| a16z Capital Management, L.L.C. |
$79244997 |
3233170 |
8.37% |
股份
|
| BlackRock, Inc. |
$69830877 |
2849077 |
7.38% |
股份
|
| Cormorant Asset Management, LP |
$58593729 |
2390605 |
6.19% |
股份
|
| Sofinnova Investments, Inc. |
$56220744 |
2293788 |
5.94% |
股份
|
| Octagon Capital Advisors LP |
$42843480 |
1748000 |
4.53% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$40972092 |
1671648 |
4.33% |
股份
|
| MPM BIOIMPACT LLC |
$40874371 |
1667661 |
4.32% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$37848685 |
1544214 |
4.00% |
股份
|
| JANUS HENDERSON GROUP PLC |
$36597368 |
2094270 |
3.87% |
股份
|
| Polar Capital Holdings Plc |
$26283151 |
1072344 |
2.78% |
股份
|
| BRAIDWELL LP |
$25321992 |
1033129 |
2.67% |
股份
|
| STATE STREET CORP |
$25036083 |
1021464 |
2.64% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$24619235 |
1004264 |
2.60% |
股份
|
| Sands Capital Alternatives, LLC |
$19273512 |
786353 |
2.04% |
股份
|
| VANGUARD GROUP INC |
$18717407 |
1414770 |
1.98% |
股份
|
| ORBIMED ADVISORS LLC |
$18435270 |
752153 |
1.95% |
股份
|
| D. E. Shaw & Co., Inc. |
$18205072 |
742761 |
1.92% |
股份
|
| Balyasny Asset Management L.P. |
$17227050 |
702858 |
1.82% |
股份
|
| Pivotal bioVenture Partners Investment Advisor LLC |
$16014197 |
653374 |
1.69% |
股份
|
| COSMIC MANAGEMENT, LLC |
$12299927 |
501833 |
1.30% |
股份
|
| STEMPOINT CAPITAL LP |
$11376831 |
464171 |
1.20% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$10053144 |
410165 |
1.06% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$9661958 |
394138 |
1.02% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$9242353 |
377085 |
0.98% |
股份
|
| Walleye Capital LLC |
$8686221 |
354395 |
0.92% |
股份
|
| Nuveen, LLC |
$8557471 |
349142 |
0.90% |
股份
|
| NORTHERN TRUST CORP |
$8410999 |
343166 |
0.89% |
股份
|
| Integral Health Asset Management, LLC |
$7353000 |
300000 |
0.78% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$7353000 |
300000 |
0.78% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$7267215 |
296500 |
0.77% |
买入期权
|
| MORGAN STANLEY |
$6921282 |
282386 |
0.73% |
股份
|
| FRANKLIN RESOURCES INC |
$6911011 |
281967 |
0.73% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$6700323 |
273371 |
0.71% |
股份
|
| Comprehensive Financial Management LLC |
$6662847 |
271842 |
0.70% |
股份
|
| GOLDMAN SACHS GROUP INC |
$6636548 |
270769 |
0.70% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$6320026 |
257855 |
0.67% |
股份
|
| Squadron Capital Management LLC |
$6127500 |
250000 |
0.65% |
买入期权
|
| JPMORGAN CHASE & CO |
$5837776 |
233979 |
0.62% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$5456441 |
222621 |
0.58% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$5382396 |
219600 |
0.57% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$5237076 |
213671 |
0.55% |
股份
|
| DIADEMA PARTNERS LP |
$4904451 |
200100 |
0.52% |
买入期权
|
| Ikarian Capital, LLC |
$4901999 |
200000 |
0.52% |
股份
|
| FMR LLC |
$4499129 |
183563 |
0.48% |
股份
|
| Yiheng Capital Management, L.P. |
$4179739 |
170532 |
0.44% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$4061307 |
165700 |
0.43% |
股份
|
| Squadron Capital Management LLC |
$3799050 |
155000 |
0.40% |
股份
|
| DIADEMA PARTNERS LP |
$3586646 |
146334 |
0.38% |
股份
|
| Ensign Peak Advisors, Inc |
$3473018 |
141698 |
0.37% |
股份
|
| Invesco Ltd. |
$3123064 |
127420 |
0.33% |
股份
|
| Bank of New York Mellon Corp |
$2630698 |
107332 |
0.28% |
股份
|
| UBS Group AG |
$2522716 |
102926 |
0.27% |
股份
|
| NEXTBio Capital Management LP |
$2468941 |
100732 |
0.26% |
股份
|
| Burkehill Global Management, LP |
$2451000 |
