Insider at

04

Insider transactions

05
0 buys (P) 2 sells (S) Net: $-16,968 + 64 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

64 other filings hidden
DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
Nov. 12, 2025 AGIO S 10b5-1 200 $43.84 $8,768 17,603 Direct -1.12% Disposed -27.5% (price as of 2026-10-02)
Oct. 8, 2025 AGIO S 10b5-1 200 $41.00 $8,200 17,603 Direct -1.12% Disposed -22.4% (price as of 2026-10-02)
Sept. 30, 2025 AGIO S 10b5-1 200 $40.00 $8,000 17,603 Direct -1.12% Disposed -20.5% (price as of 2026-10-02)
Aug. 27, 2025 AGIO S 10b5-1 200 $40.00 $8,000 17,603 Direct -1.12% Disposed -20.5% (price as of 2026-10-02)
July 10, 2025 AGIO S 10b5-1 1,400 $40.00 $56,000 17,603 Direct -7.37% Disposed -20.5% (price as of 2026-10-02)
Dec. 11, 2024 AGIO S 10b5-1 200 $46.28 $9,256 15,483 Direct -1.28% Disposed -31.3% (price as of 2026-10-02)
June 25, 2018 DNTH P 6,600 $15.00 $99,000 228,175 Direct +2.98% Acquired 488.1% (price as of 2026-10-02)
March 16, 2018 AGIO P 200 $83.44 $16,688 571 Direct +53.91% Acquired -61.9% (price as of 2026-10-02)

