DNTH Dianthus Therapeutics, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$115.97
Price · Aug 19, 2026
Fundamentals as of Aug 4, 2026
52W Range
$22–$118
98% of range
Analyst Rating
BUY
22 analysts
Price Target
$138
+19% upside
P/E (TTM)
-27.6
ROE
-40.8%
Net Profit Margin
-7973.3%

About Dianthus Therapeutics, Inc. - Common Stock Company overview from Wikipedia

DNTH Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$115.97
Market Cap
$5.01B
P/E (TTM)
-27.6
EPS (TTM)
$-4.20
Revenue (TTM)
$2M
Div Yield
—
ROE
-40.8%
Debt/Equity
—
52W Range
$22 – $118

DNTH Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $2M
7-point trend, +2036000.00
2016-12-31 → 2025-12-31
EPS $-4.20
6-point trend, -145.6%
2020-12-31 → 2025-12-31
Free Cash Flow —
4-point trend, -22.7%
2018-12-31 → 2021-12-31
Margins -7973.3%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
DNTH
Peer Median
P/E (TTM)
5-point trend, +82.1%
-27.6
37.2
P/S (TTM)
3-point trend, +1504.3%
2462.0
9.9
P/B
5-point trend, -91.5%
10.2
8.3

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
DNTH
Peer Median
Operating Margin
2-point trend, -434.9%
-8739.3%
—
Net Profit Margin
2-point trend, -485.1%
-7973.3%
-15.1%
ROA
5-point trend, +22.6%
-35.9%
-23.3%
ROE
5-point trend, +17.7%
-40.8%
-30.6%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
DNTH
Peer Median
Current Ratio
5-point trend, +0.5%
13.3
6.3
Quick Ratio
5-point trend, +1.0%
13.2
—

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
DNTH
Peer Median
Revenue YoY
5-point trend, +2036000.00
-67.3%
—

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
DNTH
Peer Median
EPS (Diluted)
5-point trend, -225.6%
$-4.20
—

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
DNTH
Peer Median

DNTH Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 22 analysts
  • Strong Buy 10 45.5%
  • Buy 11 50.0%
  • Hold 1 4.5%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

13 analysts · 2026-08-15
Median target $132.00 +13.8%
Mean target $137.62 +18.7%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
-0.02%
Period EPS Actual EPS Est Surprise
June 30, 2026 $-0.90 $-0.87 -0.03%
March 31, 2026 $-0.85 $-1.09 0.24%
Dec. 31, 2025 $-1.43 $-1.10 -0.33%
Sept. 30, 2025 $-0.97 $-0.88 -0.09%
June 30, 2025 $-0.88 $-0.89 0.01%
March 31, 2025 $-0.82 $-0.87 0.05%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
DNTH $1.78B -9.8 -67.3% -7973.3% -40.8% —
SRRK $4.78B -13.4 — — -157.9% —
MIRM $4.10B -168.1 54.7% -4.5% -8.2% —
COGT $5.72B -16.4 — — -83.1% —
CAI $7.62B -8.4 97.0% -8.4% -13.2% —
ERAS $1.06B -8.5 — — -35.7% —
TVTX $3.47B -131.8 110.5% -5.2% -34.6% —
PTCT $6.19B 9.8 114.5% 39.4% -331.5% —
ACAD $4.55B 11.6 11.9% 36.5% 38.1% —
DYN $3.23B -5.6 — — -57.8% —

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 14
Annual Income Statement data for DNTH
Metric Trend 202520242023202220212020201920182017
