| NOVO HOLDINGS A/S |
$132128532 |
3686622 |
16.40% |
股份
|
| FCPM III SERVICES B.V. |
$115634176 |
3226400 |
14.35% |
股份
|
| GOLDMAN SACHS GROUP INC |
$69827502 |
1948312 |
8.67% |
股份
|
| BlackRock, Inc. |
$36740802 |
1025134 |
4.56% |
股份
|
| Nan Fung Group Holdings Ltd |
$34809708 |
971253 |
4.32% |
股份
|
| 5AM Venture Management, LLC |
$34048394 |
950011 |
4.23% |
股份
|
| Sanofi |
$32687549 |
912041 |
4.06% |
股份
|
| STATE STREET CORP |
$30541056 |
852150 |
3.79% |
股份
|
| FMR LLC |
$29516247 |
823556 |
3.66% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$28103936 |
784150 |
3.49% |
股份
|
| Blue Owl Capital Holdings LP |
$26160655 |
729929 |
3.25% |
股份
|
| Paradigm Biocapital Advisors LP |
$24580936 |
685852 |
3.05% |
股份
|
| Pivotal bioVenture Partners Investment Advisor LLC |
$21914225 |
611446 |
2.72% |
股份
|
| Velan Capital Investment Management LP |
$17665285 |
492893 |
2.19% |
股份
|
| Siren, L.L.C. |
$16128000 |
450000 |
2.00% |
股份
|
| VANGUARD GROUP INC |
$15275718 |
869668 |
1.90% |
股份
|
| Capital World Investors |
$14899763 |
415730 |
1.85% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$14414363 |
402051 |
1.79% |
股份
|
| BAKER BROS. ADVISORS LP |
$13071027 |
364705 |
1.62% |
股份
|
| DAFNA Capital Management LLC |
$6128855 |
171006 |
0.76% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$6123694 |
170862 |
0.76% |
股份
|
| Freestone Grove Partners LP |
$6053806 |
168912 |
0.75% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$4903557 |
136818 |
0.61% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$4617661 |
128841 |
0.57% |
股份
|
| SUPERSTRING CAPITAL MANAGEMENT LP |
$4495483 |
125432 |
0.56% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$4413158 |
123135 |
0.55% |
股份
|
| UBS Group AG |
$4373484 |
122028 |
0.54% |
股份
|
| NORTHERN TRUST CORP |
$4180808 |
116652 |
0.52% |
股份
|
| STEMPOINT CAPITAL LP |
$3831511 |
106906 |
0.48% |
股份
|
| SEVEN GRAND MANAGERS, LLC |
$3584000 |
100000 |
0.44% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$3467914 |
96761 |
0.43% |
股份
|
| LAZARD ASSET MANAGEMENT LLC |
$2870139 |
80082 |
0.36% |
股份
|
| Boxer Capital Management, LLC |
$2688000 |
75000 |
0.33% |
股份
|
| Burkehill Global Management, LP |
$2688000 |
75000 |
0.33% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$2526147 |
70484 |
0.31% |
股份
|
| Trexquant Investment LP |
$2286305 |
63792 |
0.28% |
股份
|
| TD Asset Management Inc |
$1954212 |
54526 |
0.24% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$1951990 |
54464 |
0.24% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1860705 |
51917 |
0.23% |
股份
|
| Jain Global LLC |
$1632548 |
45551 |
0.20% |
股份
|
| MORGAN STANLEY |
$1372815 |
38304 |
0.17% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$1254400 |
35000 |
0.16% |
股份
|
| Weiss Asset Management LP |
$1186089 |
33094 |
0.15% |
股份
|
| JANUS HENDERSON GROUP PLC |
$1113108 |
54752 |
0.14% |
股份
|
| Bank of New York Mellon Corp |
$1089894 |
30410 |
0.14% |
股份
|
| ADAR1 Capital Management, LLC |
$949652 |
26497 |
0.12% |
股份
|
| CITADEL ADVISORS LLC |
$922916 |
25751 |
0.11% |
股份
|
| Jump Financial, LLC |
$903956 |
25222 |
0.11% |
股份
|
| XTX Topco Ltd |
$893097 |
24919 |
0.11% |
股份
|
| Ghisallo Capital Management LLC |
$716800 |
20000 |
0.09% |
股份
|
| Nuveen, LLC |
$642289 |
17921 |
0.08% |
股份
|
| CITIGROUP INC |
$611108 |
17051 |
0.08% |
股份
|
| CITADEL ADVISORS LLC |
$609280 |
17000 |
0.08% |
卖出期权
|
| RHUMBLINE ADVISERS |
$564401 |
15748 |
0.07% |
股份
|
