| RA CAPITAL MANAGEMENT, L.P. |
$234,291,284 |
6,995,858 |
14.22% |
주식
|
| TRV GP V, LLC |
$208,160,143 |
6,215,591 |
12.64% |
주식
|
| Driehaus Capital Management LLC |
$148,463,112 |
4,433,058 |
9.01% |
주식
|
| TRV GP VI, LLC |
$141,048,460 |
4,211,659 |
8.56% |
주식
|
| SAMSARA BIOCAPITAL, LLC |
$105,464,297 |
3,149,128 |
6.40% |
주식
|
| GOLDMAN SACHS GROUP INC |
$102,572,033 |
3,062,766 |
6.23% |
주식
|
| BlackRock, Inc. |
$64,705,629 |
1,932,088 |
3.93% |
주식
|
| Siren, L.L.C. |
$63,631,000 |
1,900,000 |
3.86% |
주식
|
| Avoro Capital Advisors LLC |
$44,792,875 |
1,337,500 |
2.72% |
주식
|
| VANGUARD GROUP INC |
$42,048,476 |
1,508,195 |
2.55% |
주식
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$40,913,829 |
1,221,673 |
2.48% |
주식
|
| PRIMECAP MANAGEMENT CO/CA/ |
$39,095,624 |
1,167,382 |
2.37% |
주식
|
| First Light Asset Management, LLC |
$32,259,577 |
963,260 |
1.96% |
주식
|
| ADAR1 Capital Management, LLC |
$31,505,617 |
940,747 |
1.91% |
주식
|
| GEODE CAPITAL MANAGEMENT, LLC |
$22,750,071 |
679,163 |
1.38% |
주식
|
| STATE STREET CORP |
$21,856,579 |
652,630 |
1.33% |
주식
|
| JANUS HENDERSON GROUP PLC |
$21,333,558 |
890,754 |
1.30% |
주식
|
| LOOMIS SAYLES & CO L P |
$20,922,944 |
624,752 |
1.27% |
주식
|
| Casdin Capital, LLC |
$18,528,945 |
553,268 |
1.12% |
주식
|
| Catalio Capital Management, LP |
$17,955,730 |
536,152 |
1.09% |
주식
|
| Caption Management, LLC |
$14,735,600 |
440,000 |
0.89% |
콜 옵션
|
| ALGERT GLOBAL LLC |
$13,311,840 |
397,487 |
0.81% |
주식
|
| Balyasny Asset Management L.P. |
$11,736,303 |
350,442 |
0.71% |
주식
|
| Longaeva Partners L.P. |
$9,985,747 |
298,171 |
0.61% |
주식
|
| Soleus Capital Management, L.P. |
$9,209,750 |
275,000 |
0.56% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$8,774,380 |
262,000 |
0.53% |
콜 옵션
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$7,708,862 |
230,184 |
0.47% |
주식
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$7,458,290 |
222,702 |
0.45% |
주식
|
| TWO SIGMA INVESTMENTS, LP |
$7,397,439 |
220,885 |
0.45% |
주식
|
| NORTHERN TRUST CORP |
$6,735,877 |
201,131 |
0.41% |
주식
|
| TUDOR INVESTMENT CORP ET AL |
$6,698,000 |
200,000 |
0.41% |
콜 옵션
|
| Caption Management, LLC |
$6,698,000 |
200,000 |
0.41% |
풋 옵션
|
| Kalehua Capital Management LLC |
$6,515,279 |
194,544 |
0.40% |
주식
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$6,264,003 |
187,041 |
0.38% |
주식
|
| Woodline Partners LP |
$6,213,567 |
185,535 |
0.38% |
주식
|
| VANGUARD FIDUCIARY TRUST CO |
$5,547,819 |
165,656 |
0.34% |
주식
|
| MORGAN STANLEY |
$4,500,286 |
134,377 |
0.27% |
주식
|
| TUDOR INVESTMENT CORP ET AL |
$3,349,000 |
100,000 |
0.20% |
풋 옵션
|
| UBS Group AG |
$3,009,880 |
89,874 |
0.18% |
주식
|
| JPMORGAN CHASE & CO |
$2,964,211 |
85,301 |
0.18% |
주식
|
| FEDERATED HERMES, INC. |
$2,905,358 |
