| PERCEPTIVE ADVISORS LLC |
$43320887 |
1304846 |
8.05% |
股份
|
| BVF INC/IL |
$41559362 |
1251788 |
7.73% |
股份
|
| Affinity Asset Advisors, LLC |
$38926568 |
1172487 |
7.24% |
股份
|
| BlackRock, Inc. |
$37272146 |
1122655 |
6.93% |
股份
|
| SAMSARA BIOCAPITAL, LLC |
$35287350 |
1062872 |
6.56% |
股份
|
| Kynam Capital Management, LP |
$28968926 |
872558 |
5.39% |
股份
|
| ORBIMED ADVISORS LLC |
$24698941 |
743944 |
4.59% |
股份
|
| Balyasny Asset Management L.P. |
$23610578 |
711162 |
4.39% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$23048071 |
694219 |
4.28% |
股份
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$19430698 |
585262 |
3.61% |
股份
|
| Velan Capital Investment Management LP |
$17003712 |
512160 |
3.16% |
股份
|
| Woodline Partners LP |
$15206563 |
458029 |
2.83% |
股份
|
| ADAR1 Capital Management, LLC |
$13413265 |
404014 |
2.49% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$12940982 |
389692 |
2.41% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$12150270 |
365972 |
2.26% |
股份
|
| STATE STREET CORP |
$10158503 |
305979 |
1.89% |
股份
|
| Merck & Co., Inc. |
$9042053 |
272351 |
1.68% |
股份
|
| ACUTA CAPITAL PARTNERS, LLC |
$8972333 |
270251 |
1.67% |
股份
|
| AMERIPRISE FINANCIAL INC |
$8123011 |
244669 |
1.51% |
股份
|
| Point72 Asset Management, L.P. |
$7895856 |
237827 |
1.47% |
股份
|
| KVP Capital Advisors, LP |
$7522290 |
226575 |
1.40% |
股份
|
| UBS Group AG |
$6922599 |
208512 |
1.29% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$6696042 |
201688 |
1.24% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$6559058 |
197562 |
1.22% |
股份
|
| MARSHALL WACE, LLP |
$5818167 |
175246 |
1.08% |
股份
|
| Nuveen, LLC |
$5577500 |
167997 |
1.04% |
股份
|
| JPMORGAN CHASE & CO |
$5323560 |
159627 |
0.99% |
股份
|
| GOLDMAN SACHS GROUP INC |
$4953971 |
149216 |
0.92% |
股份
|
| VANGUARD GROUP INC |
$4347844 |
375786 |
0.81% |
股份
|
| NORTHERN TRUST CORP |
$4180976 |
125933 |
0.78% |
股份
|
| Seven Fleet Capital Management LP |
$3794182 |
159118 |
0.71% |
股份
|
| Qube Research & Technologies Ltd |
$3539452 |
106610 |
0.66% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$3460502 |
104232 |
0.64% |
股份
|
| CITADEL ADVISORS LLC |
$3385238 |
101965 |
0.63% |
股份
|
| MACKENZIE FINANCIAL CORP |
$3146264 |
94767 |
0.58% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$2865957 |
86324 |
0.53% |
股份
|
| Invesco Ltd. |
$1902526 |
57305 |
0.35% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$1855183 |
55879 |
0.34% |
股份
|
| Squarepoint Ops LLC |
$1843895 |
55539 |
0.34% |
股份
|
| XTX Topco Ltd |
$1732011 |
52169 |
0.32% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1636826 |
49302 |
0.30% |
股份
|
| Sigma Planning Corp |
$1494664 |
45020 |
0.28% |
股份
|
| Bank of New York Mellon Corp |
$1373451 |
41369 |
0.26% |
股份
|
| BARCLAYS PLC |
$1226872 |
36954 |
0.23% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$1199848 |
36140 |
0.22% |
股份
|
| Fisher Asset Management, LLC |
$1171794 |
35295 |
0.22% |
股份
|
| Elmind Capital, LP |
$1063628 |
32037 |
0.20% |
股份
|
| D. E. Shaw & Co., Inc. |
$1000250 |
30128 |
0.19% |
股份
|
| Trexquant Investment LP |
$917515 |
27636 |
0.17% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$909116 |
27383 |
0.17% |
股份
|
| RHUMBLINE ADVISERS |
$684845 |
20628 |
0.13% |
股份
|
| SEI INVESTMENTS CO |
$544048 |
16387 |
0.10% |
股份
|
| Informed Momentum Co LLC |
$538902 |
16232 |
0.10% |
股份
|
| DEUTSCHE BANK AG\ |
$516692 |
15563 |
0.10% |
股份
|
| RBF Capital, LLC |
