| BAKER BROS. ADVISORS LP |
$776051487 |
19919186 |
34.06% |
股份
|
| BlackRock, Inc. |
$161113431 |
4135355 |
7.07% |
股份
|
| STATE STREET CORP |
$94260486 |
2419417 |
4.14% |
股份
|
| GOLDMAN SACHS GROUP INC |
$90231905 |
2316014 |
3.96% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$70308463 |
1804632 |
3.09% |
股份
|
| BRAIDWELL LP |
$69633909 |
1787318 |
3.06% |
股份
|
| VANGUARD GROUP INC |
$64682524 |
2313395 |
2.84% |
股份
|
| RTW INVESTMENTS, LP |
$57969909 |
1487934 |
2.54% |
股份
|
| Boxer Capital Management, LLC |
$57567296 |
1477600 |
2.53% |
股份
|
| TCG Crossover Management, LLC |
$56318161 |
1445538 |
2.47% |
股份
|
| JANUS HENDERSON GROUP PLC |
$50539675 |
1325457 |
2.22% |
股份
|
| ICONIQ Capital, LLC |
$49345294 |
1266563 |
2.17% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$41420974 |
1062955 |
1.82% |
股份
|
| Ikarian Capital, LLC |
$41287080 |
1059730 |
1.81% |
股份
|
| Artisan Partners Limited Partnership |
$37714722 |
968037 |
1.66% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$30919164 |
793613 |
1.36% |
股份
|
| Board of Trustees of The Leland Stanford Junior University |
$26951242 |
691767 |
1.18% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$21282134 |
546256 |
0.93% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$20758628 |
532819 |
0.91% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$19480000 |
500000 |
0.85% |
股份
|
| Squadron Capital Management LLC |
$19480000 |
500000 |
0.85% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$18428119 |
473001 |
0.81% |
股份
|
| MORGAN STANLEY |
$16948748 |
435029 |
0.74% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$14949303 |
383709 |
0.66% |
股份
|
| BOONE CAPITAL MANAGEMENT LLC |
$14727270 |
378010 |
0.65% |
股份
|
| NORTHERN TRUST CORP |
$14291579 |
366827 |
0.63% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$13949862 |
358056 |
0.61% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$12174462 |
312595 |
0.53% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$11375112 |
291969 |
0.50% |
股份
|
| FMR LLC |
$10791298 |
276984 |
0.47% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$10344815 |
265524 |
0.45% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$9346504 |
239900 |
0.41% |
买入期权
|
| DIADEMA PARTNERS LP |
$8497838 |
218117 |
0.37% |
股份
|
| Ikarian Capital, LLC |
$8481592 |
217700 |
0.37% |
买入期权
|
| D. E. Shaw & Co., Inc. |
$8232248 |
211300 |
0.36% |
股份
|
| DIADEMA PARTNERS LP |
$7663432 |
196700 |
0.34% |
买入期权
|
| TD Asset Management Inc |
$7563383 |
194132 |
0.33% |
股份
|
| PFM Health Sciences, LP |
$7531552 |
193315 |
0.33% |
股份
|
| UBS Group AG |
$7406880 |
190115 |
0.33% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$7371232 |
189200 |
0.32% |
股份
|
| ALGERT GLOBAL LLC |
$7265105 |
186476 |
0.32% |
股份
|
| Nuveen, LLC |
$6807481 |
174730 |
0.30% |
股份
|
| CITADEL ADVISORS LLC |
$6137135 |
157524 |
0.27% |
股份
|
| Squarepoint Ops LLC |
$5886778 |
151098 |
0.26% |
股份
|
| Ghisallo Capital Management LLC |
$5844000 |
150000 |
0.26% |
股份
|
| DIADEMA PARTNERS LP |
$5723224 |
146900 |
0.25% |
卖出期权
|
| Bruce & Co., Inc. |
$5649200 |
145000 |
0.25% |
股份
|
| FEDERATED HERMES, INC. |
$5612772 |
144065 |
0.25% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$4694485 |
120495 |
0.21% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$4444907 |
114089 |
0.20% |
股份
|
| Bank of New York Mellon Corp |
$4360988 |
111935 |
0.19% |
股份
|
| CITADEL ADVISORS LLC |
