CYCN Cyclerion Therapeutics, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$3.04
Price · May 20, 2026
Fundamentals as of May 12, 2026

CYCN Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$3.04
Market Cap
P/E (TTM)
-1.1
EPS (TTM)
$-1.11
Revenue (TTM)
$2M
Div Yield
ROE
Debt/Equity
52W Range
$1 – $8

CYCN Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $2M
7-point trend, -54.0%
2019-12-31 2025-12-31
EPS $-1.11
5-point trend, +15.9%
2021-12-31 2025-12-31
Free Cash Flow
3-point trend, +62.8%
2019-12-31 2022-12-31
Margins

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
CYCN
Peer Median
P/E (TTM)
5-point trend, +95.6%
-1.1

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
CYCN
Peer Median

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
CYCN
Peer Median

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
CYCN
Peer Median
Revenue YoY
5-point trend, -47.4%
3.7%
Revenue CAGR 3Y
5-point trend, -47.4%
91.1%
Revenue CAGR 5Y
5-point trend, -47.4%
-2.0%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
CYCN
Peer Median
EPS (Diluted)
5-point trend, +15.9%
$-1.11

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
CYCN
Peer Median

CYCN Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 7 analysts
  • Strong Buy 2 28.6%
  • Buy 4 57.1%
  • Hold 1 14.3%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

1 analysts · 2026-05-18
Median target $8.00 +163.6%
Mean target $8.00 +163.6%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.37%
Period EPS Actual EPS Est Surprise
Dec. 31, 2025 $-0.21 $-0.39 0.18%
Sept. 30, 2025 $-0.30
June 30, 2025 $-0.11
Sept. 30, 2023 $-0.93 $-0.34 -0.59%
Sept. 30, 2022 $-4.80 $-6.32 1.5%

