IONS Snapshot del titolo Prezzo, capitalizzazione di mercato, P/E, EPS, ROE, debito/capitale proprio, intervallo 52 settimane

03

Prezzo $43.54

Capitalizzazione di Mercato (MRQ) $7.21B

P/E (TTM) -12.6

EPS (TTM) $-3.46

Ricavi (TTM) $874M

ROE (TTM) -105.5%

D/E Debito/Patrimonio 3.6

Intervallo 52 sett. $43–$87

IONS Grafico del prezzo delle azioni OHLCV giornaliero con indicatori tecnici — panoramica, zoom e personalizza la tua visualizzazione

04

intervallo

barre

La granularità delle barre si adatta al periodo selezionato — passa il mouse sul grafico per vedere apertura/massimo/minimo/chiusura di una barra.

Performance decennale Andamento di ricavi, utile netto, margini e EPS

06

Ricavi·

2016-12-31 → 2017-12-31

EPS$-2.38

2016-12-31 → 2025-12-31

Flusso di cassa libero$-320M

2016-12-31 → 2025-12-31

Margine netto-64.7%

2016-12-31 → 2017-12-31

Valutazione e Rapporti 07–12

Valutazione Rapporti P/E, P/S, P/B, EV/EBITDA — il titolo è costoso o economico?

Metrica	IONS	media 5 anni	Mediana dei peer	Verdetto
P/E (TTM)	-12.6media 5 anni ≈-47.3	≈-47.3	·	·
P/S (TTM)	8.3media 5 anni ≈9.0	≈9.0	150.3	Sottovalutato
P/B (MRQ)	16.4media 5 anni ≈13.9	≈13.9	10.8	Sopravvalutato
EV / EBITDA	-16.2media 5 anni ≈-17.4	≈-17.4	·	·
Prezzo / FCF (TTM)	-12.9media 5 anni ≈27.4	≈27.4	·	·
Prezzo / Flusso di cassa (TTM)	-14.5media 5 anni ≈7.4	≈7.4	·	·
EV / Revenue (EV / Ricavi)	6.6media 5 anni ≈8.7	≈8.7	·	·
EV / FCF	-19.4media 5 anni ≈-20.0	≈-20.0	·	·
Price / Tangible Book (Prezzo / Valore contabile tangibile)	14.5media 5 anni ≈14.0	≈14.0	·	·

La mediana dei peer viene calcolata su base standardizzata per metrica e potrebbe non corrispondere sempre alla base TTM/MRQ mostrata per questo titolo.

Redditività Margini lordi, operativi e netti; ROE, ROA, ROIC

Metrica	IONS	media 5 anni	Mediana dei peer	Verdetto
Margine Operativo (TTM)	-68.0%	·	-2340.3%	Di prim'ordine
Margine ante imposte (TTM)	-64.3%	·	-552.9%	Di prim'ordine
Margine di Profitto Netto (TTM)	-64.7%	·	-1588.5%	Di prim'ordine
ROA (TTM)	-18.9%media 5 anni ≈-10.3%	≈-10.3%	-42.7%	Di prim'ordine
ROE (TTM)	-105.5%media 5 anni ≈-57.6%	≈-57.6%	-68.1%	In linea
ROIC	-17.1%media 5 anni ≈-19.0%	≈-19.0%	-33.2%	Di prim'ordine

Salute finanziaria Debito, liquidità, solvibilità — solidità del bilancio

Metrica	IONS	media 5 anni	Mediana dei peer	Verdetto
Debt / Equity (Debito / Patrimonio Netto)	3.6media 5 anni ≈2.7	≈2.7	0.9	Debito elevato
Rapporto corrente (MRQ)	7.9media 5 anni ≈7.0	≈7.0	7.9	In linea
Quick Ratio	3.4media 5 anni ≈5.2	≈5.2	6.8	Bassa liquidità
Long-Term Debt / Equity (Debito a lungo termine / Patrimonio netto)	2.7media 5 anni ≈2.5	≈2.5	0.8	Debito elevato
Interest Coverage (Copertura degli interessi)	-22.1media 5 anni ≈-26.3	≈-26.3	·	·

Metriche per Azione EPS, valore contabile per azione, flusso di cassa per azione, dividendo per azione

Metrica	IONS	media 5 anni	Mediana dei peer	Verdetto
EPS (Diluted) (EPS (Diluito))	$-2.38media 5 anni ≈$-2.02	≈$-2.02	·	·
Cash Flow / Share (Flusso di cassa / Azione)	$-1.68media 5 anni ≈$-1.78	≈$-1.78	·	·
Cash / Share (Liquidità / Azione)	$2.28media 5 anni ≈$2.94	≈$2.94	·	·

Efficienza del Capitale Rotazione delle attività, rotazione delle scorte, rotazione dei crediti

Metrica	Tendenza 5 anni	IONS	media 5 anni	Mediana dei peer	Verdetto
Inventory Turnover (Rotazione delle scorte)		1.4media 5 anni ≈0.8	≈0.8	·	·

valore · ≈ media 5 anni · mediana del settore · giudizio rispetto alla mediana

Cronologia utili EPS effettivo vs stima, surprise %, tasso di superamento, data prossimi utili

14

Sorpresa media 64.3%

Prossimo report Ott 27, 2026

Periodo	Rapporto	EPS Actual	EPS Stimato	Sorpresa
30 Giugno 2026	Lug 28, 2026	$-0.69	$-1.09	36.7%
31 Marzo 2026		$-0.56	$-0.93	39.7%
31 Dicembre 2025		$-1.41	$-1.35	-4.6%
30 Settembre 2025		$-0.80	$-1.26	36.4%
30 Giugno 2025		$0.70	$-0.44	259.6%
31 Marzo 2025		$-0.93	$-1.14	18.4%

Fondamentali Completi Tutte le metriche per anno — conto economico, stato patrimoniale, rendiconto finanziario

