| JANUS HENDERSON GROUP PLC |
$93518052 |
1284324 |
14.26% |
股份
|
| Cormorant Asset Management, LP |
$63180000 |
900000 |
9.63% |
股份
|
| BlackRock, Inc. |
$48170117 |
686184 |
7.34% |
股份
|
| Vivo Capital, LLC |
$39113474 |
557172 |
5.96% |
股份
|
| Vestal Point Capital, LP |
$38259000 |
545000 |
5.83% |
股份
|
| BRAIDWELL LP |
$33964304 |
483822 |
5.18% |
股份
|
| Driehaus Capital Management LLC |
$30423065 |
433377 |
4.64% |
股份
|
| Balyasny Asset Management L.P. |
$24222721 |
345053 |
3.69% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$23517000 |
335000 |
3.59% |
股份
|
| Point72 Asset Management, L.P. |
$22984603 |
327416 |
3.50% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$19866600 |
283000 |
3.03% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$18603000 |
265000 |
2.84% |
股份
|
| Parkman Healthcare Partners LLC |
$14394721 |
205053 |
2.19% |
股份
|
| MPM BIOIMPACT LLC |
$14188403 |
202114 |
2.16% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$12026312 |
171315 |
1.83% |
股份
|
| GOLDMAN SACHS GROUP INC |
$9384968 |
133689 |
1.43% |
股份
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$9126913 |
130013 |
1.39% |
股份
|
| STATE STREET CORP |
$8576896 |
122178 |
1.31% |
股份
|
| SEVEN GRAND MANAGERS, LLC |
$8424000 |
120000 |
1.28% |
股份
|
| GREAT POINT PARTNERS LLC |
$7694131 |
109603 |
1.17% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$7311049 |
104146 |
1.11% |
股份
|
| ORBIMED ADVISORS LLC |
$6528600 |
93000 |
1.00% |
股份
|
| ACUTA CAPITAL PARTNERS, LLC |
$6510699 |
92745 |
0.99% |
股份
|
| Ikarian Capital, LLC |
$6244361 |
88951 |
0.95% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$5620212 |
80060 |
0.86% |
股份
|
| Sio Capital Management, LLC |
$5191430 |
73952 |
0.79% |
股份
|
| Trexquant Investment LP |
$4957173 |
70615 |
0.76% |
股份
|
| B Group, Inc. |
$4738500 |
67500 |
0.72% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$4685148 |
66740 |
0.71% |
股份
|
| CITADEL ADVISORS LLC |
$4670616 |
66533 |
0.71% |
股份
|
| Schonfeld Strategic Advisors LLC |
$4652645 |
66277 |
0.71% |
股份
|
| Walleye Capital LLC |
$4640641 |
66106 |
0.71% |
股份
|
| VANGUARD GROUP INC |
$3790871 |
48576 |
0.58% |
股份
|
| Woodline Partners LP |
$3205894 |
45668 |
0.49% |
股份
|
| NORTHERN TRUST CORP |
$2981114 |
42466 |
0.45% |
股份
|
| Artia Global Partners LP |
$2696171 |
38407 |
0.41% |
股份
|
| AMERIPRISE FINANCIAL INC |
$2660720 |
37902 |
0.41% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$2509440 |
35747 |
0.38% |
股份
|
| KVP Capital Advisors, LP |
$2233273 |
31813 |
0.34% |
股份
|
| SUPERSTRING CAPITAL MANAGEMENT LP |
$2138011 |
30456 |
0.33% |
股份
|
| ADAR1 Capital Management, LLC |
$2127060 |
30300 |
0.32% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$1956474 |
27870 |
0.30% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$1893013 |
26966 |
0.29% |
股份
|
| AdvisorShares Investments LLC |
$1704035 |
24274 |
0.26% |
股份
|
| Aquatic Capital Management LLC |
$1462336 |
20831 |
0.22% |
股份
|
| PLATINUM INVESTMENT MANAGEMENT LTD |
$1342715 |
19127 |
0.20% |
股份
|
| MORGAN STANLEY |
$1305698 |
18599 |
0.20% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1265846 |
18032 |
0.19% |
股份
|
| Nuveen, LLC |
$1185608 |
16889 |
0.18% |
股份
|
| UBS Group AG |
$1090627 |
15536 |
0.17% |
股份
|
| Bank of New York Mellon Corp |
$1046100 |
14902 |
0.16% |
股份
|
| Exome Asset Management LLC |
$709722 |
10110 |
0.11% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$674341 |
9606 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$613051 |
8733 |
0.09% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$582028 |
8291 |
0.09% |
股份
|
| FRANKLIN RESOURCES INC |
$563004 |
8020 |
0.09% |
股份
|
| FMR LLC |
$551159 |
7851 |
0.08% |
股份
|
| DEUTSCHE BANK AG\ |
$548122 |
7808 |
0.08% |
股份
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$505370 |
7199 |
0.08% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$491470 |
7001 |
0.07% |
股份
|
| LPL Financial LLC |
$484029 |
6895 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$474622 |
6761 |
0.07% |
股份
|
| JANE STREET GROUP, LLC |
$449280 |
6400 |
0.07% |
股份
|
| Seven Fleet Capital Management LP |
$448929 |
6395 |
0.07% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$427588 |
6091 |
0.07% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$414470 |
5680 |
0.06% |
股份
|
| Engineers Gate Manager LP |
$379922 |
5412 |
0.06% |
股份
|
| DNB Asset Management AS |
$338504 |
4822 |
0.05% |
股份
|
| JPMORGAN CHASE & CO |
$330542 |
4778 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$316672 |
4511 |
0.05% |
股份
|
| Invesco Ltd. |
$281923 |
4016 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$271674 |
3870 |
0.04% |
股份
|
| CITIGROUP INC |
$259682 |
3612 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$239522 |
3412 |
0.04% |
股份
|
| STRS OHIO |
$231660 |
3300 |
0.04% |
股份
|
| BARCLAYS PLC |
$228571 |
3256 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$182520 |
2600 |
0.03% |
股份
|
| Russell Investments Group, Ltd. |
$179220 |
2553 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$142927 |
2036 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$86627 |
1234 |
0.01% |
股份
|
| Caitong International Asset Management Co., Ltd |
$84310 |
1201 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$80000 |
1133 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$70972 |
1011 |
0.01% |
股份
|
| Legal & General Group Plc |
$50465 |
718 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$47174 |
672 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$42120 |
600 |
0.01% |
股份
|
| State of Wyoming |
$33626 |
479 |
0.01% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$9688 |
138 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$6880 |
98 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$5616 |
80 |
0.00% |
股份
|
| Allworth Financial LP |
$3370 |
48 |
0.00% |
股份
|
| Quarry LP |
$1895 |
27 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$1825 |
26 |
0.00% |
股份
|
| GAMMA Investing LLC |
$1404 |
20 |
0.00% |
股份
|
| TD Waterhouse Canada Inc. |
$1331 |
20 |
0.00% |
股份
|
| CWM, LLC |
$803 |
11 |
0.00% |
股份
|
| Arax Advisory Partners |
$772 |
11 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$433 |
6167 |
0.00% |
股份
|
| Bell Investment Advisors, Inc |
$422 |
6 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$351 |
5 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$351 |
5 |
0.00% |
股份
|