| FMR LLC |
$57361528 |
3942373 |
11.62% |
股份
|
| Vivo Capital, LLC |
$36375000 |
2500000 |
7.37% |
股份
|
| JANUS HENDERSON GROUP PLC |
$29065739 |
1815474 |
5.89% |
股份
|
| BlackRock, Inc. |
$25142226 |
1727988 |
5.09% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$24735000 |
1700000 |
5.01% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$16690611 |
1147121 |
3.38% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$12749146 |
876230 |
2.58% |
股份
|
| Ikarian Capital, LLC |
$11459580 |
787600 |
2.32% |
股份
|
| Candriam S.C.A. |
$10896012 |
749588 |
2.21% |
股份
|
| CITADEL ADVISORS LLC |
$10600562 |
728561 |
2.15% |
股份
|
| RTW INVESTMENTS, LP |
$10135094 |
696570 |
2.05% |
股份
|
| Stonepine Capital Management, LLC |
$9603000 |
660000 |
1.95% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$9308074 |
639537 |
1.89% |
股份
|
| MARSHALL WACE, LLP |
$8520160 |
585578 |
1.73% |
股份
|
| BRAIDWELL LP |
$8503195 |
584412 |
1.72% |
股份
|
| Point72 Asset Management, L.P. |
$8100873 |
556761 |
1.64% |
股份
|
| Velan Capital Investment Management LP |
$8002282 |
549985 |
1.62% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$7858833 |
540126 |
1.59% |
股份
|
| Woodline Partners LP |
$7729746 |
531254 |
1.57% |
股份
|
| STATE STREET CORP |
$7432344 |
510814 |
1.51% |
股份
|
| Sofinnova Investments, Inc. |
$7275567 |
500039 |
1.47% |
股份
|
| MORGAN STANLEY |
$6288801 |
432220 |
1.27% |
股份
|
| Qube Research & Technologies Ltd |
$6254943 |
429893 |
1.27% |
股份
|
| Siren, L.L.C. |
$6214902 |
427141 |
1.26% |
股份
|
| Caption Management, LLC |
$5815635 |
399700 |
1.18% |
买入期权
|
| Ikarian Capital, LLC |
$5428605 |
373100 |
1.10% |
买入期权
|
| TWO SIGMA INVESTMENTS, LP |
$5141825 |
353390 |
1.04% |
股份
|
| BVF INC/IL |
$4940438 |
339549 |
1.00% |
股份
|
| Bank of New York Mellon Corp |
$4733067 |
325296 |
0.96% |
股份
|
| Trexquant Investment LP |
$4679338 |
321604 |
0.95% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$4526316 |
311087 |
0.92% |
股份
|
| DIADEMA PARTNERS LP |
$4466850 |
307000 |
0.90% |
买入期权
|
| Logos Global Management LP |
$4365000 |
300000 |
0.88% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$4207336 |
289164 |
0.85% |
股份
|
| GOLDMAN SACHS GROUP INC |
$4000464 |
274946 |
0.81% |
股份
|
| JANE STREET GROUP, LLC |
$3879845 |
266656 |
0.79% |
股份
|
| Avidity Partners Management LP |
$3869340 |
265934 |
0.78% |
股份
|
| Caption Management, LLC |
$3710250 |
255000 |
0.75% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$3686196 |
253518 |
0.75% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$3422160 |
235200 |
0.69% |
卖出期权
|
| ADAR1 Capital Management, LLC |
$3207722 |
220462 |
0.65% |
股份
|
| VANGUARD GROUP INC |
$3116545 |
255664 |
0.63% |
股份
|
| NORTHERN TRUST CORP |
$2897400 |
199134 |
0.59% |
股份
|
| Balyasny Asset Management L.P. |
$2822700 |
194000 |
0.57% |
买入期权
|
| ExodusPoint Capital Management, LP |
$2684490 |
184501 |
0.54% |
股份
|
| Ensign Peak Advisors, Inc |
$2573735 |
176889 |
0.52% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$2456637 |
168841 |
0.50% |
股份
|
| Integral Health Asset Management, LLC |
$2429850 |
167000 |
0.49% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$2386200 |
164000 |
0.48% |
股份
|
| Nuveen, LLC |
$2345271 |
161187 |
0.48% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$2284961 |
157042 |
0.46% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$2270702 |
156062 |
0.46% |
股份
|
| JANE STREET GROUP, LLC |
$2042820 |
140400 |
0.41% |
买入期权
|
| BANK OF AMERICA CORP /DE/ |
$1985027 |
136428 |
0.40% |
股份
|
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
$1924558 |
132272 |
0.39% |
股份
|
| CITADEL ADVISORS LLC |
$1897320 |
130400 |
0.38% |
买入期权
|
| SPHERA FUNDS MANAGEMENT LTD. |
$1856580 |
127600 |
0.38% |
买入期权
|
| Verdad Advisers, LP |
$1792182 |
123174 |
0.36% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$1748910 |
120200 |
0.35% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$1709364 |
117482 |
0.35% |
股份
|
| XTX Topco Ltd |
$1655310 |
113767 |
0.34% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$1616505 |
111100 |
0.33% |
买入期权
|
| Walleye Capital LLC |
$1531198 |
105237 |
0.31% |
股份
|
| UBS Group AG |