Revenue 6-point trend, +2036000.00 $2M $6M $3M · · · $0 $0 $0
R&D Expense 9-point trend, +422.0% $146M $83M $33M $29M $47M $51M $59M $41M $28M
SG&A Expense 9-point trend, +338.6% $34M $25M $18M $7M $28M $28M $24M $19M $8M
Operating Expenses 9-point trend, +403.7% $180M $108M $51M $36M $75M $79M $83M $60M $36M
Operating Income 9-point trend, -398.0% $-178M $-102M $-48M $-30M $-75M $-79M $-83M $-60M $-36M
Interest Income 3-point trend, +238.4% $16M $17M $5M · · · · · ·
Other Non-op 6-point trend, -512.7% $-974.0K $-554.0K $-60.0K $-52.0K · · · $2M $236.0K
Income Tax Flat — no change across 9 periods $0 $0 $0 $0 $0 $0 $0 $0 $0
Net Income 9-point trend, -357.4% $-162M $-85M $-44M $-28M $-71M $-75M $-77M $-58M $-35M
EPS (Basic) 6-point trend, -145.6% $-4.20 $-2.55 $-8.45 $-32.57 $-1.29 $-1.71 · · ·
EPS (Diluted) 6-point trend, -145.6% $-4.20 $-2.55 $-8.45 $-32.57 $-1.29 $-1.71 · · ·
Shares (Basic) 6-point trend, -12.1% 38,617,580 33,313,849 5,153,423 874,234 54,948,808 43,920,121 · · ·
Shares (Diluted) 6-point trend, -12.1% 38,617,580 33,313,849 5,153,423 874,234 54,948,808 43,920,121 · · ·
EBITDA 7-point trend, -201.1% $-178M $-102M $-48M · $-73M $-77M $-81M $-59M ·
Balance Sheet 22
Annual Balance Sheet data for DNTH
Metric Trend 202520242023202220212020201920182017
Cash & Equivalents 9-point trend, -0.6% $51M $23M $132M $15M $132M $58M $65M $58M $51M
Short-term Investments 8-point trend, +319.4% $353M $252M $41M $60M $45M $91M $81M $84M ·
Receivables 4-point trend, -98.9% $52.0K $0 $294.0K $5M · · · · ·
Prepaid Expense 9-point trend, +443.9% $5M $5M $3M $905.0K $4M $3M $4M $3M $936.0K
Other Current Assets 3-point trend, +86000.00 $86.0K $355.0K $0 · · · · · ·
Current Assets 9-point trend, +679.8% $409M $281M $177M $82M $181M $152M $150M $145M $53M
PP&E (Net) 9-point trend, -84.9% $296.0K $194.0K $185.0K $142.0K $7M $8M $10M $10M $2M
PP&E (Gross) 9-point trend, -74.3% $600.0K $387.0K $282.0K $172.0K $14M $13M $13M $11M $2M
Accum. Depreciation 9-point trend, -20.4% $304.0K $193.0K $97.0K $30.0K $7M $5M $3M $1M $382.0K
Other Non-current Assets · · · · · · · · $4.0K
Total Assets 9-point trend, +874.8% $531M $374M $179M $83M $190M $162M $162M $157M $54M
Accounts Payable 9-point trend, +5723.4% $10M $5M $3M $1M $3M $4M $3M $3M $167.0K
Accrued Liabilities 9-point trend, +389.4% $19M $13M $7M $7M $8M $8M $11M $7M $4M
Current Liabilities 9-point trend, +642.0% $31M $18M $10M $8M $11M $11M $14M $10M $4M
Capital Leases 5-point trend, +1019000.00 $1M $1M $168.0K $438.0K $0 · · · ·
Total Liabilities 9-point trend, +805.9% $38M $22M $11M $9M $17M $18M $20M $12M $4M
Common Stock 9-point trend, +2050.0% $43.0K $31.0K $15.0K $0 $59.0K $49.0K $39.0K $33.0K $2.0K
Retained Earnings 9-point trend, -644.8% $-337M $-174M $-89M $-46M $-326M $-254M $-179M $-103M $-45M
