ANNX Annexon, Inc. - common stock
ANNX Instantánea de la Acción Precio, capitalización bursátil, P/E, BPA, ROE, deuda/capital, rango de 52 semanas
ANNX Gráfico del Precio de la Acción OHLCV diario con indicadores técnicos — desplace, amplíe y personalice su vista
Rendimiento a 10 años Tendencias de ingresos, beneficio neto, márgenes y BPA
Valoración Ratios P/E, P/S, P/B, EV/EBITDA: ¿está la acción cara o barata?
Rentabilidad Márgenes brutos, operativos y netos; ROE, ROA, ROIC
Salud financiera Deuda, liquidez, solvencia — solidez del balance general
Crecimiento Crecimiento de ingresos, BPA y beneficio neto: interanual, CAGR a 3 años, CAGR a 5 años
Eficiencia de capital Rotación de activos, rotación de inventario, rotación de cuentas por cobrar
ANNX Consenso de analistas Opiniones de analistas alcistas y bajistas, precio objetivo a 12 meses, potencial alcista
- Compra fuerte 4 23,5%
- Compra 10 58,8%
- Mantener 2 11,8%
- Venta 1 5,9%
- Venta fuerte 0 0,0%
Precio objetivo a 12 meses
7 analistas · 2026-08-17Historial de Ganancias EPS real vs estimado, sorpresa %, tasa de aciertos, próxima fecha de resultados
| Período | EPS Actual | EPS est. | Sorpresa |
|---|---|---|---|
| 31 de marzo de 2026 | $-0.23 | $-0.29 | 0.06% |
| 31 de diciembre de 2025 | $-0.28 | $-0.32 | 0.04% |
| 30 de septiembre de 2025 | $-0.37 | $-0.35 | -0.02% |
| 30 de junio de 2025 | $-0.34 | $-0.37 | 0.03% |
| 31 de marzo de 2025 | $-0.37 | $-0.30 | -0.07% |
| 31 de diciembre de 2024 | $-0.33 | $-0.27 | -0.06% |
Comparación de pares (subindustria GICS) Métricas clave frente a competidores del sector
| Ticker | Capitalización Bursátil | P/E | Ingresos interanuales | Margen Neto | ROE | Margen Bruto |
|---|---|---|---|---|---|---|
| ANNX | $750M | -3.7 | — | — | -100.7% | — |
| KURA | $913M | -3.3 | 25.2% | -413.0% | -116.2% | — |
| JANX | $833M | -7.5 | -5.5% | -1136.2% | -11.7% | — |
| CLYM | $191M | -4.5 | — | — | -34.6% | — |
| GERN | $845M | -10.2 | -60.2% | — | -34.4% | — |
| SLDB | $445M | -2.8 | — | — | -79.5% | — |
| OLMA | $2.03B | -13.4 | — | — | -39.4% | — |
| DSGN | $567M | -7.7 | — | — | -32.8% | — |
| CADL | $310M | -7.8 | — | — | -53.7% | — |
| FTH | — | — | — | — | — | — |
Fundamentales Completos Todas las métricas por año — estado de resultados, balance general, flujo de caja
Estado de resultados 13
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 |
|---|---|---|---|---|---|---|---|---|
| R&D Expense | $185M | $119M | $114M | $113M | $100M | $49M | $25M | |
| SG&A Expense | $32M | $35M | $30M | $33M | $31M | $14M | $8M | |
| Operating Expenses | $216M | $154M | $144M | $146M | $131M | $63M | $33M | |
| Operating Income | $-216M | $-154M | $-144M | $-146M | $-131M | $-63M | $-33M | |
| Other Non-op | · | · | · | · | · | $57.0K | $1M | |
| Pretax Income | $-207M | $-138M | $134M | $142M | $130M | $-63M | $-37M | |
| Income Tax | $0 | $0 | $0 | $0 | · | · | $4.0K | |
| Net Income | $-207M | $-138M | $-134M | $-142M | $-130M | $-63M | $-37M | |
| EPS (Basic) | $-1.34 | $-1.01 | $-1.77 | $-2.60 | $-3.40 | · | · | |
| EPS (Diluted) | $-1.34 | $-1.01 | $-1.77 | $-2.60 | $-3.40 | · | · | |
| Shares (Basic) | 155,105,832 | 137,404,145 | 75,673,081 | 54,673,572 | 38,316,273 | · | · | |
| Shares (Diluted) | 155,105,832 | 137,404,145 | 75,673,081 | 54,673,572 | 38,316,273 | · | · | |
| EBITDA | $-214M | $-152M | $-142M | $-143M | $-129M | $-63M | · |
Balance general 21
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 |
|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $162M | $49M | $225M | $140M | $75M | $269M | $44M | |
| Prepaid Expense | $4M | $4M | $4M | $5M | $5M | $3M | $1M | |
| Other Current Assets | · | · | $63.0K | $203.0K | $463.0K | $3.0K | $79.0K | |
| Current Assets | $242M | $316M | $264M | $248M | $248M | $354M | $45M | |
| PP&E (Net) | $11M | $13M | $15M | $17M | $18M | $2M | $2M | |
