UPB — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| VANGUARD GROUP INC | $64 846 119 | 2 388 439 | 15,74% | Actions |
| FMR LLC | $56 487 247 | 8 162 897 | 13,71% | Actions |
| ORBIMED ADVISORS LLC | $39 399 636 | 5 693 589 | 9,56% | Actions |
| NORGES BANK | $26 078 843 | 3 768 619 | 6,33% | Actions |
| BlackRock, Inc. | $25 973 237 | 3 753 358 | 6,30% | Actions |
| Decheng Capital LLC | $18 856 087 | 2 724 868 | 4,58% | Actions |
| ENAVATE SCIENCES GP, LLC | $17 021 145 | 2 459 703 | 4,13% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $12 986 999 | 1 876 734 | 3,15% | Actions |
| MILLENNIUM MANAGEMENT LLC | $7 914 923 | 1 143 775 | 1,92% | Actions |
| D. E. Shaw & Co., Inc. | $7 169 425 | 1 036 044 | 1,74% | Actions |
| JPMORGAN CHASE & CO | $7 013 464 | 1 012 044 | 1,70% | Actions |
| Qube Research & Technologies Ltd | $6 771 220 | 978 500 | 1,64% | Actions |
| Parkman Healthcare Partners LLC | $6 471 909 | 935 247 | 1,57% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $6 445 888 | 931 261 | 1,56% | Actions |
| SEB Asset Management AB | $6 079 022 | 878 473 | 1,48% | Actions |
| Woodline Partners LP | $5 753 849 | 831 481 | 1,40% | Actions |
| STATE STREET CORP | $5 302 955 | 766 323 | 1,29% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $4 931 656 | 712 667 | 1,20% | Actions |
| Y-Intercept (Hong Kong) Ltd | $4 799 401 | 693 555 | 1,16% | Actions |
| Bain Capital Life Sciences Investors, LLC | $4 158 567 | 600 949 | 1,01% | Actions |
| AQR CAPITAL MANAGEMENT LLC | $3 770 493 | 544 869 | 0,92% | Actions |
| MORGAN STANLEY | $3 630 453 | 524 632 | 0,88% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $3 539 898 | 511 546 | 0,86% | Actions |
| Walleye Capital LLC | $3 449 551 | 498 490 | 0,84% | Actions |
| Trexquant Investment LP | $3 227 696 | 466 430 | 0,78% | Actions |
| Point72 Asset Management, L.P. | $3 134 836 | 453 011 | 0,76% | Actions |
| BANK OF AMERICA CORP /DE/ | $2 710 993 | 391 762 | 0,66% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $2 640 811 | 381 613 | 0,64% | Actions |
| Altshuler Shaham Ltd | $2 630 022 | 380 061 | 0,64% | Actions |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $2 475 672 | 357 756 | 0,60% | Actions |
| SAMSARA BIOCAPITAL, LLC | $2 447 722 | 353 717 | 0,59% | Actions |
| Propel Bio Management, LLC | $2 424 692 | 350 389 | 0,59% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $2 369 083 | 342 353 | 0,57% | Actions |
| NORTHERN TRUST CORP | $2 057 634 | 297 346 | 0,50% | Actions |
| Squarepoint Ops LLC | $2 013 056 | 290 904 | 0,49% | Actions |
| Voleon Capital Management LP | $1 973 819 | 285 234 | 0,48% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1 816 196 | 262 456 | 0,44% | Actions |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $1 751 397 | 253 092 | 0,43% | Actions |
| GOLDMAN SACHS GROUP INC | $1 708 666 | 246 917 | 0,41% | Actions |
| XTX Topco Ltd | $1 677 034 | 242 346 | 0,41% | Actions |
| DEUTSCHE BANK AG\ | $1 670 814 | 241 447 | 0,41% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $1 658 143 | 239 616 | 0,40% | Actions |
| UBS Group AG | $1 624 221 | 234 714 | 0,39% | Actions |
| Schonfeld Strategic Advisors LLC | $1 562 258 | 225 760 | 0,38% | Actions |
| Jump Financial, LLC | $1 544 703 | 223 223 | 0,37% | Actions |
| SPHERA FUNDS MANAGEMENT LTD. | $1 520 324 | 219 700 | 0,37% | Actions |
| Boxer Capital Management, LLC | $1 038 000 | 150 000 | 0,25% | Actions |
| RENAISSANCE TECHNOLOGIES LLC | $908 596 | 131 300 | 0,22% | Actions |
| EntryPoint Capital, LLC | $895 766 | 129 446 | 0,22% | Actions |