100000 |
0.26% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$2320018 |
94656 |
0.25% |
股份
|
| Alessandra Capital Management, LLC |
$2288459 |
93368 |
0.24% |
股份
|
| Russell Investments Group, Ltd. |
$1941112 |
79196 |
0.21% |
股份
|
| CITADEL ADVISORS LLC |
$1920726 |
78365 |
0.20% |
股份
|
| Caption Management, LLC |
$1838250 |
75000 |
0.19% |
买入期权
|
| BNP PARIBAS FINANCIAL MARKETS |
$1752146 |
71487 |
0.19% |
股份
|
| Birchview Capital, LP |
$1691190 |
69000 |
0.18% |
股份
|
| Squarepoint Ops LLC |
$1677366 |
68436 |
0.18% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$1504767 |
61394 |
0.16% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$1504424 |
61380 |
0.16% |
股份
|
| AMERIPRISE FINANCIAL INC |
$1450943 |
59198 |
0.15% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1431384 |
58400 |
0.15% |
卖出期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1422193 |
58025 |
0.15% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$1342658 |
54780 |
0.14% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$1254618 |
51188 |
0.13% |
股份
|
| Quantinno Capital Management LP |
$1254618 |
51188 |
0.13% |
股份
|
| SEVEN GRAND MANAGERS, LLC |
$1225500 |
50000 |
0.13% |
股份
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$1214348 |
49545 |
0.13% |
股份
|
| Moody Aldrich Partners LLC |
$1164004 |
47491 |
0.12% |
股份
|
| SIMPLEX TRADING, LLC |
$1158832 |
47280 |
0.12% |
股份
|
| RHUMBLINE ADVISERS |
$1076080 |
43904 |
0.11% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$1029420 |
42000 |
0.11% |
股份
|
| Corient Private Wealth LP |
$986724 |
40258 |
0.10% |
股份
|
| Persistent Asset Partners Ltd |
$913071 |
37253 |
0.10% |
股份
|
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
$866183 |
35340 |
0.09% |
股份
|
| DEUTSCHE BANK AG\ |
$840644 |
34298 |
0.09% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$799293 |
45700 |
0.08% |
股份
|
| CITADEL ADVISORS LLC |
$794124 |
32400 |
0.08% |
卖出期权
|
| Militia Capital Management LLC |
$791330 |
32286 |
0.08% |
股份
|
| Vanguard Global Advisers, LLC |
$781011 |
31865 |
0.08% |
股份
|
| MARSHALL WACE, LLP |
$778021 |
31743 |
0.08% |
股份
|
| CITIGROUP INC |
$746869 |
30472 |
0.08% |
股份
|
| WELLS FARGO & COMPANY/MN |
$727800 |
29694 |
0.08% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$689883 |
28147 |
0.07% |
股份
|
| CITADEL ADVISORS LLC |
$681378 |
27800 |
0.07% |
买入期权
|
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
$681084 |
27788 |
0.07% |
股份
|
| XTX Topco Ltd |
$656696 |
26793 |
0.07% |
股份
|
| WEXFORD CAPITAL LP |
$631500 |
25765 |
0.07% |
股份
|
| BARCLAYS PLC |
$627947 |
25620 |
0.07% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$612750 |
25000 |
0.06% |
买入期权
|
| JANE STREET GROUP, LLC |
$590421 |
24089 |
0.06% |
股份
|
| Caption Management, LLC |
$569612 |
23240 |
0.06% |
股份
|
| STRS OHIO |
$539220 |
22000 |
0.06% |
股份
|
| Militia Capital Partners, LP |
$533169 |
40300 |
0.06% |
股份
|
| MetLife Investment Management, LLC |
$511989 |
20889 |
0.05% |
股份
|
| Stonepine Capital Management, LLC |
$490200 |
20000 |
0.05% |
股份
|
| BANK OF NOVA SCOTIA |
$490200 |
20000 |
0.05% |
股份
|
| Creative Planning |
$454292 |
18535 |
0.05% |
股份
|
| Man Group plc |
$444783 |
18147 |
0.05% |
股份
|
| Virtus Investment Advisers, LLC |
$444538 |
18137 |
0.05% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$443386 |
18090 |
0.05% |
股份
|
| Verdad Advisers, LP |
$426327 |
17394 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$409317 |
16700 |
0.04% |
卖出期权
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$396743 |
16187 |
0.04% |
股份
|
| GREAT LAKES ADVISORS, LLC |
