CYCN Cyclerion Therapeutics, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$4.12
Price · Aug 19, 2026
Fundamentals as of Aug 4, 2026

CYCN Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$4.12
Market Cap
P/E (TTM)
-1.1
EPS (TTM)
$-1.11
Revenue (TTM)
$2M
Div Yield
ROE
Debt/Equity
52W Range
$1 – $8

CYCN Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $2M
7-point trend, -54.0%
2019-12-31 2025-12-31
EPS $-1.11
5-point trend, +15.9%
2021-12-31 2025-12-31
Free Cash Flow
3-point trend, +62.8%
2019-12-31 2022-12-31
Margins

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
CYCN
Peer Median
P/E (TTM)
5-point trend, +95.6%
-1.1

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
CYCN
Peer Median

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
CYCN
Peer Median

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
CYCN
Peer Median
Revenue YoY
5-point trend, -47.4%
3.7%
Revenue CAGR 3Y
5-point trend, -47.4%
91.1%
Revenue CAGR 5Y
5-point trend, -47.4%
-2.0%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
CYCN
Peer Median
EPS (Diluted)
5-point trend, +15.9%
$-1.11

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
CYCN
Peer Median

CYCN Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 7 analysts
  • Strong Buy 2 28.6%
  • Buy 4 57.1%
  • Hold 1 14.3%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

1 analysts · 2026-08-17
Median target $8.00 +94.2%
Mean target $8.00 +94.2%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.37%
Period EPS Actual EPS Est Surprise
Dec. 31, 2025 $-0.21 $-0.39 0.18%
Sept. 30, 2025 $-0.30
June 30, 2025 $-0.11
Sept. 30, 2023 $-0.93 $-0.34 -0.59%
Sept. 30, 2022 $-4.80 $-6.32 1.5%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
CYCN -1.1 3.7%
MRKR $25M -1.9 -46.2% -343.0% -89.1%
SKYE $25M -0.5 -175.6%
KALA $15M -0.2 -1423.8%
TPST $14M -0.5 -319.3%
KTTA

