Insider at

04

Insider transactions

05
0 buys (P) 0 sells (S) Net: $0 + 59 non-open-market transactions below last 12 months, based on the transactions shown below

Price change vs current quote, split-adjusted for corporate actions since the filing — not benchmarked, not annualized, not size-weighted

59 other filings hidden
DateTickerCodeSharesPriceValue Owned afterΔ ownA/Dvs now
Aug. 22, 2024 MREO S 105,244 $4.43 $466,231 0 Direct -100.00% Disposed -91.2% (price as of 2026-10-05)
June 7, 2024 KPTI S 2,240 $0.95 $2,128 0 Indirect -100.00% Disposed -95.3% (price as of 2026-10-05)
June 7, 2024 KPTI S 229,308 $0.95 $217,843 0 Indirect -100.00% Disposed -95.3% (price as of 2026-10-05)
June 6, 2024 KPTI S 1,145 $0.98 $1,122 2,240 Indirect -33.83% Disposed -95.4% (price as of 2026-10-05)
June 6, 2024 KPTI S 117,307 $0.98 $114,961 229,308 Indirect -33.84% Disposed -95.4% (price as of 2026-10-05)
June 5, 2024 KPTI S 4,526 $0.96 $4,345 3,385 Indirect -57.21% Disposed -95.3% (price as of 2026-10-05)
June 5, 2024 KPTI S 463,518 $0.96 $444,977 346,615 Indirect -57.22% Disposed -95.3% (price as of 2026-10-05)
June 4, 2024 KPTI S 3,298 $0.95 $3,133 7,911 Indirect -29.42% Disposed -95.3% (price as of 2026-10-05)
June 4, 2024 KPTI S 337,742 $0.95 $320,855 810,133 Indirect -29.42% Disposed -95.3% (price as of 2026-10-05)
June 3, 2024 KPTI S 3,488 $1.00 $3,488 11,209 Indirect -23.73% Disposed -95.5% (price as of 2026-10-05)
June 3, 2024 KPTI S 357,256 $1.00 $357,256 1,147,875 Indirect -23.74% Disposed -95.5% (price as of 2026-10-05)
May 31, 2024 KPTI S 1,976 $0.95 $1,877 14,697 Indirect -11.85% Disposed -95.3% (price as of 2026-10-05)
May 31, 2024 KPTI S 202,418 $0.95 $192,297 1,505,131 Indirect -11.85% Disposed -95.3% (price as of 2026-10-05)
June 10, 2022 KPTI S 13 $6.00 $78 16,673 Indirect -0.08% Disposed -99.3% (price as of 2026-10-05)
June 10, 2022 KPTI S 1,294 $6.00 $7,764 1,707,549 Indirect -0.08% Disposed -99.3% (price as of 2026-10-05)
June 9, 2022 KPTI S 2,045 $6.18 $12,638 16,686 Indirect -10.92% Disposed -99.3% (price as of 2026-10-05)
June 9, 2022 KPTI S 209,455 $6.18 $1,294,432 1,708,843 Indirect -10.92% Disposed -99.3% (price as of 2026-10-05)
June 8, 2022 KPTI S 3,152 $6.50 $20,488 18,731 Indirect -14.40% Disposed -99.3% (price as of 2026-10-05)
June 8, 2022 KPTI S 322,825 $6.50 $2,098,362 1,918,298 Indirect -14.40% Disposed -99.3% (price as of 2026-10-05)
Jan. 12, 2015 KPTI P 440 $33.00 $14,520 21,883 Indirect +2.05% Acquired -99.9% (price as of 2026-10-05)
Jan. 12, 2015 KPTI P 45,014 $33.00 $1,485,462 2,241,123 Indirect +2.05% Acquired -99.9% (price as of 2026-10-05)
May 23, 2014 KPTI P 17 $26.45 $450 21,443 Indirect +0.08% Acquired -99.8% (price as of 2026-10-05)
May 23, 2014 KPTI P 1,752 $26.45 $46,340 2,196,109 Indirect +0.08% Acquired -99.8% (price as of 2026-10-05)
May 22, 2014 KPTI P 193 $26.09 $5,035 21,426 Indirect +0.91% Acquired -99.8% (price as of 2026-10-05)
May 22, 2014 KPTI P 19,807 $26.09 $516,765 2,194,357 Indirect +0.91% Acquired -99.8% (price as of 2026-10-05)
May 21, 2014 KPTI P 896 $26.19 $23,466 21,233 Indirect +4.41% Acquired -99.8% (price as of 2026-10-05)
May 21, 2014 KPTI P 91,754 $26.19 $2,403,037 2,174,550 Indirect +4.41% Acquired -99.8% (price as of 2026-10-05)
Nov. 12, 2013 KPTI P 3,022 $16.00 $48,352 20,337 Indirect +17.45% Acquired -99.7% (price as of 2026-10-05)
Nov. 12, 2013 KPTI P 309,478 $16.00 $4,951,648 2,082,796 Indirect +17.45% Acquired -99.7% (price as of 2026-10-05)

P = Open-market purchase · S = Sale · A = Grant/award · M = Option exercise · G = Gift · F = Tax withholding

Insider transactions are not a recommendation; sales are often driven by liquidity or tax reasons.