$1427981 |
98143 |
0.29% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1408440 |
96800 |
0.29% |
买入期权
|
| STEMPOINT CAPITAL LP |
$1400772 |
96273 |
0.28% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1389714 |
95513 |
0.28% |
股份
|
| Tetragon Partners GP Ltd |
$1092705 |
75100 |
0.22% |
买入期权
|
| Creek Drive Management Group LLC |
$1076700 |
74000 |
0.22% |
股份
|
| TD Asset Management Inc |
$1064274 |
73146 |
0.22% |
股份
|
| FRED ALGER MANAGEMENT, LLC |
$1047120 |
71967 |
0.21% |
股份
|
| Velan Capital Investment Management LP |
$999585 |
68700 |
0.20% |
买入期权
|
| Caption Management, LLC |
$974850 |
67000 |
0.20% |
卖出期权
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$890082 |
61174 |
0.18% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$871545 |
59900 |
0.18% |
股份
|
| Vestal Point Capital, LP |
$777537 |
53439 |
0.16% |
股份
|
| Man Group plc |
$713590 |
49044 |
0.14% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$695999 |
47835 |
0.14% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$687473 |
47249 |
0.14% |
股份
|
| Artia Global Partners LP |
$612264 |
42080 |
0.12% |
股份
|
| Quinn Opportunity Partners LLC |
$582000 |
40000 |
0.12% |
股份
|
| CITADEL ADVISORS LLC |
$531075 |
36500 |
0.11% |
卖出期权
|
| FRANKLIN RESOURCES INC |
$513135 |
35267 |
0.10% |
股份
|
| Squarepoint Ops LLC |
$485010 |
33334 |
0.10% |
股份
|
| Persistent Asset Partners Ltd |
$481328 |
782 |
0.10% |
买入期权
|
| RHUMBLINE ADVISERS |
$455278 |
31291 |
0.09% |
股份
|
| ALPS ADVISORS INC |
$391744 |
26924 |
0.08% |
股份
|
| DEUTSCHE BANK AG\ |
$357304 |
24557 |
0.07% |
股份
|
| WELLS FARGO & COMPANY/MN |
$306772 |
21084 |
0.06% |
股份
|
| SummitTX Capital, L.P. |
$290898 |
19993 |
0.06% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$289545 |
19900 |
0.06% |
股份
|
| Ikarian Capital, LLC |
$240075 |
16500 |
0.05% |
卖出期权
|
| JANE STREET GROUP, LLC |
$225525 |
15500 |
0.05% |
卖出期权
|
| MetLife Investment Management, LLC |
$217377 |
14940 |
0.04% |
股份
|
| Verition Fund Management LLC |
$197720 |
13589 |
0.04% |
股份
|
| Invesco Ltd. |
$190547 |
13096 |
0.04% |
股份
|
| Corient Private Wealth LP |
$180245 |
12388 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$176201 |
12110 |
0.04% |
股份
|
| CITIGROUP INC |
$169115 |
11623 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$167965 |
11544 |
0.03% |
股份
|
| TWO SIGMA ADVISERS, LP |
$160640 |
13178 |
0.03% |
股份
|
| Quantbot Technologies LP |
$156194 |
10735 |
0.03% |
股份
|
| LETKO, BROSSEAU & ASSOCIATES INC |
$154958 |
10650 |
0.03% |
股份
|
| SEI INVESTMENTS CO |
$147101 |
10110 |
0.03% |
股份
|
| DIVERSIFIED TRUST CO |
$145820 |
10022 |
0.03% |
股份
|
| K2 PRINCIPAL FUND, L.P. |
$145500 |
10000 |
0.03% |
股份
|
| JPMORGAN CHASE & CO |
$141899 |
10511 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$128040 |
8800 |
0.03% |
股份
|
| BARCLAYS PLC |
$117186 |
8054 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$108034 |
7425 |
0.02% |
股份
|
| STRS OHIO |
$71295 |
4900 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$52380 |
3600 |
0.01% |
股份
|
| Legal & General Group Plc |
$35531 |
2442 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$33581 |
2308 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$33247 |
2285 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$29841 |
2051 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$11000 |
776 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$8842 |
607660 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$7377 |
507 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$7275 |
500 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$5049 |
347 |
0.00% |
股份
|
| Quarry LP |
$2794 |
192 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$2182 |
150 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$829 |
57 |
0.00% |
股份
|
| Commonwealth Retirement Investments LLC |
$29 |
2 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$15 |
1 |
0.00% |
股份
|
| Allworth Financial LP |
$15 |
1 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$15 |
1 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$13 |
1 |
0.00% |
股份
|
| Union Bancaire Privee, UBP SA |
$11 |
1 |
0.00% |
股份
|