| MARKET STREET WEALTH MANAGEMENT ADVISORS LLC |
$506204 |
14124 |
0.06% |
股份
|
| Rafferty Asset Management, LLC |
$496492 |
13853 |
0.06% |
股份
|
| BARCLAYS PLC |
$465024 |
12975 |
0.06% |
股份
|
| Virtus Investment Advisers, LLC |
$422589 |
11791 |
0.05% |
股份
|
| Quantinno Capital Management LP |
$406390 |
11339 |
0.05% |
股份
|
| MA Private Wealth |
$372342 |
10389 |
0.05% |
股份
|
| DEUTSCHE BANK AG\ |
$370084 |
10326 |
0.05% |
股份
|
| LMR Partners LLP |
$358400 |
10000 |
0.04% |
股份
|
| WELLS FARGO & COMPANY/MN |
$337577 |
9419 |
0.04% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$322488 |
8998 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$302060 |
8428 |
0.04% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$297472 |
8300 |
0.04% |
卖出期权
|
| AMERICAN CENTURY COMPANIES INC |
$267725 |
7470 |
0.03% |
股份
|
| MetLife Investment Management, LLC |
$263532 |
7353 |
0.03% |
股份
|
| Russell Investments Group, Ltd. |
$260449 |
7267 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$252314 |
7040 |
0.03% |
股份
|
| PROFUND ADVISORS LLC |
$249303 |
6956 |
0.03% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$248622 |
6937 |
0.03% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$231347 |
6455 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$227293 |
6411 |
0.03% |
股份
|
| MARSHALL WACE, LLP |
$207872 |
5800 |
0.03% |
股份
|
| Invesco Ltd. |
$205328 |
5729 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$196797 |
5491 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$189952 |
5300 |
0.02% |
股份
|
| JPMORGAN CHASE & CO |
$148587 |
4332 |
0.02% |
股份
|
| T. Rowe Price Investment Management, Inc. |
$99698 |
2781728 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$71537 |
1996 |
0.01% |
股份
|
| OSAIC HOLDINGS, INC. |
$68020 |
1898 |
0.01% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$53043 |
1480 |
0.01% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$50999 |
1422935 |
0.01% |
股份
|
| Pinnacle Wealth Planning Services, Inc. |
$45338 |
1265 |
0.01% |
股份
|
| SBI Securities Co., Ltd. |
$41574 |
1160 |
0.01% |
股份
|
| Legal & General Group Plc |
$37023 |
1033 |
0.00% |
股份
|
| Ameritas Investment Partners, Inc. |
$33905 |
946 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$19712 |
550 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$19281 |
538 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$17000 |
474 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$14336 |
400 |
0.00% |
股份
|
| State of Wyoming |
$12938 |
361 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$5161 |
144 |
0.00% |
股份
|
| GAMMA Investing LLC |
$4408 |
123 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$4301 |
120 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$3369 |
94 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$2258 |
63 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$2007 |
56 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$1863 |
51983 |
0.00% |
股份
|
| Arax Advisory Partners |
$1183 |
33 |
0.00% |
股份
|
| CWM, LLC |
$1159 |
57 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$646 |
18 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$287 |
8 |
0.00% |
股份
|
| Allworth Financial LP |
$251 |
7 |
0.00% |
股份
|
| Penserra Capital Management LLC |
$38 |
1088 |
0.00% |
股份
|
| Larson Financial Group LLC |
$36 |
1 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$8 |
231 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
16 |
0.00% |
股份
|