ZYME Snapshot del titolo Prezzo, capitalizzazione di mercato, P/E, EPS, ROE, debito/capitale proprio, intervallo 52 settimane

03

Prezzo $25.15

Capitalizzazione di Mercato (MRQ) $1.80B

P/E (TTM) -12.5

EPS (TTM) $-2.02

Ricavi (TTM) $37M

ROE (TTM) -72.3%

Intervallo 52 sett. $16–$31

ZYME Grafico del prezzo delle azioni OHLCV giornaliero con indicatori tecnici — panoramica, zoom e personalizza la tua visualizzazione

04

intervallo

barre

La granularità delle barre si adatta al periodo selezionato — passa il mouse sul grafico per vedere apertura/massimo/minimo/chiusura di una barra.

Informazioni su Zymeworks Inc. - Common Stock Panoramica della società da Wikipedia

05 · wikidata

Zymeworks Inc. is a publicly held biotechnology company based in Vancouver,

British Columbia, that develops protein therapeutics for the treatment of cancer as well as for autoimmune and inflammatory diseases. The products are based upon the company's molecular modeling software for optimizing protein structure. In 2014, Zymeworks raised $44 million across various funding rounds according to PitchBook, placing it among the top 10 HealthTech businesses in the world to raise the most capital that year. In May 2017, Zymeworks held an IPO on the Toronto Stock Exchange, raising $59 million. This was the largest Canadian biotech IPO in more than a decade. By alphabetical order, Zymeworks is the last company on the Toronto Stock Exchange.

In May 2019, Zymeworks announced that GSK has expanded its 2016 licensing and collaboration agreement for the research, development and commercialization of bispecific antibodies across multiple disease areas. The extended agreement has meant that GSK can have access to Zymeworks' heavy-light chain pairing technology, which enables the development of bispecific and multifunctional therapeutics.

In September 2019, Zymeworks announced that, following their clinical trials, it has been confirmed that their ZW25 monotherapy can provide durable disease control in patients with a variety of HER2-expressing solid tumors that have progressed following standard of care treatments.

In May 2022, Zymeworks rejected an unsolicited takeover proposal from a Dubai hedge fund, All Blue Falcons FZE, an arm of All Blue Capital.

Azymetric

This is an IgG1-based heterodimeric antibody scaffold that consists of two different heavy chains engineered to exclusively assemble into a single molecule, allowing bi-specific binding to two different antigens or drug targets. The Azymetric scaffold is engineered by making amino acid changes in the CH3 region of the constant Fc domain of the IgG1. This scaffold can also be engineered with tailored effector function and optimized serum half-life.

Awards and recognition

Deal of the Year, Lifesciences BC Awards, 2018

Life Sciences Company of the Year, Lifesciences BC Awards, 2016

Emerging company of the year – Health, BIOTECanada Gold Leaf Awards, 2015

12th Place, BC's Leading Innovators, 2011

Life Science Emerging Rocket, 2009, 2010, 2011

Early stage Company of the year – Industrial & Agriculture, BIOTECanada Gold Leaf Awards, 2009

== References ==

Leggi di più Mostra meno

Fonte: Wikipedia (Inglese), CC BY-SA 4.0 · Vedi su Wikipedia ↗

Wikidata ↗

settoreHealthcare industriaBiotechnology dipendenti231 paeseUS

Performance decennale Andamento di ricavi, utile netto, margini e EPS

06

Ricavi$106M

2020-12-31 → 2025-12-31

EPS$-1.08

2020-12-31 → 2025-12-31

Flusso di cassa libero$-35M

2023-12-31 → 2025-12-31

Margine netto-404.0%

2023-12-31 → 2025-12-31

Valutazione e Rapporti 07–12

Valutazione Rapporti P/E, P/S, P/B, EV/EBITDA — il titolo è costoso o economico?

Metrica	ZYME	media 5 anni	Mediana dei peer	Verdetto
P/E (TTM)	-12.5media 5 anni ≈-8.8	≈-8.8	·	·
P/S (TTM)	48.4media 5 anni ≈13.8	≈13.8	10.3	Sopravvalutato
P/B (MRQ)	22.3media 5 anni ≈4.0	≈4.0	3.7	Sopravvalutato
Prezzo / FCF (TTM)	-14.9media 5 anni ≈-24.0	≈-24.0	·	·
Prezzo / Flusso di cassa (TTM)	-15.0media 5 anni ≈-25.0	≈-25.0	·	·
Prezzo / Valore contabile tangibile (MRQ)	22.6media 5 anni ≈3.4	≈3.4	·	·

La mediana dei peer viene calcolata su base standardizzata per metrica e potrebbe non corrispondere sempre alla base TTM/MRQ mostrata per questo titolo.

Redditività Margini lordi, operativi e netti; ROE, ROA, ROIC

Metrica	ZYME	media 5 anni	Mediana dei peer	Verdetto
Margine Operativo (TTM)	-419.0%media 5 anni ≈-149.5%	≈-149.5%	-588.2%	Debole
EBITDA Margin (Margine EBITDA)	-87.3%media 5 anni ≈-149.5%	≈-149.5%	-588.2%	Debole
Margine ante imposte (TTM)	-407.8%media 5 anni ≈-128.3%	≈-128.3%	-709.2%	Debole
Margine di Profitto Netto (TTM)	-404.0%media 5 anni ≈-131.2%	≈-131.2%	-507.2%	Debole
ROA (TTM)	-37.2%media 5 anni ≈-21.0%	≈-21.0%	-29.6%	Di prim'ordine
ROE (TTM)	-72.3%media 5 anni ≈-29.5%	≈-29.5%	-42.0%	Di prim'ordine
ROIC	-35.1%media 5 anni ≈-35.7%	≈-35.7%	·	·