| PP&E (Gross) | $20M | $20M | $20M | $20M | $19M | $4M | $3M | |
| Accum. Depreciation | $9M | $7M | $5M | $3M | $789.0K | $2M | $1M | |
| Other Non-current Assets | $9M | $3M | · | · | · | · | $2M | |
| Total Assets | $278M | $350M | $298M | $285M | $287M | $356M | $50M | |
| Accounts Payable | $15M | $10M | $5M | $7M | $11M | $4M | $2M | |
| Accrued Liabilities | · | · | $10M | $13M | $9M | $6M | $2M | |
| Current Liabilities | $43M | $31M | $18M | $22M | $22M | $11M | $5M | |
| Capital Leases | $23M | $26M | $29M | $32M | $33M | · | · | |
| Total Liabilities | $66M | $57M | $47M | $54M | $55M | $12M | $6M | |
| Common Stock | $149.0K | $109.0K | $78.0K | $48.0K | $39.0K | $38.0K | $4.0K | |
| Paid-in Capital | $1.13B | $1.00B | $823M | $670M | $528M | $510M | $2M | |
| Retained Earnings | $-917M | $-711M | $-572M | $-438M | $-296M | $-166M | $-103M | |
| AOCI | $-29.0K | $10.0K | $-52.0K | $-372.0K | $-180.0K | $-77.0K | $-80.0K | |
| Stockholders' Equity | $212M | $293M | $251M | $231M | $232M | $344M | $-100M | |
| Liabilities + Equity | $278M | $350M | $298M | $285M | $287M | $356M | $50M | |
| Shares Outstanding | 149,362,800 | 109,381,556 | 78,369,099 | 47,722,995 | 38,560,854 | 38,157,618 | 433,749 |
Flujo de Efectivo 10
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 |
|---|---|---|---|---|---|---|---|---|
| D&A | $2M | $2M | $2M | $2M | $2M | $667.0K | $493.0K | |
| Stock-based Comp | $16M | $19M | $18M | $19M | $16M | $5M | $2M | |
| Other Non-cash | $2M | $-1M | $-7M | $5M | $6M | $5M | · | |
| Operating Cash Flow | $-186M | $-118M | $-121M | $-116M | $-106M | $-53M | $-28M | |
| CapEx | $137.0K | $15.0K | $193.0K | $7M | $2M | $464.0K | $267.0K | |
| Investing Cash Flow | $190M | $-219M | $71M | $58M | $-88M | $-83M | $-267.0K | |
| Stock Issued | $28M | $44M | $18M | · | · | · | · | |
| Net Stock Activity | $28M | $44M | · | · | · | · | · | |
| Financing Cash Flow | $109M | $161M | $136M | $123M | $2M | $361M | $28M | |
| Free Cash Flow | $-186M | $-118M | $-121M | $-123M | $-108M | $-54M | · |
Rentabilidad 3
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 |
|---|---|---|---|---|---|---|---|---|
| ROA | -65.9% | -42.7% | -46.1% | -49.6% | -40.5% | -31.2% | · | |
| ROE | -100.7% | -44.2% | -65.9% | -57.7% | -52.5% | -17.9% | · | |
| ROIC | -102.2% | -52.6% | -57.4% | · | · | · | · |
Liquidez y Solvencia 2
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 |
|---|---|---|---|---|---|---|---|---|
| Current Ratio | 5.7 | 10.4 | 14.7 | 11.1 | 11.4 | 33.3 | · | |
| Quick Ratio | 3.8 | 1.6 | 12.6 | 6.3 | 3.4 | 25.3 | · |
Valoración (TTM) 8
| Métrica | Tendencia | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 |
|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-207M | $-138M | $-134M | $-142M | $-130M | $-63M | · | |
| Market Cap | $750M | $561M | $356M | $247M | $443M | $955M | · | |
| P/E | -3.7 | -5.1 | -2.6 | -2.0 | -3.4 | · | · | |
| P/B | 3.5 | 1.9 | 1.4 | 1.1 | 1.9 | 2.8 | · | |
| P / Tangible Book | 3.5 | 1.9 | 1.4 | 1.1 | 1.9 | 2.8 | · | |
| P / Cash Flow | -4.0 | -4.8 | -2.9 | -2.1 | -4.2 | -18.0 | · | |
| P / FCF | -4.0 | -4.8 | -2.9 | -2.0 | -4.1 | -17.8 | · | |
| Earnings Yield | -26.7% | -19.7% | -39.0% | -50.3% | -29.6% | · | · |
Estado de resultados 10
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| R&D Expense | $47M | $36M | $43M | $50M | $44M | $48M | $43M | $30M | $25M | $21M | $23M | $28M | $30M | $32M | $29M | $28M | |
| SG&A Expense | $11M | $10M | $8M | $7M | $8M | $9M | $9M | $9M | $9M | $8M | $7M | $7M | $7M | $9M | $8M | $8M | |
| Operating Expenses | $57M | $46M | $50M | $57M | $52M | $57M | $52M | $39M | $34M | $29M | $30M | $35M | $38M | $41M | $37M | $36M | |
| Operating Income | $-57M | $-46M | $-50M | $-57M | $-52M | $-57M | $-52M | $-39M | $-34M | $-29M | $-30M | $-35M | $-38M | $-41M | $-37M | $-36M | |