86,753 |
0.18% |
주식
|
| CITADEL ADVISORS LLC |
$2,739,482 |
81,800 |
0.17% |
콜 옵션
|
| LAZARD ASSET MANAGEMENT LLC |
$2,525,983 |
75,425 |
0.15% |
주식
|
| DIMENSIONAL FUND ADVISORS LP |
$2,522,961 |
75,309 |
0.15% |
주식
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$2,499,995 |
74,649 |
0.15% |
주식
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$2,283,348 |
68,180 |
0.14% |
주식
|
| HUSSMAN STRATEGIC ADVISORS, INC. |
$2,109,870 |
63,000 |
0.13% |
주식
|
| AMERICAN CENTURY COMPANIES INC |
$2,041,986 |
60,973 |
0.12% |
주식
|
| DIADEMA PARTNERS LP |
$1,999,353 |
59,700 |
0.12% |
풋 옵션
|
| JANE STREET GROUP, LLC |
$1,915,628 |
57,200 |
0.12% |
콜 옵션
|
| Bank of New York Mellon Corp |
$1,881,334 |
56,176 |
0.11% |
주식
|
| XTX Topco Ltd |
$1,824,837 |
54,489 |
0.11% |
주식
|
| MILLENNIUM MANAGEMENT LLC |
$1,693,321 |
50,562 |
0.10% |
주식
|
| BARCLAYS PLC |
$1,668,506 |
49,821 |
0.10% |
주식
|
| Elmind Capital, LP |
$1,655,880 |
49,444 |
0.10% |
주식
|
| Nuveen, LLC |
$1,615,189 |
48,229 |
0.10% |
주식
|
| Sofinnova Investments, Inc. |
$1,590,976 |
47,506 |
0.10% |
주식
|
| D. E. Shaw & Co., Inc. |
$1,556,716 |
46,483 |
0.09% |
주식
|
| JANE STREET GROUP, LLC |
$1,525,537 |
45,552 |
0.09% |
주식
|
| Voleon Capital Management LP |
$1,488,128 |
44,435 |
0.09% |
주식
|
| RENAISSANCE TECHNOLOGIES LLC |
$1,387,122 |
41,419 |
0.08% |
주식
|
| Russell Investments Group, Ltd. |
$1,346,606 |
40,209 |
0.08% |
주식
|
| Caption Management, LLC |
$1,272,821 |
38,006 |
0.08% |
주식
|
| BANK OF AMERICA CORP /DE/ |
$1,201,453 |
35,875 |
0.07% |
주식
|
| Alyeska Investment Group, L.P. |
$1,172,150 |
35,000 |
0.07% |
주식
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1,135,311 |
33,900 |
0.07% |
풋 옵션
|
| Brevan Howard Capital Management LP |
$986,347 |
29,452 |
0.06% |
주식
|
| HighVista Strategies LLC |
$982,496 |
29,337 |
0.06% |
주식
|
| TUDOR INVESTMENT CORP ET AL |
$970,071 |
28,966 |
0.06% |
주식
|
| RHUMBLINE ADVISERS |
$925,521 |
27,636 |
0.06% |
주식
|
| Trexquant Investment LP |
$858,851 |
25,645 |
0.05% |
주식
|
| Invesco Ltd. |
$806,908 |
24,094 |
0.05% |
주식
|
| Logos Global Management LP |
$788,623 |
23,548 |
0.05% |
주식
|
| FMR LLC |
$778,308 |
23,240 |
0.05% |
주식
|
| FOX RUN MANAGEMENT, L.L.C. |
$738,053 |
22,038 |
0.04% |
주식
|
| DEUTSCHE BANK AG\ |
$732,527 |
21,873 |
0.04% |
주식
|
| ALLIANCEBERNSTEIN L.P. |
$718,497 |
29,900 |
0.04% |
주식
|
| TWO SIGMA ADVISERS, LP |
$716,516 |
25,700 |
0.04% |
주식
|
| Squarepoint Ops LLC |
$710,624 |
21,219 |
0.04% |
주식
|
| STRS OHIO |
$703,290 |
21,000 |
0.04% |
주식
|
| FRED ALGER MANAGEMENT, LLC |
$701,883 |
20,958 |
0.04% |
주식
|
| Jump Financial, LLC |
$676,498 |
20,200 |
0.04% |
주식
|
| Swiss National Bank |
$663,102 |
19,800 |
0.04% |
주식
|
| WELLS FARGO & COMPANY/MN |
$659,218 |
19,684 |
0.04% |
주식
|
