| ORBIMED ADVISORS LLC |
$73151963 |
13724571 |
27.36% |
股份
|
| BAKER BROS. ADVISORS LP |
$53959982 |
10123824 |
20.19% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$34516451 |
6475882 |
12.91% |
股份
|
| Soleus Capital Management, L.P. |
$18006755 |
3378378 |
6.74% |
股份
|
| Kynam Capital Management, LP |
$12872414 |
2415087 |
4.82% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$10710342 |
2009445 |
4.01% |
股份
|
| BlackRock, Inc. |
$9580681 |
1797501 |
3.58% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$5435705 |
1019832 |
2.03% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$5294657 |
993369 |
1.98% |
股份
|
| ADAR1 Capital Management, LLC |
$4801797 |
900900 |
1.80% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$4503813 |
844993 |
1.68% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$4487860 |
841862 |
1.68% |
股份
|
| VANGUARD GROUP INC |
$4100559 |
1413986 |
1.53% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$4083286 |
766095 |
1.53% |
股份
|
| MORGAN STANLEY |
$2685574 |
503860 |
1.00% |
股份
|
| STATE STREET CORP |
$2285435 |
428787 |
0.85% |
股份
|
| UBS Group AG |
$1699188 |
318797 |
0.64% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$1518442 |
284886 |
0.57% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$1498796 |
281200 |
0.56% |
股份
|
| NORTHERN TRUST CORP |
$1282393 |
240599 |
0.48% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$1033594 |
193920 |
0.39% |
股份
|
| MARSHALL WACE, LLP |
$1016387 |
190692 |
0.38% |
股份
|
| TWO SIGMA ADVISERS, LP |
$688170 |
237300 |
0.26% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$669480 |
125606 |
0.25% |
股份
|
| GOLDMAN SACHS GROUP INC |
$644045 |
120834 |
0.24% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$591630 |
111000 |
0.22% |
买入期权
|
| Hillsdale Investment Management Inc. |
$433862 |
81400 |
0.16% |
股份
|
| Bank of New York Mellon Corp |
$363436 |
68187 |
0.14% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$360425 |
67622 |
0.13% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$343785 |
64500 |
0.13% |
股份
|
| JANE STREET GROUP, LLC |
$341653 |
64100 |
0.13% |
买入期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$339521 |
63700 |
0.13% |
卖出期权
|
| Squarepoint Ops LLC |
$317348 |
59540 |
0.12% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$253569 |
47574 |
0.09% |
股份
|
| Mariner, LLC |
$241241 |
45261 |
0.09% |
股份
|
| Nuveen, LLC |
$197333 |
37023 |
0.07% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$186839 |
35210 |
0.07% |
股份
|
| Invesco Ltd. |
$185175 |
34742 |
0.07% |
股份
|
| Cerity Partners LLC |
$175224 |
32875 |
0.07% |
股份
|
| State of Wyoming |
$175154 |
32862 |
0.07% |
股份
|
| CITADEL ADVISORS LLC |
$166829 |
31300 |
0.06% |
卖出期权
|
| Graham Capital Management, L.P. |
$158674 |
29770 |
0.06% |
股份
|
| DEUTSCHE BANK AG\ |
$148302 |
27824 |
0.06% |
股份
|
| WELLS FARGO & COMPANY/MN |
$134982 |
25325 |
0.05% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$127254 |
23875 |
0.05% |
股份
|
| CITADEL ADVISORS LLC |
$120213 |
22554 |
0.04% |
股份
|
| RHUMBLINE ADVISERS |
$117649 |
22074 |
0.04% |
股份
|
| JANE STREET GROUP, LLC |
$107133 |
20100 |
0.04% |
卖出期权
|
| Vanguard Global Advisers, LLC |
$86399 |
16210 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$85813 |
16100 |
0.03% |
买入期权
|
| ExodusPoint Capital Management, LP |
$82482 |
15475 |
0.03% |
股份
|
| BARCLAYS PLC |
$77439 |
14529 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$75686 |
14200 |
0.03% |
股份
|
| HSBC HOLDINGS PLC |
$74403 |
13652 |
0.03% |
股份
|
| MANGROVE PARTNERS IM, LLC |
$71166 |
13352 |
0.03% |
股份
|
| Qube Research & Technologies Ltd |
$69876 |
13110 |
0.03% |
股份
|
| CITIGROUP INC |
$69466 |
13033 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$68139 |
12784 |
0.03% |
股份
|
| JPMORGAN CHASE & CO |
$66742 |
13538 |
0.02% |
股份
|
| Spark Investment Management LLC |
$56498 |
10600 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$55922 |
10492 |
0.02% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$36013 |
10530 |
0.01% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$34272 |
6430 |
0.01% |
股份
|
| FMR LLC |
$30003 |
5629 |
0.01% |
股份
|
| STRS OHIO |
$29315 |
5500 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$21874 |
4104 |
0.01% |
股份
|
| GROUP ONE TRADING LLC |
$20824 |
3907 |
0.01% |
股份
|
| Legal & General Group Plc |
$14386 |
2699 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$14000 |
2658 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$13432 |
2520 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$12669 |
2377 |
0.00% |
股份
|
| Russell Investments Group, Ltd. |
$11832 |
2220 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$8709 |
1634 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$6242 |
1171 |
0.00% |
股份
|
| Quarry LP |
$4024 |
755 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$3253 |
611359 |
0.00% |
股份
|
| CWM, LLC |
$1960 |
573 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$1226 |
230 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$517 |
97 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$122 |
22758 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$117 |
22 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$96 |
18 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$68 |
12672 |
0.00% |
股份
|
| Optiver Holding B.V. |
$21 |
4 |
0.00% |
股份
|