AOCI 8-point trend, +6212.5% $489.0K $106.0K $47.0K $-161.0K $-30.0K $-23.0K $8.0K $-8.0K ·
Stockholders' Equity 9-point trend, +1271.5% $493M $352M $169M $-44M $-17M $144M $141M $146M $-42M
Liabilities + Equity 9-point trend, +874.8% $531M $374M $179M $83M $190M $162M $162M $157M $54M
Shares Outstanding 9-point trend, +1738.3% 43,223,090 31,115,341 14,817,696 875,279 58,799,157 48,533,135 39,260,532 33,305,033 2,351,247
Cash Flow 12
Annual Cash Flow data for DNTH
Metric Trend 202520242023202220212020201920182017
D&A 6-point trend, +412.0% · · · $2M $2M $2M $2M $875.0K $376.0K
Stock-based Comp 9-point trend, +909.0% $23M $13M $3M $2M $10M $10M $10M $11M $2M
Other Non-cash 4-point trend, -117.8% · · · · $-723.0K $-1M $8M $4M ·
Operating Cash Flow 9-point trend, -479.7% $-129M $-78M $-37M $-29M $-60M $-64M $-57M $-42M $-22M
CapEx 6-point trend, -85.7% · · · $314.0K $1M $400.0K $3M $8M $2M
Investing Cash Flow 9-point trend, -5485.9% $-123M $-287M $20M $-60M $43M $-11M $2M $-92M $-2M
Stock Issued 8-point trend, -99.7% $317.0K $0 $0 $3M $0 $65M $61M $93M ·
Net Stock Activity 4-point trend, -99.5% $317.0K $39M · · · $65M $61M · ·
Financing Cash Flow 9-point trend, +291.9% $280M $256M $134M $97M $90M $68M $62M $142M $71M
Net Change in Cash 9-point trend, -40.0% $28M $-109M $117M $8M $73M $-7M $7M $9M $47M
Taxes Paid Flat — no change across 4 periods $0 $0 $0 $0 · · · · ·
Free Cash Flow 4-point trend, -22.7% · · · · $-61M $-64M $-60M $-50M ·
Profitability 5
Annual Profitability data for DNTH
Metric Trend 202520242023202220212020201920182017
Operating Margin 2-point trend, -434.9% -8739.3% -1633.7% · · · · · · ·
Net Margin 2-point trend, -485.1% -7973.3% -1362.8% · · · · · · ·
EBITDA Margin 2-point trend, -434.9% -8739.3% -1633.7% · · · · · · ·
ROA 7-point trend, +33.9% -35.9% -30.7% -33.2% · -40.5% -46.4% -48.2% -54.3% ·
ROE 7-point trend, -8.2% -40.8% -24.6% -25.1% · -39.3% -49.5% -50.7% -37.7% ·
Liquidity & Solvency 2
Annual Liquidity & Solvency data for DNTH
Metric Trend 202520242023202220212020201920182017
Current Ratio 7-point trend, -4.5% 13.3 15.2 18.4 · 16.6 13.3 10.6 13.9 ·
Quick Ratio 7-point trend, -3.8% 13.2 15.0 18.1 · 16.3 13.0 10.3 13.7 ·
Efficiency 2
Annual Efficiency data for DNTH
Metric Trend 202520242023202220212020201920182017
Asset Turnover 4-point trend, +0.00 0.0 0.0 · · · · 0.0 0.0 ·
Receivables Turnover 2-point trend, +591.4% 78.3 11.3 · · · · · · ·
Per Share 6
Annual Per Share data for DNTH
Metric Trend 202520242023202220212020201920182017
Book Value / Share 7-point trend, +161.0% $11.42 $11.33 $11.40 · $2.94 $2.97 $3.60 $4.37 ·
Revenue / Share 2-point trend, -71.8% $0.05 $0.19 · · · · · · ·
Cash Flow / Share 4-point trend, -208.5% $-3.34 $-2.35 $-7.15 · $-1.08 · · · ·
Cash / Share 7-point trend, -32.5% $1.18 $0.73 $8.93 · $2.24 $1.20 $1.66 $1.75 ·
Dividend / Share Flat — no change across 3 periods $0 $0 $0 · · · · · ·
