MREO Mereo BioPharma Group plc - American Depositary Shares

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$0.31
Price · Aug 18, 2026
Fundamentals as of Aug 11, 2026

MREO Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$0.31
Market Cap
$248M
P/E (TTM)
-6.2
EPS (TTM)
$-0.05
Revenue (TTM)
$500.0K
Div Yield
ROE
-88.1%
Debt/Equity
52W Range
$0 – $2

MREO Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $500.0K
4-point trend, +500000.00
2022-12-31 2025-12-31
EPS $-0.05
4-point trend, +28.6%
2022-12-31 2025-12-31
Free Cash Flow $-31M
2-point trend, -46.7%
2023-12-31 2025-12-31
Margins -8375.6%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
MREO
Peer Median
P/E (TTM)
3-point trend, +85.6%
-6.2
P/S (TTM)
2-point trend, +309.7%
495.8
1305.2
P/B
3-point trend, -74.7%
6.1
4.4
Price / FCF
2-point trend, +86.0%
-8.0

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
MREO
Peer Median
Operating Margin
2-point trend, -2722.8%
-8021.4%
Net Profit Margin
2-point trend, -2742.5%
-8375.6%
-1841.7%
ROA
3-point trend, -67.2%
-68.5%
-38.9%
ROE
3-point trend, -57.3%
-88.1%
-49.6%
ROIC
3-point trend, -77.5%
-98.0%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
MREO
Peer Median
Current Ratio
3-point trend, +55.7%
10.5
10.5
Quick Ratio
3-point trend, +57.4%
9.5

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
MREO
Peer Median

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
MREO
Peer Median
EPS (Diluted)
4-point trend, +28.6%
$-0.05

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
MREO
Peer Median

MREO Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 14 analysts
  • Strong Buy 5 35.7%
  • Buy 5 35.7%
  • Hold 4 28.6%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