Derivative holdings (Form 4 Table II) Options, RSUs and convertible securities reported on Form 4 Table II.

06
DateTickerSecurityUnderlying Exercise priceExpirationSharesA/D
Sept. 23, 2026 TBPH Share Option (Right to Buy) Ordinary Shares (17,000) $20.66 June 30, 2030 17,000 Disposed
Sept. 23, 2026 TBPH Share Option (Right to Buy) Ordinary Shares (6,000) $20.35 April 26, 2031 6,000 Disposed
Sept. 23, 2026 TBPH Share Option (Right to Buy) Ordinary Shares (28,000) $10.15 April 25, 2032 28,000 Disposed
Sept. 23, 2026 TBPH Share Option (Right to Buy) Ordinary Shares (22,044) $10.95 May 1, 2033 22,044 Disposed
Sept. 23, 2026 TBPH Share Option (Right to Buy) Ordinary Shares (23,576) $9.49 May 7, 2034 23,576 Disposed
Sept. 23, 2026 TBPH Share Option (Right to Buy) Ordinary Shares (24,258) $9.39 May 18, 2035 24,258 Disposed
Sept. 23, 2026 TBPH Share Option (Right to Buy) Ordinary Shares (13,398) $16.64 June 11, 2036 13,398 Disposed
June 12, 2026 TBPH Share Option (Right to Buy) Ordinary Shares (13,398) $16.64 June 11, 2036 13,398 Acquired
Feb. 26, 2026 MREO Share Options (Right to buy) American Depositary Shares [F2] (66,000) $0.39 Feb. 26, 2036 66,000 Acquired
May 28, 2025 KPTI Nonstatutory Stock Option (right to buy) Common Stock · May 27, 2035 4,600 Acquired
May 19, 2025 TBPH Share Option (Right to Buy) Ordinary Shares (24,258) $9.39 May 18, 2035 24,258 Acquired
Feb. 5, 2025 MREO Share Options (Right to buy) American Depositary Shares [F2] (55,000) $3.16 Feb. 5, 2035 55,000 Acquired
Aug. 22, 2024 MREO Share Options (right to buy) American Depository Shares [F1] (15,000) $3.87 Feb. 8, 2034 15,000 Disposed
Aug. 22, 2024 MREO Share Options (right to buy) American Depository Shares [F1] (55,000) $0.94 Feb. 1, 2033 55,000 Disposed
Aug. 22, 2024 MREO Share Options (right to buy) American Depository Shares [F1] (55,000) $1.31 Feb. 1, 2032 55,000 Disposed
Aug. 22, 2024 MREO Share Options (right to buy) American Depository Shares [F1] (31,500) $2.72 Feb. 1, 2031 31,500 Disposed
Aug. 22, 2024 MREO Share Options (right to buy) American Depository Shares [F1] (11,000) $1.84 Feb. 20, 2030 11,000 Disposed
Aug. 22, 2024 MREO Share Options (right to buy) American Depository Shares [F1] (5,500) $3.00 July 23, 2029 5,500 Disposed
May 29, 2024 KPTI Nonstatutory Stock Option (right to buy) Common Stock (69,000) $0.96 May 28, 2034 69,000 Acquired
May 8, 2024 TBPH Share Option (Right to Buy) Ordinary Shares (23,576) $9.49 May 7, 2034 23,576 Acquired
Feb. 8, 2024 MREO Share Options (Right to buy) American Depository Shares [F2] (45,000) $3.87 Feb. 8, 2034 45,000 Acquired
May 24, 2023 KPTI Nonstatutory Stock Option (right to buy) Common Stock (34,000) $2.50 May 23, 2033 34,000 Acquired
May 2, 2023 TBPH Share Option (Right to Buy) Ordinary Shares (22,044) $10.95 May 1, 2033 22,044 Acquired
May 19, 2022 KPTI Nonstatutory Stock Option (right to buy) Common Stock (23,900) $5.65 May 18, 2032 23,900 Acquired
April 26, 2022 TBPH Share Option (Right to Buy) Ordinary Shares (28,000) $10.15 April 25, 2032 28,000 Acquired
May 21, 2021 KPTI Nonstatutory Stock Option (right to buy) Common Stock (23,900) $9.42 May 20, 2031 23,900 Acquired
April 27, 2021 TBPH Share Option (Right to Buy) Ordinary Shares (6,000) $20.35 April 26, 2031 6,000 Acquired
July 1, 2020 TBPH Share Option (Right to Buy) Ordinary Shares (5,000) $20.66 June 30, 2020 5,000 Acquired
July 1, 2020 TBPH Share Option (Right to Buy) Ordinary Shares (12,000) $20.66 June 30, 2030 12,000 Acquired
May 21, 2020 KPTI Nonstatutory Stock Option (right to buy) Common Stock (16,400) $19.11 May 20, 2030 16,400 Acquired
June 6, 2019 KPTI Nonstatutory Stock Option (right to buy) Common Stock (25,000) $5.43 June 5, 2029 25,000 Acquired
June 19, 2018 KPTI Nonstatutory Stock Option (right to buy) Common Stock (17,000) $18.80 June 18, 2028 17,000 Acquired
June 15, 2017 KPTI Nonstatutory Stock Option (right to buy) Common Stock (17,000) $9.18 June 14, 2027 17,000 Acquired
June 16, 2016 KPTI Nonstatutory Stock Option (right to buy) Common Stock (10,000) $8.06 June 15, 2026 10,000 Acquired
May 22, 2015 KPTI Nonstatutory Stock Option (right to buy) Common Stock (10,000) $26.15 May 21, 2025 10,000 Acquired
July 8, 2014 KPTI Nonstatutory Stock Option (right to buy) Common Stock (10,000) $36.04 July 7, 2024 10,000 Acquired
Dec. 5, 2013 KPTI Nonstatutory Stock Option (right to buy) Common Stock (20,000) $16.03 Dec. 4, 2023 20,000 Acquired
Nov. 12, 2013 KPTI Series B-1 Convertible Preferred Stock Common Stock (2,663) · · 2,663 Disposed
Nov. 12, 2013 KPTI Series B-1 Convertible Preferred Stock Common Stock (272,818) · · 272,818 Disposed
Nov. 12, 2013 KPTI Series B Convertible Preferred Stock Common Stock (14,652) · · 14,652 Disposed
Nov. 12, 2013 KPTI Series B Convertible Preferred Stock Common Stock (1,500,500) · · 1,500,500 Disposed

