BLTE — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| Darwin Global Management, Ltd. | $456 588 244 | 3 077 219 | 32,41% | Actions |
| Paradigm Biocapital Advisors LP | $189 844 565 | 1 232 877 | 13,48% | Actions |
| RTW INVESTMENTS, LP | $110 150 398 | 715 332 | 7,82% | Actions |
| MILLENNIUM MANAGEMENT LLC | $76 155 438 | 494 564 | 5,41% | Actions |
| MAVERICK CAPITAL LTD | $61 025 949 | 396 311 | 4,33% | Actions |
| EVENTIDE ASSET MANAGEMENT, LLC | $60 181 804 | 390 829 | 4,27% | Actions |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $55 003 288 | 357 199 | 3,90% | Actions |
| Holocene Advisors, LP | $38 655 624 | 251 035 | 2,74% | Actions |
| Logos Global Management LP | $38 496 250 | 250 000 | 2,73% | Actions |
| MORGAN STANLEY | $36 197 407 | 235 071 | 2,57% | Actions |
| UBS Group AG | $34 644 931 | 224 989 | 2,46% | Actions |
| CITADEL ADVISORS LLC | $28 667 080 | 186 168 | 2,03% | Actions |
| GOLDMAN SACHS GROUP INC | $25 590 459 | 166 188 | 1,82% | Actions |
| Affinity Asset Advisors, LLC | $25 407 525 | 165 000 | 1,80% | Actions |
| MPM BIOIMPACT LLC | $21 127 974 | 137 208 | 1,50% | Actions |
| BANK OF AMERICA CORP /DE/ | $19 214 710 | 124 783 | 1,36% | Actions |
| Patient Square Capital LP | $16 938 350 | 110 000 | 1,20% | Actions |
| JANE STREET GROUP, LLC | $10 132 367 | 65 801 | 0,72% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $8 796 393 | 57 125 | 0,62% | Actions |
| RENAISSANCE TECHNOLOGIES LLC | $8 586 666 | 55 763 | 0,61% | Actions |
| Point72 Asset Management, L.P. | $7 881 877 | 51 186 | 0,56% | Actions |
| Soleus Capital Management, L.P. | $7 779 938 | 50 524 | 0,55% | Actions |
| Trexquant Investment LP | $7 624 721 | 49 516 | 0,54% | Actions |
| TWO SIGMA INVESTMENTS, LP | $5 866 829 | 38 100 | 0,42% | Actions |
| PFM Health Sciences, LP | $5 359 140 | 34 803 | 0,38% | Actions |
| JPMORGAN CHASE & CO | $5 131 442 | 33 181 | 0,36% | Actions |
| Walleye Capital LLC | $4 884 558 | 31 721 | 0,35% | Actions |
| Artia Global Partners LP | $3 847 931 | 24 989 | 0,27% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $3 486 220 | 22 640 | 0,25% | Actions |
| BALANCE CAPITAL PARTNERS L.P. | $3 464 663 | 22 500 | 0,25% | Actions |
| NATIONAL BANK OF CANADA /FI/ | $3 079 700 | 20 000 | 0,22% | Actions |
| STATE STREET CORP | $2 452 057 | 15 924 | 0,17% | Actions |
| Verdad Advisers, LP | $2 118 526 | 13 758 | 0,15% | Actions |
| ORBIMED ADVISORS LLC | $2 048 001 | 13 300 | 0,15% | Actions |
| TD Asset Management Inc | $2 003 345 | 13 010 | 0,14% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $1 960 691 | 12 733 | 0,14% | Actions |
| Qube Research & Technologies Ltd | $1 874 151 | 12 171 | 0,13% | Actions |
| Lighthouse Investment Partners, LLC | $1 539 850 | 10 000 | 0,11% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1 512 133 | 9 820 | 0,11% | Actions |
| HighVista Strategies LLC | $1 471 173 | 9 554 | 0,10% | Actions |
| Squarepoint Ops LLC | $1 352 758 | 8 785 | 0,10% | Actions |
| BARCLAYS PLC | $1 050 486 | 6 822 | 0,07% | Actions |
| Capricorn Fund Managers Ltd | $985 504 | 6 400 | 0,07% | Actions |
| Voleon Capital Management LP | $968 412 | 6 289 | 0,07% | Actions |
| SmartHarvest Portfolios, LLC | $671 221 | 4 359 | 0,05% | Actions |
| XTX Topco Ltd | $667 217 | 4 333 | 0,05% | Actions |
| Mariner, LLC | $590 533 | 3 835 | 0,04% | Actions |
| Entropy Technologies, LP | $569 745 | 3 700 | 0,04% | Actions |
| High Net Worth Advisory Group LLC | $538 948 | 3 500 | 0,04% | Actions |
| FMR LLC | $477 354 | 3 100 | 0,03% | Actions |
| AMERIPRISE FINANCIAL INC | $466 421 | 3 029 | 0,03% | Actions |
| Engineers Gate Manager LP | $427 000 | 2 773 | 0,03% | Actions |
| Yeomans Consulting Group, Inc. | $383 744 | 2 399 | 0,03% | Actions |
| Virtus Investment Advisers, LLC | $364 790 | 2 369 | 0,03% | Actions |
| Cubist Systematic Strategies, LLC | $344 100 | 4 650 | 0,02% | Actions |
| FRED ALGER MANAGEMENT, LLC | $326 294 | 2 119 | 0,02% | Actions |
| Jain Global LLC | $323 522 | 2 101 | 0,02% | Actions |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | $309 202 | 2 008 | 0,02% | Actions |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | $292 572 | 1 900 | 0,02% | Actions |
| GAMMA Investing LLC | $259 619 | 1 686 | 0,02% | Actions |
| R Squared Ltd | $206 032 | 1 338 | 0,01% | Actions |
| Independent Advisor Alliance | $203 106 | 1 319 | 0,01% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $72 373 | 470 | 0,01% | Actions |
| ROYAL BANK OF CANADA | $50 000 | 322 | 0,00% | Actions |
| Bayforest Capital Ltd | $47 273 | 307 | 0,00% | Actions |
| WELLS FARGO & COMPANY/MN | $19 094 | 124 | 0,00% | Actions |
| E Fund Management (Hong Kong) Co., Ltd. | $17 400 | 113 | 0,00% | Actions |
| Duquesne Family Office LLC | $16 338 | 106 100 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $16 301 | 105 859 | 0,00% | Actions |
| CITIGROUP INC | $7 237 | 47 | 0,00% | Actions |
| JONES FINANCIAL COMPANIES LLLP | $4 759 | 32 | 0,00% | Actions |
| SBI Securities Co., Ltd. | $3 388 | 22 | 0,00% | Actions |
| Rossby Financial, LCC | $3 080 | 20 | 0,00% | Actions |
| WEST PACES ADVISORS INC. | $2 772 | 18 | 0,00% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $2 618 | 17 | 0,00% | Actions |
| Bell Investment Advisors, Inc | $2 002 | 13 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $924 | 6 | 0,00% | Actions |
| GSA CAPITAL PARTNERS LLP | $672 | 4 364 | 0,00% | Actions |
| Farther Finance Advisors, LLC | $616 | 4 | 0,00% | Actions |
| FIDUCIARY FINANCIAL ADVISORS | $462 | 3 | 0,00% | Actions |
| Arax Advisory Partners | $308 | 2 | 0,00% | Actions |
| SG Americas Securities, LLC | $141 | 913 | 0,00% | Actions |