $2.507.290 67.004 0,08% Hisse senetleri
BARCLAYS PLC $2.466.127 65.904 0,08% Hisse senetleri
FIRST TRUST ADVISORS LP $2.370.631 63.352 0,07% Hisse senetleri
Man Group plc $2.284.229 61.043 0,07% Hisse senetleri
MetLife Investment Management, LLC $2.258.709 60.361 0,07% Hisse senetleri
CITIGROUP INC $2.255.229 60.268 0,07% Hisse senetleri
Longaeva Partners L.P. $2.184.879 58.388 0,07% Hisse senetleri
Swedbank AB $2.155.392 57.600 0,07% Hisse senetleri
STATE OF WISCONSIN INVESTMENT BOARD $2.068.016 55.265 0,06% Hisse senetleri
Jump Financial, LLC $1.923.388 51.400 0,06% Hisse senetleri
Lighthouse Investment Partners, LLC $1.871.000 50.000 0,06% Hisse senetleri
Vestmark Advisory Solutions, Inc. $1.823.252 48.724 0,06% Hisse senetleri
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $1.787.254 47.762 0,06% Hisse senetleri
VANGUARD GROUP INC $1.774.626 38.123 0,06% Hisse senetleri
Point72 Asset Management, L.P. $1.735.577 46.381 0,05% Hisse senetleri
BNP PARIBAS FINANCIAL MARKETS $1.696.398 45.334 0,05% Hisse senetleri
RAYMOND JAMES FINANCIAL INC $1.606.254 42.925 0,05% Hisse senetleri
SUSQUEHANNA INTERNATIONAL GROUP, LLP $1.549.188 41.400 0,05% Alım opsiyonu
Invesco Ltd. $1.545.446 41.300 0,05% Hisse senetleri
Vanguard Global Advisers, LLC $1.485.986 39.711 0,05% Hisse senetleri
HighMark Wealth Management LLC $1.444.224 38.595 0,04% Hisse senetleri
OAK RIDGE INVESTMENTS LLC $1.405.046 37.548 0,04% Hisse senetleri
Orion Porfolio Solutions, LLC $1.404.234 37.526 0,04% Hisse senetleri

Şirket yöneticileri 20 içeriden öğrenenler · 9 yöneticiler · 10 yönetim kurulu üyeleri

İçeriden Öğrenen Rol Son işlem Sahip olunan hisse senetleri Alımlar 12ay Satışlar 12ay Net 12ay
Tobin Schilke Chief Financial Officer 10 Mart 2025 A 52.000 0 0 $0
Marc Wilson CFO 26 Eylül 2024 M 111.092 0 0 $0
Jeff E. Knight Chief Operating Officer 19 Mart 2025 S 87.491 0 0 $0
Stephen F. Betz Chief Scientific Officer 12 Haziran 2025 M 99.713 0 0 $0
Dana Pizzuti Chief Med and Dev Officer 19 Mart 2025 S 72.233 0 0 $0
Isabel Kalofonos Chief Commercial Officer 10 Ocak 2025 A 0 0 $0
James Hassard Chief Commercial Officer 05 Temmuz 2024 M 29.259 0 0 $0
Alan Seth Krasner Chief Medical Officer 17 Ekim 2023 M 43.210 0 0 $0
Ajay Madan Chief Development Officer 28 Şubat 2022 A 176.995 0 0 $0
Coelho Rogerio Vivaldi Yönetim kurulu üyesi 02 Temmuz 2026 S 19.225 0 1 $-120.000
Caren Deardorf Yönetim kurulu üyesi 18 Haziran 2026 A 22.225 0 0 $0
Weston Nichols Yönetim kurulu üyesi 18 Haziran 2026 A 22.225 0 0 $0
Stephanie Okey Yönetim kurulu üyesi 18 Haziran 2026 A 12.325 0 2 $-246.143
Matthew K Fust Yönetim kurulu üyesi 18 Haziran 2026 A 28.761 0 0 $0
Camille L Bedrosian Yönetim kurulu üyesi 18 Haziran 2026 A 22.225 0 0 $0
Wendell Wierenga Yönetim kurulu üyesi 18 Haziran 2026 A 122.071 0 0 $0
Wendall Wierenga Yönetim kurulu üyesi 11 Haziran 2025 A 116.146 0 0 $0
Stephen W Kaldor Yönetim kurulu üyesi 19 Haziran 2020 A 0 0 $0
Jack Nielsen Yönetim kurulu üyesi 21 Haziran 2019 A 0 0 $0
Richard Scott Struthers 07 Ağustos 2026 M 424.706 0 0 $0

SEC Form 3/4/5 başvurularından yöneticiler; net = yalnızca açık piyasa Alış/Satış

Aktivistler ve %5+ sahipler 1 pozisyon

SEC Çizelge 13D dosyalayan yatırımcılar — ihraççı üzerinde nüfuz etme niyetiyle %5'in üzerinde faydalı sahiplik (aktivist hisseler, yönetim kurulu kampanyaları, M&A). Her satır, o başvuru sahibinin pozisyonunun bilinen en son durumunu gösterir.

Başvuru sahibi Dosyalandı Hisse Durum Amaç Başvuru
Perceptive Advisors LLC, Joseph Edelman, Perceptive Life Sciences Master Fund, Ltd. ×6 başvurular 01 Mart 2024 İlk başvuru SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF sahipliği 55 ETF'ler tarafından tutuluyor

Ağırlık yalnızca doğrudan öz sermaye varlıklarını (N-PORT) yansıtır; kaldıraçlı veya türev tabanlı fonlar gösterilmeyen ek swap pozisyonlarına sahip olabilir.