Exercise/conversion price is blank when not applicable (e.g. RSUs).

Initial ownership (Form 3) 18 holdings

07

Securities held when first becoming an insider, per SEC Form 3.

DateTickerSecuritySharesOwnership
July 27, 2026 FRNM Common Stock 13,918 Direct
July 27, 2026 FRNM Stock Option (right to buy)→ Common Stock (14,144) 14,144 Direct
July 27, 2026 FRNM Stock Option (right to buy)→ Common Stock (6,365) 6,365 Direct
July 27, 2026 FRNM Stock Option (right to buy)→ Common Stock (3,359) 3,359 Direct
July 27, 2026 FRNM Stock Option (right to buy)→ Common Stock (7,359) 7,359 Direct
July 27, 2026 FRNM Stock Option (right to buy)→ Common Stock (9,588) 9,588 Direct
July 27, 2026 FRNM Stock Option (right to buy)→ Common Stock (6,484) 6,484 Direct
Jan. 2, 2024 MREO Share Options (Right to buy)→ American Depositary Shares [F1] (5,500) 5,500 Direct
Jan. 2, 2024 MREO Share Options (Right to buy)→ American Depositary Shares [F1] (5,500) 5,500 Direct
Jan. 2, 2024 MREO Share Options (Right to buy)→ American Depositary Shares [F1] (11,000) 11,000 Direct
Jan. 2, 2024 MREO Share Options (Right to buy)→ American Depositary Shares [F1] (31,500) 31,500 Direct
Jan. 2, 2024 MREO Share Options (Right to buy)→ American Depositary Shares [F1] (55,000) 55,000 Direct
Jan. 2, 2024 MREO Share Options (Right to buy)→ American Depositary Shares [F1] (55,000) 55,000 Direct
Aug. 11, 2020 IRON Class B Common Stock→ Class A Common Stock (30,000) 30,000 Direct
Nov. 5, 2013 KPTI Series B Convertible Preferred Stock→ Common Stock (1,500,500) 1,500,500 Indirect
Nov. 5, 2013 KPTI Series B Convertible Preferred Stock→ Common Stock (14,652) 14,652 Indirect
Nov. 5, 2013 KPTI Series B-1 Convertible Preferred Stock→ Common Stock (272,818) 272,818 Indirect
Nov. 5, 2013 KPTI Series B-1 Convertible Preferred Stock→ Common Stock (2,663) 2,663 Indirect