KPTI Karyopharm Therapeutics Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$7.83
Price · May 20, 2026
Fundamentals as of May 14, 2026
52W Range
$4–$11
57% of range
Analyst Rating
BUY
13 analysts
Price Target
$14
+72% upside
P/E (TTM)
-0.4
ROE
73.7%
Net Profit Margin
-134.2%

KPTI Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$7.83
Market Cap
$135M
P/E (TTM)
-0.4
EPS (TTM)
$-17.93
Revenue (TTM)
$146M
Div Yield
—
ROE
73.7%
Debt/Equity
—
52W Range
$4 – $11

KPTI Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $146M
10-point trend, +94748.7%
2016-12-31 → 2025-12-31
EPS $-17.93
6-point trend, -559.2%
2020-12-31 → 2025-12-31
Free Cash Flow $-75M
10-point trend, +10.8%
2016-12-31 → 2025-12-31
Margins -134.2%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
KPTI
Peer Median
P/E (TTM)
5-point trend, +99.3%
-0.4
—
P/S (TTM)
5-point trend, -97.4%
0.9
40.2
P/B
5-point trend, +99.5%
-0.5
2.2
Price / FCF
5-point trend, +97.4%
-1.8
—

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
KPTI
Peer Median
Operating Margin
5-point trend, -32.6%
-62.1%
—
Net Profit Margin
5-point trend, -126.9%
-134.2%
-182.8%
ROA
5-point trend, -258.1%
-143.7%
-58.1%
ROE
5-point trend, -38.9%
73.7%
-170.7%
ROIC
5-point trend, -74.9%
31.0%
—

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
KPTI
Peer Median
Current Ratio
5-point trend, -70.0%
1.1
4.7
Quick Ratio
5-point trend, -67.4%
0.9
—

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
KPTI
Peer Median
Revenue YoY
5-point trend, -30.4%
0.57%
—
Revenue CAGR 3Y
5-point trend, -30.4%
-2.4%
—
Revenue CAGR 5Y
5-point trend, -30.4%
6.2%
—

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
KPTI
Peer Median
EPS (Diluted)
5-point trend, -986.7%
$-17.93
—

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
KPTI
Peer Median

KPTI Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 13 analysts
  • Strong Buy 4 30.8%
  • Buy 7 53.8%
  • Hold 2 15.4%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

6 analysts · 2026-05-20
Median target $14.50 +85.2%
Mean target $13.50 +72.4%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.20%
Period EPS Actual EPS Est Surprise
March 31, 2026 $-1.02 $-1.46 0.44%
Dec. 31, 2025 $-2.22 $-2.03 -0.19%
Sept. 30, 2025 $-3.82 $-3.19 -0.63%
June 30, 2025 $-4.32 $-4.18 -0.14%
March 31, 2025 $-2.77 $-4.26 1.5%

Peer Comparison Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
KPTI $135M -0.4 0.57% -134.2% 73.7% —
ELTX — -3.1 — — — —
ARTV — -1.3 -99.2% — — —
RNAC $188M -1.4 -92.8% -4658.6% 202.4% —
DTIL $100M -1.2 -50.1% -133.4% -72.4% —
CRBP $143M -1.4 — — -60.8% —
TNYA $154M -1.2 — — -81.2% —
ABOS $128M -1.1 — — -129.4% —
HRTX $245M -10.8 7.4% -13.0% 312.5% 73.3%
SPRO $131M 15.5 39.2% 12.8% 18.7% —