| ALGERT GLOBAL LLC | $820 920 | 118 630 | 0,20% | Actions |
| Bank of New York Mellon Corp | $593 369 | 85 747 | 0,14% | Actions |
| Nuveen, LLC | $586 608 | 84 770 | 0,14% | Actions |
| AMERICAN CENTURY COMPANIES INC | $541 102 | 78 194 | 0,13% | Actions |
| Man Group plc | $510 855 | 73 823 | 0,12% | Actions |
| ALLIANCEBERNSTEIN L.P. | $465 120 | 51 680 | 0,11% | Actions |
| Simplify Asset Management Inc. | $429 822 | 62 113 | 0,10% | Actions |
| ALPS ADVISORS INC | $382 178 | 55 228 | 0,09% | Actions |
| Quantinno Capital Management LP | $379 479 | 54 838 | 0,09% | Actions |
| Virtus Investment Advisers, LLC | $371 175 | 53 638 | 0,09% | Actions |
| Invesco Ltd. | $369 508 | 53 397 | 0,09% | Actions |
| Brevan Howard Capital Management LP | $348 553 | 50 369 | 0,08% | Actions |
| Swiss National Bank | $332 852 | 48 100 | 0,08% | Actions |
| Russell Investments Group, Ltd. | $329 000 | 47 543 | 0,08% | Actions |
| Allspring Global Investments Holdings, LLC | $298 819 | 43 182 | 0,07% | Actions |
| RHUMBLINE ADVISERS | $293 288 | 42 384 | 0,07% | Actions |
| TWO SIGMA INVESTMENTS, LP | $292 889 | 42 325 | 0,07% | Actions |
| ExodusPoint Capital Management, LP | $284 031 | 41 045 | 0,07% | Actions |
| CITIGROUP INC | $279 145 | 40 339 | 0,07% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $267 347 | 38 634 | 0,06% | Actions |
| Stonepine Capital Management, LLC | $231 349 | 33 432 | 0,06% | Actions |
| Mariner, LLC | $229 337 | 33 141 | 0,06% | Actions |
| WELLS FARGO & COMPANY/MN | $204 119 | 29 497 | 0,05% | Actions |
| BARCLAYS PLC | $202 120 | 29 208 | 0,05% | Actions |
| Creative Planning | $197 102 | 28 483 | 0,05% | Actions |
| Quantbot Technologies LP | $194 992 | 28 178 | 0,05% | Actions |
| AXQ CAPITAL, LP | $187 311 | 27 068 | 0,05% | Actions |
| nVerses Capital, LLC | $166 280 | 24 029 | 0,04% | Actions |
| DNB Asset Management AS | $163 312 | 23 600 | 0,04% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $157 250 | 22 724 | 0,04% | Actions |
| Graham Capital Management, L.P. | $155 755 | 22 508 | 0,04% | Actions |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $154 904 | 22 385 | 0,04% | Actions |
| Verdad Advisers, LP | $150 925 | 21 810 | 0,04% | Actions |
| MetLife Investment Management, LLC | $144 296 | 20 852 | 0,04% | Actions |
| SEI INVESTMENTS CO | $138 580 | 20 026 | 0,03% | Actions |
| WINTON GROUP Ltd | $137 016 | 19 800 | 0,03% | Actions |
| IEQ CAPITAL, LLC | $135 182 | 19 535 | 0,03% | Actions |
| DIADEMA PARTNERS LP | $132 124 | 19 093 | 0,03% | Actions |
| Shay Capital LLC | $124 560 | 18 000 | 0,03% | Actions |
| Quadrature Capital Ltd | $124 477 | 17 988 | 0,03% | Actions |
| Entropy Technologies, LP | $121 391 | 17 542 | 0,03% | Actions |
| STATE OF WISCONSIN INVESTMENT BOARD | $118 090 | 17 065 | 0,03% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $112 222 | 16 217 | 0,03% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $108 886 | 15 735 | 0,03% | Actions |
| JANE STREET GROUP, LLC | $107 910 | 15 594 | 0,03% | Actions |
| CITADEL ADVISORS LLC | $103 800 | 15 000 | 0,03% | Option d'achat |
| MERCER GLOBAL ADVISORS INC /ADV | $92 396 | 13 352 | 0,02% | Actions |
| Vanguard Global Advisers, LLC | $90 368 | 13 059 | 0,02% | Actions |
| Legal & General Group Plc | $86 922 | 12 561 | 0,02% | Actions |
| Engineers Gate Manager LP | $86 438 | 12 491 | 0,02% | Actions |
| STRS OHIO | $83 040 | 12 000 | 0,02% | Actions |
| JANE STREET GROUP, LLC | $82 348 | 11 900 | 0,02% | Option d'achat |
