| RA CAPITAL MANAGEMENT, L.P. |
$115026714 |
8821067 |
16.86% |
股份
|
| FMR LLC |
$88546347 |
6790364 |
12.98% |
股份
|
| UBS Group AG |
$44399453 |
3404866 |
6.51% |
股份
|
| BRAIDWELL LP |
$36477770 |
2797375 |
5.35% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$32678240 |
2506000 |
4.79% |
股份
|
| BlackRock, Inc. |
$30707531 |
2354872 |
4.50% |
股份
|
| Cormorant Asset Management, LP |
$27462240 |
2106000 |
4.02% |
股份
|
| FRONTIER CAPITAL MANAGEMENT CO LLC |
$25284808 |
1939019 |
3.71% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$22150448 |
1698654 |
3.25% |
股份
|
| Woodline Partners LP |
$20633075 |
1582291 |
3.02% |
股份
|
| CITADEL ADVISORS LLC |
$16925555 |
1297972 |
2.48% |
股份
|
| Redmile Group, LLC |
$15991343 |
1226330 |
2.34% |
股份
|
| GREAT POINT PARTNERS LLC |
$13040000 |
1000000 |
1.91% |
股份
|
| Affinity Asset Advisors, LLC |
$12674880 |
972000 |
1.86% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$11842902 |
908198 |
1.74% |
股份
|
| ADAR1 Capital Management, LLC |
$10727343 |
822649 |
1.57% |
股份
|
| Driehaus Capital Management LLC |
$10301600 |
790000 |
1.51% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$10202039 |
782199 |
1.50% |
股份
|
| STEMPOINT CAPITAL LP |
$9685395 |
742745 |
1.42% |
股份
|
| STATE STREET CORP |
$8955507 |
686772 |
1.31% |
股份
|
| AMERIPRISE FINANCIAL INC |
$8579978 |
657971 |
1.26% |
股份
|
| Parkman Healthcare Partners LLC |
$7347831 |
563484 |
1.08% |
股份
|
| SUPERSTRING CAPITAL MANAGEMENT LP |
$6794909 |
521082 |
1.00% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$6308061 |
483747 |
0.92% |
股份
|
| VANGUARD GROUP INC |
$5362016 |
1340504 |
0.79% |
股份
|
| Invesco Ltd. |
$4869724 |
373445 |
0.71% |
股份
|
| MORGAN STANLEY |
$4760747 |
365088 |
0.70% |
股份
|
| NAN FUNG TRINITY (HK) LTD |
$4702928 |
360654 |
0.69% |
股份
|
| NORTHERN TRUST CORP |
$4306981 |
330290 |
0.63% |
股份
|
| Ikarian Capital, LLC |
$3912000 |
300000 |
0.57% |
股份
|
| TD Asset Management Inc |
$3483010 |
267102 |
0.51% |
股份
|
| Qube Research & Technologies Ltd |
$3477103 |
266649 |
0.51% |
股份
|
| Ally Bridge Group (NY) LLC |
$3249203 |
249172 |
0.48% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$3125127 |
239657 |
0.46% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$3123319 |
239451 |
0.46% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$2543335 |
195041 |
0.37% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$2512808 |
192700 |
0.37% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$2381691 |
182645 |
0.35% |
股份
|
| FIFTH THIRD BANCORP |
$2150596 |
164923 |
0.32% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$2147844 |
164712 |
0.31% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$1933024 |
148238 |
0.28% |
股份
|
| JANE STREET GROUP, LLC |
$1718163 |
131761 |
0.25% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$1699112 |
130300 |
0.25% |
股份
|
| ArchPoint Investors |
$1680856 |
128900 |
0.25% |
股份
|
| Schonfeld Strategic Advisors LLC |
$1644838 |
126138 |
0.24% |
股份
|
| Bank of New York Mellon Corp |
$1612501 |
123658 |
0.24% |
股份
|
| KOTLER KEVIN |
$1600000 |
400000 |
0.23% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1364427 |
104634 |
0.20% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1262364 |
96807 |
0.19% |
股份
|
| Nuveen, LLC |
$1120592 |
85935 |
0.16% |
股份
|
| GOLDMAN SACHS GROUP INC |
$1085319 |
83230 |
0.16% |
股份
|
| Cambria Investment Management, L.P. |
$992461 |
76109 |
0.15% |
股份
|
| XTX Topco Ltd |
$944878 |
72460 |
0.14% |
股份
|
| Informed Momentum Co LLC |
$908327 |
69657 |
0.13% |
股份
|
| DeepCurrents Investment Group LLC |
$838289 |
64286 |
0.12% |
股份
|
| ALPS ADVISORS INC |
$757898 |
58121 |
0.11% |
股份
|
| LPL Financial LLC |
$667309 |
51174 |
0.10% |
股份