EPS (TTM) 6-point trend, -145.6% $-4.20 $-2.55 $-8.45 $-32.57 $-1.29 $-1.71 · · ·
Growth Rates 1
Annual Growth Rates data for DNTH
Metric Trend 202520242023202220212020201920182017
Revenue YoY 2-point trend, -155.8% -67.3% 120.6% · · · · · · ·
Valuation (TTM) 10
Annual Valuation (TTM) data for DNTH
Metric Trend 202520242023202220212020201920182017
Revenue TTM 7-point trend, +2036000.00 $2M $6M $3M · $0 $0 $0 $0 ·
Net Income TTM 8-point trend, -182.3% $-162M $-85M $-44M $-28M $-71M $-75M $-77M $-58M ·
Market Cap 7-point trend, -41.4% $1.78B $678M $154M · $4.17B $6.09B $9.52B $3.04B ·
P/E 6-point trend, +86.6% -9.8 -8.5 -1.2 -0.2 -54.9 -73.4 · · ·
P/S 3-point trend, +1504.3% 874.9 108.8 54.5 · · · · · ·
P/B 7-point trend, -82.7% 3.6 1.9 0.9 · 24.1 42.3 67.4 20.9 ·
P / Tangible Book 4-point trend, -91.5% 3.6 1.9 0.9 · · 42.3 · · ·
P / Cash Flow 7-point trend, +81.0% -13.8 -8.7 -4.2 · -70.0 -95.1 -166.8 -72.5 ·
P / FCF 4-point trend, -11.9% · · · · -68.6 -94.5 -158.3 -61.3 ·
Earnings Yield 6-point trend, -649.3% -10.2% -11.7% -81.2% -508.9% -1.8% -1.4% · · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $2M$6M$3M——
Operating Margin % -8739.3%-1633.7%———
Net Income $-162M$-85M$-44M$-28M$-71M
Diluted EPS $-4.20$-2.55$-8.45$-32.57$-1.29
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 13.315.218.4—16.6
Quick Ratio 13.215.018.1—16.3
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow ————$-61M

Latest News Recent headlines mentioning this company

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Institutional owners (13F) 283 filers · $4.7B total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
66 (-38 vs prior Q) 31 (+14 vs prior Q) 111 (+32 vs prior Q) 69 (+12 vs prior Q) +3.9M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
FMR LLC $572,883,234 5,876,931 12.24% Shares
WELLINGTON MANAGEMENT GROUP LLP $264,170,313 2,709,995 5.64% Shares
Fairmount Funds Management LLC $247,325,379 2,537,191 5.28% Shares
STATE STREET CORP $229,798,634 2,357,440 4.91% Shares
VANGUARD CAPITAL MANAGEMENT LLC $210,514,689 2,159,568 4.50% Shares
Avidity Partners Management LP $205,115,856 2,104,184 4.38% Shares
Octagon Capital Advisors LP $179,525,699 1,841,667 3.83% Shares
TCG Crossover Management, LLC $163,437,308 1,676,624 3.49% Shares
FRED ALGER MANAGEMENT, LLC $126,967,018 1,302,493 2.71% Shares
Venrock Adviser, LLC $115,026,400 1,180,000 2.46% Shares
DEERFIELD MANAGEMENT COMPANY, L.P. $109,695,511 1,125,313 2.34% Shares
GEODE CAPITAL MANAGEMENT, LLC $107,328,005 1,100,843 2.29% Shares
Polar Capital Holdings Plc $99,305,410 1,018,726 2.12% Shares
CITADEL ADVISORS LLC $95,034,324 974,911 2.03% Shares
JENNISON ASSOCIATES LLC $83,073,817 852,214 1.77% Shares
BAKER BROS. ADVISORS LP $83,068,947 852,164 1.77% Shares
Logos Global Management LP $77,984,000 800,000 1.67% Shares
