UPB Upstream Bio, Inc. - Common Stock
UPB Aperçu de l'action Prix, capitalisation boursière, P/E, EPS, ROE, dette/capitaux propres, fourchette sur 52 semaines
UPB Graphique du cours de l'action OHLCV quotidien avec indicateurs techniques — panoramique, zoom et personnalisez votre vue
Performance sur 10 ans Tendances du chiffre d'affaires, du bénéfice net, des marges et du BPA
Valorisation Ratios P/E, P/S, P/B, EV/EBITDA — l'action est-elle chère ou bon marché ?
Rentabilité Marges brutes, d'exploitation et nettes ; ROE, ROA, ROIC
Santé financière Dette, liquidité, solvabilité — solidité du bilan
Croissance Croissance du chiffre d'affaires, du BPA et du bénéfice net : Année/Année, TCAC 3 ans, TCAC 5 ans
Efficacité du capital Rotation des actifs, rotation des stocks, rotation des créances
UPB Consensus des analystes Opinions des analystes haussières et baissières, objectif de cours à 12 mois, potentiel de hausse
- Achat fort 2 15,4%
- Achat 8 61,5%
- Conserver 3 23,1%
- Vente 0 0,0%
- Vente forte 0 0,0%
Objectif de cours à 12 mois
8 analystes · 2026-08-13Historique des bénéfices BPA réel vs estimation, surprise %, taux de succès, prochaine date de publication des résultats
| Période | EPS Actual | BPA est. | Surprise |
|---|---|---|---|
| 31 mars 2026 | $-0.75 | $-0.78 | 0.03% |
| 31 décembre 2025 | $-0.79 | $-0.71 | -0.08% |
| 30 septembre 2025 | $-0.63 | $-0.79 | 0.16% |
| 30 juin 2025 | $-0.74 | $-0.62 | -0.12% |
| 31 mars 2025 | $-0.51 | $-0.49 | -0.02% |
| 31 décembre 2024 | $-1.59 | $-0.57 | -1.0% |
Comparaison des pairs (sous-secteur GICS) Indicateurs clés par rapport aux pairs du secteur
| Ticker | Capitalisation Boursière | P/E | Revenus Année/Année | Marge Nette | ROE | Marge Brute |
|---|---|---|---|---|---|---|
| UPB | $1.47B | -10.2 | 20.4% | -5026.0% | -38.3% | — |
| FENC | $263M | -22.6 | -6.1% | -21.8% | -69.6% | — |
| LXEO | $725M | -5.3 | — | — | -51.9% | — |
| FHTX | $306M | -4.6 | 36.8% | -240.3% | 80.2% | — |
| XFOR | $364M | -2.1 | 150.0% | -1218.5% | -83.2% | — |
| PALI | $375M | -7.8 | — | — | -25.4% | — |
| RCKT | — | — | — | — | — | — |
Fondamentaux complets Tous les indicateurs par an — compte de résultat, bilan, flux de trésorerie
Compte de résultat 14
| Métrique | Tendance | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue | $3M | $2M | $2M | |
| R&D Expense | $137M | $63M | $32M | |
| SG&A Expense | $26M | $17M | $11M | |
| Operating Expenses | $163M | $80M | $42M | |
| Operating Income | $-160M | $-78M | $-40M | |
| Interest Income | $17M | $12M | $4M | |
| Other Non-op | $17M | $15M | $20M | |
| Income Tax | $0 | $0 | $0 | |
| Net Income | $-143M | $-63M | $-21M | |
| EPS (Basic) | $-2.66 | $-5.58 | $-12.95 | |
| EPS (Diluted) | $-2.66 | $-5.58 | $-12.95 | |
| Shares (Basic) | 53,852,752 | 13,682,326 | 2,953,756 | |
| Shares (Diluted) | 53,852,752 | 13,682,326 | 2,953,756 | |
| EBITDA | $-160M | $-78M | · |
Bilan 22
| Métrique | Tendance | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Cash & Equivalents | $102M | $326M | $26M | |
| Short-term Investments | $240M | $145M | $84M | |
| Receivables | $668.0K | $613.0K | $98.0K | |
| Prepaid Expense | $10M | $8M | $7M | |