| CANADA PENSION PLAN INVESTMENT BOARD | $79 580 | 11 500 | 0,02% | Actions |
| HSBC HOLDINGS PLC | $77 602 | 10 793 | 0,02% | Actions |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $75 428 | 10 017 | 0,02% | Actions |
| PRELUDE CAPITAL MANAGEMENT, LLC | $73 006 | 10 550 | 0,02% | Actions |
| AMERIPRISE FINANCIAL INC | $72 570 | 10 487 | 0,02% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $69 892 | 10 100 | 0,02% | Option d'achat |
| Police & Firemen's Retirement System of New Jersey | $65 436 | 9 456 | 0,02% | Actions |
| China Universal Asset Management Co., Ltd. | $59 934 | 8 661 | 0,01% | Actions |
| KLP KAPITALFORVALTNING AS | $40 828 | 5 900 | 0,01% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $35 984 | 5 200 | 0,01% | Actions |
| CWM, LLC | $34 947 | 3 883 | 0,01% | Actions |
| Persistent Asset Partners Ltd | $33 597 | 4 855 | 0,01% | Actions |
| Tower Research Capital LLC (TRC) | $33 133 | 4 788 | 0,01% | Actions |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | $32 524 | 4 700 | 0,01% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $29 604 | 4 278 | 0,01% | Actions |
| Vanguard Investments Australia, Ltd. | $28 344 | 4 096 | 0,01% | Actions |
| Ameritas Investment Partners, Inc. | $18 968 | 2 741 | 0,00% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $16 843 | 2 434 | 0,00% | Actions |
| Global Retirement Partners, LLC | $12 940 | 1 870 | 0,00% | Actions |
| Arax Advisory Partners | $12 255 | 1 771 | 0,00% | Actions |
| GAMMA Investing LLC | $8 055 | 1 164 | 0,00% | Actions |
| GF FUND MANAGEMENT CO. LTD. | $7 923 | 1 145 | 0,00% | Actions |
| ROYAL BANK OF CANADA | $7 000 | 1 091 | 0,00% | Actions |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $6 678 | 965 | 0,00% | Actions |
| Quarry LP | $6 180 | 893 | 0,00% | Actions |
| Allworth Financial LP | $5 384 | 778 | 0,00% | Actions |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $5 292 | 588 | 0,00% | Actions |
| Rockefeller Capital Management L.P. | $5 107 | 738 | 0,00% | Actions |
| Sterling Capital Management LLC | $4 913 | 710 | 0,00% | Actions |
| PNC Financial Services Group, Inc. | $2 678 | 387 | 0,00% | Actions |
| Farther Finance Advisors, LLC | $2 443 | 353 | 0,00% | Actions |
| ROTHSCHILD INVESTMENT LLC | $1 986 | 287 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $1 882 | 272 | 0,00% | Actions |
| US BANCORP \DE\ | $1 827 | 264 | 0,00% | Actions |
| IFP Advisors, Inc | $1 675 | 242 | 0,00% | Actions |
| Torren Management, LLC | $1 458 | 162 | 0,00% | Actions |
| ACADIAN ASSET MANAGEMENT LLC | $1 208 | 175 110 | 0,00% | Actions |
| HRT FINANCIAL LP | $1 180 | 170 590 | 0,00% | Actions |
| Physician Wealth Advisors, Inc. | $1 108 | 160 | 0,00% | Actions |
| Essential Partners LLC | $1 010 | 146 | 0,00% | Actions |
| N.E.W. Advisory Services LLC | $830 | 120 | 0,00% | Actions |
| SJS Investment Consulting Inc. | $526 | 76 | 0,00% | Actions |
| GSA CAPITAL PARTNERS LLP | $480 | 69 348 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $195 | 28 058 | 0,00% | Actions |
| Silver Grove Financial Group, Inc. | $194 | 28 | 0,00% | Actions |
| SG Americas Securities, LLC | $141 | 20 338 | 0,00% | Actions |
| SIMPLEX TRADING, LLC | $138 | 20 | 0,00% | Actions |
| OSAIC HOLDINGS, INC. | $131 | 19 | 0,00% | Actions |
| Clearstead Advisors, LLC | $105 | 15 | 0,00% | Actions |
| JPL Wealth Management, LLC | $97 | 14 | 0,00% | Actions |
| Freestone Grove Partners LP | $7 | 1 | 0,00% | Actions |
| NATIONAL BANK OF CANADA /FI/ | $7 | 1 | 0,00% | Actions |
| Covestor Ltd | $0 | 39 | 0,00% | Actions |