| MPM BIOIMPACT LLC |
$155860155 |
4835872 |
15.71% |
股份
|
| EcoR1 Capital, LLC |
$155492636 |
4824469 |
15.67% |
股份
|
| Blue Owl Capital Holdings LP |
$98953158 |
3070219 |
9.97% |
股份
|
| BlackRock, Inc. |
$73431479 |
2278358 |
7.40% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$63372044 |
1966244 |
6.39% |
股份
|
| RTW INVESTMENTS, LP |
$51311546 |
1592043 |
5.17% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$42363273 |
1314405 |
4.27% |
股份
|
| BAKER BROS. ADVISORS LP |
$32112393 |
996351 |
3.24% |
股份
|
| Octagon Capital Advisors LP |
$30968099 |
960847 |
3.12% |
股份
|
| Merck & Co., Inc. |
$30710162 |
952844 |
3.09% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$26334327 |
817075 |
2.65% |
股份
|
| JANUS HENDERSON GROUP PLC |
$26022437 |
1454267 |
2.62% |
股份
|
| TCG Crossover Management, LLC |
$22450129 |
696560 |
2.26% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$16787478 |
520737 |
1.69% |
股份
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$16340610 |
507000 |
1.65% |
股份
|
| Avidity Partners Management LP |
$15605766 |
484200 |
1.57% |
股份
|
| STATE STREET CORP |
$15599642 |
484010 |
1.57% |
股份
|
| a16z Capital Management, L.L.C. |
$13375450 |
415000 |
1.35% |
股份
|
| Alyeska Investment Group, L.P. |
$9346700 |
290000 |
0.94% |
股份
|
| FMR LLC |
$9205887 |
285631 |
0.93% |
股份
|
| ArrowMark Colorado Holdings LLC |
$7924455 |
245872 |
0.80% |
股份
|
| NORTHERN TRUST CORP |
$5819933 |
180575 |
0.59% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$5377318 |
166842 |
0.54% |
股份
|
| BARCLAYS PLC |
$4889163 |
151696 |
0.49% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$4680441 |
145220 |
0.47% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$4313470 |
133834 |
0.43% |
股份
|
| TD Asset Management Inc |
$3413221 |
105902 |
0.34% |
股份
|
| SOROS FUND MANAGEMENT LLC |
$3223000 |
100000 |
0.32% |
股份
|
| Woodline Partners LP |
$3223000 |
100000 |
0.32% |
股份
|
| UBS Group AG |
$3221711 |
99960 |
0.32% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$3074742 |
95400 |
0.31% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$2347472 |
72835 |
0.24% |
股份
|
| POLEN CAPITAL MANAGEMENT LLC |
$2047056 |
63514 |
0.21% |
股份
|
| MORGAN STANLEY |
$2018758 |
62636 |
0.20% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$1626455 |
50464 |
0.16% |
股份
|
| Nuveen, LLC |
$1605569 |
49816 |
0.16% |
股份
|
| Bank of New York Mellon Corp |
$1587324 |
49250 |
0.16% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$1551005 |
48123 |
0.16% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$1548458 |
48044 |
0.16% |
股份
|
| Quantinno Capital Management LP |
$1511168 |
46887 |
0.15% |
股份
|
| GREAT LAKES ADVISORS, LLC |
$1405615 |
43612 |
0.14% |
股份
|
| Mirador Capital Partners LP |
$1293197 |
40124 |
0.13% |
股份
|
| Squarepoint Ops LLC |
$1237020 |
38381 |
0.12% |
股份
|
| Jump Financial, LLC |
$1056467 |
32779 |
0.11% |
股份
|
| Sofinnova Investments, Inc. |
$1045412 |
32436 |
0.11% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$996358 |
30914 |
0.10% |
股份
|
| READYSTATE ASSET MANAGEMENT LP |
$966900 |
30000 |
0.10% |
股份
|
| WELLS FARGO & COMPANY/MN |
$891450 |
27659 |
0.09% |
股份
|
| RHUMBLINE ADVISERS |
$868429 |
26945 |
0.09% |
股份
|
| CITADEL ADVISORS LLC |
$823058 |
25537 |
0.08% |
股份
|
| SEVEN GRAND MANAGERS, LLC |
$805750 |
25000 |
0.08% |
股份
|
| Ghisallo Capital Management LLC |
$805750 |
25000 |
0.08% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$689786 |
21402 |
0.07% |
股份
|
| GOLDMAN SACHS GROUP INC |
$685790 |
21278 |
0.07% |
股份
|
| DEUTSCHE BANK AG\ |