| Other Current Assets | $727.0K | · | · | |
| Current Assets | $352M | $479M | $117M | |
| PP&E (Net) | $559.0K | $582.0K | $159.0K | |
| PP&E (Gross) | $903.0K | $738.0K | $226.0K | |
| Accum. Depreciation | $344.0K | $156.0K | $67.0K | |
| Goodwill | · | $0 | · | |
| Total Assets | $354M | $482M | $117M | |
| Accounts Payable | $3M | $4M | $2M | |
| Current Liabilities | $13M | $11M | $7M | |
| Capital Leases | $549.0K | $1M | · | |
| Total Liabilities | $14M | $12M | $9M | |
| Common Stock | $54.0K | $53.0K | $3.0K | |
| Paid-in Capital | $673M | $661M | $5M | |
| Retained Earnings | $-334M | $-191M | $-128M | |
| AOCI | $530.0K | $-25.0K | $21.0K | |
| Stockholders' Equity | $340M | $470M | $-123M | |
| Liabilities + Equity | $354M | $482M | $117M | |
| Shares Outstanding | 54,237,750 | 53,603,398 | 2,992,479 |
Flux de trésorerie 9
| Métrique | Tendance | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| D&A | $188.0K | $89.0K | $60.0K | |
| Stock-based Comp | $10M | $6M | $3M | |
| Other Non-cash | $-352.0K | $-2M | · | |
| Operating Cash Flow | $-133M | $-59M | $-38M | |
| CapEx | $165.0K | $511.0K | $144.0K | |
| Investing Cash Flow | $-93M | $-59M | $-83M | |
| Financing Cash Flow | $2M | $419M | $130M | |
| Net Change in Cash | $-224M | $300M | $9M | |
| Free Cash Flow | $-133M | $-60M | · |
Rentabilité 5
| Métrique | Tendance | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Operating Margin | -5618.8% | -3281.2% | · | |
| Net Margin | -5026.0% | -2650.0% | · | |
| EBITDA Margin | -5612.2% | -3277.4% | · | |
| ROA | -34.3% | -21.0% | · | |
| ROE | -38.3% | -40.6% | · |
Liquidité et Solvabilité 2
| Métrique | Tendance | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Current Ratio | 26.2 | 44.6 | · | |
| Quick Ratio | 25.4 | 43.9 | · |
Efficacité 2
| Métrique | Tendance | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Asset Turnover | 0.0 | 0.0 | · | |
| Receivables Turnover | 4.5 | 6.7 | · |
Taux de croissance 1
| Métrique | Tendance | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue YoY | 20.4% | -0.42% | · |
Valorisation (TTM) 10
| Métrique | Tendance | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue TTM | $3M | $2M | · | |
| Net Income TTM | $-143M | $-63M | · | |
| Market Cap | $1.47B | $881M | · | |
| P/E | -10.2 | -2.9 | · | |
| P/S | 516.0 | 371.8 | · | |
| P/B | 4.3 | 1.9 | · | |
| P / Tangible Book | 4.3 | 1.9 | · | |
| P / Cash Flow | -11.0 | -14.9 | · | |
| P / FCF | -11.0 | -14.8 | · | |
| Earnings Yield | -9.8% | -33.9% | · |
Compte de résultat 14
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $773.0K | $1M | $668.0K | $683.0K | $937.0K | $566.0K | $613.0K | $607.0K | $510.0K | $640.0K | $450.0K | |
| R&D Expense | $36M | $37M | $40M | $33M | $38M | $26M | $22M | $15M | $14M | $12M | $12M | |
| SG&A Expense | $7M | $8M | $7M | $6M | $7M | $7M | $5M | $4M | $4M | $4M | $3M | |
| Operating Expenses | $43M | $45M | $47M | $39M | $45M | $33M | $27M | $20M | $18M | $16M | $15M | |
| Operating Income | $-42M | $-44M | $-46M | $-38M | $-44M | $-32M | $-26M | $-19M | $-18M | $-15M | $-14M | |
| Interest Income | $3M | $3M | $4M | $4M | $4M | $5M | $5M | $3M | $3M | $1M | $2M | |