15

Conto Economico 16

Metrica	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Revenue	·	·	·	·	·	·	·	·	$508M	$347M	$284M	$214M
Cost of Revenue	$16M	$11M	$9M	$14M	$11M	$12M	$4M	$2M	$0	$0	·	·
R&D Expense	$916M	$902M	$900M	·	$638M	$531M	$462M	$412M	$372M	$340M	$320M	$239M
SG&A Expense	$394M	$267M	$233M	$150M	$186M	$354M	$287M	$245M	$108M	$49M	$37M	$20M
Operating Expenses	$1.33B	$1.18B	$1.14B	$998M	$841M	$901M	$757M	$661M	$483M	$393M	$359M	$262M
Operating Income	$-382M	$-475M	$-354M	$-410M	$-30M	$-172M	$366M	$-61M	$31M	$-20M	$-76M	$-48M
Interest Expense	$17M	$17M	$13M	$8M	$9M	$10M	$12M	$45M	$45M	$39M	$37M	$22M
Other Non-op	$-15M	$1M	$14M	$-7M	$-10M	$-62.0K	$-686.0K	$-182.0K	$-4M	$0	·	·
Pretax Income	$-380M	$-460M	$-334M	$-258M	$-29M	$-135M	$339M	$-76M	$-17M	$-57M	$-88M	$-54M
Income Tax	$2M	$-6M	$32M	$12M	$-551.0K	$345M	$52M	$-291M	$-6M	$3M	$372.0K	$-15M
Net Income	$-381M	$-454M	$-366M	$-270M	$-29M	$-444M	$278M	$274M	$346.0K	$-60M	$-88M	$-39M
EPS (Basic)	$-2.38	$-3.04	$-2.56	$-1.90	$-0.20	$-3.18	$2.00	$2.09	$0.15	$-0.50	$-0.74	·
EPS (Diluted)	$-2.38	$-3.04	$-2.56	$-1.90	$-0.20	$-3.18	$1.90	$2.07	$0.15	$-0.50	$-0.74	·
Shares (Basic)	160,010,000	149,514,000	143,190,000	141,848,000	141,021,000	139,612,000	139,998,000	132,320,000	124,016,000	120,933,000	119,719,000	·
Shares (Diluted)	160,010,000	149,514,000	143,190,000	141,848,000	141,021,000	139,612,000	153,164,000	134,056,000	126,098,000	120,933,000	119,719,000	·
EBITDA	$-382M	$-475M	$-354M	$-410M	$-30M	$-172M	$366M	$-61M	$25M	$-46M	$-76M	$-48M

Stato Patrimoniale 24

Metrica	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Cash & Equivalents	$372M	$242M	$399M	$276M	$869M	$398M	$683M	$279M	$130M	$85M	$129M	$143M
Short-term Investments	$2.31B	$2.06B	$1.93B	$1.71B	$1.25B	·	·	·	·	·	·	·
Inventory	$10M	$13M	$7M	$22M	$25M	$22M	$18M	$9M	$10M	·	·	·
Other Current Assets	$237M	$218M	$205M	$168M	$143M	$140M	$140M	$102M	$73M	$17M	$15M	$16M
Current Assets	$2.99B	$2.62B	$2.64B	$2.20B	$2.35B	$2.13B	$2.72B	$2.21B	$1.17B	$798M	$837M	$837M
PP&E (Net)	$123M	$94M	$71M	$74M	$178M	$181M	$154M	$132M	$122M	$93M	$90M	$89M
Accum. Depreciation	$109M	$106M	$97M	$88M	$103M	$87M	$74M	$61M	$88M	$80M	$73M	$66M
Intangibles	·	·	·	·	$29M	$28M	$26M	$24M	$22M	$20M	·	·
Other Non-current Assets	$172M	$127M	$105M	$75M	$71M	$50M	$28M	$13M	$10M	$1M	·	·
Total Assets	$3.52B	$3.00B	$2.99B	$2.53B	$2.61B	$2.39B	$3.23B	$2.67B	$1.32B	$912M	$948M	$956M
Accounts Payable	$28M	$43M	$26M	$18M	$12M	$17M	$16M	$29M	$25M	$21M	$28M	$18M
Accrued Liabilities	$106M	$108M	$148M	$140M	$89M	$90M	$67M	$48M	$67M	$36M	$28M	$30M
Current Liabilities	$782M	$309M	$448M	$312M	$241M	$599M	$273M	$280M	$244M	$134M	$149M	$115M
Capital Leases	$262M	$162M	$171M	$179M	$19M	·	·	·	·	·	·	·
Other Non-current Liabilities	$28M	$52M	$42M	$16M	$7M	·	·	·	·	·	·	·
Total Liabilities	$3.03B	$2.42B	$2.60B	$1.96B	$1.84B	$1.65B	$1.55B	$1.48B	$957M	$813M	$747M	$698M
Long-term Debt	$1.81B	$1.25B	$1.31B	$1.19B	·	·	·	·	·	·	·	·
Total Debt	$1.76B	$1.20B	$1.24B	$1.18B	·	·	·	·	·	·	·	·
Common Stock	$163.0K	$158.0K	$144.0K	$142.0K	$141.0K	$140.0K	$140.0K	$138.0K	$125.0K	$122.0K	$120.0K	$118.0K
Retained Earnings	$-2.63B	$-2.25B	$-1.80B	$-1.43B	$-1.16B	$-1.13B	$-708M	$-967M	$-1.24B	$-1.18B	$-1.09B	$-1.01B
AOCI	$-25M	$-31M	$-33M	$-57M	$-33M	$-21M	$-25M	$-32M	$-32M	$-30M	$-14M	$40M
Stockholders' Equity	$489M	$588M	$387M	$573M	$772M	$743M	$1.47B	$1.05B	$281M	$100M	$201M	$258M
Liabilities + Equity	$3.52B	$3.00B	$2.99B	$2.53B	$2.61B	$2.39B	$3.23B	$2.67B	$1.32B	$912M	$948M	$956M
Shares Outstanding	163,304,875	157,908,815	144,340,526	142,057,736	141,210,015	140,365,594	140,339,615	137,928,828	124,976,373	121,636,273	120,351,480	118,442,726

Flusso di cassa 14

Metrica	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Stock-based Comp	$134M	$130M	$106M	$100M	$121M	$230M	$147M	$131M	$86M	$72M	$59M	$31M
Deferred Tax	$0	$0	$0	$0	$0	$342M	$904.0K	$-291M	$0	$0	$0	$-11M
Amort. of Intangibles	$2M	$2M	$3M	$2M	$2M	$2M	$2M	$2M	$2M	$2M	·	·
Operating Cash Flow	$-269M	$-501M	$-308M	$-274M	$31M	$36M	$346M	$603M	$174M	$-112M	$21M	$6M
CapEx	$51M	$45M	$24M	$16M	$12M	$35M	$31M	$14M	$35M	$7M	$8M	$8M
Investing Cash Flow	$-278M	$-134M	$-214M	$-263M	$195M	$274M	$-41M	$-930M	$-358M	$57M	$-60M	·
Stock Issued	$0	$489M	$0	$0	·	$0	$0	$448M	$72M	$0	$0	$0
Stock Repurchased	·	·	·	$0	$0	$91M	$34M	$0	$0	·	·	·
Net Stock Activity	$0	$489M	·	$0	$0	$-91M	$-34M	·	$72M	·	$0	$0
Financing Cash Flow	$676M	$478M	$644M	$-55M	$246M	$-597M	$100M	$476M	$229M	$11M	$25M	·
Net Change in Cash	$130M	$-157M	$123M	$-593M	$472M	$-286M	$404M	$149M	$45M	$-44M	$-14M	·
Taxes Paid	$-639.0K	$-6M	$48M	$5M	·	$26M	$9M	$0	$0	·	·	·
Free Cash Flow	$-320M	$-546M	$-331M	$-290M	$19M	$772.0K	$315M	$589M	$139M	$-119M	$13M	$-1M
Levered FCF	$-337M	$-563M	$-345M	$-299M	$10M	$-128M	$272M	$716M	$106M	$-159M	$-23M	$-17M