| Net Income | $-55M | $-44M | $-48M | $-55M | $-49M | $-54M | $-49M | $-35M | $-30M | $-25M | $-28M | $-32M | $-35M | $-39M | $-34M | $-35M | |
| EPS (Basic) | $-0.28 | $-0.23 | $-0.26 | $-0.37 | $-0.34 | $-0.37 | $-0.32 | $-0.25 | $-0.23 | $-0.21 | $-0.35 | $-0.43 | $-0.47 | $-0.52 | $-0.21 | $-0.51 | |
| EPS (Diluted) | $-0.28 | $-0.23 | $-0.26 | $-0.37 | $-0.34 | $-0.37 | $-0.32 | $-0.25 | $-0.23 | $-0.21 | $-0.35 | $-0.43 | $-0.47 | $-0.52 | $-0.21 | $-0.51 | |
| Shares (Basic) | 201,003,269 | 194,200,100 | -290,447,481 | 149,123,701 | 148,320,803 | 148,108,809 | -255,335,036 | 139,933,019 | 130,132,960 | 122,673,202 | -148,755,059 | 75,342,495 | 75,230,003 | 73,855,642 | -91,127,071 | 68,652,859 | |
| Shares (Diluted) | 201,003,269 | 194,200,100 | -290,447,481 | 149,123,701 | 148,320,803 | 148,108,809 | -255,335,036 | 139,933,019 | 130,132,960 | 122,673,202 | -148,755,059 | 75,342,495 | 75,230,003 | 73,855,642 | -91,127,071 | 68,652,859 | |
| EBITDA | $-57M | $-46M | · | $-57M | $-52M | $-57M | · | $-39M | $-34M | $-28M | · | $-35M | $-38M | $-41M | · | $-36M |
Balance general 21
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $199M | $175M | $162M | $139M | $132M | $97M | $49M | $80M | $157M | $152M | $225M | $133M | $114M | $144M | $140M | $211M | |
| Prepaid Expense | $4M | $3M | $4M | $4M | $4M | $4M | $4M | $4M | $5M | $6M | $4M | $4M | $5M | $4M | $5M | $5M | |
| Other Current Assets | · | · | · | · | · | · | · | · | · | $23.0K | · | $13.0K | $167.0K | $165.0K | $203.0K | $57.0K | |
| Current Assets | $213M | $228M | $242M | $193M | $231M | $268M | $316M | $344M | $374M | $271M | $264M | $169M | $198M | $233M | $248M | $275M | |
| PP&E (Net) | $10M | $10M | $11M | $11M | $12M | $12M | $13M | $13M | $14M | $14M | $15M | $15M | $16M | $16M | $17M | $17M | |
| PP&E (Gross) | $20M | $20M | $20M | $20M | $20M | $20M | $20M | $20M | $20M | $20M | $20M | $20M | $20M | $20M | $20M | $19M | |
| Accum. Depreciation | $10M | $10M | $9M | $9M | $8M | $8M | $7M | $7M | $6M | $6M | $5M | $4M | $4M | $3M | $3M | $2M | |
| Other Non-current Assets | $8M | $9M | $9M | $9M | $5M | $5M | $3M | $3M | · | $361.0K | · | · | · | $12.0K | · | $204.0K | |
| Total Assets | $246M | $263M | $278M | $229M | $265M | $303M | $350M | $379M | $406M | $304M | $298M | $204M | $233M | $269M | $285M | $313M | |
| Accounts Payable | $16M | $18M | $15M | $18M | $12M | $10M | $10M | $7M | $4M | $4M | $5M | $5M | $7M | $10M | $7M | $7M | |
| Accrued Liabilities | · | · | · | · | · | · | · | · | $11M | $7M | · | $10M | $9M | $11M | $13M | $11M | |
| Current Liabilities | $38M | $36M | $43M | $44M | $41M | $34M | $31M | $20M | $17M | $13M | $18M | $17M | $18M | $23M | $22M | $20M | |
| Capital Leases | $22M | $22M | $23M | $24M | $25M | $26M | $26M | $27M | $28M | $29M | $29M | $30M | $30M | $31M | $32M | $32M | |
| Total Liabilities | $60M | $58M | $66M | $68M | $66M | $59M | $57M | $47M | $45M | $42M | $47M | $47M | $48M | $54M | $54M | $52M | |
| Common Stock | $175.0K | $162.0K | $149.0K | $115.0K | $110.0K | $109.0K | $109.0K | $106.0K | $106.0K | $90.0K | $78.0K | $53.0K | $53.0K | $53.0K | $48.0K | $48.0K | |
| Paid-in Capital | $1.20B | $1.17B | $1.13B | $1.03B | $1.01B | $1.01B | $1.00B | $993M | $988M | $860M | $823M | $702M | $697M | $692M | $670M | $665M | |
| Retained Earnings | $-1.02B | $-962M | $-917M | $-869M | $-814M | $-765M | $-711M | $-662M | $-627M | $-598M | $-572M | $-545M | $-512M | $-477M | $-438M | $-404M | |
| AOCI | $-82.0K | $-81.0K | $-29.0K | $-76.0K | $-93.0K | $-91.0K | $10.0K | $77.0K | $-89.0K | $-102.0K | $-52.0K | $-123.0K | $-171.0K | $-217.0K | $-372.0K | $-406.0K | |
| Stockholders' Equity | $186M | $205M | $212M | $161M | $199M | $244M | $293M | $332M | $361M | $262M | $251M | $157M | $185M | $215M | $231M | $261M | |
| Liabilities + Equity | $246M | $263M | $278M | $229M | $265M | $303M | $350M | $379M | $406M | $304M | $298M | $204M | $233M | $269M | $285M | $313M | |