| Other Non-op | $3M | $3M | $4M | $4M | $4M | $5M | $5M | $3M | $3M | $4M | $2M | |
| Income Tax | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | |
| Net Income | $-40M | $-41M | $-42M | $-34M | $-40M | $-27M | $-21M | $-16M | $-15M | $-11M | $-12M | |
| EPS (Basic) | $-0.73 | $-0.75 | $-0.78 | $-0.63 | $-0.74 | $-0.51 | $12.56 | $-6.96 | $-6.50 | $-4.68 | $-5.05 | |
| EPS (Diluted) | $-0.73 | $-0.75 | $-0.78 | $-0.63 | $-0.74 | $-0.51 | $12.56 | $-6.96 | $-6.50 | $-4.68 | $-5.05 | |
| Shares (Basic) | 54,567,976 | 54,332,319 | -107,466,785 | 53,930,946 | 53,770,868 | 53,617,723 | 4,654,757 | 3,023,155 | 3,008,807 | 2,995,607 | 8,952 | |
| Shares (Diluted) | 54,567,976 | 54,332,319 | -107,466,785 | 53,930,946 | 53,770,868 | 53,617,723 | 4,654,757 | 3,023,155 | 3,008,807 | 2,995,607 | 8,952 | |
| EBITDA | $-42M | $-44M | · | $-38M | $-44M | $-32M | · | $-19M | · | · | · |
Bilan 21
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $79M | $97M | $102M | $72M | $45M | $71M | $326M | $33M | · | · | $26M | |
| Short-term Investments | $182M | $198M | $240M | $300M | $348M | $360M | $145M | $188M | · | · | $84M | |
| Receivables | $772.0K | $1M | $668.0K | $683.0K | $937.0K | $566.0K | $613.0K | $607.0K | · | · | $98.0K | |
| Prepaid Expense | $18M | $21M | $10M | $16M | $24M | $22M | $8M | $6M | · | · | $7M | |
| Other Current Assets | $1M | · | · | · | · | · | · | · | · | · | · | |
| Current Assets | $280M | $316M | $352M | $389M | $418M | $454M | $479M | $227M | · | · | $117M | |
| PP&E (Net) | $460.0K | $510.0K | $559.0K | $616.0K | $544.0K | $539.0K | $582.0K | $578.0K | · | · | $159.0K | |
| PP&E (Gross) | $903.0K | $903.0K | $903.0K | $903.0K | $785.0K | $738.0K | $738.0K | $685.0K | · | · | $226.0K | |
| Accum. Depreciation | $443.0K | $393.0K | $344.0K | $287.0K | $241.0K | $199.0K | $156.0K | $107.0K | · | · | $67.0K | |
| Total Assets | $281M | $318M | $354M | $391M | $421M | $456M | $482M | $233M | · | · | $117M | |
| Accounts Payable | $2M | $2M | $3M | $4M | $3M | $5M | $4M | $5M | · | · | $2M | |
| Current Liabilities | $10M | $14M | $13M | $12M | $11M | $10M | $11M | $11M | · | · | $7M | |
| Capital Leases | $226.0K | $390.0K | $549.0K | $703.0K | $849.0K | $992.0K | $1M | $1M | · | · | · | |
| Total Liabilities | $10M | $14M | $14M | $13M | $12M | $11M | $12M | $12M | · | · | $9M | |
| Common Stock | $54.0K | $54.0K | $54.0K | $56.0K | $54.0K | $53.0K | $53.0K | $3.0K | · | · | $3.0K | |
| Paid-in Capital | $686M | $679M | $673M | $670M | $666M | $663M | $661M | $9M | · | · | $5M | |
| Retained Earnings | $-415M | $-375M | $-334M | $-292M | $-258M | $-218M | $-191M | $-170M | · | · | $-128M | |
| AOCI | $-123.0K | $100.0K | $530.0K | $493.0K | $258.0K | $368.0K | $-25.0K | $351.0K | · | · | $21.0K | |
| Stockholders' Equity | $271M | $304M | $340M | $379M | $409M | $446M | $470M | $-160M | · | · | $-123M | |
| Liabilities + Equity | $281M | $318M | $354M | $391M | $421M | $456M | $482M | $233M | · | · | $117M | |
| Shares Outstanding | 54,771,041 | 54,419,986 | 54,237,750 | 53,999,522 | 53,798,151 | 53,640,895 | 53,603,398 | 3,025,452 | · | · | 2,992,479 |
