VOR — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| TCG Crossover Management, LLC | $104 441 366 | 5 673 078 | 11,56% | Actions |
| FMR LLC | $90 800 863 | 4 932 149 | 10,05% | Actions |
| FCPM III SERVICES B.V. | $75 800 487 | 4 117 354 | 8,39% | Actions |
| BlackRock, Inc. | $63 847 850 | 3 468 107 | 7,07% | Actions |
| Venrock Adviser, LLC | $55 998 047 | 3 041 719 | 6,20% | Actions |
| STATE STREET CORP | $48 166 746 | 2 616 336 | 5,33% | Actions |
| Frazier Life Sciences Management, L.P. | $46 833 917 | 2 543 939 | 5,18% | Actions |
| RA CAPITAL MANAGEMENT, L.P. | $44 222 569 | 2 402 095 | 4,89% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $38 372 478 | 2 084 328 | 4,25% | Actions |
| Caligan Partners LP | $35 440 465 | 1 925 066 | 3,92% | Actions |
| Paradigm Biocapital Advisors LP | $32 217 500 | 1 750 000 | 3,57% | Actions |
| GREAT POINT PARTNERS LLC | $31 297 000 | 1 700 000 | 3,46% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $19 563 726 | 1 062 469 | 2,17% | Actions |
| NEXTBio Capital Management LP | $16 369 509 | 889 164 | 1,81% | Actions |
| Nantahala Capital Management, LLC | $15 556 450 | 845 000 | 1,72% | Actions |
| ADAR1 Capital Management, LLC | $12 530 325 | 680 626 | 1,39% | Actions |
| Logos Global Management LP | $11 966 500 | 650 000 | 1,32% | Actions |
| Rosalind Advisors, Inc. | $11 940 726 | 648 600 | 1,32% | Actions |
| NAN FUNG TRINITY (HK) LTD | $11 902 986 | 646 550 | 1,32% | Actions |
| BRAIDWELL LP | $10 550 845 | 573 104 | 1,17% | Actions |
| BOOTHBAY FUND MANAGEMENT, LLC | $10 285 704 | 558 702 | 1,14% | Actions |
| VANGUARD GROUP INC | $10 074 870 | 770 250 | 1,12% | Actions |
| UBS Group AG | $9 081 248 | 493 278 | 1,01% | Actions |
| MILLENNIUM MANAGEMENT LLC | $7 880 713 | 428 067 | 0,87% | Actions |
| SPHERA FUNDS MANAGEMENT LTD. | $7 666 237 | 416 417 | 0,85% | Actions |
| Woodline Partners LP | $6 990 700 | 379 723 | 0,77% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $6 266 101 | 340 364 | 0,69% | Actions |
| GOLDMAN SACHS GROUP INC | $6 054 902 | 328 892 | 0,67% | Actions |
| NORTHERN TRUST CORP | $6 052 141 | 328 742 | 0,67% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $5 535 961 | 300 704 | 0,61% | Actions |
| Clearline Capital LP | $5 251 931 | 285 276 | 0,58% | Actions |
| BANK OF AMERICA CORP /DE/ | $3 272 175 | 177 739 | 0,36% | Actions |
| CITADEL ADVISORS LLC | $2 953 222 | 160 414 | 0,33% | Actions |
| Eversept Partners, LP | $2 755 627 | 149 681 | 0,30% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $2 234 937 | 121 398 | 0,25% | Actions |
| Bank of New York Mellon Corp | $1 799 062 | 97 722 | 0,20% | Actions |
| MARSHALL WACE, LLP | $1 760 788 | 95 643 | 0,19% | Actions |
| Nuveen, LLC | $1 745 544 | 94 815 | 0,19% | Actions |
| AXIOM INVESTORS LLC /DE | $1 695 653 | 92 105 | 0,19% | Actions |
| XTX Topco Ltd | $1 521 494 | 82 645 | 0,17% | Actions |
| Jump Financial, LLC | $1 305 066 | 70 889 | 0,14% | Actions |
| Invesco Ltd. | $1 257 421 | 68 301 | 0,14% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1 189 286 | 64 600 | 0,13% | Option de vente |
| CITIGROUP INC | $1 162 224 | 63 130 | 0,13% | Actions |
| MORGAN STANLEY | $1 133 338 | 61 561 | 0,13% | Actions |
| RHUMBLINE ADVISERS | $1 059 081 | 57 528 | 0,12% | Actions |
| ALPS ADVISORS INC | $1 012 513 | 54 998 | 0,11% | Actions |
| D. E. Shaw & Co., Inc. | $1 006 493 | 54 671 | 0,11% | Actions |
| JOHNSON & JOHNSON | $989 206 | 53 732 | 0,11% | Actions |
| Rafferty Asset Management, LLC | $898 739 | 48 818 | 0,10% | Actions |
| Walleye Capital LLC | $858 127 | 46 612 | 0,09% | Actions |