5 analysts · 2026-08-13
Median target $1.98 +536.7%
Mean target $1.99 +539.8%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
-0.03%
Period EPS Actual EPS Est Surprise
March 31, 2026 $-0.01 $-0.01 0.00%
Dec. 31, 2025 $-0.01 $-0.01 0.00%
Sept. 30, 2025 $-0.01 $-0.02 0.01%
June 30, 2025 $-0.10 $-0.02 -0.08%
March 31, 2025 $-0.10 $-0.01 -0.09%
Dec. 31, 2024 $-0.05 $-0.01 -0.04%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
MREO $332M -8.3 -8375.6% -88.1%
OKYO
BRNS $29M -0.4 1766.5% -65.0%
ROIV $19.95B -51.3 -71.6% -3629.2% -6.5%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 15
Annual Income Statement data for MREO
Metric Trend 2025202420232022
Revenue 4-point trend, +500000.00 $500.0K $0 $10M $0
R&D Expense 4-point trend, -39.7% $18M $21M $17M $29M
SG&A Expense 4-point trend, -11.9% $23M $26M $18M $26M
Operating Income 4-point trend, +26.3% $-40M $-47M $-28M $-54M
Interest Expense 4-point trend, -93.9% $255.0K $1M $3M $4M
Interest Income 4-point trend, -87.6% $104.0K $0 $2M $840.0K
Other Non-op 4-point trend, -72.4% $300.0K $0 $-10.0K $1M
Pretax Income 4-point trend, +2.5% $-42M $-43M $-30M $-43M
Income Tax 4-point trend, +100.0% $0 $0 $-532.0K $-718.0K
Net Income 4-point trend, +0.8% $-42M $-43M $-29M $-42M
EPS (Basic) 4-point trend, +28.6% $-0.05 $-0.06 $-0.04 $-0.07
EPS (Diluted) 4-point trend, +28.6% $-0.05 $-0.06 $-0.04 $-0.07
Shares (Basic) 4-point trend, +32.1% 797,119,632 739,624,264 659,453,921 603,196,403
Shares (Diluted) 4-point trend, +32.1% 797,119,632 739,624,264 659,453,921 603,196,403
EBITDA 3-point trend, -41.1% $-40M $-47M $-28M ·
Balance Sheet 22
Annual Balance Sheet data for MREO
Metric Trend 2025202420232022
Cash & Equivalents 4-point trend, -39.9% $41M $70M $57M $68M
Prepaid Expense 4-point trend, -53.5% $3M $2M $5M $5M
Current Assets 4-point trend, -40.1% $45M $75M $64M $75M
PP&E (Net) 4-point trend, -75.1% $137.0K $257.0K $405.0K $551.0K
PP&E (Gross) 4-point trend, -5.1% $1M $1M $1M $1M
Accum. Depreciation 4-point trend, +47.4% $1M $949.0K $800.0K $736.0K
Intangibles 4-point trend, +516000.00 $516.0K $643.0K $1M $0
Total Assets 4-point trend, -40.7% $46M $76M $66M $77M
Accounts Payable 4-point trend, -61.8% $1M $2M $2M $3M
Accrued Liabilities 4-point trend, -62.7% $2M $4M $5M $5M
Current Liabilities 4-point trend, -82.4% $4M $14M $9M $24M
Capital Leases 4-point trend, -100.0% $0 $187.0K $906.0K $1M
Other Non-current Liabilities 4-point trend, +661000.00 $661.0K $565.0K $764.0K $0
Total Liabilities 4-point trend, -80.8% $5M $15M $16M $26M
Common Stock 4-point trend, +26.5% $3M $3M $3M $2M
Paid-in Capital 4-point trend, +15.3% $550M $540M $486M $477M
Retained Earnings 4-point trend, -23.8% $-501M $-463M $-420M $-405M
Treasury Stock 3-point trend, -100.0% · $0 $1M $1M
AOCI 4-point trend, +50.1% $-11M $-19M $-17M $-22M
Stockholders' Equity 4-point trend, -20.4% $41M $61M $51M $51M
Liabilities + Equity 4-point trend, -40.7% $46M $76M $66M $77M
Shares Outstanding 4-point trend, +27.3% 795,658,504 775,728,034 701,217,089 624,928,519
Cash Flow 13
Annual Cash Flow data for MREO
Metric Trend 2025202420232022
Stock-based Comp 4-point trend, +59.4% $8M $7M $5M $5M
Deferred Tax Flat — no change across 3 periods · $0 $0 $0
Amort. of Intangibles 4-point trend, +465000.00 $465.0K $438.0K $395.0K $0
Operating Cash Flow 4-point trend, +36.6% $-31M $-33M $-21M $-49M
CapEx 4-point trend, +53.8% $20.0K $0 $0 $13.0K
Investing Cash Flow 4-point trend, -101.0% $-20.0K $-699.0K $-419.0K $2M
Stock Issued 4-point trend, +39000.00 $39.0K $47M $12M $0
Net Stock Activity 3-point trend, -99.7% $39.0K $47M $12M ·
Financing Cash Flow 4-point trend, +63.5% $327.0K $46M $8M $200.0K
Net Change in Cash 2-point trend, +215.1% · $12M $-11M ·
Taxes Paid 3-point trend, -100.0% · $0 $-1M $2M
Free Cash Flow 2-point trend, -46.7% $-31M · $-21M ·
Levered FCF 2-point trend, -30.4% $-31M · $-24M ·
Profitability 7
Annual Profitability data for MREO
Metric Trend 2025202420232022
Operating Margin 2-point trend, -2722.8% -8021.4% · -284.2% ·
Net Margin 2-point trend, -2742.5% -8375.6% · -294.7% ·
Pretax Margin 2-point trend, -2692.1% -8375.6% · -300.0% ·
EBITDA Margin 2-point trend, -2722.8% -8021.4% · -284.2% ·
ROA 3-point trend, -67.2% -68.5% -60.5% -40.9% ·
ROE 3-point trend, -57.3% -88.1% 747.9% -56.0% ·
ROIC 3-point trend, -77.5% -98.0% -77.7% -55.2% ·
Liquidity & Solvency 3
Annual Liquidity & Solvency data for MREO
Metric Trend 2025202420232022
Current Ratio 3-point trend, +55.7% 10.5 5.4 6.7 ·
Quick Ratio 3-point trend, +57.4% 9.5 5.0 6.1 ·
Interest Coverage 3-point trend, -1494.6% -157.3 -34.6 -9.9 ·
Efficiency 1
Annual Efficiency data for MREO
Metric Trend 2025202420232022
Asset Turnover 3-point trend, -94.1% 0.0 0.0 0.1 ·
Per Share 5
Annual Per Share data for MREO
Metric Trend 2025202420232022
Book Value / Share 3-point trend, -28.7% $0.05 $0.08 $0.07 ·
Revenue / Share 3-point trend, -96.1% $0.00 $0.00 $0.02 ·
Cash Flow / Share 3-point trend, -21.6% $-0.04 $-0.04 $-0.03 ·
Cash / Share 3-point trend, -37.1% $0.05 $0.09 $0.08 ·
EPS (TTM) 3-point trend, -25.0% $-0.05 $-0.06 $-0.04 ·
Valuation (TTM) 10
Annual Valuation (TTM) data for MREO
Metric Trend 2025202420232022
Revenue TTM 3-point trend, -95.0% $500.0K $0 $10M ·
Net Income TTM 3-point trend, -42.1% $-42M $-43M $-29M ·
Market Cap 3-point trend, -79.5% $332M $2.72B $1.62B ·
P/E 3-point trend, +85.6% -8.3 -58.3 -57.8 ·
P/S 2-point trend, +309.7% 663.6 · 162.0 ·
P/B 3-point trend, -74.7% 8.1 44.5 32.1 ·
P / Tangible Book 3-point trend, -74.9% 8.2 45.0 32.8 ·
P / Cash Flow 3-point trend, +86.0% -10.7 -82.7 -76.7 ·
P / FCF 2-point trend, +86.0% -10.7 · -76.7 ·
Earnings Yield 3-point trend, -593.1% -12.0% -1.7% -1.7% ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-31
Revenue $500.0K$0$10M$0
Operating Margin % -8021.4%-284.2%
Net Income $-42M$-43M$-29M$-42M
Diluted EPS $-0.05$-0.06$-0.04$-0.07
Balance Sheet
2025-12-312024-12-312023-12-312022-12-31
Current Ratio 10.55.46.7
Quick Ratio 9.55.06.1
Cash Flow
2025-12-312024-12-312023-12-312022-12-31
Free Cash Flow $-31M$-21M