Redditività 7

Metrica	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Operating Margin	·	·	·	·	·	·	·	·	4.8%	-13.4%	-26.7%	-22.3%
Net Margin	·	·	·	·	·	·	·	·	-1.2%	-25.0%	-31.1%	-18.2%
Pretax Margin	·	·	·	·	·	·	·	·	-4.6%	-24.1%	-31.0%	-25.4%
EBITDA Margin	·	·	·	·	·	·	·	·	4.8%	-13.4%	-26.7%	-22.3%
ROA	-11.7%	-15.2%	-13.3%	-10.5%	-1.1%	-16.1%	10.0%	13.7%	-0.53%	-9.3%	-9.2%	-4.3%
ROE	-68.1%	-71.9%	-104.3%	-40.1%	-3.8%	-39.0%	23.4%	41.2%	-2.8%	-57.6%	-38.5%	-12.3%
ROIC	-17.1%	-26.0%	-23.8%	-24.5%	-3.8%	-58.4%	21.8%	16.5%	5.5%	-48.1%	-37.9%	-13.3%

Liquidità e Solvibilità 5

Metrica	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Current Ratio	3.8	8.5	5.9	7.1	9.7	3.7	10.0	7.9	5.2	6.0	5.6	7.3
Quick Ratio	3.4	7.4	5.2	6.4	3.6	0.7	2.5	1.0	0.6	0.6	0.9	1.2
Debt / Equity	3.6	2.0	3.2	2.1	·	·	·	·	·	·	·	·
LT Debt / Equity	2.7	2.0	3.2	2.1	·	·	·	·	·	·	·	·
Interest Coverage	-22.1	-28.0	-27.9	-50.5	-3.2	-3.8	7.5	-1.4	0.5	-1.2	-2.1	-2.1

Efficienza 2

Metrica	Tendenza	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Asset Turnover		·	·	·	·	·	·	·	·	0.5	0.4	0.3	0.2
Inventory Turnover		1.4	1.1	0.4	0.6	0.5	0.6	0.3	0.2	·	·	·	·

Per Azione 5

Metrica	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Book Value / Share	$2.99	$3.80	$2.68	$4.03	$5.47	$6.01	$10.48	$7.60	$2.65	$0.82	$1.67	$2.18
Revenue / Share	·	·	·	·	·	·	·	·	$4.03	·	·	·
Cash Flow / Share	$-1.68	$-3.35	$-2.15	$-1.93	$0.22	$0.26	$2.42	$4.50	$1.38	·	·	·
Cash / Share	$2.28	$1.53	$2.77	$1.95	$6.16	$2.83	$4.87	$2.02	$1.04	$0.70	$1.07	$1.21
EPS (TTM)	$-2.38	$-3.04	$-2.56	$-1.90	$-0.20	$-3.18	$1.90	$2.07	$0.15	$-0.50	$-0.74	$-0.35

Valutazione (TTM) 14

Metrica	2025	2024	2023	2022	2021	2020	2019	2018	2017	2016	2015	2014
Revenue TTM	$944M	$705M	$788M	$587M	$810M	$729M	$1.12B	$600M	$508M	$347M	$284M	$214M
Net Income TTM	$-381M	$-454M	$-366M	$-270M	$-29M	$-444M	$278M	$274M	$346.0K	$-60M	$-88M	$-39M
Market Cap	$12.92B	$5.52B	$7.30B	$5.37B	$4.30B	$7.94B	$8.48B	$7.46B	$6.29B	$5.82B	$7.45B	$7.31B
Enterprise Value	$12.00B	$4.43B	$6.21B	$4.55B	·	·	·	·	·	·	·	·
P/E	-33.2	-11.5	-19.8	-19.9	-152.2	-17.8	31.8	26.1	335.3	-95.7	-83.7	-176.4
P/S	13.7	7.8	9.3	9.1	5.3	10.9	7.6	12.4	12.4	16.8	26.3	34.1
P/B	26.4	9.2	18.9	9.4	5.6	9.4	5.8	7.1	19.0	58.4	37.1	28.4
P / Tangible Book	26.4	9.4	18.9	9.4	5.8	11.1	·	·	·	·	·	·
P / Cash Flow	-48.1	-11.0	-23.7	-19.6	139.5	221.1	24.5	12.4	36.1	-51.9	352.8	1163.5
P / FCF	-40.4	-10.1	-22.0	-18.5	228.0	10280.1	26.9	12.7	45.1	-48.8	554.9	-5930.8
EV / EBITDA	-31.4	-9.3	-17.6	-11.1	·	·	·	·	·	·	·	·
EV / FCF	-37.5	-8.1	-18.7	-15.7	·	·	·	·	·	·	·	·
EV / Revenue	12.7	6.3	7.9	7.8	·	·	·	·	·	·	·	·
Earnings Yield	-3.0%	-8.7%	-5.1%	-5.0%	-0.66%	-5.6%	3.1%	3.8%	0.30%	-1.1%	-1.2%	-0.57%

Conto Economico 15

Metrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Revenue	$268M	$246M	$203M	$157M	$452M	$132M	$227M	$134M	$225M	$119M	$325M	$144M	$188M	$131M	$152M	$160M
Cost of Revenue	$3M	$3M	$8M	$2M	$4M	$1M	$4M	$1M	$4M	$2M	$3M	$2M	$3M	$1M	$4M	$2M
SG&A Expense	$150M	$150M	$130M	$97M	$91M	$76M	$88M	$62M	$65M	$53M	$71M	$70M	$46M	$46M	$48M	$34M
Operating Expenses	$370M	$364M	$418M	$317M	$312M	$278M	$337M	$282M	$291M	$269M	$331M	$287M	$279M	$245M	$360M	$219M
Operating Income	$-102M	$-117M	$-214M	$-160M	$140M	$-147M	$-111M	$-149M	$-66M	$-150M	$-6M	$-143M	$-90M	$-114M	$-208M	$-59M
Interest Expense	$5M	$5M	$5M	$4M	$4M	$4M	$4M	$4M	$4M	$4M	$5M	$4M	$2M	$2M	$2M	$2M
Other Non-op	$987.0K	$-456.0K	$-16M	$363.0K	$102.0K	$465.0K	$302.0K	$142.0K	$610.0K	$277.0K	$235.0K	$2M	$11M	$230.0K	$123.0K	$5M
Pretax Income	$-113M	$-92M	$-228M	$-128M	$124M	$-147M	$-107M	$-144M	$-66M	$-143M	$-3M	$-141M	$-77M	$-113M	$-44M	$-47M
Income Tax	$1M	$218.0K	$1M	$213.0K	$-20.0K	$116.0K	$-3M	$-4M	$64.0K	$75.0K	$6M	$7M	$8M	$11M	$8M	$283.0K
Net Income	$-115M	$-93M	$-229M	$-129M	$124M	$-147M	$-104M	$-140M	$-66M	$-143M	$-9M	$-147M	$-85M	$-124M	$-52M	$-47M
EPS (Basic)	$-0.69	$-0.56	$-1.41	$-0.80	$0.78	$-0.93	$-0.66	$-0.95	$-0.45	$-0.98	$-0.06	$-1.03	$-0.60	$-0.87	$-0.37	$-0.33
EPS (Diluted)	$-0.69	$-0.56	$-1.41	$-0.80	$0.70	$-0.93	$-0.66	$-0.95	$-0.45	$-0.98	$-0.06	$-1.03	$-0.60	$-0.87	$-0.37	$-0.33
Shares (Basic)	165,419,000	164,874,000	·	159,765,000	159,137,000	158,735,000	·	148,593,000	145,958,000	145,538,000	·	143,317,000	143,098,000	142,735,000	·	141,950,000
Shares (Diluted)	165,419,000	164,874,000	·	159,765,000	182,331,000	158,735,000	·	148,593,000	145,958,000	145,538,000	·	143,317,000	143,098,000	142,735,000	·	141,950,000
EBITDA	$-102M	$-117M	·	$-160M	$140M	$-147M	·	$-149M	$-66M	$-150M	·	$-143M	$-90M	$-114M	·	$-59M