Flux de trésorerie 8
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $50.0K | $49.0K | $57.0K | $46.0K | $42.0K | $43.0K | $49.0K | $14.0K | $13.0K | $13.0K | $14.0K | |
| Stock-based Comp | $4M | $5M | $3M | $3M | $3M | $3M | $2M | $2M | $1M | $643.0K | $711.0K | |
| Other Non-cash | · | $-12M | · | · | · | $-17M | · | · | · | · | · | |
| Operating Cash Flow | $-36M | $-48M | $-31M | $-22M | $-39M | $-41M | $-20M | $-14M | $-8M | $-18M | $-16M | |
| CapEx | · | · | $54.0K | $64.0K | · | · | $185.0K | · | · | · | $0 | |
| Investing Cash Flow | $16M | $42M | $59M | $48M | $13M | $-213M | $42M | $1M | $-117M | $14M | $-5M | |
| Financing Cash Flow | $3M | $598.0K | $1M | $760.0K | $612.0K | $-34.0K | $271M | $-2M | $141M | $9M | $-133.0K | |
| Net Change in Cash | $-17M | $-5M | $29M | $27M | $-26M | $-255M | $293M | $-14M | $16M | $6M | $-21M |
Rentabilité 5
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -5481.0% | -4218.1% | · | -5539.4% | -4732.9% | -5656.0% | · | -3112.5% | · | · | · | |
| Net Margin | -5136.1% | -3925.6% | · | -4941.1% | -4265.3% | -4818.0% | · | -2634.6% | · | · | · | |
| EBITDA Margin | -5481.0% | -4213.3% | · | -5539.4% | -4732.9% | -5648.4% | · | -3112.5% | · | · | · | |
| ROA | -11.3% | -10.5% | · | -10.8% | -19.0% | -12.0% | · | -13.7% | · | · | · | |
| ROE | -11.7% | -10.8% | · | -30.9% | -19.6% | -12.2% | · | 20.0% | · | · | · |
Liquidité et Solvabilité 2
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 28.0 | 23.1 | · | 32.7 | 38.3 | 47.4 | · | 20.9 | · | · | · | |
| Quick Ratio | 26.2 | 21.6 | · | 31.3 | 36.1 | 45.1 | · | 20.3 | · | · | · |
Efficacité 2
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.0 | 0.0 | · | 0.0 | 0.0 | 0.0 | · | 0.0 | · | · | · | |
| Receivables Turnover | 0.9 | 1.3 | · | 1.1 | 2.0 | 2.0 | · | 2.0 | · | · | · |
Valorisation (TTM) 9
| Métrique | Tendance | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $3M | $3M | · | $3M | $3M | $2M | · | $2M | · | · | · | |
| Net Income TTM | $-154M | $-142M | · | $-117M | $-98M | $-69M | · | $-45M | · | · | · | |
| Market Cap | $379M | $490M | · | $1.02B | $591M | $328M | · | · | · | · | · | |
| P/E | -2.4 | -3.4 | · | -2.1 | -0.7 | -0.3 | · | · | · | · | · | |
| P/S | 110.6 | 152.1 | · | 363.7 | 225.5 | 141.3 | · | · | · | · | · | |
| P/B | 1.4 | 1.6 | · | 2.7 | 1.4 | 0.7 | · | · | · | · | · | |
| P / Tangible Book | 1.4 | 1.6 | · | 2.7 | 1.4 | 0.7 | · | · | · | · | · | |
| P / Cash Flow | · | -10.2 | · | · | · | -8.0 | · | · | · | · | · | |
| Earnings Yield | -41.2% | -29.2% | · | -47.0% | -134.0% | -304.7% | · | · | · | · | · |
États financiers Compte de résultat, bilan, flux de trésorerie — annuel, sur les 5 dernières années
Compte de résultat
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Revenu | $3M | $2M | $2M |
| Marge d'exploitation % | -5618.8% | -3281.2% | — |
| Résultat net | $-143M | $-63M | $-21M |
| BPA dilué | $-2.66 | $-5.58 | $-12.95 |
Bilan
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Ratio de liquidité | 26.2 | 44.6 | — |
| Ratio de liquidité réduite | 25.4 | 43.9 | — |
Flux de trésorerie
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| Flux de trésorerie libre | $-133M | $-60M | — |