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 14
Annual Income Statement data for CYCN
Metric Trend 2025202420232022202120202019
Revenue 7-point trend, -54.0% $2M $2M $0 $297.0K $4M $2M $5M
R&D Expense 7-point trend, -99.0% $959.0K $286.0K $2M $6M $38M $56M $95M
SG&A Expense 7-point trend, -82.3% $6M $5M $8M $13M $21M $29M $34M
Operating Expenses 7-point trend, -94.6% $7M $6M $13M $19M $59M $84M $130M
Operating Income 7-point trend, +96.0% $-5M $-4M $-13M $-19M $-55M $-81M $-125M
Other Non-op 6-point trend, +145.7% $1M $571.0K $358.0K $294.0K $-16.0K $588.0K ·
Pretax Income 7-point trend, +97.1% $-4M $-3M $-5M $-44M $-52M $-122M $-122M
Income Tax Flat — no change across 7 periods $0 $0 $0 $0 $0 $0 $0
Net Income 7-point trend, +97.1% $-4M $-3M $-5M $-44M $-52M $-78M $-123M
EPS (Basic) 5-point trend, +15.9% $-1.11 $-1.21 $-2.25 $-20.28 $-1.32 · ·
EPS (Diluted) 5-point trend, +15.9% $-1.11 $-1.21 $-2.25 $-20.28 $-1.32 · ·
Shares (Basic) 5-point trend, -91.9% 3,181,000 2,518,000 2,338,000 2,173,000 39,144,000 · ·
Shares (Diluted) 5-point trend, -91.9% 3,181,000 2,518,000 2,338,000 2,173,000 39,144,000 · ·
EBITDA 5-point trend, +97.1% · $-4M $-13M $-44M $-55M · $-125M
Balance Sheet 21
Annual Balance Sheet data for CYCN
Metric Trend 2025202420232022202120202019
Cash & Equivalents 7-point trend, -96.6% $3M $3M $8M $13M $54M $54M $95M
Receivables 6-point trend, +1000000.00 $1M $556.0K $0 $96.0K $100.0K $0 ·
Prepaid Expense 7-point trend, -80.5% $384.0K $421.0K $442.0K $805.0K $928.0K $816.0K $2M
Other Current Assets 7-point trend, -99.6% $11.0K $16.0K $11.0K $537.0K $468.0K $3M $3M
Current Assets 7-point trend, -95.4% $5M $4M $8M $15M $55M $59M $101M
PP&E (Net) 7-point trend, -100.0% $0 $0 $0 $0 $65.0K $7M $12M
PP&E (Gross) 6-point trend, -99.6% · $126.0K $126.0K $2M $2M $17M $33M
Accum. Depreciation 6-point trend, -99.4% · $126.0K $126.0K $2M $2M $10M $22M
Other Non-current Assets 5-point trend, -100.0% · · $0 $2M $2M $3M $540.0K
Total Assets 7-point trend, -94.6% $10M $10M $13M $18M $59M $115M $186M
Accounts Payable 7-point trend, -84.3% $508.0K $390.0K $1M $3M $2M $1M $3M
Short-term Debt 3-point trend, -0.3% · · · $4M $4M $4M ·
Current Liabilities 7-point trend, -95.1% $900.0K $725.0K $2M $8M $11M $17M $18M
Capital Leases 3-point trend, -100.0% · · · · $0 $39M $70M
Total Debt Flat — no change across 2 periods · · · $4M $4M · ·
Common Stock Flat — no change across 6 periods $0 $0 $0 $0 $0 $0 ·
Retained Earnings 7-point trend, -216.5% $-271M $-267M $-264M $-259M $-215M $-163M $-86M
AOCI 6-point trend, +100.0% · $0 $-12.0K $-20.0K $-23.0K $-27.0K $-20.0K
Stockholders' Equity 7-point trend, -90.7% $9M $9M $11M $10M $48M $59M $98M
Liabilities + Equity 7-point trend, -94.6% $10M $10M $13M $18M $59M $115M $186M
Shares Outstanding 7-point trend, -86.2% 3,821,236 2,545,922 2,474,159 2,175,936 2,170,509 34,047,300 27,598,133
Cash Flow 11
Annual Cash Flow data for CYCN
Metric Trend 2025202420232022202120202019
D&A 5-point trend, -100.0% · · $0 $65.0K $472.0K $2M $3M
Stock-based Comp 7-point trend, -97.8% $441.0K $625.0K $1M $6M $10M $15M $20M
Restructuring 2-point trend, +57.4% · · $-565.0K $-1M · · ·
Operating Cash Flow 7-point trend, +96.8% $-3M $-4M $-21M $-41M $-37M $-72M $-102M
CapEx 4-point trend, -100.0% · · · $0 $7.0K $2M $7M
Investing Cash Flow 6-point trend, +100.0% · $0 $10M $0 $1M $18.0K $-7M
Stock Issued 4-point trend, +1375000.00 $1M $0 $5M $0 · · ·