|
| SEI INVESTMENTS CO |
$644906 |
49456 |
0.09% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$616140 |
47250 |
0.09% |
股份
|
| Verdad Advisers, LP |
$601340 |
46115 |
0.09% |
股份
|
| RHUMBLINE ADVISERS |
$580847 |
44544 |
0.09% |
股份
|
| OPPENHEIMER & CO INC |
$541134 |
41498 |
0.08% |
股份
|
| TWO SIGMA ADVISERS, LP |
$498800 |
124700 |
0.07% |
股份
|
| DEUTSCHE BANK AG\ |
$452136 |
34673 |
0.07% |
股份
|
| Integrated Quantitative Investments LLC |
$409534 |
31406 |
0.06% |
股份
|
| WELLS FARGO & COMPANY/MN |
$399806 |
30660 |
0.06% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$394838 |
30279 |
0.06% |
股份
|
| D. E. Shaw & Co., Inc. |
$375552 |
28800 |
0.06% |
股份
|
| Virtus Investment Advisers, LLC |
$372970 |
28602 |
0.05% |
股份
|
| BARCLAYS PLC |
$351089 |
26924 |
0.05% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$349472 |
26800 |
0.05% |
卖出期权
|
| Squarepoint Ops LLC |
$338466 |
25956 |
0.05% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$337736 |
25900 |
0.05% |
买入期权
|
| BANK OF AMERICA CORP /DE/ |
$334658 |
25664 |
0.05% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$329117 |
25239 |
0.05% |
股份
|
| FRANKLIN RESOURCES INC |
$321293 |
24639 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$277817 |
21305 |
0.04% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$216940 |
31670 |
0.03% |
股份
|
| CITIGROUP INC |
$215264 |
16508 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$210635 |
16153 |
0.03% |
股份
|
| STRS OHIO |
$199512 |
15300 |
0.03% |
股份
|
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. |
$198743 |
15241 |
0.03% |
股份
|
| JPMORGAN CHASE & CO |
$195724 |
14650 |
0.03% |
股份
|
| State of Wyoming |
$187437 |
14374 |
0.03% |
股份
|
| Spark Investment Management LLC |
$177344 |
13600 |
0.03% |
股份
|
| BLAIR WILLIAM & CO/IL |
$165608 |
12700 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$160392 |
12300 |
0.02% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$144170 |
11056 |
0.02% |
股份
|
| BAILARD, INC. |
$142136 |
10900 |
0.02% |
股份
|
| SummitTX Capital, L.P. |
$140715 |
10791 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$135486 |
10390 |
0.02% |
股份
|
| Vanguard Global Advisers, LLC |
$131195 |
10061 |
0.02% |
股份
|
| Cubist Systematic Strategies, LLC |
$77567 |
38591 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$72607 |
5568 |
0.01% |
股份
|
| Legal & General Group Plc |
$44584 |
3419 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$41689 |
3197 |
0.01% |
股份
|
| US BANCORP \DE\ |
$40685 |
3120 |
0.01% |
股份
|
| OSAIC HOLDINGS, INC. |
$40424 |
3100 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$37515 |
2877 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$29210 |
2240 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$27741 |
2127281 |
0.00% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$22014 |
10952 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$15000 |
1177 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$11553 |
886 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$10706 |
821 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$7472 |
573 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$6324 |
485 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$5894 |
452 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$3479 |
266 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$1200 |
92 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$964 |
74 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$613 |
47 |
0.00% |
股份
|
| Allworth Financial LP |
$587 |
45 |
0.00% |
股份
|
| Virtu Financial LLC |
$145 |
11151 |
0.00% |
股份
|
| CWM, LLC |
$123 |
18 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$59 |
4533 |
0.00% |
股份
|