$507030 |
15272 |
0.09% |
股份
|
| WELLS FARGO & COMPANY/MN |
$449661 |
13544 |
0.08% |
股份
|
| AJU IB Investment Co., Ltd. |
$435925 |
17500 |
0.08% |
股份
|
| MORGAN STANLEY |
$410219 |
12356 |
0.08% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$368520 |
11100 |
0.07% |
买入期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$365200 |
11000 |
0.07% |
卖出期权
|
| WELLINGTON MANAGEMENT GROUP LLP |
$358560 |
10800 |
0.07% |
股份
|
| MetLife Investment Management, LLC |
$312113 |
9401 |
0.06% |
股份
|
| Walleye Capital LLC |
$308959 |
9306 |
0.06% |
股份
|
| Integrated Quantitative Investments LLC |
$296775 |
8939 |
0.06% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$279743 |
8426 |
0.05% |
股份
|
| Lighthouse Investment Partners, LLC |
$277818 |
8368 |
0.05% |
股份
|
| CITIGROUP INC |
$247539 |
7456 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$242792 |
7313 |
0.05% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$242360 |
7300 |
0.05% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$232433 |
7001 |
0.04% |
股份
|
| Persistent Asset Partners Ltd |
$218091 |
6569 |
0.04% |
股份
|
| Verdad Advisers, LP |
$212480 |
6400 |
0.04% |
股份
|
| HSBC HOLDINGS PLC |
$205722 |
6234 |
0.04% |
股份
|
| TWO SIGMA ADVISERS, LP |
$203401 |
17580 |
0.04% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$185920 |
5600 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$180774 |
5445 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$156173 |
4704 |
0.03% |
股份
|
| Legal & General Group Plc |
$114939 |
3462 |
0.02% |
股份
|
| State of Wyoming |
$53718 |
1618 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$48074 |
1448 |
0.01% |
股份
|
| FMR LLC |
$44454 |
1339 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$42330 |
1275 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$28751 |
866 |
0.01% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$26943 |
31026 |
0.01% |
股份
|
| CWM, LLC |
$24487 |
983 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$23000 |
687 |
0.00% |
股份
|
| Owl Creek Wealth Partners LLC |
$16302 |
491 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$12405 |
373839 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$9329 |
281 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$7304 |
220 |
0.00% |
股份
|
| Quantbot Technologies LP |
$6673 |
201 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$6043 |
182 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$3320 |
100 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$2058 |
62 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$1859 |
56 |
0.00% |
股份
|
| Bogart Wealth, LLC |
$1660 |
50 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$1560 |
47 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$1461 |
44 |
0.00% |
股份
|
| Accredited Wealth Management, LLC |
$869 |
5 |
0.00% |
股份
|
| HighMark Wealth Management LLC |
$763 |
23 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$656 |
19749 |
0.00% |
股份
|
| Arax Advisory Partners |
$531 |
16 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$452 |
13597 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$66 |
2 |
0.00% |
股份
|
| Optiver Holding B.V. |
$66 |
2 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$66 |
2 |
0.00% |
股份
|
| COMERICA BANK |
$35 |
3 |
0.00% |
股份
|
| FNY Investment Advisers, LLC |
$33 |
1000 |
0.00% |
股份
|
| Cubist Systematic Strategies, LLC |
$9 |
10 |
0.00% |
股份
|
| Avion Wealth |
$1 |
46 |
0.00% |
股份
|