| Darwin Global Management, Ltd. |
$456588244 |
3077219 |
32.41% |
股份
|
| Paradigm Biocapital Advisors LP |
$189844565 |
1232877 |
13.48% |
股份
|
| RTW INVESTMENTS, LP |
$110150398 |
715332 |
7.82% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$76155438 |
494564 |
5.41% |
股份
|
| MAVERICK CAPITAL LTD |
$61025949 |
396311 |
4.33% |
股份
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$60181804 |
390829 |
4.27% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$55003288 |
357199 |
3.90% |
股份
|
| Holocene Advisors, LP |
$38655624 |
251035 |
2.74% |
股份
|
| Logos Global Management LP |
$38496250 |
250000 |
2.73% |
股份
|
| MORGAN STANLEY |
$36197407 |
235071 |
2.57% |
股份
|
| UBS Group AG |
$34644931 |
224989 |
2.46% |
股份
|
| CITADEL ADVISORS LLC |
$28667080 |
186168 |
2.03% |
股份
|
| GOLDMAN SACHS GROUP INC |
$25590459 |
166188 |
1.82% |
股份
|
| Affinity Asset Advisors, LLC |
$25407525 |
165000 |
1.80% |
股份
|
| MPM BIOIMPACT LLC |
$21127974 |
137208 |
1.50% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$19214710 |
124783 |
1.36% |
股份
|
| Patient Square Capital LP |
$16938350 |
110000 |
1.20% |
股份
|
| JANE STREET GROUP, LLC |
$10132367 |
65801 |
0.72% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$8796393 |
57125 |
0.62% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$8586666 |
55763 |
0.61% |
股份
|
| Point72 Asset Management, L.P. |
$7881877 |
51186 |
0.56% |
股份
|
| Soleus Capital Management, L.P. |
$7779938 |
50524 |
0.55% |
股份
|
| Trexquant Investment LP |
$7624721 |
49516 |
0.54% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$5866829 |
38100 |
0.42% |
股份
|
| PFM Health Sciences, LP |
$5359140 |
34803 |
0.38% |
股份
|
| JPMORGAN CHASE & CO |
$5131442 |
33181 |
0.36% |
股份
|
| Walleye Capital LLC |
$4884558 |
31721 |
0.35% |
股份
|
| Artia Global Partners LP |
$3847931 |
24989 |
0.27% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$3486220 |
22640 |
0.25% |
股份
|
| BALANCE CAPITAL PARTNERS L.P. |
$3464663 |
22500 |
0.25% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$3079700 |
20000 |
0.22% |
股份
|
| STATE STREET CORP |
$2452057 |
15924 |
0.17% |
股份
|
| Verdad Advisers, LP |
$2118526 |
13758 |
0.15% |
股份
|
| ORBIMED ADVISORS LLC |
$2048001 |
13300 |
0.15% |
股份
|
| TD Asset Management Inc |
$2003345 |
13010 |
0.14% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$1960691 |
12733 |
0.14% |
股份
|
| Qube Research & Technologies Ltd |
$1874151 |
12171 |
0.13% |
股份
|
| Lighthouse Investment Partners, LLC |
$1539850 |
10000 |
0.11% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$1512133 |
9820 |
0.11% |
股份
|
| HighVista Strategies LLC |
$1471173 |
9554 |
0.10% |
股份
|
| Squarepoint Ops LLC |
$1352758 |
8785 |
0.10% |
股份
|
| BARCLAYS PLC |
$1050486 |
6822 |
0.07% |
股份
|
| Capricorn Fund Managers Ltd |
$985504 |
6400 |
0.07% |
股份
|
| Voleon Capital Management LP |
$968412 |
6289 |
0.07% |
股份
|
| SmartHarvest Portfolios, LLC |
$671221 |
4359 |
0.05% |
股份
|
| XTX Topco Ltd |
$667217 |
4333 |
0.05% |
股份
|
| Mariner, LLC |
$590533 |
3835 |
0.04% |
股份
|
| Entropy Technologies, LP |
$569745 |
3700 |
0.04% |
股份
|
| High Net Worth Advisory Group LLC |
$538948 |
3500 |
0.04% |
股份
|
| FMR LLC |
$477354 |
3100 |
0.03% |
股份
|
| AMERIPRISE FINANCIAL INC |
$466421 |
3029 |
0.03% |
股份
|
| Engineers Gate Manager LP |
$427000 |
2773 |
0.03% |
股份
|
| Yeomans Consulting Group, Inc. |
$383744 |
2399 |
0.03% |
股份
|
| Virtus Investment Advisers, LLC |
$364790 |
2369 |
0.03% |
股份
|
| Cubist Systematic Strategies, LLC |
$344100 |
4650 |
0.02% |
股份
|
| FRED ALGER MANAGEMENT, LLC |
$326294 |
2119 |
0.02% |
股份
|
| Jain Global LLC |
$323522 |
2101 |
0.02% |
股份
|
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. |
$309202 |
2008 |
0.02% |
股份
|
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. |
$292572 |
1900 |
0.02% |
股份
|
| GAMMA Investing LLC |
$259619 |
1686 |
0.02% |
股份
|
| R Squared Ltd |
$206032 |
1338 |
0.01% |
股份
|
| Independent Advisor Alliance |
$203106 |
1319 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$72373 |
470 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$50000 |
322 |
0.00% |
股份
|
| Bayforest Capital Ltd |
$47273 |
307 |
0.00% |
股份
|
| WELLS FARGO & COMPANY/MN |
$19094 |
124 |
0.00% |
股份
|
| E Fund Management (Hong Kong) Co., Ltd. |
$17400 |
113 |
0.00% |
股份
|
| Duquesne Family Office LLC |
$16338 |
106100 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$16301 |
105859 |
0.00% |
股份
|
| CITIGROUP INC |
$7237 |
47 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$4759 |
32 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$3388 |
22 |
0.00% |
股份
|
| Rossby Financial, LCC |
$3080 |
20 |
0.00% |
股份
|
| WEST PACES ADVISORS INC. |
$2772 |
18 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$2618 |
17 |
0.00% |
股份
|
| Bell Investment Advisors, Inc |
$2002 |
13 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$924 |
6 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$672 |
4364 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$616 |
4 |
0.00% |
股份
|
| FIDUCIARY FINANCIAL ADVISORS |
$462 |
3 |
0.00% |
股份
|
| Arax Advisory Partners |
$308 |
2 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$141 |
913 |
0.00% |
股份
|