$677539 |
21022 |
0.07% |
股份
|
| AMERIPRISE FINANCIAL INC |
$644600 |
20000 |
0.06% |
股份
|
| Mariner, LLC |
$572697 |
17770 |
0.06% |
股份
|
| SEI INVESTMENTS CO |
$528515 |
16402 |
0.05% |
股份
|
| Virtus Investment Advisers, LLC |
$480872 |
14920 |
0.05% |
股份
|
| Invesco Ltd. |
$480485 |
14908 |
0.05% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$463435 |
14379 |
0.05% |
股份
|
| CITIGROUP INC |
$424695 |
13177 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$418797 |
12994 |
0.04% |
股份
|
| Caprock Group, LLC |
$319335 |
9908 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$314855 |
9769 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$277919 |
8623 |
0.03% |
股份
|
| JPMORGAN CHASE & CO |
$266021 |
8835 |
0.03% |
股份
|
| Russell Investments Group, Ltd. |
$249911 |
7754 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$241725 |
7500 |
0.02% |
股份
|
| AXQ CAPITAL, LP |
$226255 |
7020 |
0.02% |
股份
|
| Vanguard Global Advisers, LLC |
$221936 |
6886 |
0.02% |
股份
|
| PNC Financial Services Group, Inc. |
$197893 |
6140 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$178232 |
5530 |
0.02% |
股份
|
| LANARK FINANCIAL, INC. |
$172688 |
5358 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$105714 |
3280 |
0.01% |
股份
|
| STRS OHIO |
$99913 |
3100 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$73098 |
2268 |
0.01% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$73065 |
2267 |
0.01% |
股份
|
| Legal & General Group Plc |
$66623 |
2062 |
0.01% |
股份
|
| T. Rowe Price Investment Management, Inc. |
$66119 |
2051447 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$62043 |
1925 |
0.01% |
股份
|
| SALEM INVESTMENT COUNSELORS INC |
$32230 |
1000 |
0.00% |
股份
|
| State of Wyoming |
$31747 |
985 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$25000 |
797 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$24608 |
763499 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$22589 |
700 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$18576 |
576 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$12795 |
397 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$12731 |
395 |
0.00% |
股份
|
| Arax Advisory Partners |
$12408 |
385 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$9282 |
288 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$8057 |
250 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$6308 |
324 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$5930 |
184 |
0.00% |
股份
|
| Allworth Financial LP |
$3997 |
124 |
0.00% |
股份
|
| IFP Advisors, Inc |
$3255 |
101 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$2578 |
80 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$2414 |
77 |
0.00% |
股份
|
| HM PAYSON & CO |
$2386 |
74 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1257 |
39 |
0.00% |
股份
|
| Quarry LP |
$1096 |
34 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$1064 |
33 |
0.00% |
股份
|
| CoreCap Advisors, LLC |
$935 |
29 |
0.00% |
股份
|
| WPG Advisers, LLC |
$806 |
25 |
0.00% |
股份
|
| FWL INVESTMENT MANAGEMENT, LLC |
$741 |
23 |
0.00% |
股份
|
| GAMMA Investing LLC |
$645 |
20 |
0.00% |
股份
|
| Rossby Financial, LCC |
$580 |
18 |
0.00% |
股份
|
| CWM, LLC |
$376 |
21 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$258 |
8 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$195 |
6 |
0.00% |
股份
|
| Essential Partners LLC |
$129 |
4 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$109 |
3368 |
0.00% |
股份
|
| Freestone Grove Partners LP |
$64 |
2 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
23 |
0.00% |
股份
|