Salute finanziaria Debito, liquidità, solvibilità — solidità del bilancio

Metrica	Tendenza 5 anni	ZYME	media 5 anni	Mediana dei peer	Verdetto
Rapporto corrente (MRQ)		6.3media 5 anni ≈5.6	≈5.6	9.0	Bassa liquidità
Quick Ratio		1.1media 5 anni ≈3.2	≈3.2	5.8	Bassa liquidità

Crescita Crescita di ricavi, EPS e utile netto: YoY, CAGR 3Y, CAGR 5Y

Metrica	ZYME	media 5 anni	Mediana dei peer	Verdetto
Revenue YoY (Ricavi YoY)	38.9%media 5 anni ≈274.4%	≈274.4%	·	·
Revenue CAGR 3Y (CAGR Ricavi 3Y)	-36.4%media 5 anni ≈10.2%	≈10.2%	·	·
Revenue CAGR 5Y (CAGR Ricavi 5Y)	22.2%	·	·	·

Metriche per Azione EPS, valore contabile per azione, flusso di cassa per azione, dividendo per azione

Metrica	ZYME	media 5 anni	Mediana dei peer	Verdetto
EPS (Diluted) (EPS (Diluito))	$-1.08media 5 anni ≈$-1.43	≈$-1.43	·	·
Revenue / Share (Ricavi / Azione)	$1.41media 5 anni ≈$1.17	≈$1.17	·	·
Cash Flow / Share (Flusso di cassa / Azione)	$-0.44media 5 anni ≈$-1.20	≈$-1.20	·	·
Cash / Share (Liquidità / Azione)	$0.55media 5 anni ≈$1.25	≈$1.25	·	·

Efficienza del Capitale Rotazione delle attività, rotazione delle scorte, rotazione dei crediti

Metrica	ZYME	media 5 anni	Mediana dei peer	Verdetto
Asset Turnover (Rotazione delle attività)	0.3media 5 anni ≈0.2	≈0.2	0.2	Di prim'ordine
Receivables Turnover (Rotazione dei crediti)	3.5media 5 anni ≈2.8	≈2.8	·	·
Revenue / Employee (Ricavi / Dipendente)	≈$458.7K	·	·	·

valore · ≈ media 5 anni · mediana del settore · giudizio rispetto alla mediana

Cronologia utili EPS effettivo vs stima, surprise %, tasso di superamento, data prossimi utili

14

Sorpresa media -16.9%

Prossimo report Nov 04, 2026

Periodo	Rapporto	EPS Actual	EPS Stimato	Sorpresa
30 Giugno 2026	Ago 5, 2026	$-0.62	$-0.50	-25.1%
31 Marzo 2026	Mag 6, 2026	$-0.59	$-0.20	-201.3%
31 Dicembre 2025		$-0.55	$-0.42	-29.5%
30 Settembre 2025		$-0.26	$-0.33	20.6%
30 Giugno 2025		$0.03	$-0.50	106.0%
31 Marzo 2025		$-0.30	$-0.42	28.0%

Fondamentali Completi Tutte le metriche per anno — conto economico, stato patrimoniale, rendiconto finanziario

15

Conto Economico 14

Metrica	2025	2024	2023	2022	2021
Revenue	$106M	$76M	$76M	$412M	$27M
R&D Expense	·	·	$144M	$209M	$200M
SG&A Expense	$62M	$62M	$70M	$73M	$43M
Operating Expenses	$199M	$213M	$214M	$282M	$242M
Operating Income	$-93M	$-137M	$-138M	$131M	$-216M
Other Non-op	$51.0K	$-218.0K	$291.0K	$-42.0K	$118.0K
Pretax Income	$-80M	$-117M	$-119M	$135M	$-212M
Income Tax	$1M	$6M	$-568.0K	$11M	$-516.0K
Net Income	$-81M	$-123M	$-119M	$124M	$-212M
EPS (Basic)	$-1.08	$-1.62	$-1.72	$1.91	$-4.11
EPS (Diluted)	$-1.08	$-1.62	$-1.72	$1.90	$-4.61
Shares (Basic)	75,404,897	75,846,681	68,863,010	65,194,775	51,553,869
Shares (Diluted)	75,413,396	75,878,738	68,863,010	65,249,184	52,131,596
EBITDA	$-93M	$-137M	$-138M	·	·

Stato Patrimoniale 23

Metrica	2025	2024	2023	2022	2021
Cash & Equivalents	$41M	$66M	$158M	$401M	$202M
Short-term Investments	·	·	$217M	$91M	$51M
Receivables	$5M	$56M	$19M	$33M	$16M
Prepaid Expense	$15M	$19M	$19M	$19M	$20M
Current Assets	$249M	$300M	$413M	$545M	$288M
PP&E (Net)	$16M	$18M	$20M	$25M	$23M
PP&E (Gross)	$36M	$35M	$41M	$38M	$37M
Accum. Depreciation	$21M	$18M	$21M	$13M	$14M
Goodwill	$12M	$12M	$12M	$12M	$12M
Intangibles	$1M	$5M	$8M	$9M	$4M
Total Assets	$347M	$463M	$581M	$649M	$389M
Accounts Payable	$36M	$60M	$46M	$87M	$63M
Current Liabilities	$42M	$88M	$56M	$96M	$72M
Capital Leases	$15M	$16M	$22M	$25M	$31M
Deferred Tax	$6M	$5M	$3M	$2M	$2M
Other Non-current Liabilities	$278.0K	$923.0K	$2M	$3M	$3M
Total Liabilities	$78M	$124M	$116M	$156M	$140M
Common Stock	$1.11B	$1.02B	$997M	$886M	$741M
Retained Earnings	$-953M	$-830M	$-677M	$-559M	$-683M
AOCI	$-6M	$-7M	$-7M	$-7M	$-7M
Stockholders' Equity	$269M	$339M	$465M	$493M	$249M
Liabilities + Equity	$347M	$463M	$581M	$649M	$389M
Shares Outstanding	74,638,413	68,964,319	70,115,997	63,059,501	46,633,935