Stato Patrimoniale 23

Metrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Cash & Equivalents	$350M	$173M	$372M	$338M	$297M	$264M	$242M	$335M	$294M	$349M	·	$352M	$425M	$309M	·	$315M
Short-term Investments	$1.70B	$1.75B	$2.31B	$1.90B	$1.99B	$1.88B	$2.06B	$2.15B	$1.78B	$1.86B	·	$1.88B	$1.96B	$2.04B	·	$1.67B
Inventory	$51M	$6M	$10M	$10M	$8M	$12M	$13M	$28M	$29M	$30M	·	$26M	$26M	$22M	·	$21M
Other Current Assets	$327M	$306M	$237M	$244M	$226M	$223M	$218M	$184M	$195M	$174M	·	$181M	$178M	$160M	·	$143M
Current Assets	$2.49B	$2.94B	$2.99B	$2.52B	$2.58B	$2.42B	$2.62B	$2.71B	$2.33B	$2.42B	·	$2.58B	$2.62B	$2.54B	·	$2.15B
PP&E (Net)	$155M	$142M	$123M	$106M	$112M	$103M	$94M	$83M	$76M	$73M	·	$71M	$92M	$85M	·	$181M
Accum. Depreciation	·	·	$109M	·	·	·	$106M	·	·	·	·	·	·	·	·	·
Intangibles	·	·	·	·	·	·	·	·	·	·	·	·	·	·	·	$30M
Other Non-current Assets	$117M	$136M	$172M	$166M	$132M	$132M	$127M	$120M	$119M	$106M	·	$104M	$86M	$78M	·	$59M
Total Assets	$2.99B	$3.45B	$3.52B	$3.03B	$2.99B	$2.81B	$3.00B	$3.08B	$2.69B	$2.76B	·	$2.93B	$2.97B	$2.89B	·	$2.42B
Accounts Payable	$48M	$26M	$28M	$14M	$23M	$17M	$43M	$9M	$9M	$13M	·	$6M	$24M	$10M	·	$21M
Accrued Liabilities	$116M	$127M	$106M	$99M	$99M	$103M	$108M	$124M	$114M	$106M	·	$119M	$105M	$113M	·	$128M
Current Liabilities	$316M	$717M	$782M	$903M	$897M	$250M	$309M	$305M	$306M	$328M	·	$404M	$288M	$259M	·	$283M
Capital Leases	$262M	$259M	$262M	$263M	$164M	$159M	$162M	$168M	$166M	$169M	·	$173M	$175M	$177M	·	·
Other Non-current Liabilities	$28M	$28M	·	$29M	$59M	$56M	·	$42M	$42M	$42M	·	$49M	$16M	$7M	·	·
Total Liabilities	$2.55B	$2.96B	$3.03B	$2.42B	$2.35B	$2.34B	$2.42B	$2.42B	$2.43B	$2.47B	·	$2.62B	$2.54B	$2.40B	·	$1.83B
Long-term Debt	·	·	$1.81B	·	·	·	·	·	·	·	·	·	·	·	·	·
Common Stock	$166.0K	$166.0K	$163.0K	$161.0K	$159.0K	$159.0K	$158.0K	$158.0K	$146.0K	$146.0K	·	$143.0K	$143.0K	$143.0K	·	$142.0K
Retained Earnings	$-2.84B	$-2.72B	$-2.63B	$-2.40B	$-2.27B	$-2.40B	$-2.25B	$-2.15B	$-2.00B	$-1.94B	·	$-1.79B	$-1.64B	$-1.55B	·	$-1.38B
AOCI	$-34M	$-31M	$-25M	$-26M	$-28M	$-29M	$-31M	$-24M	$-35M	$-35M	·	$-46M	$-51M	$-49M	·	$-63M
Stockholders' Equity	$440M	$491M	$489M	$618M	$632M	$476M	$588M	$662M	$264M	$297M	$387M	$315M	$428M	$487M	$573M	$594M
Liabilities + Equity	$2.99B	$3.45B	$3.52B	$3.03B	$2.99B	$2.81B	$3.00B	$3.08B	$2.69B	$2.76B	·	$2.93B	$2.97B	$2.89B	·	$2.42B
Shares Outstanding	165,636,792	165,902,064	163,304,875	161,137,930	159,196,782	159,041,259	157,908,815	157,813,136	146,025,246	145,844,719	·	143,393,493	143,167,414	143,022,539	·	142,017,411

Flusso di cassa 11

Metrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Stock-based Comp	$46M	$43M	$43M	$31M	$30M	$30M	$36M	$32M	$31M	$31M	$26M	$26M	$27M	$27M	$26M	$24M
Amort. of Intangibles	$700.0K	$661.0K	$638.0K	$621.0K	$598.0K	$582.0K	$459.0K	$617.0K	$621.0K	$639.0K	$655.0K	$660.0K	$637.0K	$607.0K	$610.0K	$608.0K
Operating Cash Flow	$566M	$-793M	$-138M	$-131M	$151M	$-151M	$-116M	$-115M	$-120M	$-150M	$33M	$-109M	$-97M	$-134M	$-200M	$-24M
CapEx	$16M	$22M	$21M	$5M	$12M	$13M	$25M	$9M	$6M	$4M	$-819.0K	$2M	$12M	$10M	$4M	$6M
Investing Cash Flow	$23M	$537M	$-420M	$91M	$-120M	$170M	$68M	$-341M	$62M	$76M	$-27M	$69M	$70M	$-326M	$212M	$-184M
Stock Issued	·	·	$0	·	·	·	$27.0K	·	·	·	$0	·	·	·	·	·
Financing Cash Flow	$-412M	$57M	$591M	$81M	$1M	$2M	$-44M	$496M	$3M	$24M	$41M	$-32M	$144M	$492M	$-51M	$2M
Net Change in Cash	$177M	$-199M	$34M	$41M	$33M	$22M	$-93M	$41M	$-55M	$-50M	$47M	$-73M	$116M	$33M	$-39M	$-207M
Taxes Paid	$1M	$-8.0K	$22.0K	$-278.0K	$17.0K	$-400.0K	$-8M	$80.0K	$2M	$13.0K	·	·	·	·	·	·
Free Cash Flow	·	$-815M	·	·	·	$-163M	·	·	·	$-154M	·	·	·	$-144M	·	·
Levered FCF	·	$-820M	·	·	·	$-167M	·	·	·	$-159M	·	·	·	$-146M	·	·