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Institutional owners (13F) 68 filers · $17.6M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
15 (-1 vs prior Q) 17 (-6 vs prior Q) 15 (-3 vs prior Q) 15 (0 vs prior Q) -18.6M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
Rubric Capital Management LP $4,863,144 15,307,347 27.62% Shares
683 Capital Management, LLC $3,741,825 11,777,856 21.25% Shares
BANK OF AMERICA CORP /DE/ $2,597,904 8,195,281 14.75% Shares
Defilade Capital Management, L.P. $2,401,417 7,558,756 13.64% Shares
Newtyn Management, LLC $953,100 3,000,000 5.41% Shares
Tejara Capital Ltd $647,320 2,037,520 3.68% Shares
TWO SIGMA INVESTMENTS, LP $419,123 1,319,241 2.38% Shares
EcoR1 Capital, LLC $317,700 1,000,000 1.80% Shares
Ishara Investments LP $244,232 768,750 1.39% Shares
Wealthspire Advisors, LLC $243,041 765,000 1.38% Shares
CITADEL ADVISORS LLC $160,407 504,900 0.91% Call option
JANE STREET GROUP, LLC $154,711 486,971 0.88% Shares
TWO SIGMA ADVISERS, LP $104,967 251,900 0.60% Shares
Rangeley Capital, LLC $104,587 329,200 0.59% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $67,756 213,270 0.38% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $55,520 173,500 0.32% Call option
XTX Topco Ltd $55,433 174,481 0.31% Shares
GROUP ONE TRADING LLC $53,220 167,515 0.30% Shares
STATE STREET CORP $42,817 134,772 0.24% Shares
Sheets Smith Investment Management $34,793 16,890 0.20% Shares
NOMURA HOLDINGS INC $33,155 104,361 0.19% Shares
James J. Burns & Company, LLC $30,309 95,400 0.17% Shares
Quarry LP $29,784 93,750 0.17% Shares
GOLDMAN SACHS GROUP INC $27,062 85,180 0.15% Shares
JMN Financial LLC $24,383 76,748 0.14% Shares
BlackRock, Inc. $22,137 69,678 0.13% Shares
JPMORGAN CHASE & CO $18,887 56,923 0.11% Shares
RENAISSANCE TECHNOLOGIES LLC $16,552 52,100 0.09% Shares
CITADEL ADVISORS LLC $16,203 51,000 0.09% Put option
SUSQUEHANNA INTERNATIONAL GROUP, LLP $14,720 46,000 0.08% Put option
MARSHALL WACE, LLP $10,532 32,913 0.06% Shares
Significant Wealth Partners LLC $10,382 32,677 0.06% Shares
Clear Harbor Asset Management, LLC $10,083 32,000 0.06% Shares
RHUMBLINE ADVISERS $8,511 26,784 0.05% Shares
Centiva Capital, LP $7,943 25,000 0.05% Shares
Engineers Gate Manager LP $7,610 23,953 0.04% Shares
SIMPLEX TRADING, LLC $5,972 18,780 0.03% Shares
NFSG Corp $5,957 18,750 0.03% Shares
OneDigital Investment Advisors LLC $5,814 18,300 0.03% Shares
IHT Wealth Management, LLC $4,766 15,000 0.03% Shares
CITADEL ADVISORS LLC $4,250 13,378 0.02% Shares
TWO SIGMA SECURITIES, LLC $4,098 12,900 0.02% Shares
J. Safra Sarasin Holding AG $4,081 12,841 0.02% Shares
MML INVESTORS SERVICES, LLC $3,876 12,200 0.02% Shares
JANE STREET GROUP, LLC $3,749 11,800 0.02% Call option
World Investment Advisors $3,300 10,000 0.02% Shares
Astoria Portfolio Advisors LLC. $3,177 10,000 0.02% Shares
GAMMA Investing LLC $2,957 9,308 0.02% Shares
UBS Group AG $1,880 5,912 0.01% Shares
Arax Advisory Partners $1,849 5,819 0.01% Shares
Rockefeller Capital Management L.P. $635 2,000 0.00% Shares
Allworth Financial LP $477 1,500 0.00% Shares
OSAIC HOLDINGS, INC. $320 1,000 0.00% Shares
New England Capital Financial Advisors LLC $96 300 0.00% Shares
MERCER GLOBAL ADVISORS INC /ADV $71 225 0.00% Shares
SBI Securities Co., Ltd. $36 114 0.00% Shares
EverSource Wealth Advisors, LLC $32 100 0.00% Shares
Virtu Financial LLC $19 61,285 0.00% Shares
CITIGROUP INC $17 52 0.00% Shares
US BANCORP \DE\ $4 13 0.00% Shares
SG Americas Securities, LLC $4 12,802 0.00% Shares
MORGAN STANLEY $1 1 0.00% Shares
BNP PARIBAS FINANCIAL MARKETS $1 3 0.00% Shares
Integrated Wealth Concepts LLC $0 1 0.00% Shares
Axiom Investment Management LLC $0 1 0.00% Shares
Caitong International Asset Management Co., Ltd $0 1 0.00% Shares
SIT INVESTMENT ASSOCIATES INC $0 970 0.00% Shares
WELLS FARGO & COMPANY/MN $0 1 0.00% Shares

