| FMR LLC |
$151909702 |
12143062 |
11.15% |
股份
|
| Paradigm Biocapital Advisors LP |
$108468906 |
8670576 |
7.96% |
股份
|
| JANUS HENDERSON GROUP PLC |
$106013431 |
7108488 |
7.78% |
股份
|
| VANGUARD GROUP INC |
$89033875 |
3561355 |
6.53% |
股份
|
| Bain Capital Life Sciences Investors, LLC |
$88636465 |
7085249 |
6.50% |
股份
|
| BlackRock, Inc. |
$84000783 |
6714691 |
6.16% |
股份
|
| BVF INC/IL |
$66251621 |
5295893 |
4.86% |
股份
|
| Siren, L.L.C. |
$60760432 |
4856949 |
4.46% |
股份
|
| STATE STREET CORP |
$53993886 |
4316058 |
3.96% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$41798625 |
3341217 |
3.07% |
股份
|
| Logos Global Management LP |
$40143026 |
3208875 |
2.95% |
股份
|
| FRANKLIN RESOURCES INC |
$29393321 |
2349586 |
2.16% |
股份
|
| Cormorant Asset Management, LP |
$26896500 |
2150000 |
1.97% |
股份
|
| MORGAN STANLEY |
$22921685 |
1832269 |
1.68% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$22759853 |
1819029 |
1.67% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$20806857 |
1663218 |
1.53% |
股份
|
| GOLDMAN SACHS GROUP INC |
$19615417 |
1567979 |
1.44% |
股份
|
| Deep Track Capital, LP |
$18765000 |
1500000 |
1.38% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$17718405 |
1416533 |
1.30% |
股份
|
| LIGHTSPEED MANAGEMENT COMPANY, L.L.C. |
$16954790 |
1355299 |
1.24% |
股份
|
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
$15012000 |
1200000 |
1.10% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$14154239 |
1131434 |
1.04% |
股份
|
| Point72 Asset Management, L.P. |
$13397572 |
1070949 |
0.98% |
股份
|
| Defilade Capital Management, L.P. |
$11568723 |
924758 |
0.85% |
股份
|
| AMERIPRISE FINANCIAL INC |
$10516481 |
840646 |
0.77% |
股份
|
| Woodline Partners LP |
$9395385 |
751030 |
0.69% |
股份
|
| Candriam S.C.A. |
$9387633 |
751133 |
0.69% |
股份
|
| NORTHERN TRUST CORP |
$8443561 |
674945 |
0.62% |
股份
|
| Vivo Capital, LLC |
$8404756 |
671843 |
0.62% |
股份
|
| Qube Research & Technologies Ltd |
$8298121 |
663319 |
0.61% |
股份
|
| CITADEL ADVISORS LLC |
$8029268 |
641828 |
0.59% |
股份
|
| Squarepoint Ops LLC |
$7699530 |
615470 |
0.56% |
股份
|
| READYSTATE ASSET MANAGEMENT LP |
$7428801 |
593829 |
0.55% |
股份
|
| Jones Hill Capital LP |
$7182817 |
574166 |
0.53% |
股份
|
| Hudson Bay Capital Management LP |
$7085664 |
566400 |
0.52% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$6585839 |
526446 |
0.48% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$6484458 |
518342 |
0.48% |
股份
|
| Vestal Point Capital, LP |
$5236073 |
418551 |
0.38% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$5192338 |
415055 |
0.38% |
股份
|
| Ikarian Capital, LLC |
$4794845 |
383281 |
0.35% |
股份
|
| SEB Asset Management AB |
$4246649 |
339461 |
0.31% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$4189287 |
334875 |
0.31% |
股份
|
| Fisher Asset Management, LLC |
$3712015 |
296724 |
0.27% |
股份
|
| Rock Springs Capital Management LP |
$2942077 |
235178 |
0.22% |
股份
|
| UBS Group AG |
$2788141 |
222873 |
0.20% |
股份
|
| Bank of New York Mellon Corp |
$2779441 |
222177 |
0.20% |
股份
|
| Pier Capital, LLC |
$2760944 |
220699 |
0.20% |
股份
|
| Ikarian Capital, LLC |
$2502000 |
200000 |
0.18% |
买入期权
|
| Birchview Capital, LP |
$2489490 |
199000 |
0.18% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$2280573 |
182300 |
0.17% |
卖出期权
|
| Jump Financial, LLC |
$2272717 |
181672 |
0.17% |
股份
|
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. |
$2024566 |
161836 |
0.15% |
股份
|
| Nuveen, LLC |
$2015236 |
161090 |
0.15% |
股份
|
| HighVista Strategies LLC |
$2003689 |
160167 |
0.15% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$1847339 |
147669 |
0.14% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$1784051 |
142610 |
0.13% |
股份
|
| JPMORGAN CHASE & CO |
$1748003 |
143279 |
0.13% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1665769 |
133155 |
0.12% |
股份
|
| CITIGROUP INC |
$1570768 |
125561 |
0.12% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1563150 |
124952 |
0.11% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$1530810 |
102670 |
0.11% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$1525306 |
121927 |
0.11% |
股份
|
| Invesco Ltd. |
$1468825 |
117412 |
0.11% |
股份
|
| SCHRODER INVESTMENT MANAGEMENT GROUP |
$1393142 |
114192 |
0.10% |
股份
|
| TD Asset Management Inc |
