| JANUS HENDERSON GROUP PLC |
$72062327 |
1317410 |
13.23% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$61776696 |
667207 |
11.34% |
股份
|
| BlackRock, Inc. |
$32297151 |
348819 |
5.93% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$29975550 |
323745 |
5.50% |
股份
|
| Saturn V Capital Management LP |
$28885858 |
311976 |
5.30% |
股份
|
| Siren, L.L.C. |
$25010226 |
270118 |
4.59% |
股份
|
| ADAR1 Capital Management, LLC |
$20147121 |
217595 |
3.70% |
股份
|
| Polar Capital Holdings Plc |
$19857685 |
214469 |
3.65% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$19417141 |
209711 |
3.56% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$19369365 |
209195 |
3.56% |
股份
|
| VANGUARD GROUP INC |
$19186185 |
293816 |
3.52% |
股份
|
| TCG Crossover Management, LLC |
$18826047 |
203327 |
3.46% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$14669682 |
158437 |
2.69% |
股份
|
| ORBIMED ADVISORS LLC |
$14575796 |
157423 |
2.68% |
股份
|
| Candriam S.C.A. |
$13258989 |
143339 |
2.43% |
股份
|
| Balyasny Asset Management L.P. |
$12457336 |
134543 |
2.29% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$10426384 |
112578 |
1.91% |
股份
|
| Alyeska Investment Group, L.P. |
$9259000 |
100000 |
1.70% |
股份
|
| STATE STREET CORP |
$8569297 |
92551 |
1.57% |
股份
|
| Vivo Capital, LLC |
$8379395 |
90500 |
1.54% |
股份
|
| Driehaus Capital Management LLC |
$7781264 |
84040 |
1.43% |
股份
|
| Bank of New York Mellon Corp |
$7124057 |
76942 |
1.31% |
股份
|
| Vestal Point Capital, LP |
$7011563 |
75727 |
1.29% |
股份
|
| Longaeva Partners L.P. |
$5169670 |
55834 |
0.95% |
股份
|
| NEUBERGER BERMAN GROUP LLC |
$5110413 |
55194 |
0.94% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$4658295 |
50311 |
0.86% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$4519873 |
48816 |
0.83% |
股份
|
| Ikarian Capital, LLC |
$4431450 |
47861 |
0.81% |
股份
|
| CITADEL ADVISORS LLC |
$3426200 |
37004 |
0.63% |
股份
|
| NORTHERN TRUST CORP |
$3207411 |
34641 |
0.59% |
股份
|
| DEUTSCHE BANK AG\ |
$2871031 |
31008 |
0.53% |
股份
|
| STEMPOINT CAPITAL LP |
$2789274 |
30125 |
0.51% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$2618445 |
28280 |
0.48% |
股份
|
| UBS Group AG |
$2523911 |
27259 |
0.46% |
股份
|
| MORGAN STANLEY |
$1659121 |
17919 |
0.30% |
股份
|
| AMERIPRISE FINANCIAL INC |
$1648102 |
17800 |
0.30% |
股份
|
| GOLDMAN SACHS GROUP INC |
$1496347 |
16161 |
0.27% |
股份
|
| Russell Investments Group, Ltd. |
$1374961 |
14850 |
0.25% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$1360055 |
14689 |
0.25% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1291908 |
13953 |
0.24% |
股份
|
| Ishara Investments LP |
$1138857 |
12300 |
0.21% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$1134413 |
12252 |
0.21% |
股份
|
| Trexquant Investment LP |
$1111450 |
12004 |
0.20% |
股份
|
| Creative Planning |
$719239 |
7768 |
0.13% |
股份
|
| XTX Topco Ltd |
$605168 |
6536 |
0.11% |
股份
|
| Nuveen, LLC |
$553688 |
5980 |
0.10% |
股份
|
| BARCLAYS PLC |
$540077 |
5833 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$521271 |
5630 |
0.10% |
股份
|
| GERBER, LLC |
$518597 |
5601 |
0.10% |
股份
|
| Virtus Investment Advisers, LLC |
$506838 |
5474 |
0.09% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$506838 |
5474 |
0.09% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$490727 |
5300 |
0.09% |
股份
|
| WELLS FARGO & COMPANY/MN |
$366471 |
3958 |
0.07% |
股份
|
| Aquatic Capital Management LLC |
$354342 |
3827 |
0.07% |
股份
|
| Engineers Gate Manager LP |
$322121 |
3479 |
0.06% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$300918 |
3250 |
0.06% |
股份
|
| MetLife Investment Management, LLC |
$269252 |
2908 |
0.05% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$260800 |
4760 |
0.05% |
股份
|
| EP Wealth Advisors, LLC |
$241012 |
2603 |
0.04% |
股份
|
| Entropy Technologies, LP |
$240734 |
2600 |
0.04% |
股份
|
| JPMORGAN CHASE & CO |
$236967 |
2506 |
0.04% |
股份
|
| WINTON GROUP Ltd |
$231475 |
2500 |
0.04% |
股份
|
| GABELLI FUNDS LLC |
$231475 |
2500 |
0.04% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$228605 |
2469 |
0.04% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$222216 |
2400 |
0.04% |
股份
|
| Invesco Ltd. |
$218142 |
2356 |
0.04% |
股份
|
| Martin Investment Management, LLC |
$215457 |
2327 |
0.04% |
股份
|
| Schonfeld Strategic Advisors LLC |
$213882 |
2310 |
0.04% |
股份
|
| CITIGROUP INC |
$193328 |
2088 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$192217 |
2076 |
0.04% |
股份
|
| DIADEMA PARTNERS LP |
$150922 |
1630 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$143792 |
1553 |
0.03% |
股份
|
| Quarry LP |
$139070 |
1502 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$135922 |
1468 |
0.02% |
股份
|
| AlphaQuest LLC |
$129490 |
1983 |
0.02% |
股份
|
| MEEDER ASSET MANAGEMENT INC |
$128608 |
1389 |
0.02% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$124996 |
1350 |
0.02% |
股份
|
| Persistent Asset Partners Ltd |
$117682 |
1271 |
0.02% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$68609 |
741 |
0.01% |
股份
|
| NewEdge Advisors, LLC |
$55554 |
600 |
0.01% |
股份
|
| FMR LLC |
$49073 |
530 |
0.01% |
股份
|
| Legal & General Group Plc |
$43054 |
465 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$37869 |
409 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$31944 |
345 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$13000 |
136 |
0.00% |
股份
|
| Allworth Financial LP |
$10278 |
111 |
0.00% |
股份
|
| C M BIDWELL & ASSOCIATES LTD |
$8703 |
94 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$6666 |
72 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$5741 |
62 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$2963 |
32 |
0.00% |
股份
|
| GAMMA Investing LLC |
$2315 |
25 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$2222 |
24 |
0.00% |
股份
|
| CWM, LLC |
$822 |
15 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$697 |
7532 |
0.00% |
股份
|
| US BANCORP \DE\ |
$556 |
6 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$556 |
6 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$343 |
3699 |
0.00% |
股份
|
| Arax Advisory Partners |
$278 |
3 |
0.00% |
股份
|