| FMR LLC |
$202799207 |
9126877 |
13.07% |
股份
|
| Fairmount Funds Management LLC |
$101178637 |
4553494 |
6.52% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$81571464 |
3671083 |
5.26% |
股份
|
| Venrock Adviser, LLC |
$71556488 |
3220364 |
4.61% |
股份
|
| Bellevue Group AG |
$67948671 |
3057996 |
4.38% |
股份
|
| Paradigm Biocapital Advisors LP |
$63491539 |
2857405 |
4.09% |
股份
|
| BlackRock, Inc. |
$62248241 |
2801451 |
4.01% |
股份
|
| FRANKLIN RESOURCES INC |
$62040028 |
2792080 |
4.00% |
股份
|
| STATE STREET CORP |
$51890033 |
2335285 |
3.34% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$49878856 |
2244773 |
3.21% |
股份
|
| JANUS HENDERSON GROUP PLC |
$43557008 |
3105669 |
2.81% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$42458243 |
1910812 |
2.74% |
股份
|
| Polar Capital Holdings Plc |
$41039940 |
1846982 |
2.64% |
股份
|
| Avidity Partners Management LP |
$37789732 |
1700708 |
2.43% |
股份
|
| Remedium Capital Partners, LLC |
$35057605 |
1577750 |
2.26% |
股份
|
| Soleus Capital Management, L.P. |
$34456332 |
1550690 |
2.22% |
股份
|
| JPMORGAN CHASE & CO |
$32613997 |
1475079 |
2.10% |
股份
|
| VANGUARD GROUP INC |
$32337685 |
2095767 |
2.08% |
股份
|
| BAKER BROS. ADVISORS LP |
$27340066 |
1230426 |
1.76% |
股份
|
| Logos Global Management LP |
$24997500 |
1125000 |
1.61% |
股份
|
| Versant Venture Management, LLC |
$22037418 |
991783 |
1.42% |
股份
|
| ACORN CAPITAL ADVISORS, LLC |
$21925807 |
986760 |
1.41% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$21896658 |
985178 |
1.41% |
股份
|
| CITADEL ADVISORS LLC |
$20651423 |
929407 |
1.33% |
股份
|
| Foresite Capital Management VI LLC |
$19701741 |
886667 |
1.27% |
股份
|
| Balyasny Asset Management L.P. |
$19525292 |
878726 |
1.26% |
股份
|
| Affinity Asset Advisors, LLC |
$18672577 |
840350 |
1.20% |
股份
|
| SAMSARA BIOCAPITAL, LLC |
$16359186 |
736237 |
1.05% |
股份
|
| GOLDMAN SACHS GROUP INC |
$16336678 |
735224 |
1.05% |
股份
|
| Pictet Asset Management Holding SA |
$16304325 |
733768 |
1.05% |
股份
|
| Aberdeen Group plc |
$13801020 |
621108 |
0.89% |
股份
|
| MARSHALL WACE, LLP |
$13015609 |
585761 |
0.84% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$10820140 |
486955 |
0.70% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$10255152 |
461528 |
0.66% |
股份
|
| Blackstone Inc. |
$9672810 |
435320 |
0.62% |
股份
|
| Ikarian Capital, LLC |
$9495694 |
427349 |
0.61% |
股份
|
| Walleye Capital LLC |
$8116344 |
365272 |
0.52% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$6989257 |
314548 |
0.45% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$6774145 |
304867 |
0.44% |
股份
|
| NORTHERN TRUST CORP |
$6556700 |
295081 |
0.42% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$4825229 |
217157 |
0.31% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$4431312 |
199429 |
0.29% |
股份
|
| Jump Financial, LLC |
$3838439 |
172747 |
0.25% |
股份
|
| Point72 Asset Management, L.P. |
$3715273 |
167204 |
0.24% |
股份
|
| Russell Investments Group, Ltd. |
$3623746 |
163084 |
0.23% |
股份
|
| Opaleye Management Inc. |
$3221900 |
145000 |
0.21% |
股份
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$3114989 |
140886 |
0.20% |
股份
|
| UBS Group AG |
$2834761 |
127577 |
0.18% |
股份
|
| MORGAN STANLEY |
$2766679 |
124513 |
0.18% |
股份
|
| Quantinno Capital Management LP |
$2548990 |
114716 |
0.16% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$2504261 |
112703 |
0.16% |
股份
|
| Sofinnova Investments, Inc. |
$2386228 |
107391 |
0.15% |
股份
|
| AMERIPRISE FINANCIAL INC |
$2378718 |
107053 |
0.15% |
股份
|
| Woodline Partners LP |
$2227977 |
100269 |
0.14% |
股份
|
| SEVEN GRAND MANAGERS, LLC |
$2222000 |
100000 |
0.14% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$2221489 |
99977 |
0.14% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$2008599 |
90396 |
0.13% |
股份
|
| Atle Fund Management AB |
$1967714 |
88556 |
0.13% |
股份
|
| Bank of New York Mellon Corp |
$1896321 |
85343 |
0.12% |
股份
|
| Swiss National Bank |
$1850926 |
83300 |
0.12% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$1749225 |
78723 |
0.11% |
股份
|
| Longaeva Partners L.P. |
$1744292 |
78501 |
0.11% |
股份
|
| Nuveen, LLC |
$1689764 |
76047 |
0.11% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$1635192 |
73591 |
0.11% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$1532736 |
68980 |
0.10% |
股份
|
| Trexquant Investment LP |
$1517982 |
68316 |
0.10% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1517626 |
68300 |
0.10% |
卖出期权
|
| Harvest Investment Services, LLC |
$1399482 |
62983 |
0.09% |
股份
|
| Corient Private Wealth LP |
$1367198 |
61530 |
0.09% |
股份
|
| XTX Topco Ltd |
$1313046 |
59093 |
0.08% |
股份
|
| Verdad Advisers, LP |
$1252852 |
56384 |
0.08% |
股份
|
| Squarepoint Ops LLC |
$1210012 |
54456 |
0.08% |
股份
|
| CITIGROUP INC |
$1208324 |
54380 |
0.08% |
股份
|
| D. E. Shaw & Co., Inc. |
$1144197 |
51494 |
0.07% |
股份
|
| Maven Securities LTD |
$1111000 |
50000 |
0.07% |
股份
|
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
$1074870 |
48374 |
0.07% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$1007921 |