$4266120 |
109500 |
0.19% |
买入期权
|
| WELLS FARGO & COMPANY/MN |
$3928921 |
100845 |
0.17% |
股份
|
| CITADEL ADVISORS LLC |
$3884312 |
99700 |
0.17% |
卖出期权
|
| Harvest Investment Services, LLC |
$3812080 |
97846 |
0.17% |
股份
|
| Point72 Asset Management, L.P. |
$3802379 |
97597 |
0.17% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$3775146 |
96898 |
0.17% |
股份
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$3662824 |
94015 |
0.16% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$3631072 |
93200 |
0.16% |
卖出期权
|
| VICTORY CAPITAL MANAGEMENT INC |
$3491206 |
89610 |
0.15% |
股份
|
| RIA Advisory Group LLC |
$3398442 |
87229 |
0.15% |
股份
|
| JPMORGAN CHASE & CO |
$3383429 |
87824 |
0.15% |
股份
|
| Caption Management, LLC |
$3186928 |
81800 |
0.14% |
买入期权
|
| SPHERA FUNDS MANAGEMENT LTD. |
$3186772 |
81796 |
0.14% |
股份
|
| Atom Investors LP |
$2993803 |
76843 |
0.13% |
股份
|
| STEMPOINT CAPITAL LP |
$2955973 |
75872 |
0.13% |
股份
|
| Invesco Ltd. |
$2901156 |
74465 |
0.13% |
股份
|
| TWO SIGMA ADVISERS, LP |
$2882676 |
103100 |
0.13% |
股份
|
| Qube Research & Technologies Ltd |
$2882183 |
73978 |
0.13% |
股份
|
| FRANKLIN RESOURCES INC |
$2769900 |
71096 |
0.12% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$2639812 |
67757 |
0.12% |
股份
|
| ExodusPoint Capital Management, LP |
$2636501 |
67672 |
0.12% |
股份
|
| Pictet Asset Management Holding SA |
$2497778 |
66015 |
0.11% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$2446688 |
62800 |
0.11% |
买入期权
|
| CITIGROUP INC |
$2430325 |
62380 |
0.11% |
股份
|
| Swiss National Bank |
$2415520 |
62000 |
0.11% |
股份
|
| Persistent Asset Partners Ltd |
$2183786 |
56052 |
0.10% |
股份
|
| Emerald Investment Advisers, LLC |
$2167384 |
55631 |
0.10% |
股份
|
| DEUTSCHE BANK AG\ |
$2156320 |
55347 |
0.09% |
股份
|
| Jain Global LLC |
$2151098 |
55213 |
0.09% |
股份
|
| Resolute Capital Asset Partners LLC |
$2001960 |
51385 |
0.09% |
股份
|
| RHUMBLINE ADVISERS |
$1955700 |
50198 |
0.09% |
股份
|
| Informed Momentum Co LLC |
$1894157 |
48618 |
0.08% |
股份
|
| Balyasny Asset Management L.P. |
$1809536 |
46446 |
0.08% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$1800026 |
47220 |
0.08% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1717123 |
44074 |
0.08% |
股份
|
| JANE STREET GROUP, LLC |
$1706448 |
43800 |
0.07% |
买入期权
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$1667788 |
43751 |
0.07% |
股份
|
| Rafferty Asset Management, LLC |
$1619294 |
41563 |
0.07% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$1585672 |
40700 |
0.07% |
股份
|
| HighVista Strategies LLC |
$1581387 |
40590 |
0.07% |
股份
|
| POLEN CAPITAL MANAGEMENT LLC |
$1381872 |
35469 |
0.06% |
股份
|
| Russell Investments Group, Ltd. |
$1358566 |
34870 |
0.06% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1335977 |
34291 |
0.06% |
股份
|
| PANAGORA ASSET MANAGEMENT INC |
$1332042 |
34190 |
0.06% |
股份
|
| Caption Management, LLC |
$1297368 |
33300 |
0.06% |
卖出期权
|
| MILLENNIUM MANAGEMENT LLC |
$1213760 |
31154 |
0.05% |
股份
|
| Vanguard Global Advisers, LLC |
$1192955 |
30620 |
0.05% |
股份
|
| Trexquant Investment LP |
$1171332 |
30065 |
0.05% |
股份
|
| Engineers Gate Manager LP |
$1150762 |
29537 |
0.05% |
股份
|
| Legal & General Group Plc |
$1141880 |
29309 |
0.05% |
股份
|
| XTX Topco Ltd |
$1140009 |
29261 |
0.05% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$986390 |
25318 |
0.04% |
股份
|
| Aries Wealth Management |
$974000 |