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
June 18, 2026 AGIO Stock options (right to buy) Common stock (14,950) $34.16 June 18, 2036 14,950 Acquired
June 18, 2026 AGIO Restricted stock units Common stock (2,927) · · 2,927 Acquired
June 18, 2026 AGIO Restricted stock units Common stock (2,816) · · 2,816 Disposed
June 17, 2026 EDIT Stock Option (right to buy) Common Stock (51,700) $2.55 June 16, 2036 51,700 Acquired
Nov. 12, 2025 AGIO Stock options (right to buy) Common stock (200) $18.09 June 21, 2032 200 Disposed
Oct. 8, 2025 AGIO Stock options (right to buy) Common stock (200) $18.09 June 21, 2032 200 Disposed
Sept. 30, 2025 AGIO Stock options (right to buy) Common stock (200) $18.09 June 21, 2032 200 Disposed
Aug. 27, 2025 AGIO Stock options (right to buy) Common stock (200) $18.09 June 21, 2032 200 Disposed
July 10, 2025 AGIO Stock options (right to buy) Common stock (1,400) $18.09 June 21, 2032 1,400 Disposed
June 20, 2025 AGIO Restricted stock units Common stock (2,120) · · 2,120 Disposed
June 18, 2025 AGIO Restricted stock units Common stock (2,816) · · 2,816 Acquired
June 18, 2025 AGIO Stock options (right to buy) Common stock (15,768) $35.50 June 18, 2035 15,768 Acquired
June 6, 2025 EDIT Stock Option (right to buy) Common Stock (37,500) $1.91 June 5, 2035 37,500 Acquired
Dec. 11, 2024 AGIO Stock options (right to buy) Common stock (200) $18.09 June 21, 2032 200 Disposed
June 20, 2024 AGIO Restricted stock units Common stock (2,120) · · 2,120 Acquired
June 20, 2024 AGIO Stock options (right to buy) Common stock (11,774) $42.45 June 20, 2034 11,774 Acquired
June 13, 2024 AGIO Restricted stock units Common stock (3,388) · · 3,388 Disposed
May 30, 2024 EDIT Stock Option (right to buy) Common Stock (25,000) $5.17 May 29, 2034 25,000 Acquired
June 21, 2023 AGIO Restricted stock unit Common stock (4,975) · · 4,975 Disposed
June 13, 2023 AGIO Restricted stock units Common stock (3,388) · · 3,388 Acquired
June 13, 2023 AGIO Stock options (right to buy) Common stock (18,958) $26.56 June 13, 2033 18,958 Acquired
June 1, 2023 EDIT Stock Option (right to buy) Common Stock (25,000) $9.55 May 31, 2033 25,000 Acquired
June 28, 2022 DNTH Stock Option (Right to Buy) Common Stock (20,000) $1.21 June 27, 2032 20,000 Acquired
June 21, 2022 AGIO Restricted stock unit Common stock (4,975) · · 4,975 Acquired
June 21, 2022 AGIO Stock options (right to buy) Common stock (29,307) $18.09 June 21, 2032 29,307 Acquired
June 9, 2022 EDIT Stock Option (right to buy) Common Stock (25,000) $12.31 June 8, 2032 25,000 Acquired
May 20, 2022 AGIO Restricted stock unit Common stock (1,585) · · 1,585 Disposed
June 3, 2021 EDIT Stock Option (right to buy) Common Stock (11,538) $33.36 June 2, 2031 11,538 Acquired
June 1, 2021 DNTH Stock Option (Right to Buy) Common Stock (18,188) $12.91 May 31, 2031 18,188 Acquired
May 28, 2021 AGIO Restricted stock units Common stock (1,686) · · 1,686 Disposed
May 20, 2021 AGIO Restricted stock unit Common stock (1,585) · · 1,585 Acquired
May 20, 2021 AGIO Stock options (right to buy) Common stock (8,888) $56.76 May 20, 2031 8,888 Acquired
June 10, 2020 EDIT Stock Option (right to buy) Common Stock (11,538) $27.49 June 9, 2030 11,538 Acquired
June 5, 2020 DNTH Stock Option (Right to Buy) Common Stock (18,188) $9.99 June 4, 2030 18,188 Acquired
May 29, 2020 AGIO Restricted stock units Common stock (1,878) · · 1,878 Disposed
May 28, 2020 AGIO Stock options (right to buy) Common stock (8,096) $53.35 May 28, 2030 8,096 Acquired
May 28, 2020 AGIO Restricted stock units Common stock (1,686) · · 1,686 Acquired
June 7, 2019 DNTH Stock Option (Right to Buy) Common Stock (18,188) $13.40 June 6, 2029 18,188 Acquired
May 31, 2019 AGIO Restricted stock units Common stock (1,400) · · 1,400 Disposed
May 29, 2019 AGIO Restricted stock units Common stock (1,878) · · 1,878 Acquired
May 29, 2019 AGIO Stock option (right to buy) Common stock (8,919) $47.91 May 29, 2029 8,919 Acquired
Feb. 5, 2019 EDIT Stock Option (right to buy) Common Stock (23,076) $21.14 Feb. 4, 2029 23,076 Acquired
June 25, 2018 DNTH Series C Preferred Stock Common Stock (6,228) · · 16,094 Disposed
June 25, 2018 DNTH Series B Preferred Stock Common Stock (2,488) · · 6,429 Disposed
June 25, 2018 DNTH Series A Preferred Stock Common Stock (19,360) · · 50,025 Disposed
May 31, 2018 AGIO Restricted stock units Common stock (1,400) · · 1,400 Acquired
May 31, 2018 AGIO Stock option (right to buy) Common stock (5,700) $93.50 May 30, 2028 5,700 Acquired
June 13, 2017 AGIO Stock option (right to buy) Common stock (8,000) $50.73 June 12, 2027 8,000 Acquired
May 27, 2017 AGIO Stock option (right to buy) Common stock (16,000) $48.20 May 26, 2027 16,000 Acquired

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 7 holdings

07

Securities held when first becoming an insider, per SEC Form 3.

DateTickerSecuritySharesOwnership
Feb. 7, 2019 EDIT No securities are beneficially owned 0 Direct
June 20, 2018 DNTH Common Stock 193,499 Direct
June 20, 2018 DNTH Common Stock 580,499 Indirect
June 20, 2018 DNTH Series A Preferred Stock→ Common Stock (19,360) 19,360 Direct
June 20, 2018 DNTH Series B Preferred Stock→ Common Stock (2,488) 2,488 Direct
June 20, 2018 DNTH Series C Preferred Stock→ Common Stock (6,228) 6,228 Direct
May 31, 2017 AGIO Common stock 371 Direct