Redditività 7

Metrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Operating Margin	-38.2%	-47.7%	·	-102.2%	30.9%	-111.6%	·	-111.1%	-29.3%	-125.1%	·	-99.4%	-47.9%	-87.5%	·	-37.0%
Net Margin	-42.8%	-37.6%	·	-82.1%	27.3%	-111.6%	·	-105.0%	-29.4%	-119.5%	·	-102.2%	-45.3%	-95.2%	·	-29.4%
Pretax Margin	-42.3%	-37.5%	·	-81.9%	27.3%	-111.6%	·	-107.7%	-29.4%	-119.4%	·	-97.6%	-41.1%	-86.5%	·	-29.2%
EBITDA Margin	-38.2%	-47.7%	·	-102.2%	30.9%	-111.6%	·	-111.1%	-29.3%	-125.1%	·	-99.4%	-47.9%	-87.5%	·	-37.0%
ROA	-3.8%	-2.9%	·	-4.2%	4.3%	-5.3%	·	-4.7%	-2.3%	-5.1%	·	-5.5%	-3.1%	-4.6%	·	-1.9%
ROE	-21.4%	-19.1%	·	-20.1%	27.6%	-38.0%	·	-28.7%	-19.1%	-36.5%	·	-32.4%	-16.2%	-20.8%	·	-8.3%
ROIC	-23.5%	-23.9%	·	-26.0%	22.1%	-30.9%	·	-21.9%	-25.1%	-50.4%	·	-47.5%	-23.2%	-25.8%	·	-10.0%

Liquidità e Solvibilità 3

Metrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Current Ratio	7.9	4.1	·	2.8	2.9	9.7	·	8.9	7.6	7.4	·	6.4	9.1	9.8	·	7.6
Quick Ratio	6.5	2.7	·	2.5	2.6	8.6	·	8.2	6.8	6.7	·	5.5	8.3	9.1	·	7.0
Interest Coverage	-22.2	-22.8	·	-38.0	34.0	-35.7	·	-35.7	-14.7	-36.0	·	-34.1	-39.4	-71.0	·	-27.7

Efficienza 2

Metrica	Tendenza	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Asset Turnover		0.1	0.1	·	0.1	0.2	0.0	·	0.0	0.1	0.0	·	0.1	0.1	0.0	·	0.1
Inventory Turnover		0.1	0.3	·	0.1	0.2	0.1	·	0.0	0.2	0.1	·	0.1	0.1	0.1	·	0.1

Per Azione 5

Metrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Book Value / Share	$2.65	$2.96	·	$3.83	$3.97	$2.99	·	$4.20	$1.81	$2.03	·	$2.20	$2.99	$3.40	·	$4.19
Revenue / Share	$1.62	$1.49	·	$0.98	$2.48	$0.83	·	$0.90	$1.54	$0.82	·	$1.01	$1.32	$0.91	·	$1.13
Cash Flow / Share	·	$-4.81	·	·	·	$-0.95	·	·	·	$-1.03	·	·	·	$-0.94	·	·
Cash / Share	$2.11	$1.05	·	$2.10	$1.87	$1.66	·	$2.12	$2.01	$2.39	·	$2.46	$2.97	$2.16	·	$2.22
EPS (TTM)	$-3.46	$-2.07	·	$-1.69	$-1.84	$-2.99	·	$-2.44	$-2.52	$-2.67	·	$-2.87	$-2.17	$-2.31	·	$0.06

Valutazione (TTM) 9

Metrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Revenue TTM	$874M	$1.06B	·	$967M	$944M	$717M	·	$803M	$813M	$777M	·	$615M	$631M	$576M	·	$875M
Net Income TTM	$-565M	$-327M	·	$-256M	$-268M	$-458M	·	$-359M	$-366M	$-385M	·	$-409M	$-309M	$-329M	·	$7M
Market Cap	$13.13B	$12.46B	·	$10.54B	$6.29B	$4.80B	·	$6.32B	$6.96B	$6.32B	·	$6.50B	$5.87B	$5.11B	·	$6.28B
P/E	-22.9	-36.3	·	-38.7	-21.5	-10.1	·	-16.4	-18.9	-16.2	·	-15.8	-18.9	-15.5	·	737.2
P/S	15.0	11.8	·	10.9	6.7	6.7	·	7.9	8.6	8.1	·	10.6	9.3	8.9	·	7.2
P/B	29.9	25.4	·	17.1	10.0	10.1	·	9.5	26.4	21.3	·	20.6	13.7	10.5	·	10.6
P / Tangible Book	29.9	25.4	·	17.1	10.0	10.1	·	9.5	26.4	21.3	·	20.6	13.7	10.5	·	11.1
P / Cash Flow	·	-15.7	·	·	·	-31.8	·	·	·	-42.2	·	·	·	-38.1	·	·
Earnings Yield	-4.4%	-2.8%	·	-2.6%	-4.7%	-9.9%	·	-6.1%	-5.3%	-6.2%	·	-6.3%	-5.3%	-6.5%	·	0.14%

Periodo più recente a sinistra · valori nulli mostrati come ·

Bilanci Conto economico, stato patrimoniale, flusso di cassa — annuale, ultimi 5 anni

16

Metrica	2025-12-31	2024-12-31	2023-12-31	2022-12-31	2021-12-31
Utile netto	$-381M	$-454M	$-366M	$-270M	$-29M
EPS Diluito	$-2.38	$-3.04	$-2.56	$-1.90	$-0.20

Metrica	2025-12-31	2024-12-31	2023-12-31	2022-12-31	2021-12-31
Debito / Patrimonio Netto	3.6	2.0	3.2	2.1	·
Rapporto corrente	3.8	8.5	5.9	7.1	9.7
Quick Ratio	3.4	7.4	5.2	6.4	3.6

Metrica	2025-12-31	2024-12-31	2023-12-31	2022-12-31	2021-12-31
Flusso di cassa libero	$-320M	$-546M	$-331M	$-290M	$19M

Proprietari istituzionali (13F) 573 filer · $15.7B totale · Aggiornato al 30 Settembre 2026

17

Istituzioni che segnalano il possesso di questo titolo nel loro Modulo SEC 13F trimestrale. Solo posizioni lunghe; un singolo depositante può apparire due volte per diverse gambe di opzioni. Grandi posizioni put/call contrapposte riflettono tipicamente market-making o inventario coperto, non convinzione direzionale.

