| Flagship Pioneering, LLC |
$61849706 |
12674120 |
26.98% |
股份
|
| BVF INC/IL |
$28508960 |
5842000 |
12.44% |
股份
|
| FMR LLC |
$27845075 |
5705958 |
12.15% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$21444511 |
4394367 |
9.35% |
股份
|
| BlackRock, Inc. |
$12818939 |
2626832 |
5.59% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$12151093 |
2489978 |
5.30% |
股份
|
| VANGUARD GROUP INC |
$10416557 |
1928992 |
4.54% |
股份
|
| Euclidean Capital LLC |
$7679954 |
1573761 |
3.35% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$7293702 |
1494611 |
3.18% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$4446091 |
910866 |
1.94% |
股份
|
| Siren, L.L.C. |
$3517114 |
720720 |
1.53% |
股份
|
| STATE STREET CORP |
$3403649 |
697469 |
1.48% |
股份
|
| AMERIPRISE FINANCIAL INC |
$2726383 |
558685 |
1.19% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$1844328 |
377936 |
0.80% |
股份
|
| Candriam S.C.A. |
$1529700 |
313765 |
0.67% |
股份
|
| NORTHERN TRUST CORP |
$1511703 |
309775 |
0.66% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$1490518 |
305434 |
0.65% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$1485628 |
304432 |
0.65% |
股份
|
| Birchview Capital, LP |
$1375853 |
281937 |
0.60% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$1290379 |
264422 |
0.56% |
股份
|
| Qube Research & Technologies Ltd |
$992084 |
203296 |
0.43% |
股份
|
| Woodline Partners LP |
$986468 |
202145 |
0.43% |
股份
|
| B Group, Inc. |
$976000 |
200000 |
0.43% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$855981 |
175406 |
0.37% |
股份
|
| GOLDMAN SACHS GROUP INC |
$801569 |
164256 |
0.35% |
股份
|
| CITADEL ADVISORS LLC |
$775051 |
158822 |
0.34% |
股份
|
| Squarepoint Ops LLC |
$636088 |
130346 |
0.28% |
股份
|
| DAFNA Capital Management LLC |
$545872 |
111859 |
0.24% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$535731 |
109781 |
0.23% |
股份
|
| SCS Capital Management LLC |
$522062 |
106980 |
0.23% |
股份
|
| MORGAN STANLEY |
$449429 |
92096 |
0.20% |
股份
|
| Palumbo Wealth Management LLC |
$447687 |
91739 |
0.20% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$437248 |
89600 |
0.19% |
股份
|
| Bank of New York Mellon Corp |
$387253 |
79355 |
0.17% |
股份
|
| Invesco Ltd. |
$381298 |
78135 |
0.17% |
股份
|
| DIADEMA PARTNERS LP |
$326511 |
66908 |
0.14% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$323247 |
66239 |
0.14% |
股份
|
| Nuveen, LLC |
$317390 |
65039 |
0.14% |
股份
|
| Lynx1 Capital Management LP |
$300549 |
61588 |
0.13% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$283499 |
58094 |
0.12% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$261124 |
53509 |
0.11% |
股份
|
| Verdad Advisers, LP |
$259767 |
53231 |
0.11% |
股份
|
| Persistent Asset Partners Ltd |
$228735 |
46872 |
0.10% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$224358 |
45975 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$193152 |
39582 |
0.08% |
股份
|
| DEUTSCHE BANK AG\ |
$178301 |
36537 |
0.08% |
股份
|
| Jump Financial, LLC |
$177549 |
36383 |
0.08% |
股份
|
| WELLS FARGO & COMPANY/MN |
$172268 |
35301 |
0.08% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$142253 |
29760 |
0.06% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$127383 |
26103 |
0.06% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$122488 |
25100 |
0.05% |
股份
|
| JPMORGAN CHASE & CO |
$99304 |
20433 |
0.04% |
股份
|
| BARCLAYS PLC |
$93642 |
19189 |
0.04% |
股份
|
| CITIGROUP INC |
$90494 |
18544 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$82091 |
16822 |
0.04% |
股份
|
| EntryPoint Capital, LLC |
$75557 |
15483 |
0.03% |
股份
|
| DIVERSIFIED TRUST CO |
$72370 |
14830 |
0.03% |
股份
|
| Russell Investments Group, Ltd. |
$70413 |
14429 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$62625 |
12833 |
0.03% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$60732 |
12445 |
0.03% |
股份
|
| TWO SIGMA ADVISERS, LP |
$56160 |
10400 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$55271 |
11326 |
0.02% |
股份
|
| UBS Group AG |
$54808 |
11231 |
0.02% |
股份
|
| Fiduciary Trust Co |
$53090 |
10879 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$51025 |
10456 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$45599 |
9344 |
0.02% |
股份
|
| STRS OHIO |
$41968 |
8600 |
0.02% |
股份
|
| Evelyn Partners Asset Management Ltd |
$33938 |
7100 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$16314 |
3343 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$16016 |
3282 |
0.01% |
股份
|
| CWM, LLC |
$15989 |
3345 |
0.01% |
股份
|
| Legal & General Group Plc |
$14567 |
2985 |
0.01% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$13747 |
2876 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$12815 |
2626 |
0.01% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
$10985 |
2251 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$9232 |
1892 |
0.00% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$9130 |
1871 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$6056 |
1241 |
0.00% |
股份
|
| Arax Advisory Partners |
$5544 |
1136 |
0.00% |
股份
|
| TD Waterhouse Canada Inc. |
$5010 |
1000 |
0.00% |
股份
|
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC |
$5010 |
1000 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$5000 |
1097 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$4780 |
1000 |
0.00% |
股份
|
| GAMMA Investing LLC |
$3099 |
635 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$2362 |
484 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$1205 |
247 |
0.00% |
股份
|
| Allworth Financial LP |
$1172 |
240 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$974 |
200 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$883 |
181 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$625 |
128 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$625 |
128 |
0.00% |
股份
|
| TFC Financial Management, Inc. |
$601 |
123 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$488 |
100 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$381 |
78 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$317 |
65 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$187 |
38784 |
0.00% |
股份
|
| Essential Partners LLC |
$171 |
35 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$161 |
33 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$144 |
29506 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$120 |
24478 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$83 |
17 |
0.00% |
股份
|
| True Wealth Design, LLC |
$69 |
14 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$44 |
9 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$44 |
9 |
0.00% |
股份
|
| Optiver Holding B.V. |
$29 |
6 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$24 |
5 |
0.00% |
股份
|