VANGUARD GROUP INC $75,241,465 1,825,806 1.61% Shares
Cormorant Asset Management, LP $73,110,000 750,000 1.56% Shares
ALLIANCEBERNSTEIN L.P. $70,001,868 834,150 1.50% Shares
BRAIDWELL LP $57,957,904 594,562 1.24% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $55,574,810 570,115 1.19% Shares
AMERIPRISE FINANCIAL INC $49,641,680 509,247 1.06% Shares
Woodline Partners LP $48,793,419 500,548 1.04% Shares
MPM BIOIMPACT LLC $40,941,795 420,002 0.87% Shares
Affinity Asset Advisors, LLC $38,992,000 400,000 0.83% Shares
SILVERARC CAPITAL MANAGEMENT, LLC $38,017,200 390,000 0.81% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $35,674,073 365,963 0.76% Shares
Bain Capital Life Sciences Investors, LLC $35,333,576 362,470 0.75% Shares
Spruce Street Capital LP $34,587,464 354,816 0.74% Shares
Vivo Capital, LLC $34,507,725 353,998 0.74% Shares
WESTFIELD CAPITAL MANAGEMENT CO LP $30,697,817 314,914 0.66% Shares
DIMENSIONAL FUND ADVISORS LP $29,702,156 304,700 0.63% Shares
VANGUARD FIDUCIARY TRUST CO $29,485,945 302,482 0.63% Shares
Driehaus Capital Management LLC $28,782,530 295,266 0.61% Shares
First Turn Management, LLC $27,856,957 285,771 0.59% Shares
Assenagon Asset Management S.A. $27,357,665 280,649 0.58% Shares
TANG CAPITAL MANAGEMENT LLC $25,802,176 264,692 0.55% Shares
Artisan Partners Limited Partnership $25,176,062 258,269 0.54% Shares
RTW INVESTMENTS, LP $24,181,181 248,063 0.52% Shares
EMERALD ADVISERS, LLC $24,156,031 247,805 0.52% Shares
Pictet Asset Management Holding SA $24,106,317 247,295 0.51% Shares
TD Asset Management Inc $21,965,558 225,334 0.47% Shares
EVENTIDE ASSET MANAGEMENT, LLC $21,958,442 225,261 0.47% Shares
Candriam S.C.A. $19,887,628 204,214 0.42% Shares
STEMPOINT CAPITAL LP $19,578,955 200,851 0.42% Shares
Qube Research & Technologies Ltd $19,196,152 196,924 0.41% Shares
BANK OF AMERICA CORP /DE/ $19,072,742 195,658 0.41% Shares
Nicholas Investment Partners, LP $18,206,242 186,769 0.39% Shares
ADAGE CAPITAL PARTNERS GP, L.L.C. $18,033,800 185,000 0.39% Shares
GOLDMAN SACHS GROUP INC $17,941,974 184,058 0.38% Shares
Ensign Peak Advisors, Inc $16,979,749 174,187 0.36% Shares
Artia Global Partners LP $15,888,265 162,990 0.34% Shares
Balyasny Asset Management L.P. $15,792,247 162,005 0.34% Shares
Alyeska Investment Group, L.P. $14,679,708 150,592 0.31% Shares
Eagle Health Investments LP $12,803,413 131,344 0.27% Shares
EMERALD MUTUAL FUND ADVISERS TRUST $12,771,635 131,018 0.27% Shares
PFM Health Sciences, LP $11,816,721 121,222 0.25% Shares
Tri Locum Partners LP $11,767,006 120,712 0.25% Shares
ORBIMED ADVISORS LLC $11,210,200 115,000 0.24% Shares
Patient Square Capital LP $10,527,840 108,000 0.22% Shares
TWO SIGMA INVESTMENTS, LP $10,474,713 107,455 0.22% Shares
NEUBERGER BERMAN GROUP LLC $10,217,951 104,821 0.22% Shares
Caption Management, LLC $10,128,172 103,900 0.22% Call option