Detentori 573

Valore detenuto $15.7B

Nuove posizioni 73

Posizioni chiuse 41

Attività istituzionale — Q2 2026 vs trimestre precedente

Nuove posizioni	Posizioni chiuse	Aumentato	Diminuito	Variazione netta delle azioni
73 (-19 vs trimestre precedente)	41 (-24 vs trimestre precedente)	213 (+26 vs trimestre precedente)	159 (+3 vs trimestre precedente)	+10.5M

Confrontato con Q1 2026. Le dichiarazioni SEC Form 13F sono dovute entro 45 giorni dalla fine del trimestre più un breve margine per i dichiaranti in ritardo — i trimestri ancora all'interno di questa finestra vengono saltati a favore della coppia più recente completamente riportata.

Istituzione	Valore	Azioni	% di 13F tracciati	Tipo
FMR LLC	$1.953.067.764	24.631.956	12,47%	Azioni
Capital World Investors	$1.718.152.930	21.669.226	10,97%	Azioni
VANGUARD GROUP INC	$1.300.604.712	16.440.459	8,31%	Azioni
BlackRock, Inc.	$848.772.532	10.704.660	5,42%	Azioni
VANGUARD PORTFOLIO MANAGEMENT LLC	$623.182.054	7.859.529	3,98%	Azioni
WELLINGTON MANAGEMENT GROUP LLP	$606.680.694	7.651.415	3,87%	Azioni
VANGUARD CAPITAL MANAGEMENT LLC	$571.799.597	7.211.497	3,65%	Azioni
TWO SIGMA INVESTMENTS, LP	$495.748.197	6.252.342	3,17%	Azioni
ROYAL BANK OF CANADA	$490.209.000	6.182.479	3,13%	Azioni
STATE STREET CORP	$343.710.098	4.334.848	2,20%	Azioni
GEODE CAPITAL MANAGEMENT, LLC	$294.752.810	3.584.024	1,88%	Azioni
TWO SIGMA ADVISERS, LP	$241.452.501	3.052.111	1,54%	Azioni
JPMORGAN CHASE & CO	$216.198.792	2.671.717	1,38%	Azioni
Artisan Partners Limited Partnership	$209.327.536	2.640.024	1,34%	Azioni
Tweedy, Browne Co LLC	$180.805.859	2.280.311	1,15%	Azioni
Deep Track Capital, LP	$174.438.000	2.200.000	1,11%	Azioni
GOLDMAN SACHS GROUP INC	$167.297.540	2.109.945	1,07%	Azioni
BAKER BROS. ADVISORS LP	$162.364.274	2.047.727	1,04%	Azioni
DEERFIELD MANAGEMENT COMPANY, L.P.	$156.967.955	1.979.669	1,00%	Azioni
AMERICAN CENTURY COMPANIES INC	$154.383.816	1.947.076	0,99%	Azioni
FRANKLIN RESOURCES INC	$128.717.601	1.623.377	0,82%	Azioni
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	$127.264.731	1.605.054	0,81%	Azioni
BARCLAYS PLC	$127.112.653	1.603.136	0,81%	Azioni
Pictet Asset Management Holding SA	$126.981.913	1.596.998	0,81%	Azioni
Polar Capital Holdings Plc	$115.289.325	1.454.021	0,74%	Azioni
Alyeska Investment Group, L.P.	$112.426.560	1.417.916	0,72%	Azioni
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	$110.805.207	1.475.632	0,71%	Azioni
SUSQUEHANNA INTERNATIONAL GROUP, LLP	$103.108.716	1.300.400	0,66%	Opzione Call
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	$103.108.000	1.300.392	0,66%	Azioni
MORGAN STANLEY	$101.605.768	1.281.444	0,65%	Azioni
Invesco Ltd.	$88.860.858	1.120.707	0,57%	Azioni
VANGUARD FIDUCIARY TRUST CO	$84.114.400	1.060.845	0,54%	Azioni
Bellevue Group AG	$77.090.336	972.258	0,49%	Azioni
GROUPAMA ASSET MANAGMENT	$75.195.315	937.083	0,48%	Azioni
NORTHERN TRUST CORP	$72.440.137	913.610	0,46%	Azioni
Capital International Investors	$65.316.248	823.764	0,42%	Azioni
SUSQUEHANNA INTERNATIONAL GROUP, LLP	$65.184.309	822.100	0,42%	Opzione Put
Davern Capital Partners, LP	$63.329.637	798.709	0,40%	Azioni
BANK OF AMERICA CORP /DE/	$62.717.591	790.990	0,40%	Azioni
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC	$62.422.083	787.263	0,40%	Azioni
BNP PARIBAS ASSET MANAGEMENT Holding S.A.	$58.216.225	734.219	0,37%	Azioni
Nuveen, LLC	$57.586.900	726.282	0,37%	Azioni
Connor, Clark & Lunn Investment Management Ltd.	$54.253.072	684.236	0,35%	Azioni
Eversept Partners, LP	$52.702.794	664.684	0,34%	Azioni
VOLORIDGE INVESTMENT MANAGEMENT, LLC	$51.970.948	655.454	0,33%	Azioni
MASSACHUSETTS FINANCIAL SERVICES CO /MA/	$51.682.490	651.816	0,33%	Azioni
NEUBERGER BERMAN GROUP LLC	$50.232.832	633.533	0,32%	Azioni
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	$50.113.500	632.028	0,32%	Azioni
Caption Management, LLC	$49.952.700	630.000	0,32%	Opzione Call
UBS Group AG	$49.546.260	624.874	0,32%	Azioni

Mostra tutti i 573 proprietari istituzionali →

Attivisti e proprietari del 5%+ 5 partecipazioni

18

Investitori che hanno depositato SEC Schedule 13D — proprietà effettiva superiore al 5% con l'intento di influenzare l'emittente (partecipazioni attiviste, campagne per il consiglio di amministrazione, M&A). Ogni riga mostra lo stato più recente noto della posizione di quel depositante.

Depositante	Depositato	Partecipazione	Stato	Scopo	Deposito
Ionis Pharmaceuticals, Inc. (“Ionis”) ×8 depositi	13 Ottobre 2020	·	Deposito iniziale	M&A / vendita	SEC
Isis Pharmaceuticals, Inc. (“ Isis ”)	31 Luglio 2015	·	Deposito iniziale	·	SEC
Isis Pharmaceuticals, Inc. (“Isis”), Stanley T. Crooke (“Crooke”), B. Lynne Parshall (“Parshall”) ×2 depositi	06 Novembre 2014	·	Deposito iniziale	·	SEC
Genzyme Corporation	15 Gennaio 2008	·	Deposito iniziale	Investimento passivo	SEC
Persona segnalante non divulgata	12 Aprile 2001	·	Deposito iniziale	Investimento passivo	SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Insider aziendali 47 insider · 30 dirigenti · 19 direttori