Flusso di cassa 14

Metrica	2025	2024	2023	2022	2021
Stock-based Comp	$28M	$18M	$8M	$4M	$11M
Deferred Tax	$945.0K	$691.0K	$-757.0K	$2M	$-953.0K
Amort. of Intangibles	$4M	$4M	$3M	$1M	$3M
Restructuring	·	·	$0	·	·
Operating Cash Flow	$-33M	$-110M	$-118M	$144M	$-192M
CapEx	$2M	$2M	$2M	$8M	$12M
Investing Cash Flow	$27M	$39M	$-207M	$-54M	$145M
Stock Issued	$0	$0	$26M	$108M	$0
Stock Repurchased	$42M	$30M	$0	$0	·
Net Stock Activity	$-42M	$-30M	$26M	·	·
Financing Cash Flow	$-19M	$-20M	$82M	$109M	$8M
Net Change in Cash	$-25M	$-91M	$-243M	$199M	$-40M
Taxes Paid	$1M	$3M	$165.0K	$10M	·
Free Cash Flow	$-35M	$-112M	$-121M	·	·

Redditività 7

Metrica	2025	2024	2023	2022	2021
Operating Margin	-87.3%	-179.7%	-181.6%	·	·
Net Margin	-76.6%	-160.8%	-156.1%	·	·
Pretax Margin	-75.3%	-152.8%	-156.9%	·	·
EBITDA Margin	-87.3%	-179.7%	-181.6%	·	·
ROA	-20.0%	-23.5%	-19.3%	·	·
ROE	-26.9%	-34.8%	-26.7%	·	·
ROIC	-35.1%	-42.6%	-29.6%	·	·

Liquidità e Solvibilità 2

Metrica	Tendenza	2025	2024	2023	2022	2021
Current Ratio		5.9	3.4	7.4	·	·
Quick Ratio		1.1	1.4	7.1	·	·

Efficienza 2

Metrica	Tendenza	2025	2024	2023	2022	2021
Asset Turnover		0.3	0.1	0.1	·	·
Receivables Turnover		3.5	2.0	2.9	·	·

Per Azione 5

Metrica	2025	2024	2023	2022	2021
Book Value / Share	$3.60	$4.91	$6.63	·	·
Revenue / Share	$1.41	$1.01	$1.10	·	·
Cash Flow / Share	$-0.44	$-1.45	$-1.72	·	·
Cash / Share	$0.55	$0.96	$2.25	·	·
EPS (TTM)	$-1.08	$-1.62	$-1.72	$1.90	·

Tassi di Crescita 3

Metrica	2025	2024	2023	2022	2021
Revenue YoY	38.9%	0.38%	-81.6%	1446.0%	-31.5%
Revenue CAGR 3Y	-36.4%	41.9%	25.0%	·	·
Revenue CAGR 5Y	22.2%	·	·	·	·

Valutazione (TTM) 10

Metrica	2025	2024	2023	2022	2021
Revenue TTM	$106M	$76M	$76M	$412M	·
Net Income TTM	$-81M	$-123M	$-119M	$124M	·
Market Cap	$1.97B	$1.01B	$729M	·	·
P/E	-24.4	-9.0	-6.0	4.1	·
P/S	18.5	13.2	9.6	·	·
P/B	7.3	3.0	1.6	·	·
P / Tangible Book	7.7	3.1	1.6	1.0	·
P / Cash Flow	-59.5	-9.2	-6.2	·	·
P / FCF	-56.9	-9.0	-6.0	·	·
Earnings Yield	-4.1%	-11.1%	-16.6%	24.2%	·

Conto Economico 14

Metrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Revenue	$5M	$2M	$3M	$28M	$49M	$27M	$31M	$16M	$19M	$10M	$17M	$17M	$7M	$36M	$402M	$3M
R&D Expense	·	·	·	·	·	·	·	·	·	$32M	·	$33M	$39M	$46M	·	$37M
SG&A Expense	$19M	$15M	$15M	$14M	$15M	$17M	$16M	$14M	$16M	$16M	$15M	$17M	$22M	$17M	$30M	$16M
Operating Expenses	$47M	$50M	$47M	$50M	$49M	$53M	$53M	$50M	$62M	$48M	$40M	$50M	$61M	$63M	$83M	$53M
Operating Income	$-42M	$-47M	$-44M	$-22M	$-674.0K	$-26M	$-22M	$-34M	$-43M	$-38M	$-23M	$-33M	$-54M	$-27M	$319M	$-50M
Other Non-op	$196.0K	$120.0K	$-18.0K	$26.0K	$-621.0K	$49.0K	$-253.0K	$-37.0K	$53.0K	$19.0K	$-278.0K	$370.0K	$230.0K	$-31.0K	$-27.0K	$-98.0K
Pretax Income	$-45M	$-46M	$-41M	$-18M	$2M	$-22M	$-18M	$-30M	$-38M	$-32M	$-19M	$-28M	$-49M	$-23M	$320M	$-48M
Income Tax	$-273.0K	$-2M	$-270.0K	$1M	$-186.0K	$496.0K	$6M	$226.0K	$68.0K	$75.0K	$-5M	$1M	$2M	$1M	$11M	$-29.0K
Net Income	$-45M	$-44M	$-41M	$-20M	$2M	$-23M	$-24M	$-30M	$-38M	$-32M	$-14M	$-29M	$-51M	$-24M	$309M	$-48M
EPS (Basic)	$-0.62	$-0.59	$-0.55	$-0.26	$0.03	$-0.30	$-0.32	$-0.39	$-0.49	$-0.42	$-0.19	$-0.41	$-0.76	$-0.36	$4.78	$-0.72
EPS (Diluted)	$-0.62	$-0.59	$-0.55	$-0.26	$0.03	$-0.30	$-0.32	$-0.39	$-0.49	$-0.42	$-0.18	$-0.41	$-0.76	$-0.37	$4.78	$-0.72
Shares (Basic)	72,993,313	74,668,790	·	75,767,778	75,337,168	75,171,020	·	76,128,531	76,392,593	76,214,833	·	70,575,773	67,281,028	66,739,308	·	66,477,016
Shares (Diluted)	72,993,313	74,694,762	·	75,775,214	77,378,449	75,226,387	·	76,157,101	76,396,217	76,248,158	·	70,575,773	67,284,511	66,742,030	·	66,478,157
EBITDA	$-42M	$-47M	·	$-22M	$-674.0K	$-26M	·	$-34M	$-43M	$-38M	·	$-33M	$-54M	$-27M	·	$-50M