Net Stock Activity 2-point trend, -100.0% · $0 $5M · · · ·
Financing Cash Flow 7-point trend, -98.4% $3M $0 $5M $29.0K $31M $28M $212M
Net Change in Cash 7-point trend, -100.0% $8.0K $-4M $-6M $-41M $-4M $-44M $103M
Free Cash Flow 3-point trend, +62.8% · · · $-41M $-37M · $-109M
Profitability 7
Annual Profitability data for CYCN
Metric Trend 2025202420232022202120202019
Operating Margin 4-point trend, +93.5% · -181.4% · -2730.6% -1400.2% · -2774.3%
Net Margin 4-point trend, +94.4% · -152.8% · -2712.5% -1310.2% · -2729.3%
Pretax Margin 4-point trend, +94.4% · -152.8% · -2712.5% -1310.2% · -2715.9%
EBITDA Margin 4-point trend, +93.5% · -181.4% · -2730.6% -1400.2% · -2774.3%
ROA 4-point trend, +73.6% · · -33.5% -113.9% -59.1% · -126.9%
ROE 4-point trend, +61.6% · · -43.6% -326.8% -98.7% · -113.4%
ROIC 4-point trend, +10.3% · · -114.7% -318.0% -106.7% · -127.9%
Liquidity & Solvency 3
Annual Liquidity & Solvency data for CYCN
Metric Trend 2025202420232022202120202019
Current Ratio 4-point trend, -30.6% · · 3.8 1.9 5.0 · 5.5
Quick Ratio 4-point trend, -30.2% · · 3.6 1.8 4.9 · 5.2
Debt / Equity 2-point trend, +361.9% · · · 0.3 0.1 · ·
Efficiency 2
Annual Efficiency data for CYCN
Metric Trend 2025202420232022202120202019
Asset Turnover 4-point trend, -100.0% · · 0.0 0.0 0.0 · 0.0
Receivables Turnover 3-point trend, -100.0% · · 0.0 16.6 78.8 · ·
Per Share 5
Annual Per Share data for CYCN
Metric Trend 2025202420232022202120202019
Book Value / Share 4-point trend, +28.8% · · $4.56 $0.24 $1.11 · $3.54
Revenue / Share 3-point trend, +2023.8% · $0.79 $0.00 $0.04 · · ·
Cash Flow / Share 3-point trend, -84.2% · $-1.72 $-9.09 $-0.93 · · ·
Cash / Share 4-point trend, -11.0% · · $3.06 $0.31 $1.24 · $3.44
EPS (TTM) 5-point trend, +15.9% $-1.11 $-1.21 $-2.25 $-20.28 $-1.32 · ·
Growth Rates 3
Annual Growth Rates data for CYCN
Metric Trend 2025202420232022202120202019
Revenue YoY 3-point trend, -94.8% 3.7% · · -92.5% 71.7% · ·
Revenue CAGR 3Y 2-point trend, +550.3% 91.1% -20.2% · · · · ·
Revenue CAGR 5Y -2.0% · · · · · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for CYCN
Metric Trend 2025202420232022202120202019
Revenue TTM 7-point trend, -54.0% $2M $2M $0 $297.0K $4M $2M $5M
Net Income TTM 7-point trend, +97.1% $-4M $-3M $-5M $-44M $-52M $-78M $-123M
Market Cap 4-point trend, -99.4% · · $8M $571M $1.49B · $1.50B
Enterprise Value 2-point trend, -61.1% · · · $561M $1.44B · ·
P/E 5-point trend, +95.6% -1.1 -2.7 -1.5 -0.6 -26.1 · ·
P/S 3-point trend, +477.1% · · · 1922.4 378.8 · 333.1
P/B 4-point trend, -95.2% · · 0.7 54.6 31.0 · 15.4
P / Tangible Book 6-point trend, -98.5% 0.5 0.9 0.7 54.6 31.0 35.0 ·
P / Cash Flow 4-point trend, +97.3% · · -0.4 -14.1 -40.9 · -14.7
P / FCF 3-point trend, -2.2% · · · -14.1 -40.9 · -13.8
EV / EBITDA 2-point trend, +51.6% · · · -12.6 -26.1 · ·
EV / FCF 2-point trend, +65.0% · · · -13.8 -39.5 · ·
EV / Revenue 2-point trend, +416.1% · · · 1889.2 366.0 · ·
Earnings Yield 5-point trend, -2176.0% -87.4% -37.6% -67.2% -154.6% -3.8% · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $2M$2M$0$297.0K$4M
Operating Margin % -181.4%-2730.6%-1400.2%
Net Income $-4M$-3M$-5M$-44M$-52M
Diluted EPS $-1.11$-1.21$-2.25$-20.28$-1.32
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debt / Equity 0.30.1
Current Ratio 3.81.95.0
Quick Ratio 3.61.84.9
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-41M$-37M

