| SAMSARA BIOCAPITAL, LLC |
$54003644 |
1717127 |
9.61% |
股份
|
| Casdin Capital, LLC |
$48601603 |
1545361 |
8.65% |
股份
|
| Redmile Group, LLC |
$44413659 |
1412199 |
7.90% |
股份
|
| RTW INVESTMENTS, LP |
$42849241 |
1362456 |
7.62% |
股份
|
| EcoR1 Capital, LLC |
$39983706 |
1271342 |
7.11% |
股份
|
| BlackRock, Inc. |
$33273565 |
1057983 |
5.92% |
股份
|
| BAKER BROS. ADVISORS LP |
$31188682 |
991691 |
5.55% |
股份
|
| Balyasny Asset Management L.P. |
$25748307 |
818706 |
4.58% |
股份
|
| Trails Edge Capital Partners, LP |
$22483133 |
714885 |
4.00% |
股份
|
| TORONTO DOMINION BANK |
$21428049 |
681337 |
3.81% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$16873711 |
536525 |
3.00% |
股份
|
| JENNISON ASSOCIATES LLC |
$16309405 |
518582 |
2.90% |
股份
|
| VANGUARD GROUP INC |
$13525383 |
656572 |
2.41% |
股份
|
| CITADEL ADVISORS LLC |
$12862484 |
408982 |
2.29% |
股份
|
| GREAT POINT PARTNERS LLC |
$11076061 |
352180 |
1.97% |
股份
|
| ArrowMark Colorado Holdings LLC |
$10770147 |
342453 |
1.92% |
股份
|
| FMR LLC |
$9295393 |
295561 |
1.65% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$9222612 |
293182 |
1.64% |
股份
|
| STATE STREET CORP |
$7054927 |
224322 |
1.26% |
股份
|
| FRANKLIN RESOURCES INC |
$6424606 |
204280 |
1.14% |
股份
|
| MORGAN STANLEY |
$6029719 |
191724 |
1.07% |
股份
|
| UBS Group AG |
$5387039 |
171289 |
0.96% |
股份
|
| BLAIR WILLIAM & CO/IL |
$4620162 |
146905 |
0.82% |
股份
|
| Driehaus Capital Management LLC |
$4513956 |
143528 |
0.80% |
股份
|
| Point72 Asset Management, L.P. |
$4463384 |
141920 |
0.79% |
股份
|
| MOORE CAPITAL MANAGEMENT, LP |
$4454452 |
141636 |
0.79% |
股份
|
| Rock Springs Capital Management LP |
$3357288 |
106750 |
0.60% |
股份
|
| DEUTSCHE BANK AG\ |
$3354457 |
106660 |
0.60% |
股份
|
| NORTHERN TRUST CORP |
$3259509 |
103641 |
0.58% |
股份
|
| GOLDMAN SACHS GROUP INC |
$3185131 |
101276 |
0.57% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$3006651 |
95601 |
0.53% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2905980 |
92400 |
0.52% |
买入期权
|
| DAFNA Capital Management LLC |
$2800056 |
89032 |
0.50% |
股份
|
| Woodline Partners LP |
$2636611 |
83835 |
0.47% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$2335540 |
74262 |
0.42% |
股份
|
| Trexquant Investment LP |
$2319815 |
73762 |
0.41% |
股份
|
| JPMORGAN CHASE & CO |
$1997551 |
61882 |
0.36% |
股份
|
| XTX Topco Ltd |
$1743085 |
55424 |
0.31% |
股份
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$1688244 |
52300 |
0.30% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$1343984 |
42734 |
0.24% |
股份
|
| Raiffeisen Bank International AG |
$1097520 |
34000 |
0.20% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1029736 |
32742 |
0.18% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$1026150 |
32628 |
0.18% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$987310 |
31393 |
0.18% |
股份
|
| Bank of New York Mellon Corp |
$903897 |
28741 |
0.16% |
股份
|
| Nuveen, LLC |
$875065 |
27824 |
0.16% |
股份
|
| CITADEL ADVISORS LLC |
$839715 |
26700 |
0.15% |
买入期权
|
| JANE STREET GROUP, LLC |
$820499 |
26089 |
0.15% |
股份
|
| Quadrature Capital Ltd |
$764864 |
24320 |
0.14% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$733729 |
23330 |
0.13% |
股份
|
| Seven Fleet Capital Management LP |
$693787 |
22060 |
0.12% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$641737 |
20405 |
0.11% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$590662 |
18781 |
0.11% |
股份
|
| ALPS ADVISORS INC |
$504458 |
16040 |
0.09% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$473668 |
15061 |
0.08% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$462315 |
14700 |
0.08% |
卖出期权
|
| RHUMBLINE ADVISERS |
$445104 |
14153 |
0.08% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$434104 |
13803 |
0.08% |
股份
|