Stato Patrimoniale 23

Metrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Cash & Equivalents	$179M	$244M	$41M	$65M	$98M	$76M	$66M	$122M	$71M	$115M	·	$94M	$142M	$182M	·	$96M
Short-term Investments	·	·	·	·	·	·	·	·	·	·	·	$201M	$198M	$159M	·	$70M
Receivables	$6M	$5M	$5M	$29M	$3M	$25M	$56M	$24M	$32M	$31M	·	$67M	$49M	$67M	·	$7M
Prepaid Expense	$22M	$16M	$15M	$10M	$12M	$17M	$19M	$23M	$21M	$18M	·	$12M	$31M	$19M	·	$18M
Current Assets	$298M	$386M	$249M	$292M	$296M	$306M	$300M	$344M	$383M	$394M	·	$375M	$420M	$426M	·	$191M
PP&E (Net)	$14M	$15M	$16M	$16M	$16M	$17M	$18M	$18M	$18M	$19M	·	$21M	$22M	$24M	·	$26M
PP&E (Gross)	·	·	$36M	·	·	·	$35M	·	·	·	·	·	·	·	·	·
Accum. Depreciation	·	·	$21M	·	·	·	$18M	·	·	·	·	·	·	·	·	·
Goodwill	$12M	$12M	$12M	$12M	$12M	$12M	$12M	$12M	$12M	$12M	·	$12M	$12M	$12M	·	$12M
Intangibles	$998.0K	$1M	$1M	$1M	$2M	$3M	$5M	$6M	$7M	$7M	·	$8M	$7M	$8M	·	$9M
Total Assets	$397M	$478M	$347M	$397M	$408M	$426M	$463M	$487M	$516M	$554M	·	$556M	$602M	$601M	·	$300M
Accounts Payable	$27M	$30M	$36M	$34M	$31M	$38M	$60M	$52M	$44M	$47M	·	$68M	$70M	$59M	·	$52M
Current Liabilities	$47M	$36M	$42M	$42M	$39M	$65M	$88M	$84M	$55M	$57M	·	$73M	$94M	$67M	·	$58M
Capital Leases	$13M	$14M	$15M	$16M	$15M	$15M	$16M	$17M	$17M	$21M	·	$22M	$23M	$24M	·	$25M
Deferred Tax	$4M	$4M	$6M	$5M	$5M	$5M	$5M	$3M	$3M	$3M	·	$2M	$2M	$2M	·	$2M
Other Non-current Liabilities	$278.0K	$278.0K	$278.0K	$278.0K	$828.0K	$856.0K	$923.0K	$929.0K	$1M	$2M	·	$2M	$4M	$4M	·	$3M
Total Liabilities	$317M	$315M	$78M	$77M	$74M	$101M	$124M	$120M	$109M	$116M	·	$132M	$153M	$127M	·	$121M
Common Stock	$1.13B	$1.13B	$1.11B	$1.09B	$1.07B	$1.02B	$1.02B	$1.01B	$1.01B	$1.00B	·	$932M	$929M	$900M	·	$885M
Retained Earnings	$-1.17B	$-1.07B	$-953M	$-886M	$-851M	$-853M	$-830M	$-798M	$-747M	$-709M	·	$-663M	$-634M	$-583M	·	$-868M
AOCI	$-7M	$-7M	$-6M	$-6M	$-6M	$-6M	$-7M	$-6M	$-8M	$-8M	·	$-8M	$-8M	$-6M	·	$-7M
Stockholders' Equity	$80M	$164M	$269M	$320M	$335M	$325M	$339M	$367M	$406M	$438M	$465M	$424M	$449M	$474M	$493M	$180M
Liabilities + Equity	$397M	$478M	$347M	$397M	$408M	$426M	$463M	$487M	$516M	$554M	·	$556M	$602M	$601M	·	$300M
Shares Outstanding	71,412,072	73,102,689	74,638,413	75,139,281	74,846,147	69,584,811	68,964,319	69,584,882	70,831,545	70,677,106	·	67,922,559	67,687,384	64,083,770	·	61,694,387