| FRANKLIN RESOURCES INC |
$623,148 |
18,607 |
0.04% |
주식
|
| CITIGROUP INC |
$596,390 |
17,808 |
0.04% |
주식
|
| Aquatic Capital Management LLC |
$583,630 |
17,427 |
0.04% |
주식
|
| Engineers Gate Manager LP |
$581,052 |
17,350 |
0.04% |
주식
|
| BNP PARIBAS FINANCIAL MARKETS |
$567,522 |
16,946 |
0.03% |
주식
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$555,833 |
16,597 |
0.03% |
주식
|
| State of Wyoming |
$548,533 |
16,379 |
0.03% |
주식
|
| Vanguard Global Advisers, LLC |
$544,112 |
16,247 |
0.03% |
주식
|
| AQR CAPITAL MANAGEMENT LLC |
$515,646 |
15,397 |
0.03% |
주식
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$445,417 |
13,300 |
0.03% |
주식
|
| Verdad Advisers, LP |
$434,365 |
12,970 |
0.03% |
주식
|
| MetLife Investment Management, LLC |
$431,351 |
12,880 |
0.03% |
주식
|
| OSAIC HOLDINGS, INC. |
$421,772 |
12,594 |
0.03% |
주식
|
| Man Group plc |
$384,097 |
11,469 |
0.02% |
주식
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$363,902 |
10,866 |
0.02% |
주식
|
| China Universal Asset Management Co., Ltd. |
$360,821 |
10,774 |
0.02% |
주식
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$341,364 |
10,193 |
0.02% |
주식
|
| Legal & General Group Plc |
$336,976 |
10,062 |
0.02% |
주식
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$334,297 |
9,982 |
0.02% |
주식
|
| Gotham Asset Management, LLC |
$312,194 |
9,322 |
0.02% |
주식
|
| Virtus Investment Advisers, LLC |
$304,826 |
9,102 |
0.02% |
주식
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$298,061 |
8,900 |
0.02% |
주식
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$284,665 |
8,500 |
0.02% |
주식
|
| FIRST TRUST ADVISORS LP |
$259,179 |
7,739 |
0.02% |
주식
|
| Creative Planning |
$255,729 |
7,636 |
0.02% |
주식
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$248,496 |
7,420 |
0.02% |
주식
|
| Quantinno Capital Management LP |
$245,482 |
7,330 |
0.01% |
주식
|
| CIBC Bancorp USA Inc. |
$241,865 |
7,222 |
0.01% |
주식
|
| Rangeley Capital, LLC |
$241,128 |
7,200 |
0.01% |
주식
|
| OCCUDO QUANTITATIVE STRATEGIES LP |
$240,827 |
7,191 |
0.01% |
주식
|
| WINTON GROUP Ltd |
$240,525 |
7,182 |
0.01% |
주식
|
| Police & Firemen's Retirement System of New Jersey |
$218,589 |
6,527 |
0.01% |
주식
|
| CITADEL ADVISORS LLC |
$212,662 |
6,350 |
0.01% |
주식
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$211,121 |
6,304 |
0.01% |
주식
|
| CAPTRUST FINANCIAL ADVISORS |
$208,006 |
6,211 |
0.01% |
주식
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$204,122 |
6,095 |
0.01% |
주식
|
| Chung Wu Investment Group, LLC |
$160,752 |
4,800 |
0.01% |
주식
|
| Congress Wealth Management LLC / DE / |
$133,065 |
12,589 |
0.01% |
주식
|
| Vanguard Investments Australia, Ltd. |
$130,444 |
3,895 |
0.01% |
주식
|
| Lindbrook Capital, LLC |
$121,590 |
21,000 |
0.01% |
주식
|
| KLP KAPITALFORVALTNING AS |