| Shares Outstanding | · | · | 149,362,800 | · | · | · | 109,381,556 | · | · | · | 78,369,099 | · | · | · | 47,722,995 | · |
Flujo de Efectivo 10
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $540.0K | $539.0K | $543.0K | $546.0K | $540.0K | $537.0K | $537.0K | $538.0K | $537.0K | $538.0K | $538.0K | $538.0K | $536.0K | $536.0K | $530.0K | $518.0K | |
| Stock-based Comp | $5M | $4M | $3M | $4M | $4M | $5M | $5M | $5M | $5M | $5M | $4M | $5M | $5M | $5M | $5M | $5M | |
| Other Non-cash | · | $-7M | · | · | · | $-1M | · | · | · | $-8M | · | · | · | $540.0K | · | · | |
| Operating Cash Flow | $-48M | $-47M | $-46M | $-52M | $-38M | $-50M | $-36M | $-32M | $-22M | $-28M | $-23M | $-28M | $-36M | $-33M | $-27M | $-31M | |
| CapEx | $137.0K | $0 | $0 | $48.0K | $15.0K | $74.0K | $6.0K | · | · | · | $7.0K | $19.0K | $30.0K | $137.0K | $282.0K | $169.0K | |
| Investing Cash Flow | $40M | $27M | $-27M | $46M | $73M | $98M | $1M | $-46M | $-97M | $-77M | $-2M | $48M | $6M | $20M | $-44M | $14M | |
| Stock Issued | $32M | $34M | $14M | $14M | $0 | $0 | $5M | $0 | $7M | $33M | $0 | $450.0K | $450.0K | $18M | · | · | |
| Net Stock Activity | · | $34M | · | · | · | · | · | · | · | $33M | · | · | · | $18M | · | · | |
| Financing Cash Flow | $32M | $33M | $95M | $14M | $153.0K | $59.0K | $5M | $175.0K | $124M | $32M | $118M | $0 | $345.0K | $18M | $108.0K | $123M | |
| Free Cash Flow | · | $-47M | · | · | · | $-50M | · | · | · | · | · | · | · | $-33M | · | · |
Rentabilidad 2
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROA | -21.7% | -15.6% | · | -18.1% | -14.7% | -17.9% | · | -11.9% | -9.3% | -9.1% | · | -13.8% | -15.5% | · | · | -11.3% | |
| ROE | -28.7% | -19.7% | · | -22.3% | -17.5% | -21.5% | · | -14.3% | -10.8% | -10.9% | · | -17.5% | -20.0% | · | · | -13.4% |
Liquidez y Solvencia 2
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 5.5 | 6.4 | · | 4.4 | 5.7 | 8.0 | · | 17.2 | 21.8 | 20.6 | · | 9.9 | 11.0 | · | · | 13.6 | |
| Quick Ratio | 5.2 | 4.9 | · | 3.2 | 3.3 | 2.9 | · | 4.0 | 9.2 | 11.6 | · | 7.8 | 6.4 | · | · | 10.4 |
Valoración (TTM) 3
| Métrica | Tendencia | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 | Q3 2023 | Q2 2023 | Q1 2023 | Q4 2022 | Q3 2022 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Net Income TTM | $-204M | $-203M | · | $-193M | $-168M | $-144M | · | $-122M | $-122M | $-132M | · | $-141M | $-146M | $-146M | · | $-143M | |
| P/E | -4.7 | -4.2 | · | -2.3 | -2.0 | -1.8 | · | -5.3 | -3.7 | -4.4 | · | -1.2 | -1.4 | -1.3 | · | -1.9 | |
| Earnings Yield | -21.4% | -23.6% | · | -43.6% | -49.6% | -54.9% | · | -18.9% | -27.4% | -22.7% | · | -81.8% | -69.9% | -75.6% | · | -53.7% |
Estados Financieros Estado de resultados, balance general, flujo de caja — anual, últimos 5 años
Estado de resultados
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Beneficio neto | $-207M | $-138M | $-134M | $-142M | $-130M |
| EPS Diluido | $-1.34 | $-1.01 | $-1.77 | $-2.60 | $-3.40 |
Balance general
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Ratio corriente | 5.7 | 10.4 | 14.7 | 11.1 | 11.4 |
| Ratio Rápido | 3.8 | 1.6 | 12.6 | 6.3 | 3.4 |
Flujo de Efectivo
| 2025-12-31 | 2024-12-31 | 2023-12-31 | 2022-12-31 | 2021-12-31 | |
|---|---|---|---|---|---|
| Flujo de caja libre | $-186M | $-118M | $-121M | $-123M | $-108M |
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Propietarios institucionales (13F) 231 declarantes · $903.8M total · A fecha de 30 de junio de 2026
Instituciones que informan tener esta acción en su Formulario 13F trimestral de la SEC. Solo posiciones largas; un solo presentador puede aparecer dos veces para tramos de opciones separados. Las patas de put/call de compensación grandes suelen reflejar la creación de mercado o el inventario cubierto, no la convicción direccional.