| Mariner, LLC |
$385552 |
12260 |
0.07% |
股份
|
| Virtus Investment Advisers, LLC |
$353624 |
11244 |
0.06% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$349850 |
11124 |
0.06% |
股份
|
| Creative Planning |
$332772 |
10581 |
0.06% |
股份
|
| D. E. Shaw & Co., Inc. |
$307612 |
9781 |
0.05% |
股份
|
| WELLS FARGO & COMPANY/MN |
$297863 |
9471 |
0.05% |
股份
|
| Pale Fire Capital SE |
$297517 |
9460 |
0.05% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$277603 |
13770 |
0.05% |
股份
|
| Brevan Howard Capital Management LP |
$263771 |
8387 |
0.05% |
股份
|
| CITIGROUP INC |
$247449 |
7868 |
0.04% |
股份
|
| ADAR1 Capital Management, LLC |
$245310 |
7800 |
0.04% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$235592 |
7491 |
0.04% |
股份
|
| Invesco Ltd. |
$209395 |
6658 |
0.04% |
股份
|
| Mitsubishi UFJ Asset Management Co., Ltd. |
$191531 |
6090 |
0.03% |
股份
|
| Russell Investments Group, Ltd. |
$188385 |
5990 |
0.03% |
股份
|
| MetLife Investment Management, LLC |
$186561 |
5932 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$163760 |
5207 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$152658 |
4854 |
0.03% |
股份
|
| AlphaQuest LLC |
$148629 |
7215 |
0.03% |
股份
|
| PNC Financial Services Group, Inc. |
$141557 |
4501 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$132090 |
4200 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$120957 |
3846 |
0.02% |
股份
|
| NATIXIS |
$117025 |
3721 |
0.02% |
股份
|
| BARCLAYS PLC |
$104098 |
3310 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$79097 |
2515 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$76000 |
2406 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$59692 |
1898 |
0.01% |
股份
|
| Cubist Systematic Strategies, LLC |
$39200 |
2262 |
0.01% |
股份
|
| Legal & General Group Plc |
$34532 |
1098 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$31733 |
1009 |
0.01% |
股份
|
| State of Wyoming |
$30821 |
980 |
0.01% |
股份
|
| Arax Advisory Partners |
$28494 |
906 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$22235 |
707 |
0.00% |
股份
|
| CWM, LLC |
$20765 |
1030 |
0.00% |
股份
|
| GAMMA Investing LLC |
$17140 |
545 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$14561 |
463 |
0.00% |
股份
|
| Point72 (DIFC) Ltd |
$14465 |
835 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$13838 |
440 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$10441 |
332 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$7265 |
231 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$7171 |
228 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$5887 |
292 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$5646 |
176 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$4906 |
156 |
0.00% |
股份
|
| US BANCORP \DE\ |
$4623 |
147 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$3931 |
125 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1667 |
53 |
0.00% |
股份
|
| Truvestments Capital LLC |
$1447 |
46 |
0.00% |
股份
|
| Allworth Financial LP |
$1133 |
36 |
0.00% |
股份
|
| Parallel Advisors, LLC |
$1101 |
35 |
0.00% |
股份
|
| Optiver Holding B.V. |
$1006 |
32 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$849 |
27 |
0.00% |
股份
|
| Essential Partners LLC |
$629 |
20 |
0.00% |
股份
|
| Investors Portfolio Services LLC |
$472 |
15 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$280 |
8896 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$252 |
8 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$249 |
8 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$63 |
2 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$40 |
2 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$32 |
1 |
0.00% |
股份
|
| Larson Financial Group LLC |
$31 |
1 |
0.00% |
股份
|
| IFP Advisors, Inc |
$31 |
1 |
0.00% |
股份
|