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 16
Annual Income Statement data for KPTI
Metric Trend 202520242023202220212020201920182017201620152014
Revenue 12-point trend, +63684.7% $146M $145M $146M $157M $210M $108M $41M $30M $2M $154.0K $250.0K $229.0K
R&D Expense 12-point trend, +108.9% $126M $143M $139M $149M $161M $151M $122M $161M $107M $87M $98M $60M
SG&A Expense 12-point trend, +559.7% $105M $115M $132M $145M $144M $126M $105M $49M $25M $24M $22M $16M
Operating Expenses 12-point trend, +211.2% $237M $265M $276M $299M $308M $280M $230M $210M $132M $111M $119M $76M
Operating Income 12-point trend, -19.6% $-91M $-119M $-130M $-142M $-98M $-172M $-189M $-180M $-131M $-111M $-119M $-76M
Interest Expense 7-point trend, +2382200.0% · · $24M $25M $26M $27M $16M $2M · · · $1.0K
Interest Income 12-point trend, +2758.8% $3M $7M $11M $2M $582.0K $3M $5M $4M $2M $1M $897.0K $97.0K
Other Non-op 12-point trend, +663.0% $152.0K $28M $-356.0K $-83.0K $-85.0K $206.0K $-50.0K $-33.0K $-81.0K $10.0K $-2.0K $-27.0K
Pretax Income 12-point trend, -158.6% $-196M $-76M $-143M $-165M $-124M $-196M $-200M $-178M $-129M $-109M $-118M $-76M
Income Tax 12-point trend, +100.1% $43.0K $57.0K $323.0K $369.0K $268.0K $309.0K $40.0K $26.0K $63.0K $139.0K $-118M $-76M
Net Income 12-point trend, -158.7% $-196M $-76M $-143M $-165M $-124M $-196M $-200M $-178M $-129M $-110M $-118M $-76M
EPS (Basic) 6-point trend, -559.2% $-17.93 $-9.41 $-18.79 $-2.02 $-1.65 $-2.72 · · · · · ·
EPS (Diluted) 6-point trend, -559.2% $-17.93 $-14.00 $-18.79 $-2.02 $-1.65 $-2.72 · · · · · ·
Shares (Basic) 6-point trend, -100.0% 10,935 8,125 7,616 81,871 75,218,000 72,044,000 · · · · · ·
Shares (Diluted) 6-point trend, -100.0% 10,935 8,455 7,616 81,871 75,218,000 72,044,000 · · · · · ·
EBITDA 12-point trend, -19.6% $-91M $-119M $-130M $-142M $-98M $-172M $-189M $-180M $-131M $-111M $-119M $-76M
Balance Sheet 26
Annual Balance Sheet data for KPTI
Metric Trend 202520242023202220212020201920182017201620152014
Cash & Equivalents 12-point trend, -59.8% $61M $62M $52M $135M $190M $86M $129M $118M $69M $50M $58M $151M
Short-term Investments 4-point trend, +40.6% · · · · · · · · $77M $80M $117M $55M
Receivables 7-point trend, +233.0% $26M $31M $27M $47M $22M $13M $8M · · · · ·
Inventory 7-point trend, +1067.1% $4M $5M $3M $4M $4M $3M $346.0K · · · · ·
Prepaid Expense 12-point trend, +353.2% $9M $12M $12M $20M $14M $9M $7M $6M $2M $2M $2M $2M
Other Current Assets · · · · $2M · · · · · · ·
Current Assets 12-point trend, -50.4% $103M $156M $234M $350M $276M $277M $279M $335M $148M $132M $178M $208M
PP&E (Net) 12-point trend, -96.2% $104.0K $400.0K $606.0K $1M $2M $2M $3M $4M $2M $3M $3M $3M
PP&E (Gross) 12-point trend, +72.8% $6M $7M $7M $8M $8M $7M $7M $7M $5M $5M $5M $3M
Accum. Depreciation 12-point trend, +1015.4% $6M $7M $7M $7M $6M $5M $4M $3M $3M $2M $1M $494.0K
Other Non-current Assets · · · · · · · · · · · $774.0K
Total Assets 12-point trend, -50.8% $108M $164M $240M $358M $305M $313M $295M $341M $180M $180M $215M $220M
Accounts Payable 12-point trend, -36.3% $4M $5M $3M $3M $2M $4M $985.0K $4M $6M $5M $4M $6M
Accrued Liabilities 12-point trend, +1007.3% $64M $61M $61M $58M $69M $53M $41M $32M $21M $11M $11M $6M