| Nuevas posiciones | Posiciones cerradas | Aumentado | Disminuido | Cambio neto de acciones |
|---|---|---|---|---|
| 38 (-24 vs trimestre anterior) | 25 (+10 vs trimestre anterior) | 85 (+4 vs trimestre anterior) | 69 (+15 vs trimestre anterior) | +33.9M |
Comparado con Q1 2026. Las presentaciones del Formulario 13F de la SEC vencen dentro de los 45 días posteriores al final del trimestre, más un pequeño margen para los presentadores tardíos; los trimestres que aún se encuentran dentro de esa ventana se omiten en favor del par más reciente completamente reportado.
| Institución | Valor | Acciones | % de 13F rastreadas | Tipo |
|---|---|---|---|---|
| FMR LLC | $103 712 963 | 18 163 391 | 11,48% | Acciones |
| Redmile Group, LLC | $67 776 998 | 11 869 877 | 7,50% | Acciones |
| STATE STREET CORP | $56 096 873 | 9 824 321 | 6,21% | Acciones |
| BVF INC/IL | $49 666 568 | 8 698 173 | 5,50% | Acciones |
| Woodline Partners LP | $39 542 133 | 6 925 067 | 4,38% | Acciones |
| VANGUARD CAPITAL MANAGEMENT LLC | $39 233 496 | 6 871 015 | 4,34% | Acciones |
| SATTER MANAGEMENT CO., L.P. | $37 992 903 | 7 406 024 | 4,20% | Acciones |
| VANGUARD GROUP INC | $34 414 053 | 6 855 389 | 3,81% | Acciones |
| MAK CAPITAL ONE LLC | $33 473 048 | 5 862 180 | 3,70% | Acciones |
| Siren, L.L.C. | $25 458 869 | 4 458 646 | 2,82% | Acciones |
| Bain Capital Life Sciences Investors, LLC | $25 339 444 | 4 437 731 | 2,80% | Acciones |
| Bellevue Group AG | $23 411 091 | 4 100 016 | 2,59% | Acciones |
| MPM BIOIMPACT LLC | $20 238 261 | 3 544 354 | 2,24% | Acciones |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $19 985 000 | 3 500 000 | 2,21% | Acciones |
| GREAT POINT PARTNERS LLC | $19 985 000 | 3 500 000 | 2,21% | Acciones |
| GEODE CAPITAL MANAGEMENT, LLC | $19 758 078 | 3 459 611 | 2,19% | Acciones |
| AMERIPRISE FINANCIAL INC | $19 595 144 | 3 431 724 | 2,17% | Acciones |
| GOLDMAN SACHS GROUP INC | $17 924 655 | 3 139 169 | 1,98% | Acciones |
| Palo Alto Investors LP | $16 833 594 | 2 948 090 | 1,86% | Acciones |
| Balyasny Asset Management L.P. | $16 164 873 | 2 830 976 | 1,79% | Acciones |
| Qube Research & Technologies Ltd | $15 702 277 | 2 749 961 | 1,74% | Acciones |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $12 829 228 | 2 246 800 | 1,42% | Acciones |
| Opaleye Management Inc. | $9 789 515 | 1 714 451 | 1,08% | Acciones |
| Logos Global Management LP | $8 565 000 | 1 500 000 | 0,95% | Acciones |
| DIMENSIONAL FUND ADVISORS LP | $8 139 776 | 1 425 530 | 0,90% | Acciones |
| Point72 Asset Management, L.P. | $7 895 211 | 1 382 699 | 0,87% | Acciones |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $7 182 032 | 1 257 799 | 0,79% | Acciones |
| Tetragon Partners GP Ltd | $7 094 418 | 1 242 455 | 0,78% | Acciones |
| Candriam S.C.A. | $6 817 695 | 1 195 142 | 0,75% | Acciones |
| MILLENNIUM MANAGEMENT LLC | $6 765 956 | 1 184 931 | 0,75% | Acciones |
| VANGUARD FIDUCIARY TRUST CO | $6 312 120 | 1 105 450 | 0,70% | Acciones |
| PANAGORA ASSET MANAGEMENT INC | $5 526 857 | 967 926 | 0,61% | Acciones |
| KENNEDY CAPITAL MANAGEMENT LLC | $5 129 830 | 898 394 | 0,57% | Acciones |
| Ishara Investments LP | $4 682 200 | 820 000 | 0,52% | Acciones |
| Ensign Peak Advisors, Inc | $4 570 946 | 800 516 | 0,51% | Acciones |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $4 213 609 | 737 935 | 0,47% | Acciones |
| Y-Intercept (Hong Kong) Ltd | $4 194 480 | 734 585 | 0,46% | Acciones |