Company insiders 13 insiders · 5 officers · 9 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Denise Scots-Knight Chief Executive Officer Feb. 1, 2026 A 808,921 0 0 $0
Chrisitne Ann Fox Chief Financial Officer Feb. 1, 2026 A 89,285 0 0 $0
Alexandra Hughes-Wilson Chief Patient Access and Commercial Planning Feb. 1, 2026 A 50,475 0 0 $0
Charles Sermon General Counsel Feb. 1, 2026 A 219,061 0 0 $0
John A. Lewicki Chief Scientific Officer Feb. 1, 2026 A 78,630 0 0 $0
Anders Ekblom Director Feb. 26, 2026 A 0 0 $0
Daniel Shames Director Feb. 26, 2026 A 0 0 $0
Jeremy Bender Director Feb. 26, 2026 A 12,550 0 0 $0
Pierre Jacquet Director Feb. 26, 2026 A 0 0 $0
Annalisa Jenkins Director Feb. 26, 2026 A 0 0 $0
Marc J Yoskowitz Director Feb. 26, 2026 A 0 0 $0
Deepika Pakianathan Director Feb. 26, 2026 A 0 0 0 $0
Michael S Wyzga Director Feb. 26, 2026 A 25,050 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 2 positions

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Rubric Capital Management LP, David Rosen ×16 filings June 17, 2024 Initial filing SEC
Mereo BioPharma Group plc, Dr. Denise Scots-Knight Dec. 17, 2018 Initial filing M&A / sale SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 1 ETF

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
BBC · ETFis Series Trust I 0.09% 127,193 NS April 30, 2026 N-PORT