$83,725 |
2,500 |
0.01% |
주식
|
| ROYAL BANK OF CANADA |
$70,000 |
2,098 |
0.00% |
주식
|
| Mirae Asset Global Investments Co., Ltd. |
$67,516 |
2,016 |
0.00% |
주식
|
| Ameritas Investment Partners, Inc. |
$65,105 |
1,944 |
0.00% |
주식
|
| Steward Partners Investment Advisory, LLC |
$44,374 |
1,325 |
0.00% |
주식
|
| GAMMA Investing LLC |
$37,475 |
1,119 |
0.00% |
주식
|
| Tower Research Capital LLC (TRC) |
$35,466 |
1,059 |
0.00% |
주식
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$32,519 |
971 |
0.00% |
주식
|
| SIGNATUREFD, LLC |
$32,351 |
966 |
0.00% |
주식
|
| GF FUND MANAGEMENT CO. LTD. |
$31,816 |
950 |
0.00% |
주식
|
| NISA INVESTMENT ADVISORS, LLC |
$25,720 |
768 |
0.00% |
주식
|
| CWM, LLC |
$21,483 |
894 |
0.00% |
주식
|
| Persistent Asset Partners Ltd |
$18,207 |
152 |
0.00% |
풋 옵션
|
| Quantbot Technologies LP |
$17,247 |
515 |
0.00% |
주식
|
| Amova Asset Management Americas, Inc. |
$16,934 |
507 |
0.00% |
주식
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$12,123 |
362 |
0.00% |
주식
|
| Pinnacle Wealth Planning Services, Inc. |
$10,784 |
322 |
0.00% |
주식
|
| Versant Capital Management, Inc |
$10,213 |
261 |
0.00% |
주식
|
| Arax Advisory Partners |
$7,904 |
236 |
0.00% |
주식
|
| US BANCORP \DE\ |
$7,368 |
220 |
0.00% |
주식
|
| Sterling Capital Management LLC |
$6,698 |
200 |
0.00% |
주식
|
| Larson Financial Group LLC |
$6,564 |
196 |
0.00% |
주식
|
| N.E.W. Advisory Services LLC |
$6,028 |
180 |
0.00% |
주식
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$3,725 |
155 |
0.00% |
주식
|
| MassMutual Private Wealth & Trust, FSB |
$3,483 |
104 |
0.00% |
주식
|
| Aster Capital Management (DIFC) Ltd |
$3,416 |
102 |
0.00% |
주식
|
| Caitong International Asset Management Co., Ltd |
$2,579 |
77 |
0.00% |
주식
|
| EverSource Wealth Advisors, LLC |
$2,142 |
64 |
0.00% |
주식
|
| SBI Securities Co., Ltd. |
$1,842 |
55 |
0.00% |
주식
|
| Cornerstone Financial Management LLC |
$1,741 |
52 |
0.00% |
주식
|
| PNC Financial Services Group, Inc. |
$1,507 |
45 |
0.00% |
주식
|
| HRT FINANCIAL LP |
$1,407 |
42,022 |
0.00% |
주식
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$1,183 |
35,323 |
0.00% |
주식
|
| ROTHSCHILD INVESTMENT LLC |
$1,005 |
30 |
0.00% |
주식
|
| ACADIAN ASSET MANAGEMENT LLC |
$701 |
20,996 |
0.00% |
주식
|
| Fortitude Family Office, LLC |
$670 |
20 |
0.00% |
주식
|
| Ameritas Advisory Services, LLC |
$603 |
18 |
0.00% |
주식
|
| NATIONAL BANK OF CANADA /FI/ |
$234 |
7 |
0.00% |
주식
|
| SJS Investment Consulting Inc. |
$201 |
6 |
0.00% |
주식
|
| Global Retirement Partners, LLC |
$100 |
3 |
0.00% |
주식
|
| Covestor Ltd |
$72 |
2,123 |
0.00% |
주식
|
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM |
$65 |
1,946 |
0.00% |
주식
|
| Allworth Financial LP |
$34 |
1 |
0.00% |
주식
|
| Silver Grove Financial Group, Inc. |
$33 |
1 |
0.00% |
주식
|