Latest News Recent headlines mentioning this company

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Institutional owners (13F) 24 filers · $10.6M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
11 (+8 vs prior Q) 5 (0 vs prior Q) 3 (+2 vs prior Q) 2 (0 vs prior Q) +2.9M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
Kalehua Capital Management LLC $5,598,077 1,651,350 52.72% Shares
FMR LLC $1,226,457 361,787 11.55% Shares
Balyasny Asset Management L.P. $1,076,362 317,511 10.14% Shares
ADAR1 Capital Management, LLC $1,012,786 298,757 9.54% Shares
BRAIDWELL LP $531,857 156,890 5.01% Shares
TYNDALL CAPITAL PARTNERS L P $451,594 155,187 4.25% Shares
CITADEL ADVISORS LLC $202,705 59,795 1.91% Shares
GEODE CAPITAL MANAGEMENT, LLC $150,759 44,460 1.42% Shares
VANGUARD CAPITAL MANAGEMENT LLC $104,802 30,915 0.99% Shares
Rangeley Capital, LLC $82,411 24,310 0.78% Shares
BlackRock, Inc. $56,942 16,797 0.54% Shares
TWO SIGMA ADVISERS, LP $35,941 28,300 0.34% Shares
DIMENSIONAL FUND ADVISORS LP $31,680 9,345 0.30% Shares
VANGUARD FIDUCIARY TRUST CO $24,927 7,353 0.23% Shares
VANGUARD GROUP INC $20,494 16,137 0.19% Shares
Tower Research Capital LLC (TRC) $6,268 1,849 0.06% Shares
UBS Group AG $1,939 572 0.02% Shares
GROUP ONE TRADING LLC $651 192 0.01% Shares
OSAIC HOLDINGS, INC. $440 130 0.00% Shares
Activest Wealth Management $339 100 0.00% Shares
BARCLAYS PLC $295 87 0.00% Shares
WHI TRUST Co LLC $244 72 0.00% Shares
HRT FINANCIAL LP $74 22,054 0.00% Shares
BNP PARIBAS FINANCIAL MARKETS $14 4 0.00% Shares

Company insiders 21 insiders · 7 officers · 13 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Regina Margaret Graul President and Chief Executive Officer Aug. 14, 2026 M 107,523 0 0 $0
Rhonda M. Chicko Chief Financial Officer Aug. 14, 2026 M 25,018 0 0 $0
Anjeza Gjino Chief Financial Officer Jan. 20, 2022 A 31,599 0 0 $0
Mark G Currie President and CSO Dec. 28, 2020 S 251,648 0 0 $0
Cheryl Gault Chief Operating Officer Jan. 20, 2022 A 0 0 $0
Andreas Busch Chief Scientific Officer Jan. 20, 2022 A 254,704 0 0 $0
Christopher I Wright Chief Medical Officer Feb. 25, 2021 S 42,728 0 0 $0
Peter M. Hecht Director July 16, 2026 C 910,240 0 0 $0
Michael J Higgins Director March 25, 2025 A 30,740 0 0 $0
Steven Hyman Director Nov. 30, 2023 A 20,000 0 0 $0
Errol B Desouza Director Nov. 30, 2023 A 30,000 0 0 $0
Terrance McGuire Director Nov. 30, 2023 A 5,552 0 0 $0
Stephanie Lovell Director June 14, 2022 A 2,421 0 0 $0
Ole Isacson Director June 14, 2022 A 2,421 0 0 $0
Michael Mendelsohn Director June 14, 2022 A 2,421 0 0 $0
Marsha Fanucci Director June 14, 2022 A 16,950 0 0 $0
George N Conrades Director June 14, 2022 A 4,334 0 0 $0
Kevin Churchwell Director June 24, 2021 A 2,421 0 0 $0
Amy Schulman Director June 16, 2020 A 21,635 0 0 $0
IRONWOOD PHARMACEUTICALS INC 10% owner April 1, 2019 J 0 0 0 $0
William Huyett Nov. 6, 2020 S 67,590 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 2 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Peter M. Hecht ×9 filings July 20, 2026 19.40% Amendment SEC
SLATE PATH MASTER FUND LP, SLATE PATH CAPITAL LP, JADES GP, LLC, DAVID GREENSPAN Oct. 21, 2022 Initial filing Passive investment SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 2 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
ONEQ · Fidelity Commonwealth Trust 0.00% 21,200 NS May 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.00% 30,915 SH Aug. 8, 2026 Daily