$1328737 |
106214 |
0.10% |
股份
|
| Swiss National Bank |
$1313550 |
105000 |
0.10% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1297287 |
103700 |
0.10% |
买入期权
|
| Integral Health Asset Management, LLC |
$1251000 |
100000 |
0.09% |
股份
|
| RHUMBLINE ADVISERS |
$1245110 |
99530 |
0.09% |
股份
|
| DEUTSCHE BANK AG\ |
$1198883 |
95834 |
0.09% |
股份
|
| Trexquant Investment LP |
$1156074 |
92412 |
0.08% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$1125775 |
89990 |
0.08% |
股份
|
| XTX Topco Ltd |
$1119958 |
89525 |
0.08% |
股份
|
| TEMA ETFS LLC |
$1112625 |
44505 |
0.08% |
股份
|
| ALPS ADVISORS INC |
$1108999 |
88649 |
0.08% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$1026195 |
82030 |
0.08% |
股份
|
| ALGERT GLOBAL LLC |
$1012409 |
80928 |
0.07% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$977794 |
78161 |
0.07% |
股份
|
| FEDERATED HERMES, INC. |
$966598 |
77266 |
0.07% |
股份
|
| Rafferty Asset Management, LLC |
$944780 |
75522 |
0.07% |
股份
|
| Creative Planning |
$878990 |
70263 |
0.06% |
股份
|
| ExodusPoint Capital Management, LP |
$877476 |
70142 |
0.06% |
股份
|
| WELLS FARGO & COMPANY/MN |
$846514 |
67667 |
0.06% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$827699 |
66163 |
0.06% |
股份
|
| NOMURA HOLDINGS INC |
$825660 |
66000 |
0.06% |
卖出期权
|
| PRUDENTIAL FINANCIAL INC |
$751351 |
60060 |
0.06% |
股份
|
| LPL Financial LLC |
$737352 |
58941 |
0.05% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$732285 |
58536 |
0.05% |
股份
|
| Quantinno Capital Management LP |
$699046 |
55879 |
0.05% |
股份
|
| D. E. Shaw & Co., Inc. |
$694543 |
55519 |
0.05% |
股份
|
| CITADEL ADVISORS LLC |
$691803 |
55300 |
0.05% |
买入期权
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$689564 |
55121 |
0.05% |
股份
|
| Swedbank AB |
$689301 |
55100 |
0.05% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$688050 |
55000 |
0.05% |
买入期权
|
| Engineers Gate Manager LP |
$669961 |
53554 |
0.05% |
股份
|
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
$626000 |
50000 |
0.05% |
股份
|
| PORTLAND INVESTMENT COUNSEL INC. |
$625500 |
50000 |
0.05% |
股份
|
| MetLife Investment Management, LLC |
$581715 |
46500 |
0.04% |
股份
|
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
$565590 |
45211 |
0.04% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$558617 |
44871 |
0.04% |
股份
|
| Russell Investments Group, Ltd. |
$523017 |
41808 |
0.04% |
股份
|
| Headlands Technologies LLC |
$515937 |
41242 |
0.04% |
股份
|
| NOMURA HOLDINGS INC |
$505404 |
40400 |
0.04% |
买入期权
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$482811 |
38594 |
0.04% |
股份
|
| PROFUND ADVISORS LLC |
$479871 |
38359 |
0.04% |
股份
|
| Legal & General Group Plc |
$469625 |
37540 |
0.03% |
股份
|
| Aristotle Atlantic Partners, LLC |
$456728 |
36509 |
0.03% |
股份
|
| NOMURA HOLDINGS INC |
$423539 |
33856 |
0.03% |
股份
|
| Virtus Investment Advisers, LLC |
$414707 |
33150 |
0.03% |
股份
|
| JANE STREET GROUP, LLC |
$401571 |
32100 |
0.03% |
买入期权
|
| Seven Fleet Capital Management LP |
$393765 |
31476 |
0.03% |
股份
|
| Caption Management, LLC |
$375300 |
30000 |
0.03% |
买入期权
|
| Caption Management, LLC |
$375300 |
30000 |
0.03% |
卖出期权
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$373122 |
25025 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$356535 |
28500 |
0.03% |
卖出期权
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$339872 |
27168 |
0.02% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$332804 |
26603 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$325260 |
26000 |
0.02% |
卖出期权
|
| INTECH INVESTMENT MANAGEMENT LLC |
$301328 |
24087 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$290395 |
23213 |
0.02% |
股份
|
| GROUP ONE TRADING LLC |
$284552 |
22746 |
0.02% |
股份
|
| BARCLAYS PLC |
$279799 |
22366 |
0.02% |
股份
|
| Brevan Howard Capital Management LP |
$276471 |
22100 |
0.02% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$258957 |
20700 |
0.02% |
股份
|
| OPTIMIZE FINANCIAL INC. |
$256405 |
20496 |
0.02% |
股份
|
| Point72 Asset Management, L.P. |
$252702 |
20200 |
0.02% |
买入期权
|
| Jain Global LLC |
$241743 |
19324 |
0.02% |
股份
|
| Vanguard Global Advisers, LLC |
$238516 |
19066 |
0.02% |
股份
|
| Caption Management, LLC |
$225180 |
18000 |
0.02% |
股份
|
| VIRGINIA RETIREMENT SYSTEMS ET Al |
$220176 |
