| GordonMD Global Investments LP |
$37821328 |
4244818 |
10.19% |
股份
|
| GILEAD SCIENCES, INC. |
$36763720 |
4126119 |
9.90% |
股份
|
| BlackRock, Inc. |
$27931130 |
3134807 |
7.52% |
股份
|
| Vida Ventures Advisors, LLC |
$27143544 |
4523924 |
7.31% |
股份
|
| Bain Capital Life Sciences Investors, LLC |
$25705350 |
2885000 |
6.93% |
股份
|
| AIGH Capital Management LLC |
$24910552 |
2795797 |
6.71% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$17820000 |
2000000 |
4.80% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$16906288 |
1897451 |
4.55% |
股份
|
| VANGUARD GROUP INC |
$16743815 |
1781257 |
4.51% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$9352537 |
1049430 |
2.52% |
股份
|
| Insight Holdings Group, LLC |
$8812471 |
989054 |
2.37% |
股份
|
| MORGAN STANLEY |
$8752355 |
982307 |
2.36% |
股份
|
| STATE STREET CORP |
$8751696 |
982233 |
2.36% |
股份
|
| Propel Bio Management, LLC |
$7869294 |
883198 |
2.12% |
股份
|
| Woodline Partners LP |
$7531846 |
845325 |
2.03% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$5700440 |
639780 |
1.54% |
股份
|
| MBB PUBLIC MARKETS I LLC |
$5474990 |
614477 |
1.48% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$4455000 |
500000 |
1.20% |
股份
|
| D. E. Shaw & Co., Inc. |
$4181872 |
469346 |
1.13% |
股份
|
| WELLS FARGO & COMPANY/MN |
$3323510 |
373009 |
0.90% |
股份
|
| UBS Group AG |
$3257264 |
365574 |
0.88% |
股份
|
| GOLDMAN SACHS GROUP INC |
$2986899 |
335230 |
0.80% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$2975040 |
333899 |
0.80% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$2848224 |
319666 |
0.77% |
股份
|
| NORTHERN TRUST CORP |
$2809805 |
315354 |
0.76% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$2767731 |
310632 |
0.75% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$2514304 |
282189 |
0.68% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$2364759 |
265405 |
0.64% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$2313633 |
259667 |
0.62% |
股份
|
| Walleye Capital LLC |
$2188180 |
245587 |
0.59% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$2159668 |
242387 |
0.58% |
股份
|
| Nuveen, LLC |
$2082650 |
233743 |
0.56% |
股份
|
| Burkehill Global Management, LP |
$1782000 |
200000 |
0.48% |
股份
|
| Simplify Asset Management Inc. |
$1626993 |
182603 |
0.44% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1388178 |
155800 |
0.37% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$1335609 |
149900 |
0.36% |
股份
|
| CITADEL ADVISORS LLC |
$1315357 |
147627 |
0.35% |
股份
|
| TD Asset Management Inc |
$1298027 |
145682 |
0.35% |
股份
|
| STIFEL FINANCIAL CORP |
$1247088 |
139965 |
0.34% |
股份
|
| Qube Research & Technologies Ltd |
$1101686 |
123646 |
0.30% |
股份
|
| CITADEL ADVISORS LLC |
$1098603 |
123300 |
0.30% |
买入期权
|
| BARCLAYS PLC |
$1049991 |
117844 |
0.28% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1046409 |
117442 |
0.28% |
股份
|
| WESBANCO BANK INC |
$982773 |
110300 |
0.26% |
股份
|
| Jump Financial, LLC |
$903046 |
101352 |
0.24% |
股份
|
| Bank of New York Mellon Corp |
$893504 |
100281 |
0.24% |
股份
|
| FMR LLC |
$855813 |
96051 |
0.23% |
股份
|
| Balyasny Asset Management L.P. |
$855788 |
96048 |
0.23% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$791609 |
88845 |
0.21% |
股份
|
| Squarepoint Ops LLC |
$738345 |
82867 |
0.20% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$732464 |
82207 |
0.20% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$698713 |
78419 |
0.19% |
股份
|
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
$623700 |
70000 |
0.17% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$617917 |
69351 |
0.17% |
股份
|
| Man Group plc |
$611582 |
68640 |
0.16% |
股份
|
| Invesco Ltd. |
$497240 |
55807 |
0.13% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$492723 |
55300 |
0.13% |
卖出期权
|
| TWO SIGMA ADVISERS, LP |
$464360 |
49400 |
0.13% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$457252 |
51319 |
0.12% |
股份
|
| CITADEL ADVISORS LLC |
$454410 |
51000 |
0.12% |
卖出期权
|
| RHUMBLINE ADVISERS |
$447168 |
50188 |
0.12% |
股份
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$404158 |
45360 |
0.11% |
股份
|
| DEUTSCHE BANK AG\ |
$399640 |
44853 |
0.11% |
股份
|
| ACT CAPITAL MANAGEMENT, LLC |
$356400 |
40000 |
0.10% |
股份
|
| Kera Capital Partners, Inc. |
$356400 |
40000 |