Flusso di cassa 12

Metrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Stock-based Comp	$11M	$7M	$9M	$7M	$6M	$6M	$5M	$5M	$5M	$4M	$3M	$2M	$367.0K	$2M	$4M	$5M
Amort. of Intangibles	$176.0K	$176.0K	$185.0K	$648.0K	$2M	$2M	$2M	$980.0K	$812.0K	$702.0K	$673.0K	$672.0K	$678.0K	$679.0K	$529.0K	$166.0K
Operating Cash Flow	$-32M	$-46M	$-10M	$-31M	$12M	$-3M	$-42M	$-6M	$-25M	$-38M	$14M	$-43M	$-6M	$-83M	$327M	$-73M
CapEx	$0	$216.0K	$581.0K	$410.0K	$514.0K	$16.0K	$314.0K	$899.0K	$593.0K	$185.0K	$356.0K	$930.0K	$802.0K	$386.0K	$348.0K	$981.0K
Investing Cash Flow	$17M	$70M	$5M	$368.0K	$9M	$12M	$-6M	$72M	$-20M	$-7M	$-1M	$-7M	$-61M	$-138M	$-22M	$-30M
Stock Issued	·	·	·	·	·	·	$0	$0	·	·	$0	$0	$26M	$0	$0	$0
Stock Repurchased	$52M	$76M	$25M	$16M	$0	$0	$9M	·	·	·	$0	·	·	·	·	·
Net Stock Activity	·	$-76M	·	·	·	·	·	·	·	·	·	·	·	$0	·	·
Financing Cash Flow	$-50M	$179M	$-19M	$-2M	$1M	$1M	$-9M	$-15M	$1M	$2M	$51M	$2M	$28M	$2M	$-377.0K	$628.0K
Net Change in Cash	$-65M	$203M	$-24M	$-33M	$22M	$10M	$-56M	$51M	$-44M	$-43M	$63M	$-48M	$-39M	$-219M	$305M	$-103M
Taxes Paid	$863.0K	$245.0K	$107.0K	$660.0K	$196.0K	$387.0K	$3M	$106.0K	$106.0K	$0	·	·	·	·	·	·
Free Cash Flow	·	$-46M	·	·	·	$-3M	·	·	·	$-38M	·	·	·	$-84M	·	·

Redditività 7

Metrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Operating Margin	-919.0%	-1956.7%	·	-80.1%	-1.4%	-94.5%	·	-213.8%	-222.9%	-376.9%	·	-201.4%	-772.8%	-76.7%	·	-1914.0%
Net Margin	-980.8%	-1834.0%	·	-71.0%	4.8%	-83.5%	·	-186.6%	-195.8%	-315.6%	·	-173.8%	-730.5%	-68.5%	·	-1818.6%
Pretax Margin	-986.8%	-1925.0%	·	-66.1%	4.4%	-81.7%	·	-185.2%	-195.5%	-314.8%	·	-167.1%	-706.9%	-64.5%	·	-1819.7%
EBITDA Margin	-919.0%	-1956.7%	·	-80.1%	-1.4%	-94.5%	·	-213.8%	-222.9%	-376.9%	·	-201.4%	-772.8%	-76.7%	·	-1914.0%
ROA	-11.2%	-9.8%	·	-4.4%	0.50%	-4.6%	·	-5.7%	-6.7%	-5.5%	·	-6.7%	-17.0%	-8.1%	·	-31.9%
ROE	-21.7%	-18.1%	·	-5.7%	0.63%	-5.9%	·	-7.5%	-8.8%	-6.9%	·	-9.5%	-22.8%	-10.3%	·	-53.2%
ROIC	-52.2%	-27.4%	·	-7.4%	-0.22%	-8.1%	·	-9.4%	-10.6%	-8.6%	·	-8.2%	-12.5%	-6.1%	·	-28.0%

Liquidità e Solvibilità 2

Metrica	Tendenza	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Current Ratio		6.3	10.8	·	6.9	7.7	4.7	·	4.1	7.0	6.9	·	5.1	4.5	6.3	·	3.3
Quick Ratio		3.9	7.0	·	2.2	2.6	1.5	·	1.7	1.9	2.6	·	5.0	4.2	6.1	·	3.0

Efficienza 2

Metrica	Tendenza	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Asset Turnover		0.0	0.0	·	0.1	0.1	0.1	·	0.0	0.0	0.0	·	0.0	0.0	0.1	·	0.0
Receivables Turnover		1.1	0.2	·	1.0	2.8	1.0	·	0.4	0.5	0.2	·	0.4	0.3	1.1	·	0.8

Per Azione 5

Metrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Book Value / Share	$1.13	$2.24	·	$4.26	$4.47	$4.67	·	$5.27	$5.73	$6.20	·	$6.25	$6.63	$7.39	·	$2.91
Revenue / Share	$0.06	$0.03	·	$0.36	$0.63	$0.36	·	$0.21	$0.25	$0.13	·	$0.23	$0.10	$0.53	·	$0.04
Cash Flow / Share	·	$-0.61	·	·	·	$-0.05	·	·	·	$-0.49	·	·	·	$-1.25	·	·
Cash / Share	$2.51	$3.34	·	$0.86	$1.31	$1.10	·	$1.76	$1.00	$1.62	·	$1.39	$2.10	$2.83	·	$1.56
EPS (TTM)	$-2.02	$-1.37	·	$-0.85	$-0.98	$-1.50	·	$-1.48	$-1.50	$-1.77	·	$3.24	$2.93	$2.72	·	$-3.83