Peer Comparison Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
CYCN -1.1 3.7%
INAB $23M -0.5 -90.8%
ERNA
INTS $1M -0.0 -165.1%
PHIO $12M -0.2 -57.5%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 14
Annual Income Statement data for CYCN
Metric Trend 2025202420232022202120202019
Revenue 7-point trend, -54.0% $2M $2M $0 $297.0K $4M $2M $5M
R&D Expense 7-point trend, -99.0% $959.0K $286.0K $2M $6M $38M $56M $95M
SG&A Expense 7-point trend, -82.3% $6M $5M $8M $13M $21M $29M $34M
Operating Expenses 7-point trend, -94.6% $7M $6M $13M $19M $59M $84M $130M
Operating Income 7-point trend, +96.0% $-5M $-4M $-13M $-19M $-55M $-81M $-125M
Other Non-op 6-point trend, +145.7% $1M $571.0K $358.0K $294.0K $-16.0K $588.0K ·
Pretax Income 7-point trend, +97.1% $-4M $-3M $-5M $-44M $-52M $-122M $-122M
Income Tax Flat — no change across 7 periods $0 $0 $0 $0 $0 $0 $0
Net Income 7-point trend, +97.1% $-4M $-3M $-5M $-44M $-52M $-78M $-123M
EPS (Basic) 5-point trend, +15.9% $-1.11 $-1.21 $-2.25 $-20.28 $-1.32 · ·
EPS (Diluted) 5-point trend, +15.9% $-1.11 $-1.21 $-2.25 $-20.28 $-1.32 · ·
Shares (Basic) 5-point trend, -91.9% 3,181,000 2,518,000 2,338,000 2,173,000 39,144,000 · ·
Shares (Diluted) 5-point trend, -91.9% 3,181,000 2,518,000 2,338,000 2,173,000 39,144,000 · ·
EBITDA 5-point trend, +97.1% · $-4M $-13M $-44M $-55M · $-125M
Balance Sheet 21
Annual Balance Sheet data for CYCN
Metric Trend 2025202420232022202120202019
Cash & Equivalents 7-point trend, -96.6% $3M $3M $8M $13M $54M $54M $95M
Receivables 6-point trend, +1000000.00 $1M $556.0K $0 $96.0K $100.0K $0 ·
Prepaid Expense 7-point trend, -80.5% $384.0K $421.0K $442.0K $805.0K $928.0K $816.0K $2M
Other Current Assets 7-point trend, -99.6% $11.0K $16.0K $11.0K $537.0K $468.0K $3M $3M
Current Assets 7-point trend, -95.4% $5M $4M $8M $15M $55M $59M $101M
PP&E (Net) 7-point trend, -100.0% $0 $0 $0 $0 $65.0K $7M $12M
PP&E (Gross) 6-point trend, -99.6% · $126.0K $126.0K $2M $2M $17M $33M
Accum. Depreciation 6-point trend, -99.4% · $126.0K $126.0K $2M $2M $10M $22M
Other Non-current Assets 5-point trend, -100.0% · · $0 $2M $2M $3M $540.0K
Total Assets 7-point trend, -94.6% $10M $10M $13M $18M $59M $115M $186M
Accounts Payable 7-point trend, -84.3% $508.0K $390.0K $1M $3M $2M $1M $3M
Short-term Debt 3-point trend, -0.3% · · · $4M $4M $4M ·
Current Liabilities 7-point trend, -95.1% $900.0K $725.0K $2M $8M $11M $17M $18M
Capital Leases 3-point trend, -100.0% · · · · $0 $39M $70M
Total Debt Flat — no change across 2 periods · · · $4M $4M · ·
Common Stock Flat — no change across 6 periods $0 $0 $0 $0 $0 $0 ·
Retained Earnings 7-point trend, -216.5% $-271M $-267M $-264M $-259M $-215M $-163M $-86M
AOCI 6-point trend, +100.0% · $0 $-12.0K $-20.0K $-23.0K $-27.0K $-20.0K
Stockholders' Equity 7-point trend, -90.7% $9M $9M $11M $10M $48M $59M $98M
Liabilities + Equity 7-point trend, -94.6% $10M $10M $13M $18M $59M $115M $186M
Shares Outstanding 7-point trend, -86.2% 3,821,236 2,545,922 2,474,159 2,175,936 2,170,509 34,047,300 27,598,133
Cash Flow 11
Annual Cash Flow data for CYCN
Metric Trend 2025202420232022202120202019
D&A 5-point trend, -100.0% · · $0 $65.0K $472.0K $2M $3M
Stock-based Comp 7-point trend, -97.8% $441.0K $625.0K $1M $6M $10M $15M $20M
Restructuring 2-point trend, +57.4% · · $-565.0K $-1M · · ·
Operating Cash Flow 7-point trend, +96.8% $-3M $-4M $-21M $-41M $-37M $-72M $-102M
CapEx 4-point trend, -100.0% · · · $0 $7.0K $2M $7M
Investing Cash Flow 6-point trend, +100.0% · $0 $10M $0 $1M $18.0K $-7M