SEVEN GRAND MANAGERS, LLC $9,748,000 100,000 0.21% Shares
Iron Triangle Partners LP $9,508,383 230,730 0.20% Shares
Atika Capital Management LLC $9,417,738 96,612 0.20% Shares
FIRST TRUST ADVISORS LP $9,177,936 94,152 0.20% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $9,133,876 93,700 0.20% Call option
BlackRock, Inc. $9,082,017 93,168 0.19% Shares
MILLENNIUM MANAGEMENT LLC $8,952,368 91,838 0.19% Shares
VICTORY CAPITAL MANAGEMENT INC $8,608,947 88,315 0.18% Shares
Russell Investments Group, Ltd. $8,608,137 88,306 0.18% Shares
AMERICAN CENTURY COMPANIES INC $8,564,593 87,860 0.18% Shares
Rhenman & Partners Asset Management AB $8,395,660 86,127 0.18% Shares
Caption Management, LLC $7,505,960 77,000 0.16% Put option
SAMLYN CAPITAL, LLC $7,304,859 74,937 0.16% Shares
Moody Aldrich Partners LLC $7,267,329 74,552 0.16% Shares
Swiss National Bank $7,194,024 73,800 0.15% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $7,116,040 73,000 0.15% Put option
MERCER GLOBAL ADVISORS INC /ADV $6,402,779 65,683 0.14% Shares
LPL Financial LLC $6,365,029 65,295 0.14% Shares
SummitTX Capital, L.P. $6,225,658 63,866 0.13% Shares
MANUFACTURERS LIFE INSURANCE COMPANY, THE $6,124,571 62,829 0.13% Shares
NEW YORK STATE COMMON RETIREMENT FUND $5,853,479 60,048 0.13% Shares
Sio Capital Management, LLC $5,776,080 59,254 0.12% Shares
RHUMBLINE ADVISERS $5,704,614 58,521 0.12% Shares
Jones Hill Capital LP $5,566,108 57,100 0.12% Shares
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC $5,560,454 57,042 0.12% Shares
ALPS ADVISORS INC $5,388,792 55,281 0.12% Shares
CITIGROUP INC $5,274,935 54,113 0.11% Shares
HighVista Strategies LLC $4,983,665 51,125 0.11% Shares
Burkehill Global Management, LP $4,874,000 50,000 0.10% Shares
Universal- Beteiligungs- und Servicegesellschaft mbH $4,738,406 48,609 0.10% Shares
JANE STREET GROUP, LLC $4,484,080 46,000 0.10% Call option
Seven Fleet Capital Management LP $4,257,147 43,672 0.09% Shares
CITADEL ADVISORS LLC $4,230,632 43,400 0.09% Put option
Schonfeld Strategic Advisors LLC $4,223,027 43,322 0.09% Shares
D. E. Shaw & Co., Inc. $4,184,621 42,928 0.09% Shares
JANE STREET GROUP, LLC $3,986,932 40,900 0.09% Put option

Company insiders 36 insiders · 10 officers · 14 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Ryan Savitz EVP, CFO & CBO July 9, 2026 M 0 0 4 $-3,857,151
Simrat Randhawa EVP, Head of R&D June 1, 2026 M 4,000 0 3 $-2,404,077
David Wayne Nichols Chief Technical Officer Aug. 1, 2022 A 14,306 0 0 $0
Lisa Olson Title: Head of Research and Chief Scientific Officer Exhibit 24.1: Power of Attorney Aug. 1, 2022 A 14,264 0 0 $0
Jeffrey Humphrey Chief Medical Officer Aug. 1, 2022 A — 0 0 $0
John C. Davis JR Title: Head of Research and Development and Chief Medical Officer Feb. 11, 2021 A 8,304 0 0 $0