| Parkman Healthcare Partners LLC | $3 660 276 | 641 029 | 0,40% | Acciones |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $3 334 143 | 583 913 | 0,37% | Acciones |
| SIRIOS CAPITAL MANAGEMENT L P | $3 250 566 | 569 276 | 0,36% | Acciones |
| Schonfeld Strategic Advisors LLC | $3 046 666 | 533 567 | 0,34% | Acciones |
| TWO SIGMA INVESTMENTS, LP | $2 928 065 | 512 796 | 0,32% | Acciones |
| Board of Trustees of The Leland Stanford Junior University | $2 755 360 | 482 550 | 0,30% | Acciones |
| RENAISSANCE TECHNOLOGIES LLC | $2 620 890 | 459 000 | 0,29% | Acciones |
| BANK OF AMERICA CORP /DE/ | $2 487 008 | 435 553 | 0,28% | Acciones |
| Ikarian Capital, LLC | $2 456 693 | 430 244 | 0,27% | Acciones |
| MOORE CAPITAL MANAGEMENT, LP | $2 428 646 | 425 332 | 0,27% | Acciones |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2 352 520 | 412 000 | 0,26% | Opción de compra |
| Trexquant Investment LP | $2 339 199 | 409 667 | 0,26% | Acciones |
| Susquehanna Portfolio Strategies, LLC | $2 256 763 | 395 230 | 0,25% | Acciones |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $2 253 166 | 394 600 | 0,25% | Acciones |
| DIADEMA PARTNERS LP | $2 016 772 | 353 200 | 0,22% | Opción de compra |
| Engineers Gate Manager LP | $1 821 815 | 319 057 | 0,20% | Acciones |
| DAFNA Capital Management LLC | $1 700 507 | 297 812 | 0,19% | Acciones |
| Jump Financial, LLC | $1 700 438 | 297 800 | 0,19% | Acciones |
| STATE OF WISCONSIN INVESTMENT BOARD | $1 635 201 | 286 375 | 0,18% | Acciones |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $1 427 643 | 250 025 | 0,16% | Acciones |
| UBS Group AG | $1 413 653 | 247 575 | 0,16% | Acciones |
| Swiss National Bank | $1 396 666 | 244 600 | 0,15% | Acciones |
| CITADEL ADVISORS LLC | $1 340 137 | 234 700 | 0,15% | Opción de compra |
| CITIGROUP INC | $1 296 318 | 227 026 | 0,14% | Acciones |
| Cinctive Capital Management LP | $1 231 921 | 215 748 | 0,14% | Acciones |
| MARSHALL WACE, LLP | $1 202 566 | 210 607 | 0,13% | Acciones |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1 086 042 | 190 200 | 0,12% | Opción de venta |
| RHUMBLINE ADVISERS | $1 082 480 | 189 578 | 0,12% | Acciones |
| Bank of New York Mellon Corp | $1 002 413 | 175 554 | 0,11% | Acciones |
| Squarepoint Ops LLC | $989 457 | 173 285 | 0,11% | Acciones |
| Rafferty Asset Management, LLC | $989 423 | 173 279 | 0,11% | Acciones |
| Point72 Europe (London) LLP | $923 726 | 302 861 | 0,10% | Acciones |
| OSAIC HOLDINGS, INC. | $842 767 | 147 595 | 0,09% | Acciones |
| ALLIANCEBERNSTEIN L.P. | $815 710 | 147 240 | 0,09% | Acciones |
| WELLS FARGO & COMPANY/MN | $809 090 | 141 697 | 0,09% | Acciones |
| BlackRock, Inc. | $782 276 | 137 001 | 0,09% | Acciones |
| WELLINGTON MANAGEMENT GROUP LLP | $738 234 | 129 288 | 0,08% | Acciones |
| VICTORY CAPITAL MANAGEMENT INC | $727 100 | 127 338 | 0,08% | Acciones |
| BOOTHBAY FUND MANAGEMENT, LLC | $685 937 | 120 129 | 0,08% | Acciones |
| IEQ CAPITAL, LLC | $685 257 | 120 010 | 0,08% | Acciones |
| J. Goldman & Co LP | $662 623 | 116 046 | 0,07% | Acciones |
| XTX Topco Ltd | $640 359 | 112 147 | 0,07% | Acciones |
| Vanguard Global Advisers, LLC | $582 803 | 102 067 | 0,06% | Acciones |
| Quarry LP | $571 000 | 100 000 | 0,06% | Acciones |
| Russell Investments Group, Ltd. | $566 711 | 99 249 | 0,06% | Acciones |
| SCS Capital Management LLC | $565 290 | 99 000 | 0,06% | Acciones |
| Nuveen, LLC | $564 508 | 98 863 | 0,06% | Acciones |
| MetLife Investment Management, LLC | $519 639 | 91 005 | 0,06% | Acciones |