Current Liabilities 12-point trend, +648.4% $92M $92M $69M $66M $74M $60M $46M $47M $49M $16M $15M $12M
Capital Leases 7-point trend, -56.5% $6M $7M $3M $6M $9M $11M $13M · · · · ·
Other Non-current Liabilities 4-point trend, +11095000.00 $11M $2M $978.0K $0 · · · · · · · ·
Total Liabilities 12-point trend, +2863.5% $401M $350M $377M $375M $385M $263M $245M $158M $51M $18M $17M $14M
Long-term Debt · · · · $169M · · · · · · ·
Common Stock 12-point trend, +366.7% $14.0K $13.0K $12.0K $12.0K $8.0K $7.0K $7.0K $6.0K $5.0K $4.0K $4.0K $3.0K
Paid-in Capital · · · · · · · · · · · $345M
Retained Earnings 12-point trend, -1171.8% $-1.76B $-1.56B $-1.49B $-1.34B $-1.18B $-1.07B $-873M $-674M $-495M $-366M $-257M $-138M
AOCI 12-point trend, +344.8% $71.0K $-356.0K $-161.0K $-638.0K $191.0K $518.0K $-37.0K $-244.0K $-217.0K $-274.0K $-282.0K $-29.0K
Stockholders' Equity 12-point trend, -241.7% $-293M $-186M $-136M $-17M $-80M $51M $50M $183M $129M $162M $198M $207M
Liabilities + Equity 12-point trend, -50.8% $108M $164M $240M $358M $305M $313M $295M $341M $180M $180M $215M $220M
Shares Outstanding 12-point trend, -44.0% 18,311,000 8,413,000 114,915,000 113,213,000 75,746,000 73,923,000 65,370,000 60,829,308 49,533,150 41,887,829 35,864,765 32,699,380
Cash Flow 12
Annual Cash Flow data for KPTI
Metric Trend 202520242023202220212020201920182017201620152014
D&A 6-point trend, +201.5% · · · · · · $974.0K $735.0K $713.0K $717.0K $634.0K $323.0K
Stock-based Comp 12-point trend, -1.3% $14M $18M $22M $35M $30M $24M $15M $17M $20M $22M $17M $14M
Deferred Tax Flat — no change across 8 periods $0 $0 $0 $0 $0 $0 $0 $0 · · · ·
Operating Cash Flow 12-point trend, -46.5% $-75M $-127M $-93M $-150M $-107M $-160M $-191M $-159M $-74M $-84M $-94M $-51M
CapEx 12-point trend, -100.0% $0 $142.0K $0 $118.0K $212.0K $145.0K $206.0K $2M $62.0K $70.0K $1M $3M
Investing Cash Flow 10-point trend, +76.4% $43M $95M $8M $-104M $142M $-54M $78M $-108M $17M $25M · ·
Stock Issued · · · · · · · · · · · $113M
Net Stock Activity · · · · · · · · · · · $113M
Financing Cash Flow 10-point trend, -41.3% $30M $42M $1M $194M $74M $172M $124M $316M $76M $51M · ·
Net Change in Cash 12-point trend, +64.2% $-2M $10M $-84M $-61M $108M $-42M $12M $49M $19M $-9M $-92M $-5M
Free Cash Flow 12-point trend, -38.8% $-75M $-128M $-93M $-150M $-107M $-160M $-191M $-161M $-74M $-84M $-95M $-54M
Levered FCF 6-point trend, +28.9% · · $-117M $-175M $-133M $-188M $-207M $-164M · · · ·
Profitability 7
Annual Profitability data for KPTI
Metric Trend 202520242023202220212020201920182017201620152014
Operating Margin 11-point trend, +99.8% -62.1% -82.2% -88.7% -90.5% -46.8% -159.0% -462.8% -593.0% · -71903.9% -47630.4% -33120.5%
Net Margin 11-point trend, +99.6% -134.2% -52.6% -98.0% -105.2% -59.1% -181.6% -488.1% -588.1% · -71153.9% -47272.4% -33090.4%
Pretax Margin 9-point trend, +99.8% -134.2% -52.6% -97.8% -105.0% -59.0% -181.3% -488.0% -588.0% · -71063.6% · ·
EBITDA Margin 11-point trend, +99.8% -62.1% -82.2% -88.7% -90.5% -46.8% -159.0% -462.8% -593.0% · -71903.9% -47630.4% -33120.5%
ROA 12-point trend, -259.0% -143.7% -37.8% -47.8% -49.8% -40.1% -64.6% -62.7% -68.4% -71.5% -55.4% -54.2% -40.0%
ROE 12-point trend, +275.9% 73.7% 44.2% 121.0% 210.7% 120.7% -292.3% -364.1% -100.7% -88.4% -60.8% -58.3% -41.9%