Valutazione (TTM) 9

Metrica	Q2 2026	Q1 2026	Q4 2025	Q3 2025	Q2 2025	Q1 2025	Q4 2024	Q3 2024	Q2 2024	Q1 2024	Q4 2023	Q3 2023	Q2 2023	Q1 2023	Q4 2022	Q3 2022
Revenue TTM	$37M	$81M	·	$134M	$123M	$93M	·	$62M	$63M	$50M	·	$462M	$448M	$446M	·	$30M
Net Income TTM	$-150M	$-103M	·	$-63M	$-74M	$-114M	·	$-114M	$-113M	$-126M	·	$205M	$186M	$173M	·	$-224M
Market Cap	$1.87B	$1.83B	·	$1.28B	$939M	$829M	·	$873M	$603M	$744M	·	$431M	$585M	$579M	·	$379M
P/E	-12.9	-18.3	·	-20.1	-12.8	-7.9	·	-8.5	-5.7	-5.9	·	2.0	2.9	3.3	·	-1.6
P/S	50.3	22.5	·	9.5	7.6	8.9	·	14.0	9.6	14.7	·	0.9	1.3	1.3	·	12.7
P/B	23.2	11.2	·	4.0	2.8	2.6	·	2.4	1.5	1.7	·	1.0	1.3	1.2	·	2.1
P / Tangible Book	27.7	12.2	·	4.2	2.9	2.7	·	2.5	1.6	1.8	·	1.1	1.4	1.3	·	2.4
P / Cash Flow	·	-40.0	·	·	·	-243.3	·	·	·	-19.7	·	·	·	-7.0	·	·
Earnings Yield	-7.7%	-5.5%	·	-5.0%	-7.8%	-12.6%	·	-11.8%	-17.6%	-16.8%	·	51.1%	33.9%	30.1%	·	-62.3%

Periodo più recente a sinistra · valori nulli mostrati come ·

Bilanci Conto economico, stato patrimoniale, flusso di cassa — annuale, ultimi 5 anni

16

Metrica	2025-12-31	2024-12-31	2023-12-31	2022-12-31	2021-12-31
Ricavi	$106M	$76M	$76M	$412M	$27M
Margine Operativo %	-87.3%	-179.7%	-181.6%	·	·
Utile netto	$-81M	$-123M	$-119M	$124M	$-212M
EPS Diluito	$-1.08	$-1.62	$-1.72	$1.90	$-4.61

Metrica	2025-12-31	2024-12-31	2023-12-31	2022-12-31	2021-12-31
Rapporto corrente	5.9	3.4	7.4	·	·
Quick Ratio	1.1	1.4	7.1	·	·

Metrica	2025-12-31	2024-12-31	2023-12-31	2022-12-31	2021-12-31
Flusso di cassa libero	$-35M	$-112M	$-121M	·	·

Proprietari istituzionali (13F) 212 filer · $1.9B totale · Aggiornato al 30 Settembre 2026

17

Istituzioni che segnalano il possesso di questo titolo nel loro Modulo SEC 13F trimestrale. Solo posizioni lunghe; un singolo depositante può apparire due volte per diverse gambe di opzioni. Grandi posizioni put/call contrapposte riflettono tipicamente market-making o inventario coperto, non convinzione direzionale.

Detentori 212

Valore detenuto $1.9B

Nuove posizioni 22

Posizioni chiuse 31

Attività istituzionale — Q2 2026 vs trimestre precedente

Nuove posizioni	Posizioni chiuse	Aumentato	Diminuito	Variazione netta delle azioni
22 (-20 vs trimestre precedente)	31 (0 vs trimestre precedente)	59 (-16 vs trimestre precedente)	73 (+13 vs trimestre precedente)	-2.0M

Confrontato con Q1 2026. Le dichiarazioni SEC Form 13F sono dovute entro 45 giorni dalla fine del trimestre più un breve margine per i dichiaranti in ritardo — i trimestri ancora all'interno di questa finestra vengono saltati a favore della coppia più recente completamente riportata.

Istituzione	Valore	Azioni	% di 13F tracciati	Tipo
EcoR1 Capital, LLC	$600.445.942	22.970.388	32,29%	Azioni
Rubric Capital Management LP	$182.980.000	7.000.000	9,84%	Azioni
BlackRock, Inc.	$111.121.925	4.251.030	5,98%	Azioni
PERCEPTIVE ADVISORS LLC	$109.342.391	4.182.953	5,88%	Azioni
BVF INC/IL	$95.388.572	3.649.142	5,13%	Azioni
VANGUARD GROUP INC	$61.315.382	2.328.727	3,30%	Azioni
MORGAN STANLEY	$58.325.141	2.231.260	3,14%	Azioni
BNP PARIBAS ASSET MANAGEMENT Holding S.A.	$46.558.373	1.781.116	2,50%	Azioni
VANGUARD CAPITAL MANAGEMENT LLC	$40.752.208	1.558.998	2,19%	Azioni
Assenagon Asset Management S.A.	$32.727.986	1.252.027	1,76%	Azioni
Nextech Invest Ltd.	$29.118.548	1.113.946	1,57%	Azioni
STATE STREET CORP	$28.445.966	1.088.216	1,53%	Azioni
DIMENSIONAL FUND ADVISORS LP	$25.995.770	994.955	1,40%	Azioni
CITADEL ADVISORS LLC	$23.895.516	914.136	1,29%	Azioni
NOMURA ASSET MANAGEMENT INTERNATIONAL INC.	$23.259.000	889.802	1,25%	Azioni
FMR LLC	$18.365.133	702.568	0,99%	Azioni
GEODE CAPITAL MANAGEMENT, LLC	$18.099.012	692.410	0,97%	Azioni
Prosight Management, LP	$17.629.705	674.434	0,95%	Azioni
Qube Research & Technologies Ltd	$15.516.443	593.590	0,83%	Azioni
VANGUARD PORTFOLIO MANAGEMENT LLC	$13.332.236	510.032	0,72%	Azioni
Redmile Group, LLC	$12.851.836	491.654	0,69%	Azioni
Capricorn Fund Managers Ltd	$12.717.868	486.529	0,68%	Azioni
GOLDMAN SACHS GROUP INC	$12.307.288	470.822	0,66%	Azioni
ARROWSTREET CAPITAL, LIMITED PARTNERSHIP	$10.939.512	418.497	0,59%	Azioni
DEUTSCHE BANK AG\	$10.382.547	397.190	0,56%	Azioni
Hillsdale Investment Management Inc.	$10.009.581	382.922	0,54%	Azioni
FIRST TRUST ADVISORS LP	$8.897.088	340.363	0,48%	Azioni
Granahan Investment Management, LLC	$8.787.144	336.157	0,47%	Azioni
NORTHERN TRUST CORP	$8.392.849	321.073	0,45%	Azioni
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC	$7.997.401	319.385	0,43%	Azioni
Pictet Asset Management Holding SA	$7.446.189	308.187	0,40%	Azioni
PICTON MAHONEY ASSET MANAGEMENT	$7.092.908	271.343	0,38%	Azioni
SILVERCREST ASSET MANAGEMENT GROUP LLC	$5.849.243	223.766	0,31%	Azioni
BANK OF AMERICA CORP /DE/	$5.726.515	219.071	0,31%	Azioni
WELLS FARGO & COMPANY/MN	$5.677.573	217.199	0,31%	Azioni
SummitTX Capital, L.P.	$5.510.364	210.802	0,30%	Azioni
Man Group plc	$5.509.763	210.779	0,30%	Azioni
FEDERATED HERMES, INC.	$4.914.190	187.995	0,26%	Azioni
RAYMOND JAMES FINANCIAL INC	$4.350.114	166.416	0,23%	Azioni
STATE OF WISCONSIN INVESTMENT BOARD	$4.066.835	155.579	0,22%	Azioni
CHARLES SCHWAB INVESTMENT MANAGEMENT INC	$3.984.154	152.416	0,21%	Azioni
KENNEDY CAPITAL MANAGEMENT LLC	$3.800.390	145.386	0,20%	Azioni
D. E. Shaw & Co., Inc.	$3.785.255	144.807	0,20%	Azioni
DIADEMA PARTNERS LP	$3.715.330	142.132	0,20%	Azioni
CITIGROUP INC	$3.435.868	131.441	0,18%	Azioni
Bank of New York Mellon Corp	$3.427.107	131.106	0,18%	Azioni
SUSQUEHANNA INTERNATIONAL GROUP, LLP	$3.408.656	130.400	0,18%	Opzione Call
XTX Topco Ltd	$3.290.425	125.877	0,18%	Azioni
Nuveen, LLC	$3.120.829	119.389	0,17%	Azioni
PANAGORA ASSET MANAGEMENT INC	$3.100.282	118.603	0,17%	Azioni