| JANE STREET GROUP, LLC | $516 755 | 90 500 | 0,06% | Opción de compra |
| J. Safra Sarasin Holding AG | $516 681 | 90 487 | 0,06% | Acciones |
| CITADEL ADVISORS LLC | $507 619 | 88 900 | 0,06% | Opción de venta |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $505 438 | 88 518 | 0,06% | Acciones |
| CAPTRUST FINANCIAL ADVISORS | $501 960 | 87 909 | 0,06% | Acciones |
| PROFUND ADVISORS LLC | $499 676 | 87 509 | 0,06% | Acciones |
| VANGUARD ASSET MANAGEMENT, Ltd | $453 865 | 79 486 | 0,05% | Acciones |
| DNB Asset Management AS | $417 669 | 73 147 | 0,05% | Acciones |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $408 448 | 71 532 | 0,05% | Acciones |
| Virtus Investment Advisers, LLC | $396 662 | 69 468 | 0,04% | Acciones |
| Jain Global LLC | $369 545 | 64 719 | 0,04% | Acciones |
| China Universal Asset Management Co., Ltd. | $354 454 | 62 076 | 0,04% | Acciones |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $354 437 | 62 073 | 0,04% | Acciones |
| DIVERSIFIED TRUST CO | $352 860 | 61 797 | 0,04% | Acciones |
| Invesco Ltd. | $351 696 | 61 593 | 0,04% | Acciones |
Informantes de la empresa 11 insiders · 3 directivos · 7 consejeros
| Insider | Rol | Última actividad | Acciones en propiedad | Compras 12m | Ventas 12m | Neto 12m |
|---|---|---|---|---|---|---|
| Jennifer Lew | EVP & Chief Financial Officer | 11 de julio de 2023 S | 47 460 | 0 | 0 | $0 |
| Ted Yednock | EVP & CHIEF INNOVATION OFFICER | 11 de junio de 2026 M | 184 807 | 0 | 0 | $0 |
| Michael Overdorf | EVP & Chief Business Officer | 11 de julio de 2023 S | 45 802 | 0 | 0 | $0 |
| Bettina M. Cockroft | Consejero | 11 de junio de 2026 A | — | 0 | 0 | $0 |
| William H. Carson | Consejero | 11 de junio de 2026 A | — | 0 | 0 | $0 |
| Jung Choi | Consejero | 11 de junio de 2026 A | — | 0 | 0 | $0 |
| William D. Waddill | Consejero | 11 de junio de 2026 A | — | 0 | 0 | $0 |
| William A Jones JR | Consejero | 11 de junio de 2026 A | — | 0 | 0 | $0 |
| Satter Muneer A | Consejero | 11 de junio de 2026 A | 10 342 134 | 6 | 0 | $11 974 803 |
| Ricky Sun | Consejero | 2 de junio de 2021 A | — | 0 | 0 | $0 |
| Mark S. Blumenkranz | — | 10 de agosto de 2026 A | — | 0 | 0 | $0 |
Informantes de las presentaciones SEC Form 3/4/5; neto = solo P/S de mercado abierto
Activistas y propietarios del %+ 5 3 tenencias
Inversores que presentaron el Anexo 13D de la SEC — propiedad beneficiosa superior al % 5 con la intención de influir en el emisor (participaciones activistas, campañas de la junta directiva, M&A). Cada fila muestra el estado conocido más reciente de la posición de ese declarante.
| Declarante | Presentado | Participación | Estado | Propósito | Presentación |
|---|---|---|---|---|---|
| Satter Muneer A | 21 de noviembre de 2025 | 7,20% | Enmienda | — | SEC |
| Muneer A. Satter ×2 presentaciones | 17 de febrero de 2023 | — | Presentación inicial | — | SEC |
| Clarus Lifesciences III, L.P., Clarus Ventures III GP, L.P., Blackstone Clarus III L.L.C., Blackstone Holdings II L.P., Blackstone Holdings I/II GP L.L.C., Blackstone Inc., Blackstone Group Management L.L.C., Stephen A. Schwarzman ×2 presentaciones | 27 de agosto de 2021 | — | Presentación inicial | — | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
Propiedad de ETFs Mantenido por 38 ETFs
El peso refleja solo las tenencias directas de acciones (N-PORT); los fondos apalancados o basados en derivados pueden tener exposición adicional a swaps no mostrada.