ROIC 10-point trend, +145.3% 31.0% 64.3% 95.3% 855.7% 123.6% -340.5% -380.4% -98.2% -100.9% -68.3% · ·
Liquidity & Solvency 3
Annual Liquidity & Solvency data for KPTI
Metric Trend 202520242023202220212020201920182017201620152014
Current Ratio 12-point trend, -93.4% 1.1 1.7 3.4 5.3 3.7 4.6 6.0 7.1 3.0 8.0 11.7 16.9
Quick Ratio 12-point trend, -94.4% 0.9 1.0 1.1 2.8 2.9 1.6 2.9 2.5 3.0 7.9 11.6 16.7
Interest Coverage 7-point trend, +100.0% · · -5.4 -5.7 -3.8 -6.3 -12.1 -72.2 · · · -75846.0
Efficiency 2
Annual Efficiency data for KPTI
Metric Trend 202520242023202220212020201920182017201620152014
Asset Turnover 11-point trend, +89125.0% 1.1 0.7 0.5 0.5 0.7 0.4 0.1 0.1 · 0.0 0.0 0.0
Receivables Turnover 7-point trend, -50.7% 5.1 5.0 3.9 4.5 11.9 10.4 10.4 · · · · ·
Per Share 5
Annual Per Share data for KPTI
Metric Trend 202520242023202220212020201920182017201620152014
Book Value / Share 12-point trend, -353.0% $-16.00 $-1.47 $-1.19 $-0.15 $-1.05 $0.68 $0.76 $3.01 $2.61 $3.87 $5.53 $6.32
Revenue / Share 4-point trend, +696123.8% $13357.75 $1145.32 $1.28 $1.92 · · · · · · · ·
Cash Flow / Share 4-point trend, -377217.3% $-6892.46 $-1005.34 $-0.81 $-1.83 · · · · · · · ·
Cash / Share 12-point trend, -28.2% $3.31 $0.50 $0.45 $1.19 $2.51 $1.16 $1.97 $1.94 $1.39 $1.19 $1.63 $4.61
EPS (TTM) 6-point trend, -559.2% $-17.93 $-14.00 $-18.79 $-2.02 $-1.65 $-2.72 · · · · · ·
Growth Rates 3
Annual Growth Rates data for KPTI
Metric Trend 202520242023202220212020201920182017201620152014
Revenue YoY 5-point trend, -99.4% 0.57% -0.55% -7.0% -25.1% 94.1% · · · · · · ·
Revenue CAGR 3Y 3-point trend, -122.7% -2.4% -11.5% 10.5% · · · · · · · · ·
Revenue CAGR 5Y 6.2% · · · · · · · · · · ·
Valuation (TTM) 10
Annual Valuation (TTM) data for KPTI
Metric Trend 202520242023202220212020201920182017201620152014
Revenue TTM 12-point trend, +63684.7% $146M $145M $146M $157M $210M $108M $41M $30M $2M $154.0K $250.0K $229.0K
Net Income TTM 12-point trend, -158.7% $-196M $-76M $-143M $-165M $-124M $-196M $-200M $-178M $-129M $-110M $-118M $-76M
Market Cap 12-point trend, -99.3% $135M $1.28B $1.49B $5.77B $7.31B $17.16B $18.80B $8.55B $7.13B $5.91B $7.13B $18.36B
P/E 6-point trend, +99.5% -0.4 -0.7 -0.7 -25.2 -58.5 -85.4 · · · · · ·
P/S 12-point trend, -100.0% 0.9 8.8 10.2 36.8 34.8 158.8 459.7 281.8 4444.1 38351.8 28512.5 80170.6
P/B 12-point trend, -100.5% -0.5 -6.9 -10.9 -346.7 -91.7 339.6 377.7 46.7 55.1 36.4 35.9 88.8
P / Tangible Book · · · · · 339.6 · · · · · ·
P / Cash Flow 12-point trend, +99.5% -1.8 -10.0 -16.1 -38.6 -68.2 -107.1 -98.5 -53.7 -96.8 -70.0 -75.8 -356.9
P / FCF 12-point trend, +99.5% -1.8 -10.0 -16.1 -38.6 -68.1 -107.0 -98.4 -52.9 -96.7 -69.9 -74.7 -338.2
Earnings Yield 6-point trend, -20721.4% -243.6% -138.1% -144.8% -4.0% -1.7% -1.2% · · · · · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $146M$145M$146M$157M$210M
Operating Margin % -62.1%-82.2%-88.7%-90.5%-46.8%
Net Income $-196M$-76M$-143M$-165M$-124M
Diluted EPS $-17.93$-14.00$-18.79$-2.02$-1.65
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 1.11.73.45.33.7
Quick Ratio 0.91.01.12.82.9
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-75M$-128M$-93M$-150M$-107M

Latest News Recent headlines mentioning this company

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