17600 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$211532 |
16909 |
0.02% |
股份
|
| Inscription Capital, LLC |
$191065 |
15273 |
0.01% |
股份
|
| Jefferies Financial Group Inc. |
$187650 |
15000 |
0.01% |
卖出期权
|
| EntryPoint Capital, LLC |
$180820 |
14454 |
0.01% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$180519 |
14430 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$173902 |
13901 |
0.01% |
股份
|
| ProShare Advisors LLC |
$164331 |
13136 |
0.01% |
股份
|
| STRS OHIO |
$160128 |
12800 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$159628 |
12760 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$148869 |
11900 |
0.01% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$148043 |
11834 |
0.01% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$143865 |
11500 |
0.01% |
股份
|
| Jefferies Financial Group Inc. |
$137610 |
11000 |
0.01% |
股份
|
| E Fund Management Co., Ltd. |
$133219 |
10649 |
0.01% |
股份
|
| Wealthspire Advisors, LLC |
$127252 |
10172 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$125250 |
10012 |
0.01% |
股份
|
| PSP Research LLC |
$125100 |
10000 |
0.01% |
股份
|
| CWM, LLC |
$94142 |
6314 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$89009 |
7115 |
0.01% |
股份
|
| Quantbot Technologies LP |
$76511 |
6116 |
0.01% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$49214 |
3934 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$48877 |
3907 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$43000 |
3384 |
0.00% |
股份
|
| AlphaQuest LLC |
$42250 |
1690 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$37302 |
3275 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$29361 |
2347 |
0.00% |
股份
|
| Point72 Asset Management, L.P. |
$27522 |
2200 |
0.00% |
卖出期权
|
| Federation des caisses Desjardins du Quebec |
$25020 |
2000 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$21242 |
1698 |
0.00% |
股份
|
| State of Wyoming |
$21154 |
1691 |
0.00% |
股份
|
| Arax Advisory Partners |
$18078 |
1445 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$16926 |
1353 |
0.00% |
股份
|
| Duquesne Family Office LLC |
$12345 |
986827 |
0.00% |
股份
|
| Truvestments Capital LLC |
$10483 |
838 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$10341 |
826569 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$9694 |
1122 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$9207 |
736 |
0.00% |
股份
|
| WOLFF WIESE MAGANA LLC |
$7506 |
600 |
0.00% |
股份
|
| GAMMA Investing LLC |
$7456 |
596 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$7256 |
580 |
0.00% |
股份
|
| J.Safra Asset Management Corp |
$6993 |
559 |
0.00% |
股份
|
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
$6880 |
550 |
0.00% |
股份
|
| US BANCORP \DE\ |
$6630 |
530 |
0.00% |
股份
|
| Allworth Financial LP |
$6068 |
485 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$4892 |
391 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$4417 |
353 |
0.00% |
股份
|
| Point72 Europe (London) LLP |
$3958 |
404 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$3503 |
280 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$2727 |
218 |
0.00% |
股份
|
| Optiver Holding B.V. |
$2540 |
203 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$2289 |
183 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$2252 |
180 |
0.00% |
股份
|
| Parkside Financial Bank & Trust |
$1692 |
135 |
0.00% |
股份
|
| Quarry LP |
$1389 |
111 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$1288 |
103 |
0.00% |
股份
|
| True Wealth Design, LLC |
$764 |
61 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$763 |
61 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$488 |
40 |
0.00% |
股份
|
| Hurley Capital, LLC |
$363 |
29 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$349 |
27885 |
0.00% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$320 |
26 |
0.00% |
股份
|
| Ares Financial Consulting, LLC |
$300 |
24 |
0.00% |
股份
|
| Axiom Investment Management LLC |
$125 |
10 |
0.00% |
股份
|
| IFP Advisors, Inc |
$75 |
6 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$16 |
1261 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$13 |
1 |
0.00% |
股份
|
| TORONTO DOMINION BANK |
$13 |
1 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
19 |
0.00% |
股份
|
| BESSEMER GROUP INC |
$0 |
26 |
0.00% |
股份
|