Mostra tutti i 212 proprietari istituzionali →

Attivisti e proprietari del 5%+ 2 partecipazioni

18

Investitori che hanno depositato SEC Schedule 13D — proprietà effettiva superiore al 5% con l'intento di influenzare l'emittente (partecipazioni attiviste, campagne per il consiglio di amministrazione, M&A). Ogni riga mostra lo stato più recente noto della posizione di quel depositante.

Depositante	Depositato	Partecipazione	Stato	Scopo	Deposito
EcoR1 Capital, LLC, Oleg Nodelman, EcoR1 Capital Fund Qualified, L.P. ×8 depositi	19 Novembre 2025	30,70%	Modifica	Campagna per il consiglio di amministrazione	SEC
All Blue Falcons FZE, Daniel Edward Llewellen Cookson ×2 depositi	28 Dicembre 2022	·	Deposito iniziale	·	SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

Insider aziendali 28 insider · 12 dirigenti · 17 direttori

19

Insider	Ruolo	Ultima attività	Azioni possedute	Vendite 12m	Netto 12m
Kenneth Galbraith	Chair & CEO	12 Gennaio 2026 A	226.842	4	$-3.337.929
Kristin Stafford	EVP, Chief Financial Officer	06 Aprile 2026 A	·	0	$0
Christopher Astle	SVP & Chief Financial Officer	05 Gennaio 2024 A	6.503	0	$0
Neil A Klompas	President & COO	10 Marzo 2023 M	17.032	0	$0
Mark Hollywood	EVP & Chief Operating Officer	06 Luglio 2026 A	133.852	1	$-138.740
Paul R Schneider	EVP, General Counsel	13 Maggio 2026 A	·	0	$0
Adam Schayowitz	EVP, Head of Research & Development	09 Aprile 2026 A	·	0	$0
Scott Platshon	EVP, Chief Business Officer	09 Aprile 2026 A	·	0	$0
Paul Andrew Moore	Chief Scientific Officer	12 Gennaio 2026 A	48.497	3	$-721.486
Jeffrey T L Smith	EVP & Chief Medical Officer	12 Gennaio 2026 M	26.708	2	$-475.562
Leone D Patterson	EVP, Chief Bus & Fin Officer	06 Gennaio 2026 A	459	0	$0
Neil Josephson	Chief Medical Officer	10 Novembre 2022 M	14.449	0	$0
Gregory A. Ciongoli	Direttore	12 Gennaio 2026 A	488.500	0	$0
Alessandra Cesano	Direttore	12 Gennaio 2026 A	·	0	$0
Carlos Campoy	Direttore	12 Gennaio 2026 A	·	0	$0
Robert E Landry	Direttore	12 Gennaio 2026 A	·	0	$0
Kelvin Neu	Direttore	12 Gennaio 2026 A	·	0	$0
Susan Mahony	Direttore	12 Gennaio 2026 A	·	0	$0
Brian N Cherry	Direttore	12 Gennaio 2026 A	·	0	$0
EcoR1 Capital, LLC	Direttore	17 Gennaio 2025 P	15.720.161	0	$0
Nancy Davidson	Direttore	10 Dicembre 2024 A	·	0	$0
Neil Gallagher	Direttore	10 Dicembre 2024 A	·	0	$0
Derek John Michael Miller	Direttore	10 Dicembre 2024 A	·	0	$0
Troy Cox	Direttore	10 Dicembre 2024 A	·	0	$0
Kenneth J. Hillan	Direttore	07 Dicembre 2023 A	·	0	$0
Hollings Renton	Direttore	07 Dicembre 2023 A	·	0	$0
Natalie Sacks	Direttore	21 Dicembre 2022 A	·	0	$0
Lota S. Zoth	Direttore	21 Dicembre 2022 A	·	0	$0

Insider dai depositi SEC Modulo 3/4/5; netto = solo acquisti/vendite di mercato

Proprietà ETF Posseduti da 30 ETF

20

Il peso riflette solo le partecipazioni azionarie dirette (N-PORT); fondi a leva o basati su derivati possono detenere ulteriore esposizione swap non mostrata.