19

Insider	Ruolo	Ultima attività	Azioni possedute	Acquisti 12m	Vendite 12m	Netto 12m
Brett P Monia	Chief Executive Officer	31 Agosto 2026 J	242.760	0	14	$-30.354.355
HOUGEN ELIZABETH L	EVP, Finance & CFO	16 Marzo 2026 M	82.660	0	5	$-17.867.127
Kleanthis G Xanthopoulos	President of Regulus	03 Dicembre 2007 A	·	0	0	$0
Brian Birchler	EVP, Corp and Development Ops	31 Agosto 2026 J	102.883	0	6	$-3.556.351
O'NEIL PATRICK R.	EVP CLO & General Counsel	31 Agosto 2026 J	59.205	0	6	$-3.159.716
BENNETT C FRANK	EVP, Chief Scientific Officer	31 Agosto 2026 J	60.128	0	10	$-16.705.490
Holly B. Kordasiewicz	EVP, Chief Development Officer	07 Luglio 2026 S	22.096	0	4	$-4.810.107
Eugene Schneider	EVP, Chf Clinical Develop Ofcr	26 Giugno 2026 M	77.114	0	4	$-3.738.554
Joseph Baroldi	EVP, Chief Business Officer	26 Giugno 2026 M	4.669	0	12	$-2.680.735
Eric Swayze	EVP Research	25 Giugno 2026 S	21.759	0	10	$-5.712.145
Kyle Jenne	EVP, Chf GL Pdt Str Ofcr	15 Aprile 2026 M	23.713	0	4	$-3.334.240
Shannon L. Devers	EVP, Chief Human Resources Ofc	02 Aprile 2026 S	16.348	0	14	$-8.661.485
Richard S Geary	EVP, Chief Development Officer	06 Novembre 2025 M	59.657	0	11	$-9.577.499
Onaiza Cadoret-Manier	EVP,Chf GL Pdt Str & Oper Ofc	02 Febbraio 2024 S	35.788	0	0	$0
Stanley T Crooke	Exec Chairman of the Board	26 Gennaio 2021 S	2.021	0	0	$0
Damien Mcdevitt	Chief Business Officer	15 Luglio 2019 M	2.573	0	0	$0
Sarah Boyce	Chief Business Officer	15 Gennaio 2018 M	8.931	0	0	$0
ECKER DAVID J	Vice President	02 Settembre 2008 M	0	0	0	$0
Michael J Treble	Vice President, Pres of Ibis	11 Agosto 2008 M	0	0	0	$0
Jeffrey M Jonas	Executive Vice President	02 Gennaio 2008 A	·	0	0	$0
Mark K Wedel	VP & Chief Medical Officer	06 Luglio 2007 M	6.603	0	0	$0
LEVIN ARTHUR A	Vice President	25 Aprile 2007 M	1.674	0	0	$0
BROWN RICHARD K	Vice President	08 Marzo 2006 M	2.348	0	0	$0
MCNEIL JOHN A	Vice President	03 Gennaio 2005 A	·	0	0	$0
LOWENSTAM PATRICIA	Vice President	03 Gennaio 2005 A	603	0	0	$0
STEIN ARON	Vice President	01 Luglio 2004 J	1.536	0	0	$0
Hans A De Haan	VP, Drug Development	27 Aprile 2004 S	0	0	0	$0
LUNDSTEDT KAREN S	Vice President	10 Marzo 2004 M	5.407	0	0	$0
COLE DOUGLAS L	Vice President	09 Marzo 2004 M	9.616	0	0	$0
HOLMLUND JON T	Vice President	01 Luglio 2003 J	983	0	0	$0
Michael R Hayden	Direttore	31 Luglio 2026 P	24.000	2	0	$1.058.700
Peter N Reikes	Direttore	15 Luglio 2026 A	14.222	0	0	$0
Ludwig Hantson	Direttore	15 Luglio 2026 A	·	0	0	$0
Joan E Herman	Direttore	15 Luglio 2026 M	51.306	0	2	$-3.173.720
BERTHELSEN SPENCER R	Direttore	15 Luglio 2026 M	161.233	0	2	$-1.193.280
Allene M. Diaz	Direttore	07 Luglio 2026 M	3.811	0	4	$-5.218.027
Michael J. Yang	Direttore	01 Luglio 2026 A	7.940	0	0	$0
Joseph Loscalzo	Direttore	01 Luglio 2026 A	36.330	0	5	$-7.085.472
Joseph Klein III	Direttore	01 Luglio 2026 A	11.014	0	12	$-5.996.036
Lynne B Parshall	Direttore	15 Aprile 2026 S	51.344	0	4	$-1.153.667
Joseph H Wender	Direttore	01 Dicembre 2025 S	36.035	0	6	$-4.335.515
MUTO FREDERICK T	Direttore	15 Luglio 2022 M	59.597	0	0	$0
Breaux Castleman	Direttore	01 Luglio 2020 A	19.183	0	0	$0
REED JOHN C	Direttore	06 Settembre 2012 M	0	0	0	$0
Richard D Dimarchi	Direttore	01 Luglio 2010 A	·	0	0	$0
GARIELI CHRISTOPHER	Direttore	01 Luglio 2005 A	155.431	0	0	$0
SKALETSKY MARK B	Direttore	01 Luglio 2004 A	·	0	0	$0

Insider dai depositi SEC Modulo 3/4/5; netto = solo acquisti/vendite di mercato

Proprietà ETF Posseduti da 59 ETF

20

Il peso riflette solo le partecipazioni azionarie dirette (N-PORT); fondi a leva o basati su derivati possono detenere ulteriore esposizione swap non mostrata.