Zoran Zdraveski Title: Secretary and Chief Legal and Technology Operations Officer Feb. 11, 2021 A 140,092 0 0 $0
Christina K. Isacson Chief Business Officer Feb. 10, 2020 A 103,531 0 0 $0
Jason Ryan Title: Chief Operating and Financial Officer Feb. 10, 2020 A — 0 0 $0
COOKE MICHAEL P. Chief Scientific Officer Feb. 5, 2019 A 293,023 0 0 $0
Jonathan Violin Director May 22, 2025 A — 0 0 $0
Paula Soteropoulos Director May 22, 2025 A — 0 0 $0
Steven J. Romano Director May 22, 2025 A — 0 0 $0
Alison Frances Lawton Director May 22, 2025 A — 0 0 $0
MOULDER LEON O JR Director May 23, 2024 A 1,436,745 0 0 $0
Michael Vasconcelles Director Aug. 15, 2022 A — 0 0 $0
David Scadden Director June 28, 2022 A 228,175 0 0 $0
Jeffrey W. Albers Director June 28, 2022 A 4,152 0 0 $0
Thomas O Daniel Director June 28, 2022 A 101,926 0 0 $0
Bruce Booth Director June 28, 2022 A 1,250,000 0 0 $0
Amy L Ronneberg Director June 28, 2022 A 593,611 0 0 $0
Alexis Borisy Director Aug. 26, 2021 J 4,100 0 0 $0
Michael W Bonney Director June 1, 2021 A 215,346 0 0 $0
Blake Byers Director June 5, 2020 A 3,339,137 0 0 $0
Atlas Venture Fund X, L.P. 10% owner Feb. 11, 2021 J 3,148,399 0 0 $0
Adam M Veness — Aug. 13, 2026 M 15,000 0 5 $-4,632,790
Anne Mcgeorge — Aug. 10, 2026 M 0 0 5 $-844,822
Simon Read — Aug. 10, 2026 M 0 0 6 $-304,232
Marino Garcia — Aug. 7, 2026 M 65,292 0 7 $-17,945,450
Sujay Kango — May 21, 2026 A — 0 0 $0
Edward Carr — March 12, 2026 M 0 0 5 $-3,559,495
Caren Deardorf — Nov. 30, 2022 A 19,762 0 0 $0
Kristen Stants — Nov. 30, 2022 A 20,264 0 0 $0
Stephen F. Mahoney — Nov. 30, 2022 A 17,264 0 0 $0
Thomas W. Beetham — Nov. 30, 2022 A 19,897 0 0 $0
Jason Gardner — Nov. 30, 2022 A 292,872 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 4 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Fairmount Funds Management LLC, Fairmount Healthcare Fund II L.P., Peter Evan Harwin, Tomas Kiselak ×5 filings Nov. 25, 2025 4.90% Amendment — SEC
Avidity Partners Management LP, Avidity Partners Management (GP) LLC, Avidity Capital Partners Fund (GP) LP, Avidity Capital Partners (GP) LLC, Avidity Private Master Fund I LP, Michael Gregory ×4 filings Nov. 19, 2025 4.90% Amendment Passive investment SEC
Viridian, LLC ×2 filings Sept. 12, 2024 — Initial filing — SEC
ATLAS VENTURE FUND X, L.P., ATLAS VENTURE ASSOCIATES X, L.P., Atlas Venture Associates X, LLC, Atlas Venture Opportunity Fund I, L.P., Atlas Venture Associates Opportunity I, L.P., Atlas Venture Associates Opportunity I, LLC ×4 filings Sept. 15, 2023 — Initial filing — SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 49 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
LFSC · RBB Fund, Inc. 3.09% 34,884 NS May 31, 2026 N-PORT
SBIO · ALPS ETF Trust 2.64% 45,839 NS May 31, 2026 N-PORT
BBC · ETFis Series Trust I 1.54% 6,551 NS April 30, 2026 N-PORT