Mes métriques Votre watchlist personnelle — lignes sélectionnées de Fondamentaux Complets
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Détenteurs institutionnels (13F) 157 déclarants · $351.5M total · Au 30 juin 2026
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Nouvelles positions | Positions clôturées | Augmenté | Diminué | Variation nette des actions |
|---|---|---|---|---|
| 45 (+1 vs T. préc.) | 25 (-11 vs T. préc.) | 59 (+14 vs T. préc.) | 30 (-4 vs T. préc.) | +6.8M |
Comparé à Q1 2026. Les dépôts de formulaire 13F de la SEC sont dus dans les 45 jours suivant la fin du trimestre, plus une courte période tampon pour les déposants tardifs — les trimestres encore dans cette fenêtre sont ignorés au profit de la paire la plus récente entièrement déclarée.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| VANGUARD GROUP INC | $57 916 706 | 2 133 212 | 16,48% | Actions |
| FMR LLC | $50 318 247 | 7 271 423 | 14,31% | Actions |
| ORBIMED ADVISORS LLC | $39 399 636 | 5 693 589 | 11,21% | Actions |
| NORGES BANK | $26 078 843 | 3 768 619 | 7,42% | Actions |
| Decheng Capital LLC | $18 856 087 | 2 724 868 | 5,36% | Actions |
| ENAVATE SCIENCES GP, LLC | $17 021 145 | 2 459 703 | 4,84% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $12 986 999 | 1 876 734 | 3,69% | Actions |
| MILLENNIUM MANAGEMENT LLC | $7 914 923 | 1 143 775 | 2,25% | Actions |
| Qube Research & Technologies Ltd | $6 771 220 | 978 500 | 1,93% | Actions |
| Parkman Healthcare Partners LLC | $6 471 909 | 935 247 | 1,84% | Actions |
| SEB Asset Management AB | $6 079 022 | 878 473 | 1,73% | Actions |
| D. E. Shaw & Co., Inc. | $5 795 971 | 837 568 | 1,65% | Actions |
| Woodline Partners LP | $5 753 849 | 831 481 | 1,64% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $5 539 562 | 800 289 | 1,58% | Actions |
| STATE STREET CORP | $5 302 955 | 766 323 | 1,51% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $4 931 656 | 712 667 | 1,40% | Actions |
| Y-Intercept (Hong Kong) Ltd | $4 799 401 | 693 555 | 1,37% | Actions |
| Bain Capital Life Sciences Investors, LLC | $4 158 567 | 600 949 | 1,18% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $3 539 898 | 511 546 | 1,01% | Actions |
| Walleye Capital LLC | $3 449 551 | 498 490 | 0,98% | Actions |
| Trexquant Investment LP | $3 227 696 | 466 430 | 0,92% | Actions |
| Point72 Asset Management, L.P. | $3 134 836 | 453 011 | 0,89% | Actions |
| BANK OF AMERICA CORP /DE/ | $2 710 993 | 391 762 | 0,77% | Actions |
| Altshuler Shaham Ltd | $2 630 022 | 380 061 | 0,75% | Actions |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $2 475 672 | 357 756 | 0,70% | Actions |
| SAMSARA BIOCAPITAL, LLC | $2 447 722 | 353 717 | 0,70% | Actions |
| Propel Bio Management, LLC | $2 424 692 | 350 389 | 0,69% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $2 369 083 | 342 353 | 0,67% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $2 363 464 | 341 541 | 0,67% | Actions |
| Squarepoint Ops LLC | $2 013 056 | 290 904 | 0,57% | Actions |