| Fondo | Ponderación | Unidades | A fecha de | Fuente |
|---|---|---|---|---|
| BBC · ETFis Series Trust I | 0,87% | 55 535 NS | 30 de abril de 2026 | N-PORT |
| IBRN · iShares Trust | 0,81% | 11 173 SH | 8 de agosto de 2026 | Diario |
| LABU · Direxion Shares ETF Trust | 0,25% | 218 784 NS | 30 de abril de 2026 | N-PORT |
| IWC · iShares Trust | 0,20% | 527 497 SH | 8 de agosto de 2026 | Diario |
| VFMO · VANGUARD WELLINGTON FUND | 0,13% | 451 913 SH | 8 de agosto de 2026 | Diario |
| OMFS · Invesco Exchange-Traded Self-Indexe… | 0,07% | 37 506 SH | 8 de agosto de 2026 | Diario |
| IBB · iShares Trust | 0,06% | 1 058 884 SH | 8 de agosto de 2026 | Diario |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0,06% | 8 919 SH | 8 de agosto de 2026 | Diario |
| IWO · iShares Trust | 0,05% | 1 395 356 SH | 8 de agosto de 2026 | Diario |
| VTWG · VANGUARD SCOTTSDALE FUNDS | 0,05% | 166 500 SH | 8 de agosto de 2026 | Diario |
| BIB · ProShares Trust | 0,04% | 5 349 NS | 31 de mayo de 2026 | N-PORT |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0,04% | 198 690 SH | 8 de agosto de 2026 | Diario |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0,03% | 893 974 SH | 8 de agosto de 2026 | Diario |
| IWM · iShares Trust | 0,03% | 3 979 848 SH | 8 de agosto de 2026 | Diario |
| ISCV · iShares Trust | 0,02% | 31 162 SH | 8 de agosto de 2026 | Diario |
| RSSL · Global X Funds | 0,02% | 57 102 NS | 30 de abril de 2026 | N-PORT |
| ITWO · ProShares Trust | 0,02% | 6 206 NS | 31 de mayo de 2026 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0,02% | 637 833 NS | 31 de mayo de 2026 | N-PORT |
| ISCB · iShares Trust | 0,01% | 6 291 SH | 8 de agosto de 2026 | Diario |
| FHLC · FIDELITY COVINGTON TRUST | 0,01% | 54 687 NS | 30 de abril de 2026 | N-PORT |
| UWM · ProShares Trust | 0,01% | 4 853 NS | 31 de mayo de 2026 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | 0,01% | 1 754 465 SH | 8 de agosto de 2026 | Diario |
| VHT · VANGUARD WORLD FUND | 0,01% | 366 971 SH | 8 de agosto de 2026 | Diario |
| URTY · ProShares Trust | 0,01% | 4 907 NS | 31 de mayo de 2026 | N-PORT |
| DFAS · Dimensional ETF Trust | 0,01% | 179 974 NS | 30 de abril de 2026 | N-PORT |
| WSML · iShares Trust | 0,01% | 7 256 SH | 8 de agosto de 2026 | Diario |
| ONEQ · Fidelity Commonwealth Trust | 0,00% | 69 949 NS | 31 de mayo de 2026 | N-PORT |
| HDG · ProShares Trust | 0,00% | 123 NS | 31 de mayo de 2026 | N-PORT |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0,00% | 3 773 NS | 31 de mayo de 2026 | N-PORT |
| DFAC · Dimensional ETF Trust | 0,00% | 180 473 NS | 30 de abril de 2026 | N-PORT |
| AVSC · AMERICAN CENTURY ETF TRUST | 0,00% | 9 567 NS | 31 de mayo de 2026 | N-PORT |
| IWV · iShares Trust | 0,00% | 54 273 SH | 8 de agosto de 2026 | Diario |
| ITOT · iShares Trust | 0,00% | 219 943 SH | 8 de agosto de 2026 | Diario |
| SCHB · SCHWAB STRATEGIC TRUST | 0,00% | 79 390 NS | 31 de mayo de 2026 | N-PORT |
| DFAU · Dimensional ETF Trust | 0,00% | 15 085 NS | 30 de abril de 2026 | N-PORT |
| DFUS · Dimensional ETF Trust | 0,00% | 13 707 NS | 30 de abril de 2026 | N-PORT |
| VTI · VANGUARD INDEX FUNDS | 0,00% | 4 970 636 SH | 8 de agosto de 2026 | Diario |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0,00% | 13 754 SH | 8 de agosto de 2026 | Diario |