LABU · Direxion Shares ETF Trust 0.57% 33,605 NS April 30, 2026 N-PORT
FYC · First Trust Exchange-Traded AlphaDE… 0.47% 55,660 NS April 30, 2026 N-PORT
AVSC · AMERICAN CENTURY ETF TRUST 0.26% 76,617 NS May 31, 2026 N-PORT
MMSC · First Trust Exchange-Traded Fund VI… 0.20% 1,151 NS May 31, 2026 N-PORT
FYX · First Trust Exchange-Traded AlphaDE… 0.18% 24,819 NS April 30, 2026 N-PORT
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0.17% 14,250 NS April 30, 2026 N-PORT
FFSM · FIDELITY COVINGTON TRUST 0.15% 22,043 NS April 30, 2026 N-PORT
RSSL · Global X Funds 0.10% 15,526 NS April 30, 2026 N-PORT
FAD · First Trust Exchange-Traded AlphaDE… 0.09% 5,190 NS April 30, 2026 N-PORT
ITWO · ProShares Trust 0.08% 1,687 NS May 31, 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0.07% 177,996 NS May 31, 2026 N-PORT
AVIE · AMERICAN CENTURY ETF TRUST 0.06% 66 NS May 31, 2026 N-PORT
GSSC · Goldman Sachs ETF Trust 0.05% 5,283 NS May 31, 2026 N-PORT
FHLC · FIDELITY COVINGTON TRUST 0.05% 16,047 NS April 30, 2026 N-PORT
UWM · ProShares Trust 0.05% 1,320 NS May 31, 2026 N-PORT
DFAS · Dimensional ETF Trust 0.04% 71,218 NS April 30, 2026 N-PORT
URTY · ProShares Trust 0.04% 1,340 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.01% 34 NS May 31, 2026 N-PORT
DCOR · Dimensional ETF Trust 0.01% 3,958 NS April 30, 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.01% 869 NS May 31, 2026 N-PORT
ONEQ · Fidelity Commonwealth Trust 0.01% 11,461 NS May 31, 2026 N-PORT
DFAU · Dimensional ETF Trust 0.01% 7,297 NS April 30, 2026 N-PORT
DFAC · Dimensional ETF Trust 0.01% 27,975 NS April 30, 2026 N-PORT
SCHB · SCHWAB STRATEGIC TRUST 0.00% 21,529 NS May 31, 2026 N-PORT
TILT · FlexShares Trust 0.00% 770 NS April 30, 2026 N-PORT
DFUS · Dimensional ETF Trust 0.00% 4,404 NS April 30, 2026 N-PORT
AVUS · AMERICAN CENTURY ETF TRUST 0.00% 1,591 NS May 31, 2026 N-PORT
AVSU · AMERICAN CENTURY ETF TRUST 0.00% 31 NS May 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS — — July 15, 2026 Daily
VTI · VANGUARD INDEX FUNDS — — July 15, 2026 Daily
VFMO · VANGUARD WELLINGTON FUND — — July 30, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS — — July 15, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS — — July 15, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS — — July 15, 2026 Daily
ITOT · iShares Trust — — July 22, 2026 Daily
IWV · iShares Trust — — Aug. 18, 2026 Daily
IWO · iShares Trust — — Aug. 18, 2026 Daily
IWM · iShares Trust — — Aug. 18, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust — — July 23, 2026 Daily
VHT · VANGUARD WORLD FUND — — July 20, 2026 Daily
ISCB · iShares Trust — — July 21, 2026 Daily
ISCV · iShares Trust — — July 20, 2026 Daily
SMMV · iShares Trust — — Aug. 18, 2026 Daily
ESML · iShares Trust — — Aug. 14, 2026 Daily
IBRN · iShares Trust — — Aug. 6, 2026 Daily
WSML · iShares Trust — — July 20, 2026 Daily