| Voleon Capital Management LP | $1 973 819 | 285 234 | 0,56% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1 816 196 | 262 456 | 0,52% | Actions |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $1 751 397 | 253 092 | 0,50% | Actions |
| GOLDMAN SACHS GROUP INC | $1 708 666 | 246 917 | 0,49% | Actions |
| XTX Topco Ltd | $1 677 034 | 242 346 | 0,48% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $1 658 143 | 239 616 | 0,47% | Actions |
| UBS Group AG | $1 624 200 | 234 711 | 0,46% | Actions |
| Schonfeld Strategic Advisors LLC | $1 562 258 | 225 760 | 0,44% | Actions |
| SPHERA FUNDS MANAGEMENT LTD. | $1 520 324 | 219 700 | 0,43% | Actions |
| BlackRock, Inc. | $1 054 823 | 152 431 | 0,30% | Actions |
| Boxer Capital Management, LLC | $1 038 000 | 150 000 | 0,30% | Actions |
| RENAISSANCE TECHNOLOGIES LLC | $908 596 | 131 300 | 0,26% | Actions |
| EntryPoint Capital, LLC | $895 766 | 129 446 | 0,25% | Actions |
| ALGERT GLOBAL LLC | $820 920 | 118 630 | 0,23% | Actions |
| AMERICAN CENTURY COMPANIES INC | $541 102 | 78 194 | 0,15% | Actions |
| Man Group plc | $510 855 | 73 823 | 0,15% | Actions |
| JPMORGAN CHASE & CO | $505 093 | 72 885 | 0,14% | Actions |
| ALLIANCEBERNSTEIN L.P. | $465 120 | 51 680 | 0,13% | Actions |
| Simplify Asset Management Inc. | $429 822 | 62 113 | 0,12% | Actions |
| ALPS ADVISORS INC | $382 178 | 55 228 | 0,11% | Actions |
| Quantinno Capital Management LP | $379 479 | 54 838 | 0,11% | Actions |
| Nuveen Asset Management, LLC | $371 314 | 22 586 | 0,11% | Actions |
| Virtus Investment Advisers, LLC | $371 175 | 53 638 | 0,11% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $356 949 | 39 661 | 0,10% | Actions |
| Brevan Howard Capital Management LP | $348 553 | 50 369 | 0,10% | Actions |
| Swiss National Bank | $332 852 | 48 100 | 0,09% | Actions |
| MORGAN STANLEY | $311 220 | 44 974 | 0,09% | Actions |
| Allspring Global Investments Holdings, LLC | $298 819 | 43 182 | 0,09% | Actions |
| RHUMBLINE ADVISERS | $293 288 | 42 384 | 0,08% | Actions |
| TWO SIGMA INVESTMENTS, LP | $292 889 | 42 325 | 0,08% | Actions |
| ExodusPoint Capital Management, LP | $284 031 | 41 045 | 0,08% | Actions |
| CITIGROUP INC | $265 084 | 38 307 | 0,08% | Actions |
| Stonepine Capital Management, LLC | $231 349 | 33 432 | 0,07% | Actions |
| Mariner, LLC | $229 337 | 33 141 | 0,07% | Actions |
| DEUTSCHE BANK AG\ | $228 561 | 33 029 | 0,07% | Actions |
| WELLS FARGO & COMPANY/MN | $204 119 | 29 497 | 0,06% | Actions |
| Bank of New York Mellon Corp | $197 711 | 28 571 | 0,06% | Actions |
| Quantbot Technologies LP | $194 992 | 28 178 | 0,06% | Actions |
| BARCLAYS PLC | $193 608 | 27 978 | 0,06% | Actions |
| AXQ CAPITAL, LP | $187 311 | 27 068 | 0,05% | Actions |
| nVerses Capital, LLC | $166 280 | 24 029 | 0,05% | Actions |
| DNB Asset Management AS | $163 312 | 23 600 | 0,05% | Actions |
| VANGUARD ASSET MANAGEMENT, Ltd | $157 250 | 22 724 | 0,04% | Actions |
| Graham Capital Management, L.P. | $155 755 | 22 508 | 0,04% | Actions |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $154 904 | 22 385 | 0,04% | Actions |
| Verdad Advisers, LP | $150 925 | 21 810 | 0,04% | Actions |
| MetLife Investment Management, LLC | $144 296 | 20 852 | 0,04% | Actions |