Fon Ağırlık Birimler Tarih itibarıyla Kaynak
SBIO · ALPS ETF Trust 2,37% 107.892 NS 31 Mayıs 2026 N-PORT
FMED · Fidelity Covington Trust 1,65% 19.000 NS 31 Mayıs 2026 N-PORT
PILL · Direxion Shares ETF Trust 1,40% 4.666 NS 30 Nisan 2026 N-PORT
BBP · ETFis Series Trust I 1,23% 18.743 NS 30 Nisan 2026 N-PORT
MMSC · First Trust Exchange-Traded Fund VI… 0,75% 11.043 NS 31 Mayıs 2026 N-PORT
NUSC · Nushares ETF Trust 0,28% 93.045 NS 30 Nisan 2026 N-PORT
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0,20% 38.553 NS 30 Nisan 2026 N-PORT
BIB · ProShares Trust 0,19% 3.872 NS 31 Mayıs 2026 N-PORT
BKSE · BNY Mellon ETF Trust 0,15% 3.142 NS 30 Nisan 2026 N-PORT
FNY · First Trust Exchange-Traded AlphaDE… 0,14% 18.879 NS 30 Nisan 2026 N-PORT
RSSL · Global X Funds 0,12% 42.391 NS 30 Nisan 2026 N-PORT
FFSM · FIDELITY COVINGTON TRUST 0,10% 31.759 NS 30 Nisan 2026 N-PORT
ITWO · ProShares Trust 0,09% 4.601 NS 31 Mayıs 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0,08% 492.431 NS 31 Mayıs 2026 N-PORT
FNX · First Trust Exchange-Traded AlphaDE… 0,07% 24.991 NS 30 Nisan 2026 N-PORT
FHLC · FIDELITY COVINGTON TRUST 0,06% 41.183 NS 30 Nisan 2026 N-PORT
DFAS · Dimensional ETF Trust 0,05% 196.549 NS 30 Nisan 2026 N-PORT
UWM · ProShares Trust 0,05% 3.599 NS 31 Mayıs 2026 N-PORT
FAD · First Trust Exchange-Traded AlphaDE… 0,04% 5.196 NS 30 Nisan 2026 N-PORT
AVIE · AMERICAN CENTURY ETF TRUST 0,04% 112 NS 31 Mayıs 2026 N-PORT
URTY · ProShares Trust 0,04% 3.643 NS 31 Mayıs 2026 N-PORT
GSSC · Goldman Sachs ETF Trust 0,02% 5.689 NS 31 Mayıs 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0,02% 3.773 NS 31 Mayıs 2026 N-PORT
HDG · ProShares Trust 0,02% 91 NS 31 Mayıs 2026 N-PORT
DFAC · Dimensional ETF Trust 0,01% 125.853 NS 30 Nisan 2026 N-PORT
ONEQ · Fidelity Commonwealth Trust 0,01% 28.694 NS 31 Mayıs 2026 N-PORT
DCOR · Dimensional ETF Trust 0,01% 5.863 NS 30 Nisan 2026 N-PORT
TILT · FlexShares Trust 0,01% 3.388 NS 30 Nisan 2026 N-PORT
DFUS · Dimensional ETF Trust 0,01% 31.413 NS 30 Nisan 2026 N-PORT
DFAU · Dimensional ETF Trust 0,01% 15.024 NS 30 Nisan 2026 N-PORT
SCHB · SCHWAB STRATEGIC TRUST 0,01% 60.503 NS 31 Mayıs 2026 N-PORT
DXUV · Dimensional ETF Trust 0,00% 468 NS 30 Nisan 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 15 Temmuz 2026 Günlük
VB · VANGUARD INDEX FUNDS 15 Temmuz 2026 Günlük
VBK · VANGUARD INDEX FUNDS 15 Temmuz 2026 Günlük
VTI · VANGUARD INDEX FUNDS 15 Temmuz 2026 Günlük
VT · VANGUARD INTERNATIONAL EQUITY INDEX… 15 Temmuz 2026 Günlük
VTWO · VANGUARD SCOTTSDALE FUNDS 15 Temmuz 2026 Günlük
VTWG · VANGUARD SCOTTSDALE FUNDS 15 Temmuz 2026 Günlük
VTHR · VANGUARD SCOTTSDALE FUNDS 15 Temmuz 2026 Günlük
ITOT · iShares Trust 05 Ağustos 2026 Günlük
IWV · iShares Trust 18 Ağustos 2026 Günlük
IWO · iShares Trust 18 Ağustos 2026 Günlük
IWM · iShares Trust 18 Ağustos 2026 Günlük
IBB · iShares Trust 18 Ağustos 2026 Günlük
IHE · iShares Trust 18 Ağustos 2026 Günlük
PRFZ · Invesco Exchange-Traded Fund Trust 04 Ağustos 2026 Günlük
OMFS · Invesco Exchange-Traded Self-Indexe… 13 Temmuz 2026 Günlük
VHT · VANGUARD WORLD FUND 20 Temmuz 2026 Günlük
ESGV · VANGUARD WORLD FUND 30 Temmuz 2026 Günlük