| ARCH Venture Management, LLC |
$45525211 |
3247162 |
18.97% |
股份
|
| MWG Caph Ltd |
$31029810 |
1008116 |
12.93% |
股份
|
| VANGUARD GROUP INC |
$25437516 |
826430 |
10.60% |
股份
|
| GSK plc |
$21252859 |
1512659 |
8.86% |
股份
|
| MWG Management Ltd. |
$16371804 |
1008116 |
6.82% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$11054175 |
786774 |
4.61% |
股份
|
| Orland Properties Ltd |
$10603507 |
754698 |
4.42% |
股份
|
| BlackRock, Inc. |
$10177005 |
724342 |
4.24% |
股份
|
| Almitas Capital LLC |
$8168768 |
581407 |
3.40% |
股份
|
| Foresite Capital Management V, LLC |
$6693223 |
476386 |
2.79% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$5162996 |
367473 |
2.15% |
股份
|
| Opaleye Management Inc. |
$4833551 |
344025 |
2.01% |
股份
|
| venBio Partners LLC |
$4744643 |
337697 |
1.98% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$4365887 |
310636 |
1.82% |
股份
|
| Alphabet Inc. |
$4120247 |
293256 |
1.72% |
股份
|
| STATE STREET CORP |
$2603774 |
185322 |
1.08% |
股份
|
| HSG Holding Ltd |
$2139801 |
152299 |
0.89% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$1829169 |
130190 |
0.76% |
股份
|
| NORTHERN TRUST CORP |
$1664925 |
118500 |
0.69% |
股份
|
| Qube Research & Technologies Ltd |
$1552961 |
110531 |
0.65% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1511359 |
107570 |
0.63% |
股份
|
| MARSHALL WACE, LLP |
$1493516 |
106300 |
0.62% |
股份
|
| Velan Capital Investment Management LP |
$1475250 |
105000 |
0.61% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$1307985 |
93095 |
0.54% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$1291069 |
91891 |
0.54% |
股份
|
| MIC Capital Management UK LLP |
$1222743 |
87028 |
0.51% |
股份
|
| GOLDMAN SACHS GROUP INC |
$1219245 |
86779 |
0.51% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$957066 |
68315 |
0.40% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$743624 |
52927 |
0.31% |
股份
|
| JANE STREET GROUP, LLC |
$646455 |
46011 |
0.27% |
股份
|
| Squarepoint Ops LLC |
$594624 |
42322 |
0.25% |
股份
|
| Ikarian Capital, LLC |
$577188 |
41081 |
0.24% |
股份
|
| MORGAN STANLEY |
$520553 |
37050 |
0.22% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$413225 |
29411 |
0.17% |
股份
|
| Point72 Asset Management, L.P. |
$366424 |
26080 |
0.15% |
股份
|
| UBS Group AG |
$365048 |
25982 |
0.15% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$363895 |
25900 |
0.15% |
买入期权
|
| Bank of New York Mellon Corp |
$346656 |
24673 |
0.14% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$344787 |
24540 |
0.14% |
股份
|
| Jump Financial, LLC |
$308482 |
21956 |
0.13% |
股份
|
| Clearstead Advisors, LLC |
$280410 |
19958 |
0.12% |
股份
|
| EntryPoint Capital, LLC |
$272710 |
19410 |
0.11% |
股份
|
| CITADEL ADVISORS LLC |
$262665 |
18695 |
0.11% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$252900 |
18000 |
0.11% |
股份
|
| CITADEL ADVISORS LLC |
$251495 |
17900 |
0.10% |
卖出期权
|
| Susquehanna Portfolio Strategies, LLC |
$251144 |
17875 |
0.10% |
股份
|
| CITADEL ADVISORS LLC |
$238850 |
17000 |
0.10% |
买入期权
|
| Allspring Global Investments Holdings, LLC |
$226837 |
16145 |
0.09% |
股份
|
| RHUMBLINE ADVISERS |
$217234 |
15462 |
0.09% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$199510 |
14200 |
0.08% |
卖出期权
|
| Invesco Ltd. |
$195492 |
13914 |
0.08% |
股份
|
| Nuveen, LLC |
$176960 |
12595 |
0.07% |
股份
|
| Graham Capital Management, L.P. |
$163008 |
11602 |
0.07% |
股份
|
| Brevan Howard Capital Management LP |
$162376 |
11557 |
0.07% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$152737 |
10871 |
0.06% |
股份
|
| Walleye Capital LLC |
$146837 |
10451 |
0.06% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$133545 |
9505 |
0.06% |
股份
|
| DEUTSCHE BANK AG\ |
$129091 |
9188 |
0.05% |
股份
|
| WELLS FARGO & COMPANY/MN |
$112470 |
8005 |
0.05% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$110222 |
7845 |
0.05% |
股份
|
| Vanguard Global Advisers, LLC |
$72568 |
5165 |
0.03% |
股份
|
| CITIGROUP INC |
$70601 |
5025 |
0.03% |
股份
|
| BARCLAYS PLC |
$66246 |
4715 |
0.03% |
股份
|
| JPMORGAN CHASE & CO |
$61149 |
4796 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$60879 |
4333 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$57605 |
4100 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$52182 |
3714 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$48416 |
3446 |
0.02% |
股份
|
| FMR LLC |
$30222 |
2151 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$19164 |
1364 |
0.01% |
股份
|
| Advisors Asset Management, Inc. |
$17452 |
567 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$14668 |
1044 |
0.01% |
股份
|
| Legal & General Group Plc |
$12884 |
917 |
0.01% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$12715 |
905 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$11999 |
854 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$11900 |
1025 |
0.00% |
股份
|
| Russell Investments Group, Ltd. |
$10565 |
752 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$10000 |
742 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$6351 |
452 |
0.00% |
股份
|
| Truvestments Capital LLC |
$4215 |
300 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$3175 |
226 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$2670 |
190 |
0.00% |
股份
|
| Quarry LP |
$2515 |
179 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$1236 |
88 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$955 |
68 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$836 |
59748 |
0.00% |
股份
|
| US BANCORP \DE\ |
$815 |
58 |
0.00% |
股份
|
| Cornerstone Financial Management LLC |
$646 |
46 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$513 |
36575 |
0.00% |
股份
|
| GAMMA Investing LLC |
$492 |
35 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$431 |
30657 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$368 |
26225 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$351 |
25 |
0.00% |
股份
|
| Optiver Holding B.V. |
$281 |
20 |
0.00% |
股份
|
| CWM, LLC |
$40 |
2 |
0.00% |
股份
|