Fondo	Peso	Unità	Aggiornato al	Fonte
BBP · ETFis Series Trust I	1,32%	59.315 NS	31 Luglio 2026	N-PORT
OMFS · Invesco Exchange-Traded Self-Indexe…	0,15%	14.705 SH	01 Ottobre 2026	Giornaliero
IBB · iShares Trust	0,14%	537.742 SH	11 Settembre 2026	Giornaliero
IBBQ · Invesco Exchange-Traded Fund Trust …	0,12%	5.008 SH	01 Ottobre 2026	Giornaliero
FYC · First Trust Exchange-Traded AlphaDE…	0,11%	65.877 NS	31 Luglio 2026	N-PORT
VFMO · VANGUARD WELLINGTON FUND	0,10%	74.514 SH	19 Agosto 2026	Giornaliero
IWO · iShares Trust	0,08%	439.290 SH	11 Settembre 2026	Giornaliero
VTWG · VANGUARD SCOTTSDALE FUNDS	0,07%	50.443 SH	19 Agosto 2026	Giornaliero
PRFZ · Invesco Exchange-Traded Fund Trust	0,07%	68.050 SH	01 Ottobre 2026	Giornaliero
IWM · iShares Trust	0,04%	1.202.863 SH	11 Settembre 2026	Giornaliero
VTWO · VANGUARD SCOTTSDALE FUNDS	0,04%	270.692 SH	19 Agosto 2026	Giornaliero
RSSL · Global X Funds	0,03%	22.528 NS	31 Luglio 2026	N-PORT
DFAS · Dimensional ETF Trust	0,03%	189.632 NS	31 Luglio 2026	N-PORT
FAD · First Trust Exchange-Traded AlphaDE…	0,02%	5.969 NS	31 Luglio 2026	N-PORT
ISCG · iShares Trust	0,02%	5.910 SH	11 Settembre 2026	Giornaliero
FHLC · FIDELITY COVINGTON TRUST	0,01%	18.267 NS	31 Luglio 2026	N-PORT
WSML · iShares Trust	0,01%	3.039 SH	11 Settembre 2026	Giornaliero
VHT · VANGUARD WORLD FUND	0,01%	110.298 SH	19 Agosto 2026	Giornaliero
TILT · FlexShares Trust	0,01%	5.508 NS	31 Luglio 2026	N-PORT
DFAC · Dimensional ETF Trust	0,00%	70.572 NS	31 Luglio 2026	N-PORT
DCOR · Dimensional ETF Trust	0,00%	3.968 NS	31 Luglio 2026	N-PORT
DFAU · Dimensional ETF Trust	0,00%	12.951 NS	31 Luglio 2026	N-PORT
IWV · iShares Trust	0,00%	14.406 SH	10 Settembre 2026	Giornaliero
DFUS · Dimensional ETF Trust	0,00%	8.364 NS	31 Luglio 2026	N-PORT
DXUV · Dimensional ETF Trust	0,00%	130 NS	31 Luglio 2026	N-PORT
VTI · VANGUARD INDEX FUNDS	0,00%	1.508.613 SH	19 Agosto 2026	Giornaliero
VTHR · VANGUARD SCOTTSDALE FUNDS	0,00%	4.085 SH	19 Agosto 2026	Giornaliero
ISCB · iShares Trust	·	1.999 SH	11 Settembre 2026	Giornaliero
ISCV · iShares Trust	·	5.753 SH	11 Settembre 2026	Giornaliero
SMMV · iShares Trust	·	16.029 SH	19 Agosto 2026	Giornaliero

ZYME Consenso degli analisti Opinioni degli analisti, sia rialziste che ribassiste, target price a 12 mesi, potenziale di rialzo

21

rating · 18 analisti COMPRA

Target mediano $38.00 +51,1%

6 33,3% Acquisto forte

11 61,1% Compra

1 5,6% Mantieni

0 0,0% Vendi

0 0,0% Vendita forte

Target Price a 12 Mesi

13 analisti · 2026-09-27

Target medio $41.23 +63,9%

← Sotto tutti i target Prezzo attuale $25.15

Basso$32.00 Media$41.23 Alto$60.00

Confronto Peer (GICS sub-settore industriale) Metriche chiave rispetto ai pari del settore

22

Base FY, prezzi alla chiusura dell'ultimo anno fiscale di ciascuna società.

Ticker	Capitalizzazione di Mercato	P/E	Rev YoY	Margine Netto	ROE	Margine lordo
ZYME	$1.97B	-24.4	38.9%	-76.6%	-26.9%	·
AUPH	$2.11B	7.7	20.4%	101.5%	62.7%	·
ABUS	$926M	-28.3	128.2%	-237.9%	-42.0%	·
ACOG	$141M	-5.5	·	-202.2%	-43.8%	·
ENGN	·	·	·	·	·	·
XENE	$3.59B	-10.3	·	-4612.1%	-56.9%	·

Le Mie Metriche La tua watchlist personale — righe selezionate da Fondamentali Completi

26

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ZYME Zymeworks Inc. - Common Stock