Fondo	Peso	Unità	Aggiornato al	Fonte
ARKG · ARK ETF Trust	1,77%	531.633 NS	31 Luglio 2026	N-PORT
BBP · ETFis Series Trust I	0,97%	18.522 NS	31 Luglio 2026	N-PORT
FXH · First Trust Exchange-Traded AlphaDE…	0,89%	179.574 NS	31 Luglio 2026	N-PORT
IBB · iShares Trust	0,67%	1.239.007 SH	11 Settembre 2026	Giornaliero
NUSC · Nushares ETF Trust	0,61%	151.535 NS	31 Luglio 2026	N-PORT
IBBQ · Invesco Exchange-Traded Fund Trust …	0,49%	11.744 SH	01 Ottobre 2026	Giornaliero
LABU · Direxion Shares ETF Trust	0,48%	46.023 NS	31 Luglio 2026	N-PORT
QQQJ · Invesco Exchange-Traded Fund Trust …	0,38%	98.367 SH	01 Ottobre 2026	Giornaliero
VBK · VANGUARD INDEX FUNDS	0,34%	2.078.639 SH	19 Agosto 2026	Giornaliero
FNY · First Trust Exchange-Traded AlphaDE…	0,31%	34.728 NS	31 Luglio 2026	N-PORT
ISCG · iShares Trust	0,30%	52.262 SH	11 Settembre 2026	Giornaliero
IWP · iShares Trust	0,25%	873.674 SH	11 Settembre 2026	Giornaliero
BKMC · BNY Mellon ETF Trust	0,21%	26.705 NS	31 Luglio 2026	N-PORT
MEDI · Harbor ETF Trust	0,20%	1.631 NS	31 Luglio 2026	N-PORT
VFMO · VANGUARD WELLINGTON FUND	0,20%	50.927 SH	19 Agosto 2026	Giornaliero
BBMC · J.P. Morgan Exchange-Traded Fund Tr…	0,18%	72.134 NS	31 Luglio 2026	N-PORT
VHT · VANGUARD WORLD FUND	0,18%	471.609 SH	19 Agosto 2026	Giornaliero
PRFZ · Invesco Exchange-Traded Fund Trust	0,18%	106.774 SH	01 Ottobre 2026	Giornaliero
ESML · iShares Trust	0,16%	78.845 SH	11 Settembre 2026	Giornaliero
FSMD · FIDELITY COVINGTON TRUST	0,15%	74.249 NS	31 Luglio 2026	N-PORT
VXF · VANGUARD INDEX FUNDS	0,15%	1.895.610 SH	19 Agosto 2026	Giornaliero
VB · VANGUARD INDEX FUNDS	0,15%	3.600.281 SH	19 Agosto 2026	Giornaliero
JMOM · J.P. Morgan Exchange-Traded Fund Tr…	0,15%	71.364 NS	31 Luglio 2026	N-PORT
IYH · iShares Trust	0,15%	96.087 SH	11 Settembre 2026	Giornaliero
FFLG · FIDELITY COVINGTON TRUST	0,14%	16.403 NS	31 Luglio 2026	N-PORT
PWS · Pacer Funds Trust	0,14%	629 NS	31 Luglio 2026	N-PORT
SMMD · iShares Trust	0,13%	87.867 SH	11 Settembre 2026	Giornaliero
FHLC · FIDELITY COVINGTON TRUST	0,12%	74.568 NS	31 Luglio 2026	N-PORT
FNX · First Trust Exchange-Traded AlphaDE…	0,10%	25.981 NS	31 Luglio 2026	N-PORT
FAD · First Trust Exchange-Traded AlphaDE…	0,09%	10.429 NS	31 Luglio 2026	N-PORT
WSML · iShares Trust	0,08%	9.648 SH	11 Settembre 2026	Giornaliero
EQAL · Invesco Exchange-Traded Fund Trust …	0,08%	13.559 SH	01 Ottobre 2026	Giornaliero
IWR · iShares Trust	0,07%	673.792 SH	11 Settembre 2026	Giornaliero
LRND · New York Life Investments ETF Trust	0,05%	3.731 NS	31 Luglio 2026	N-PORT
VONG · VANGUARD SCOTTSDALE FUNDS	0,04%	244.940 SH	19 Agosto 2026	Giornaliero
DYNF · BlackRock ETF Trust	0,04%	269.218 SH	11 Settembre 2026	Giornaliero
IWF · iShares Trust	0,03%	582.970 SH	11 Settembre 2026	Giornaliero
VTI · VANGUARD INDEX FUNDS	0,02%	4.990.066 SH	19 Agosto 2026	Giornaliero
VONE · VANGUARD SCOTTSDALE FUNDS	0,02%	27.263 SH	19 Agosto 2026	Giornaliero
VTHR · VANGUARD SCOTTSDALE FUNDS	0,02%	13.860 SH	19 Agosto 2026	Giornaliero
ESGV · VANGUARD WORLD FUND	0,02%	37.171 SH	19 Agosto 2026	Giornaliero
TILT · FlexShares Trust	0,01%	6.110 NS	31 Luglio 2026	N-PORT
IWB · iShares Trust	0,01%	113.547 SH	11 Settembre 2026	Giornaliero
IYY · iShares Trust	0,01%	6.926 SH	10 Settembre 2026	Giornaliero
ITOT · iShares Trust	0,01%	218.402 SH	11 Settembre 2026	Giornaliero
IWV · iShares Trust	0,01%	45.548 SH	10 Settembre 2026	Giornaliero
RECS · Columbia ETF Trust I	0,01%	14.074 NS	31 Luglio 2026	N-PORT
VT · VANGUARD INTERNATIONAL EQUITY INDEX…	0,01%	144.631 SH	19 Agosto 2026	Giornaliero
IWS · iShares Trust	0,01%	13.733 SH	10 Settembre 2026	Giornaliero
DCOR · Dimensional ETF Trust	0,00%	2.712 NS	31 Luglio 2026	N-PORT
IWD · iShares Trust	0,00%	20.479 SH	11 Settembre 2026	Giornaliero
DFUS · Dimensional ETF Trust	0,00%	5.654 NS	31 Luglio 2026	N-PORT
REVS · Columbia ETF Trust I	0,00%	82 NS	31 Luglio 2026	N-PORT
DFAU · Dimensional ETF Trust	0,00%	1.669 NS	31 Luglio 2026	N-PORT
DFSU · Dimensional ETF Trust	0,00%	236 NS	31 Luglio 2026	N-PORT
VONV · VANGUARD SCOTTSDALE FUNDS	0,00%	5.617 SH	19 Agosto 2026	Giornaliero
ISCB · iShares Trust	·	7.426 SH	11 Settembre 2026	Giornaliero
SMLF · iShares Trust	·	134.548 SH	11 Settembre 2026	Giornaliero
SMMV · iShares Trust	·	15.473 SH	01 Settembre 2026	Giornaliero

IONS Consenso degli analisti Opinioni degli analisti, sia rialziste che ribassiste, target price a 12 mesi, potenziale di rialzo

21

rating · 32 analisti COMPRA

Target mediano $85.00 +95,2%

8 25,0% Acquisto forte

17 53,1% Compra

7 21,9% Mantieni

0 0,0% Vendi

0 0,0% Vendita forte

Target Price a 12 Mesi

22 analisti · 2026-09-29

Target medio $83.64 +92,1%

← Sotto tutti i target Prezzo attuale $43.54

Basso$54.00 Media$83.64 Alto$105.00

Confronto Peer (GICS sub-settore industriale) Metriche chiave rispetto ai pari del settore

22

Base FY, prezzi alla chiusura dell'ultimo anno fiscale di ciascuna società.

Ticker	Capitalizzazione di Mercato	P/E	Rev YoY	Margine Netto	ROE	Margine lordo
IONS	$12.92B	-33.2	·	·	-68.1%	·
PRAX	$7.43B	-21.9	249.5%	·	-47.3%	·
SYRE	$2.56B	10.1	-62.0%	·	-26.5%	·
CAI	$7.62B	-8.4	97.0%	-8.4%	-13.2%	·
IMVT	$5.07B	-9.0	229.2%	·	-73.7%	·
RYTM	$7.19B	-34.4	45.8%	-103.6%	-309.1%	·
IOVA	$1.12B	-2.5	60.6%	-148.4%	-56.0%	·
GRAL	$3.45B	-7.7	17.2%	-277.5%	-16.7%	·

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26

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IONS Ionis Pharmaceuticals, Inc. - Common Stock