| SEI INVESTMENTS CO | $138 580 | 20 026 | 0,04% | Actions |
| WINTON GROUP Ltd | $137 016 | 19 800 | 0,04% | Actions |
| IEQ CAPITAL, LLC | $135 182 | 19 535 | 0,04% | Actions |
| DIADEMA PARTNERS LP | $132 124 | 19 093 | 0,04% | Actions |
| Shay Capital LLC | $124 560 | 18 000 | 0,04% | Actions |
| Quadrature Capital Ltd | $124 477 | 17 988 | 0,04% | Actions |
| Entropy Technologies, LP | $121 391 | 17 542 | 0,03% | Actions |
| STATE OF WISCONSIN INVESTMENT BOARD | $118 090 | 17 065 | 0,03% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $112 222 | 16 217 | 0,03% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $108 886 | 15 735 | 0,03% | Actions |
| CITADEL ADVISORS LLC | $103 800 | 15 000 | 0,03% | Option d'achat |
| MERCER GLOBAL ADVISORS INC /ADV | $92 396 | 13 352 | 0,03% | Actions |
| Vanguard Global Advisers, LLC | $90 368 | 13 059 | 0,03% | Actions |
| Engineers Gate Manager LP | $86 438 | 12 491 | 0,02% | Actions |
| Invesco Ltd. | $84 611 | 12 227 | 0,02% | Actions |
| STRS OHIO | $83 040 | 12 000 | 0,02% | Actions |
| JANE STREET GROUP, LLC | $82 348 | 11 900 | 0,02% | Option d'achat |
| CANADA PENSION PLAN INVESTMENT BOARD | $79 580 | 11 500 | 0,02% | Actions |
| HSBC HOLDINGS PLC | $77 602 | 10 793 | 0,02% | Actions |
| JANE STREET GROUP, LLC | $77 324 | 11 174 | 0,02% | Actions |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $75 428 | 10 017 | 0,02% | Actions |
| PRELUDE CAPITAL MANAGEMENT, LLC | $73 006 | 10 550 | 0,02% | Actions |
| AMERIPRISE FINANCIAL INC | $72 570 | 10 487 | 0,02% | Actions |
Initiés de la société 12 initiés · 5 dirigeants · 7 administrateurs
| Dirigeant | Rôle | Dernière activité | Actions détenues | Achats 12m | Ventes 12m | Net 12m |
|---|---|---|---|---|---|---|
| Everett Rand Sutherland | Chief Executive Officer | 16 juin 2026 S | 70 812 | 0 | 2 | $-32 224 |
| Michael Gray | CFO and COO | 16 juin 2026 S | 28 795 | 0 | 2 | $-13 118 |
| Allison Ambrose | General Counsel | 16 juin 2026 S | 16 048 | 0 | 2 | $-7 323 |
| Aaron Deykin | Chief Medical Officer | 16 juin 2026 S | 33 197 | 0 | 2 | $-13 765 |
| Adam Houghton | Chief Business Officer | 16 juin 2026 S | 23 601 | 0 | 2 | $-10 764 |
| Marcella K. Ruddy | Administrateur | 9 juin 2026 A | — | 0 | 0 | $0 |
| Harold Edward Fleming | Administrateur | 9 juin 2026 A | — | 0 | 0 | $0 |
| CHIMOVITS EREZ | Administrateur | 9 juin 2026 A | 4 554 873 | 0 | 0 | $0 |
| Liam Ratcliffe | Administrateur | 9 juin 2026 A | — | 0 | 0 | $0 |
| Daniella Beckman | Administrateur | 9 juin 2026 A | — | 0 | 0 | $0 |
| Ronald C Renaud JR | Administrateur | 9 juin 2026 A | — | 0 | 0 | $0 |
| Wellington Biomedical Innovation Master Investors (Cayman) II L.P. | Détenteur de 10% | 15 octobre 2024 C | 894 733 | 0 | 0 | $0 |
Initiés issus des déclarations SEC Form 3/4/5 ; net = uniquement P/S de marché
Activistes et détenteurs de 5%+ 2 participations
Investisseurs ayant déposé un Schedule 13D auprès de la SEC — détention effective supérieure à 5% avec l'intention d'influencer l'émetteur (participations activistes, campagnes pour le conseil d'administration, fusions-acquisitions). Chaque ligne montre le dernier état connu de la position du déposant.