25000 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$947079 |
24309 |
0.04% |
股份
|
| State of Wyoming |
$905586 |
23244 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$895418 |
22983 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$888476 |
22956 |
0.04% |
股份
|
| BARCLAYS PLC |
$819717 |
21040 |
0.04% |
股份
|
| PROFUND ADVISORS LLC |
$819524 |
21035 |
0.04% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$723137 |
18561 |
0.03% |
股份
|
| OPTIMIZE FINANCIAL INC. |
$692202 |
17767 |
0.03% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$682774 |
17525 |
0.03% |
股份
|
| Artia Global Partners LP |
$663060 |
17019 |
0.03% |
股份
|
| SEI INVESTMENTS CO |
$620547 |
15928 |
0.03% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$606296 |
15562 |
0.03% |
股份
|
| Palumbo Wealth Management LLC |
$605478 |
15541 |
0.03% |
股份
|
| SIMPLEX TRADING, LLC |
$569205 |
14610 |
0.02% |
股份
|
| Brevan Howard Capital Management LP |
$546336 |
14023 |
0.02% |
股份
|
| Edgestream Partners, L.P. |
$527207 |
13532 |
0.02% |
股份
|
| Continuum Advisory, LLC |
$520194 |
13352 |
0.02% |
股份
|
| FRED ALGER MANAGEMENT, LLC |
$501220 |
12865 |
0.02% |
股份
|
| LPL Financial LLC |
$491753 |
12622 |
0.02% |
股份
|
| Cerity Partners LLC |
$488871 |
12548 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$478702 |
12287 |
0.02% |
股份
|
| Campbell & CO Investment Adviser LLC |
$476442 |
12229 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$460624 |
11823 |
0.02% |
股份
|
| Quantinno Capital Management LP |
$453066 |
11629 |
0.02% |
股份
|
| Creative Planning |
$445430 |
11433 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$422755 |
10851 |
0.02% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$404989 |
10395 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$389561 |
9999 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$388003 |
9959 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$374250 |
9606 |
0.02% |
股份
|
| STIFEL FINANCIAL CORP |
$369193 |
9476 |
0.02% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$360926 |
9264 |
0.02% |
股份
|
| Skopos Labs, Inc. |
$346473 |
9089 |
0.02% |
股份
|
| Persistent Asset Partners Ltd |
$344930 |
372 |
0.02% |
卖出期权
|
| ARIZONA STATE RETIREMENT SYSTEM |
$332446 |
8533 |
0.01% |
股份
|
| ALLSTATE CORP |
$327615 |
8409 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$319472 |
8200 |
0.01% |
股份
|
| NORGES BANK |
$298083 |
7651 |
0.01% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$287914 |
7390 |
0.01% |
股份
|
| J. Goldman & Co LP |
$284759 |
7309 |
0.01% |
股份
|
| ProShare Advisors LLC |
$280784 |
7207 |
0.01% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$255032 |
6546 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$249344 |
6400 |
0.01% |
股份
|
| MANGROVE PARTNERS IM, LLC |
$239565 |
6149 |
0.01% |
股份
|
| PSP Research LLC |
$233760 |
6000 |
0.01% |
股份
|
| HSBC HOLDINGS PLC |
$232415 |
6004 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$228345 |
5861 |
0.01% |
股份
|
| Persistent Asset Partners Ltd |
$215919 |
502 |
0.01% |
买入期权
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$206605 |
5303 |
0.01% |
股份
|
| VARCOV Co. |
$204696 |
5254 |
0.01% |
股份
|
| GROUP ONE TRADING LLC |
$153580 |
3942 |
0.01% |
股份
|
| Mitsubishi UFJ Trust & Banking Corp |
$145827 |
3743 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$139204 |
3573 |
0.01% |
股份
|
| CWM, LLC |
$131476 |
3449 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$131000 |