| DEUTSCHE BANK AG\ | $742 862 | 40 351 | 0,08% | Actions |
| ALLIANCEBERNSTEIN L.P. | $685 036 | 37 210 | 0,08% | Actions |
| TWO SIGMA INVESTMENTS, LP | $681 391 | 37 012 | 0,08% | Actions |
| Engineers Gate Manager LP | $680 268 | 36 951 | 0,08% | Actions |
| WELLS FARGO & COMPANY/MN | $667 786 | 36 273 | 0,07% | Actions |
| RENAISSANCE TECHNOLOGIES LLC | $607 733 | 33 011 | 0,07% | Actions |
| Jefferies Financial Group Inc. | $601 326 | 32 663 | 0,07% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $498 911 | 27 100 | 0,06% | Actions |
| Sarissa Capital Management LP | $467 596 | 25 399 | 0,05% | Actions |
| PROFUND ADVISORS LLC | $452 720 | 24 591 | 0,05% | Actions |
| MetLife Investment Management, LLC | $449 977 | 24 442 | 0,05% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $449 932 | 24 381 | 0,05% | Actions |
| Squarepoint Ops LLC | $427 683 | 23 231 | 0,05% | Actions |
| SEI INVESTMENTS CO | $423 855 | 23 019 | 0,05% | Actions |
| Virtus Investment Advisers, LLC | $419 472 | 22 785 | 0,05% | Actions |
| JPMORGAN CHASE & CO | $402 150 | 21 621 | 0,04% | Actions |
| TUDOR INVESTMENT CORP ET AL | $361 204 | 19 620 | 0,04% | Actions |
| Scientech Research LLC | $346 623 | 18 828 | 0,04% | Actions |
| Vanguard Global Advisers, LLC | $330 404 | 17 947 | 0,04% | Actions |
| Y-Intercept (Hong Kong) Ltd | $317 352 | 17 238 | 0,04% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $302 918 | 16 454 | 0,03% | Actions |
| FOX RUN MANAGEMENT, L.L.C. | $281 691 | 15 301 | 0,03% | Actions |
| BARCLAYS PLC | $268 142 | 14 565 | 0,03% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $263 263 | 14 300 | 0,03% | Actions |
| Shay Capital LLC | $252 125 | 13 695 | 0,03% | Actions |
| Police & Firemen's Retirement System of New Jersey | $221 564 | 12 035 | 0,02% | Actions |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $198 699 | 10 793 | 0,02% | Actions |
| EntryPoint Capital, LLC | $198 552 | 10 785 | 0,02% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $197 134 | 10 708 | 0,02% | Actions |
| China Universal Asset Management Co., Ltd. | $158 768 | 8 624 | 0,02% | Actions |
| Legal & General Group Plc | $147 482 | 8 011 | 0,02% | Actions |
| Ameritas Investment Partners, Inc. | $68 172 | 3 703 | 0,01% | Actions |
| Russell Investments Group, Ltd. | $59 942 | 3 256 | 0,01% | Actions |
| GROUP ONE TRADING LLC | $54 549 | 2 963 | 0,01% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $44 607 | 2 423 | 0,00% | Actions |
| Global Retirement Partners, LLC | $38 458 | 2 089 | 0,00% | Actions |
| Pinnacle Wealth Planning Services, Inc. | $36 360 | 1 975 | 0,00% | Actions |
| Tower Research Capital LLC (TRC) | $32 052 | 1 741 | 0,00% | Actions |
| ROYAL BANK OF CANADA | $23 000 | 1 260 | 0,00% | Actions |
| GF FUND MANAGEMENT CO. LTD. | $19 736 | 1 072 | 0,00% | Actions |
| Versant Capital Management, Inc | $13 890 | 728 | 0,00% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $10 346 | 562 | 0,00% | Actions |
| Sterling Capital Management LLC | $6 536 | 355 | 0,00% | Actions |
| PNC Financial Services Group, Inc. | $5 670 | 308 | 0,00% | Actions |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | $3 314 | 180 | 0,00% | Actions |
| SIGNATUREFD, LLC | $2 706 | 147 | 0,00% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $770 | 41 815 | 0,00% | Actions |
| WPG Advisers, LLC | $405 | 22 | 0,00% | Actions |
| Allworth Financial LP | $185 | 10 | 0,00% | Actions |
| Parallel Advisors, LLC | $92 | 5 | 0,00% | Actions |
| SBI Securities Co., Ltd. | $55 | 3 | 0,00% | Actions |
| OSAIC HOLDINGS, INC. | $37 | 2 | 0,00% | Actions |
| Pacer Advisors, Inc. | $15 | 815 | 0,00% | Actions |