Stock Issued 4-point trend, +1375000.00 $1M $0 $5M $0 · · ·
Net Stock Activity 2-point trend, -100.0% · $0 $5M · · · ·
Financing Cash Flow 7-point trend, -98.4% $3M $0 $5M $29.0K $31M $28M $212M
Net Change in Cash 7-point trend, -100.0% $8.0K $-4M $-6M $-41M $-4M $-44M $103M
Free Cash Flow 3-point trend, +62.8% · · · $-41M $-37M · $-109M
Profitability 7
Annual Profitability data for CYCN
Metric Trend 2025202420232022202120202019
Operating Margin 4-point trend, +93.5% · -181.4% · -2730.6% -1400.2% · -2774.3%
Net Margin 4-point trend, +94.4% · -152.8% · -2712.5% -1310.2% · -2729.3%
Pretax Margin 4-point trend, +94.4% · -152.8% · -2712.5% -1310.2% · -2715.9%
EBITDA Margin 4-point trend, +93.5% · -181.4% · -2730.6% -1400.2% · -2774.3%
ROA 4-point trend, +73.6% · · -33.5% -113.9% -59.1% · -126.9%
ROE 4-point trend, +61.6% · · -43.6% -326.8% -98.7% · -113.4%
ROIC 4-point trend, +10.3% · · -114.7% -318.0% -106.7% · -127.9%
Liquidity & Solvency 3
Annual Liquidity & Solvency data for CYCN
Metric Trend 2025202420232022202120202019
Current Ratio 4-point trend, -30.6% · · 3.8 1.9 5.0 · 5.5
Quick Ratio 4-point trend, -30.2% · · 3.6 1.8 4.9 · 5.2
Debt / Equity 2-point trend, +361.9% · · · 0.3 0.1 · ·
Efficiency 2
Annual Efficiency data for CYCN
Metric Trend 2025202420232022202120202019
Asset Turnover 4-point trend, -100.0% · · 0.0 0.0 0.0 · 0.0
Receivables Turnover 3-point trend, -100.0% · · 0.0 16.6 78.8 · ·
Per Share 5
Annual Per Share data for CYCN
Metric Trend 2025202420232022202120202019
Book Value / Share 4-point trend, +28.8% · · $4.56 $0.24 $1.11 · $3.54
Revenue / Share 3-point trend, +2023.8% · $0.79 $0.00 $0.04 · · ·
Cash Flow / Share 3-point trend, -84.2% · $-1.72 $-9.09 $-0.93 · · ·
Cash / Share 4-point trend, -11.0% · · $3.06 $0.31 $1.24 · $3.44
EPS (TTM) 5-point trend, +15.9% $-1.11 $-1.21 $-2.25 $-20.28 $-1.32 · ·
Growth Rates 3
Annual Growth Rates data for CYCN
Metric Trend 2025202420232022202120202019
Revenue YoY 3-point trend, -94.8% 3.7% · · -92.5% 71.7% · ·
Revenue CAGR 3Y 2-point trend, +550.3% 91.1% -20.2% · · · · ·
Revenue CAGR 5Y -2.0% · · · · · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for CYCN
Metric Trend 2025202420232022202120202019
Revenue TTM 7-point trend, -54.0% $2M $2M $0 $297.0K $4M $2M $5M
Net Income TTM 7-point trend, +97.1% $-4M $-3M $-5M $-44M $-52M $-78M $-123M
Market Cap 4-point trend, -99.4% · · $8M $571M $1.49B · $1.50B
Enterprise Value 2-point trend, -61.1% · · · $561M $1.44B · ·
P/E 5-point trend, +95.6% -1.1 -2.7 -1.5 -0.6 -26.1 · ·
P/S 3-point trend, +477.1% · · · 1922.4 378.8 · 333.1
P/B 4-point trend, -95.2% · · 0.7 54.6 31.0 · 15.4
P / Tangible Book 6-point trend, -98.5% 0.5 0.9 0.7 54.6 31.0 35.0 ·
P / Cash Flow 4-point trend, +97.3% · · -0.4 -14.1 -40.9 · -14.7
P / FCF 3-point trend, -2.2% · · · -14.1 -40.9 · -13.8
EV / EBITDA 2-point trend, +51.6% · · · -12.6 -26.1 · ·
EV / FCF 2-point trend, +65.0% · · · -13.8 -39.5 · ·
EV / Revenue 2-point trend, +416.1% · · · 1889.2 366.0 · ·
Earnings Yield 5-point trend, -2176.0% -87.4% -37.6% -67.2% -154.6% -3.8% · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $2M$2M$0$297.0K$4M
Operating Margin % -181.4%-2730.6%-1400.2%
Net Income $-4M$-3M$-5M$-44M$-52M
Diluted EPS $-1.11$-1.21$-2.25$-20.28$-1.32
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debt / Equity 0.30.1
Current Ratio 3.81.95.0
Quick Ratio 3.61.84.9
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-41M$-37M

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