| Déclarant | Déposé | Participation | Statut | Objectif | Dépôt |
|---|---|---|---|---|---|
| AI Upstream LLC, Access Industries Holdings LLC, AI Biotechnology LLC, Access Industries Management, LLC, Len Blavatnik | 22 octobre 2024 | — | Dépôt initial | — | SEC |
| OrbiMed Advisors LLC, OrbiMed Capital GP VIII LLC, OrbiMed Advisors Israel II Limited, OrbiMed Israel GP II, L.P. | 17 octobre 2024 | — | Dépôt initial | — | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
Détention d'ETF Détenu par 32 ETFs
Le poids reflète uniquement les participations directes en actions (N-PORT) ; les fonds à effet de levier ou basés sur des dérivés peuvent détenir une exposition supplémentaire aux swaps non indiquée.
| Fonds | Poids | Unités | Au | Source |
|---|---|---|---|---|
| FMED · Fidelity Covington Trust | 0,51% | 24 900 NS | 31 mai 2026 | N-PORT |
| SBIO · ALPS ETF Trust | 0,29% | 55 699 NS | 31 mai 2026 | N-PORT |
| BBC · ETFis Series Trust I | 0,25% | 10 169 NS | 30 avril 2026 | N-PORT |
| FFSM · FIDELITY COVINGTON TRUST | 0,07% | 92 201 NS | 30 avril 2026 | N-PORT |
| IBBQ · Invesco Exchange-Traded Fund Trust … | 0,03% | 2 927 SH | 8 août 2026 | Quotidien |
| BIB · ProShares Trust | 0,02% | 1 997 NS | 31 mai 2026 | N-PORT |
| VTWV · VANGUARD SCOTTSDALE FUNDS | 0,02% | 31 318 SH | 8 août 2026 | Quotidien |
| IBB · iShares Trust | 0,02% | 264 706 SH | 8 août 2026 | Quotidien |
| AVSC · AMERICAN CENTURY ETF TRUST | 0,02% | 62 606 NS | 31 mai 2026 | N-PORT |
| IWN · iShares Trust | 0,02% | 334 907 SH | 8 août 2026 | Quotidien |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0,01% | 202 528 SH | 8 août 2026 | Quotidien |
| RSSL · Global X Funds | 0,01% | 14 420 NS | 30 avril 2026 | N-PORT |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0,01% | 33 677 SH | 8 août 2026 | Quotidien |
| IWM · iShares Trust | 0,01% | 902 359 SH | 8 août 2026 | Quotidien |
| DFAS · Dimensional ETF Trust | 0,01% | 108 557 NS | 30 avril 2026 | N-PORT |
| ITWO · ProShares Trust | 0,01% | 1 544 NS | 31 mai 2026 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0,01% | 161 663 NS | 31 mai 2026 | N-PORT |
| UWM · ProShares Trust | 0,00% | 1 208 NS | 31 mai 2026 | N-PORT |
| FHLC · FIDELITY COVINGTON TRUST | 0,00% | 11 160 NS | 30 avril 2026 | N-PORT |
| URTY · ProShares Trust | 0,00% | 1 224 NS | 31 mai 2026 | N-PORT |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0,00% | 1 388 NS | 31 mai 2026 | N-PORT |
| HDG · ProShares Trust | 0,00% | 31 NS | 31 mai 2026 | N-PORT |
| DFAU · Dimensional ETF Trust | 0,00% | 10 145 NS | 30 avril 2026 | N-PORT |
| DCOR · Dimensional ETF Trust | 0,00% | 2 366 NS | 30 avril 2026 | N-PORT |
| ITOT · iShares Trust | 0,00% | 49 987 SH | 8 août 2026 | Quotidien |
| SCHB · SCHWAB STRATEGIC TRUST | 0,00% | 20 416 NS | 31 mai 2026 | N-PORT |
| IWV · iShares Trust | 0,00% | 9 569 SH | 8 août 2026 | Quotidien |
| AVSU · AMERICAN CENTURY ETF TRUST | 0,00% | 34 NS | 31 mai 2026 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | 0,00% | 386 877 SH | 8 août 2026 | Quotidien |
| VTI · VANGUARD INDEX FUNDS | 0,00% | 1 443 025 SH | 8 août 2026 | Quotidien |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0,00% | 2 529 SH | 8 août 2026 | Quotidien |
| VHT · VANGUARD WORLD FUND | 0,00% | 72 742 SH | 8 août 2026 | Quotidien |