$390493 |
15932 |
0.04% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$373532 |
15240 |
0.04% |
股份
|
| Engineers Gate Manager LP |
$343508 |
14015 |
0.04% |
股份
|
| Persistent Asset Partners Ltd |
$342710 |
510 |
0.04% |
买入期权
|
| JANE STREET GROUP, LLC |
$335787 |
13700 |
0.04% |
买入期权
|
| Valor Management LLC |
$321204 |
13105 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$303924 |
12400 |
0.03% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$293556 |
11977 |
0.03% |
股份
|
| GLENMEDE TRUST CO NA |
$268629 |
10960 |
0.03% |
股份
|
| PROFUND ADVISORS LLC |
$266669 |
10880 |
0.03% |
股份
|
| TWO SIGMA ADVISERS, LP |
$257985 |
19500 |
0.03% |
股份
|
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. |
$256669 |
10472 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$254095 |
10367 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$233556 |
9529 |
0.02% |
股份
|
| Quadrature Capital Ltd |
$232355 |
9480 |
0.02% |
股份
|
| RWA WEALTH PARTNERS, LLC |
$222820 |
9091 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$173408 |
7075 |
0.02% |
股份
|
| State of Wyoming |
$153776 |
6274 |
0.02% |
股份
|
| Legal & General Group Plc |
$83653 |
3413 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$78530 |
3204 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$78187 |
3190 |
0.01% |
股份
|
| CWM, LLC |
$64328 |
3678 |
0.01% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$51397 |
2097 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$48726 |
1988 |
0.01% |
股份
|
| PNC Financial Services Group, Inc. |
$48382 |
1974 |
0.01% |
股份
|
| US BANCORP \DE\ |
$32132 |
1311 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$26000 |
1070 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$24682 |
1007 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$22574 |
921 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$21250 |
867 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$15956 |
651 |
0.00% |
股份
|
| Arax Advisory Partners |
$13284 |
542 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$10368 |
423 |
0.00% |
股份
|
| TD Waterhouse Canada Inc. |
$6212 |
256 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$5499 |
224453 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$4484 |
183 |
0.00% |
股份
|
| Torren Management, LLC |
$3725 |
213 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$3555 |
145 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$3304 |
133 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$3137 |
128 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$3064 |
125 |
0.00% |
股份
|
| Truvestments Capital LLC |
$2917 |
119 |
0.00% |
股份
|
| Cornerstone Financial Management LLC |
$2696 |
110 |
0.00% |
股份
|
| Essential Partners LLC |
$2353 |
96 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$2353 |
96 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$2328 |
95 |
0.00% |
股份
|
| Cornerstone Planning Group LLC |
$2238 |
102 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$2132 |
87 |
0.00% |
股份
|
| True Wealth Design, LLC |
$1961 |
80 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$717 |
29247 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$368 |
15 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$270 |
11 |
0.00% |
股份
|
| GAMMA Investing LLC |
$221 |
9 |
0.00% |
股份
|
| IFP Advisors, Inc |
$221 |
9 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$122 |
7 |
0.00% |
股份
|
| Allworth Financial LP |
$99 |
4 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$98 |
4 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$52 |
3 |
0.00% |
股份
|