0.10% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$356400 |
40000 |
0.10% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$314523 |
35300 |
0.08% |
买入期权
|
| FEDERATED HERMES, INC. |
$273582 |
30705 |
0.07% |
股份
|
| JANE STREET GROUP, LLC |
$245025 |
27500 |
0.07% |
卖出期权
|
| Mitsubishi UFJ Asset Management Co., Ltd. |
$229352 |
25741 |
0.06% |
股份
|
| MetLife Investment Management, LLC |
$228319 |
25625 |
0.06% |
股份
|
| Spark Investment Management LLC |
$223641 |
25100 |
0.06% |
股份
|
| JPMORGAN CHASE & CO |
$201805 |
22984 |
0.05% |
股份
|
| XTX Topco Ltd |
$195111 |
21898 |
0.05% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$190723 |
22100 |
0.05% |
股份
|
| Quantbot Technologies LP |
$189667 |
21287 |
0.05% |
股份
|
| CITIGROUP INC |
$185845 |
20858 |
0.05% |
股份
|
| Phoenix Wealth Advisors |
$176418 |
19800 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$176418 |
19800 |
0.05% |
买入期权
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$171428 |
19240 |
0.05% |
股份
|
| Vanguard Personalized Indexing Management, LLC |
$160264 |
17987 |
0.04% |
股份
|
| WINTON GROUP Ltd |
$155034 |
17400 |
0.04% |
股份
|
| JANE STREET GROUP, LLC |
$154268 |
17314 |
0.04% |
股份
|
| AlphaQuest LLC |
$153624 |
16343 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$133552 |
14989 |
0.04% |
股份
|
| Cubist Systematic Strategies, LLC |
$122676 |
20446 |
0.03% |
股份
|
| IFP Advisors, Inc |
$111375 |
12500 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$110270 |
12376 |
0.03% |
股份
|
| CAXTON CORP |
$110009 |
12347 |
0.03% |
股份
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$105580 |
11850 |
0.03% |
股份
|
| Ethic Inc. |
$105343 |
11823 |
0.03% |
股份
|
| Samalin Investment Counsel, LLC |
$103310 |
11595 |
0.03% |
股份
|
| ExodusPoint Capital Management, LP |
$102251 |
11476 |
0.03% |
股份
|
| Allianz Asset Management GmbH |
$98010 |
11000 |
0.03% |
股份
|
| State of Wyoming |
$96665 |
10849 |
0.03% |
股份
|
| CAPITAL ADVISORS INC/OK |
$89100 |
10000 |
0.02% |
股份
|
| Grey Ledge Advisors, LLC |
$89100 |
10000 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$86213 |
9676 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$80190 |
9000 |
0.02% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$76475 |
8583 |
0.02% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$64704 |
10784 |
0.02% |
股份
|
| ROYAL BANK OF CANADA |
$61000 |
6877 |
0.02% |
股份
|
| Russell Investments Group, Ltd. |
$41592 |
4668 |
0.01% |
股份
|
| Legal & General Group Plc |
$36282 |
4072 |
0.01% |
股份
|
| OSAIC HOLDINGS, INC. |
$35104 |
3940 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$33929 |
3808 |
0.01% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$27737 |
3113 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$24226 |
2719 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$20965 |
2353 |
0.01% |
股份
|
| Parallel Advisors, LLC |
$15094 |
1694 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$13632 |
1530 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$10799 |
1212 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$10569 |
1186023 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$6994 |
785 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$5150 |
578 |
0.00% |
股份
|
| Accent Capital Management, LLC |
$4856 |
545 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$4152 |
466 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$3542 |
398 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$2682 |
301 |
0.00% |
股份
|
| TFC Financial Management, Inc. |
$2673 |
300 |
0.00% |
股份
|
| Fourth Dimension Wealth, LLC |
$2228 |
250 |
0.00% |
股份
|
| CWM, LLC |
$2045 |
237 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$1782 |
200 |
0.00% |
股份
|
| Optiver Holding B.V. |
$1265 |
142 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$1203 |
135 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$1149 |
129 |
0.00% |
股份
|
| Allworth Financial LP |
$482 |
54 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$372 |
41907 |
0.00% |
股份
|
| Larson Financial Group LLC |
$356 |
40 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$312 |
37 |
0.00% |
股份
|
| Banque Cantonale Vaudoise |
$298 |
33444 |
0.00% |
股份
|
| Virtu Financial LLC |
$121 |
13577 |
0.00% |
股份
|
| Arax Advisory Partners |
$98 |
11 |
0.00% |
股份
|