45361 |
0.06% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1002366 |
45111 |
0.06% |
股份
|
| Rafferty Asset Management, LLC |
$947216 |
42629 |
0.06% |
股份
|
| RHUMBLINE ADVISERS |
$908965 |
40908 |
0.06% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$812963 |
36587 |
0.05% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$797698 |
35900 |
0.05% |
买入期权
|
| DEUTSCHE BANK AG\ |
$770634 |
34682 |
0.05% |
股份
|
| Vanguard Global Advisers, LLC |
$757546 |
34093 |
0.05% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$702441 |
31613 |
0.05% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$664987 |
47330 |
0.04% |
股份
|
| WELLS FARGO & COMPANY/MN |
$660401 |
29721 |
0.04% |
股份
|
| Voleon Capital Management LP |
$617205 |
27777 |
0.04% |
股份
|
| Man Group plc |
$580453 |
26123 |
0.04% |
股份
|
| Legal & General Group Plc |
$520393 |
23420 |
0.03% |
股份
|
| BARCLAYS PLC |
$502928 |
22634 |
0.03% |
股份
|
| Engineers Gate Manager LP |
$502594 |
22619 |
0.03% |
股份
|
| Aquatic Capital Management LLC |
$498417 |
22431 |
0.03% |
股份
|
| PROFUND ADVISORS LLC |
$475775 |
21412 |
0.03% |
股份
|
| Virtus Investment Advisers, LLC |
$473930 |
21329 |
0.03% |
股份
|
| Ghisallo Capital Management LLC |
$444400 |
20000 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$442589 |
19943 |
0.03% |
股份
|
| MetLife Investment Management, LLC |
$438601 |
19739 |
0.03% |
股份
|
| Invesco Ltd. |
$402604 |
18119 |
0.03% |
股份
|
| KLP KAPITALFORVALTNING AS |
$306636 |
13800 |
0.02% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$295769 |
13311 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$292037 |
13143 |
0.02% |
股份
|
| Creative Planning |
$271018 |
12197 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$256019 |
11522 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$221445 |
9966 |
0.01% |
股份
|
| Brevan Howard Capital Management LP |
$215623 |
9704 |
0.01% |
股份
|
| DELTEC ASSET MANAGEMENT LLC |
$209668 |
9436 |
0.01% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$204824 |
9218 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$173916 |
7827 |
0.01% |
股份
|
| STRS OHIO |
$73326 |
3300 |
0.00% |
股份
|
| Ameritas Investment Partners, Inc. |
$65660 |
2955 |
0.00% |
股份
|
| State of Wyoming |
$65060 |
2928 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$41308 |
1859 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$33552 |
1510 |
0.00% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$26131 |
1176 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$24997 |
1125 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$24000 |
1050 |
0.00% |
股份
|
| GAMMA Investing LLC |
$20354 |
916 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$16265 |
732 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$12715 |
905 |
0.00% |
股份
|
| Persistent Asset Partners Ltd |
$8858 |
88 |
0.00% |
卖出期权
|
| Arax Advisory Partners |
$8554 |
385 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$6927 |
493 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$5940 |
270 |
0.00% |
股份
|
| LORD, ABBETT & CO. LLC |
$5035 |
226606 |
0.00% |
股份
|
| Allworth Financial LP |
$3311 |
149 |
0.00% |
股份
|
| DIADEMA PARTNERS LP |
$3174 |
1046 |
0.00% |
卖出期权
|
| Sterling Capital Management LLC |
$2533 |
114 |
0.00% |
股份
|
| Optiver Holding B.V. |
$2311 |
104 |
0.00% |
股份
|
| Larson Financial Group LLC |
$2311 |
104 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$2066 |
93 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$1460 |
66 |
0.00% |
股份
|
| US BANCORP \DE\ |
$1178 |
53 |
0.00% |
股份
|
| CWM, LLC |
$1054 |
75 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$1044 |
47 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$1000 |
45 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$933 |
42 |
0.00% |
股份
|
| Quarry LP |
$867 |
39 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$644 |
29 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$590 |
26546 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$510 |
23 |
0.00% |
股份
|
| Ares Financial Consulting, LLC |
$444 |
20 |
0.00% |
股份
|
| Essential Partners LLC |
$178 |
8 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$178 |
8 |
0.00% |
股份
|
| Owl Creek Wealth Partners LLC |
$156 |
7 |
0.00% |
股份
|
| IFP Advisors, Inc |
$133 |
6 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$89 |
4 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$89 |
4 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$68 |
3 |
0.00% |
股份
|
| TFC Financial Management, Inc. |
$67 |
3 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$44 |
2 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$44 |
2 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$22 |
1 |
0.00% |
股份
|
| ASSETMARK, INC |
$22 |
1 |
0.00% |
股份
|
| Wealth Enhancement Trust Services, Inc. |
$22 |
1 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$16 |
712 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
17 |
0.00% |
股份
|
| Avion Wealth |
$0 |
7 |
0.00% |
股份
|
| Capital Advisors, Ltd. LLC |
$0 |
6 |
0.00% |
股份
|