| TANG CAPITAL MANAGEMENT LLC |
$28504500 |
1550000 |
14.07% |
股份
|
| BlackRock, Inc. |
$18413632 |
1001285 |
9.09% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$18390000 |
1000000 |
9.08% |
股份
|
| Soleus Capital Management, L.P. |
$18390000 |
1000000 |
9.08% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$16044944 |
872482 |
7.92% |
股份
|
| IRIDIAN ASSET MANAGEMENT LLC/CT |
$14290464 |
777078 |
7.05% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$7951022 |
432273 |
3.92% |
股份
|
| Occam Crest Management LP |
$7389371 |
357147 |
3.65% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$7042359 |
382945 |
3.48% |
股份
|
| BALDWIN WEALTH PARTNERS LLC/MA |
$7025256 |
382015 |
3.47% |
股份
|
| VANGUARD GROUP INC |
$6383541 |
845502 |
3.15% |
股份
|
| Alyeska Investment Group, L.P. |
$5057250 |
275000 |
2.50% |
股份
|
| STATE STREET CORP |
$4564361 |
248198 |
2.25% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$3995890 |
217286 |
1.97% |
股份
|
| Avidity Partners Management LP |
$3678000 |
200000 |
1.82% |
股份
|
| Caption Management, LLC |
$2947917 |
160300 |
1.46% |
买入期权
|
| NORTHERN TRUST CORP |
$2698071 |
146714 |
1.33% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$2345718 |
127554 |
1.16% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$2175482 |
118297 |
1.07% |
股份
|
| CITADEL ADVISORS LLC |
$2124633 |
115532 |
1.05% |
股份
|
| Kalehua Capital Management LLC |
$1839000 |
100000 |
0.91% |
股份
|
| JANE STREET GROUP, LLC |
$1513497 |
82300 |
0.75% |
买入期权
|
| OPPENHEIMER & CO INC |
$1352879 |
73566 |
0.67% |
股份
|
| UBS Group AG |
$1272588 |
69200 |
0.63% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1250520 |
68000 |
0.62% |
买入期权
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1050676 |
57133 |
0.52% |
股份
|
| CITADEL ADVISORS LLC |
$937890 |
51000 |
0.46% |
买入期权
|
| CIBC Bancorp USA Inc. |
$917661 |
67155 |
0.45% |
股份
|
| Informed Momentum Co LLC |
$867420 |
47168 |
0.43% |
股份
|
| Nuveen, LLC |
$750735 |
40823 |
0.37% |
股份
|
| Stonepine Capital Management, LLC |
$735600 |
40000 |
0.36% |
股份
|
| Squadron Capital Management LLC |
$711693 |
38700 |
0.35% |
买入期权
|
| Bank of New York Mellon Corp |
$676192 |
36770 |
0.33% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$586385 |
31886 |
0.29% |
股份
|
| SIMPLEX TRADING, LLC |
$577335 |
31394 |
0.28% |
股份
|
| SEI INVESTMENTS CO |
$514240 |
27963 |
0.25% |
股份
|
| STRS OHIO |
$500208 |
27200 |
0.25% |
股份
|
| JANE STREET GROUP, LLC |
$485496 |
26400 |
0.24% |
卖出期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$461589 |
25100 |
0.23% |
卖出期权
|
| Shay Capital LLC |
$386190 |
21000 |
0.19% |
股份
|
| Austin Wealth Management, LLC |
$385193 |
20125 |
0.19% |
股份
|
| GOLDMAN SACHS GROUP INC |
$376627 |
20480 |
0.19% |
股份
|
| DAFNA Capital Management LLC |
$367800 |
20000 |
0.18% |
股份
|
| MORGAN STANLEY |
$344279 |
18721 |
0.17% |
股份
|
| MARTINGALE ASSET MANAGEMENT L P |
$331462 |
18024 |
0.16% |
股份
|
| RHUMBLINE ADVISERS |
$317606 |
17271 |
0.16% |
股份
|
| DEUTSCHE BANK AG\ |
$310313 |
16874 |
0.15% |
股份
|
| CITADEL ADVISORS LLC |
$288723 |
15700 |
0.14% |
卖出期权
|
| WELLS FARGO & COMPANY/MN |
$286774 |
15594 |
0.14% |
股份
|
| JANE STREET GROUP, LLC |
$286553 |
15582 |
0.14% |
股份
|
| Avalon Trust Co |
$257460 |
14000 |
0.13% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$218290 |
11870 |
0.11% |
股份
|
| Schonfeld Strategic Advisors LLC |
$216172 |
11755 |
0.11% |
股份
|
| JPMORGAN CHASE & CO |
$202306 |
7091 |
0.10% |
股份
|
| MetLife Investment Management, LLC |
$177500 |
9652 |
0.09% |
股份
|
| FMR LLC |
$148242 |
8061 |
0.07% |
股份
|
| CITIGROUP INC |
$147396 |
8015 |
0.07% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$144766 |
7872 |
0.07% |
股份
|
| GROUP ONE TRADING LLC |
$142596 |
7754 |
0.07% |
股份
|
| LANARK FINANCIAL, INC. |
$110340 |
6000 |
0.05% |
股份
|
| Vanguard Global Advisers, LLC |
$105982 |
5763 |
0.05% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$103260 |
5615 |
0.05% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$91950 |
5000 |
0.05% |
股份
|
| TORONTO DOMINION BANK |
$88713 |
4824 |
0.04% |
股份
|
| Russell Investments Group, Ltd. |
$86911 |
4726 |
0.04% |
股份
|
| BARCLAYS PLC |
$56292 |
3061 |
0.03% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$54673 |
2973 |
0.03% |
股份
|
| Legal & General Group Plc |
$30546 |
1661 |
0.02% |
股份
|
| Tower Research Capital LLC (TRC) |
$29626 |
1611 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$24164 |
1314 |
0.01% |
股份
|
| Arax Advisory Partners |
$14620 |
795 |
0.01% |
股份
|
| ROYAL BANK OF CANADA |
$10000 |
535 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$9195 |
500 |
0.00% |
股份
|
| GAMMA Investing LLC |
$8993 |
489 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$3991 |
217 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$3844 |
209 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$1839 |
100 |
0.00% |
股份
|
| IFP Advisors, Inc |
$1655 |
90 |
0.00% |
股份
|
| Allworth Financial LP |
$1527 |
83 |
0.00% |
股份
|
| CWM, LLC |
$1314 |
170 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$1103 |
60 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$993 |
54 |
0.00% |
股份
|
| FEDERATED HERMES, INC. |
$920 |
50 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$515 |
28 |
0.00% |
股份
|
| Essential Partners LLC |
$497 |
27 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$423 |
23 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$386 |
21 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$276 |
15 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$254 |
13805 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$74 |
4 |
0.00% |
股份
|
| True Wealth Design, LLC |
$74 |
4 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$8 |
1 |
0.00% |
股份
|