3362 |
0.01% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$126567 |
3248611 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$115360 |
2961 |
0.01% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$113023 |
2901 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$109049 |
2799 |
0.00% |
股份
|
| Bayforest Capital Ltd |
$105932 |
2719 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$96582 |
2479 |
0.00% |
股份
|
| T. Rowe Price Investment Management, Inc. |
$57546 |
1477033 |
0.00% |
股份
|
| STRS OHIO |
$50648 |
1300 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$50414 |
1294 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$47414 |
1217 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$41183 |
2516 |
0.00% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$39622 |
1017 |
0.00% |
股份
|
| Activest Wealth Management |
$38999 |
1001 |
0.00% |
股份
|
| GAMMA Investing LLC |
$34752 |
892 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$27876 |
730 |
0.00% |
股份
|
| FIFTH THIRD BANCORP |
$27496 |
706 |
0.00% |
股份
|
| V-Square Quantitative Management LLC |
$26960 |
692 |
0.00% |
股份
|
| Larson Financial Group LLC |
$25675 |
659 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$24895 |
639 |
0.00% |
股份
|
| Spire Wealth Management |
$24662 |
633 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$23766 |
610 |
0.00% |
股份
|
| Ameritas Advisory Services, LLC |
$20727 |
532 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$17610 |
452 |
0.00% |
股份
|
| Allworth Financial LP |
$15000 |
385 |
0.00% |
股份
|
| TOKIO MARINE ASSET MANAGEMENT CO LTD |
$13285 |
341 |
0.00% |
股份
|
| Accent Capital Management, LLC |
$8844 |
227 |
0.00% |
股份
|
| Arax Advisory Partners |
$7247 |
186 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$5922 |
152 |
0.00% |
股份
|
| AlphaQuest LLC |
$5872 |
210 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$5376 |
138 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$2961 |
76 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$1714 |
44 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1636 |
42 |
0.00% |
股份
|
| FINANCIAL CONSULATE, INC |
$1169 |
30 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$1072 |
27525 |
0.00% |
股份
|
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY |
$990 |
25419 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$818 |
21 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$781 |
20057 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$585 |
15 |
0.00% |
股份
|
| True Wealth Design, LLC |
$507 |
13 |
0.00% |
股份
|
| Quarry LP |
$468 |
12 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$390 |
10 |
0.00% |
股份
|
| Axiom Investment Management LLC |
$390 |
10 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$273 |
7 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$253 |
6 |
0.00% |
股份
|
| IFP Advisors, Inc |
$234 |
6 |
0.00% |
股份
|
| Essential Partners LLC |
$195 |
5 |
0.00% |
股份
|
| CANADA LIFE ASSURANCE Co |
$192 |
4951 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$156 |
4 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$78 |
2 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$54 |
1415 |
0.00% |
股份
|
| KBC Group NV |
$40 |
1014 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$27 |
694 |
0.00% |
股份
|
| Avion Wealth |
$13 |
352 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
17 |
0.00% |
股份
|