| Merck & Co., Inc. |
$188202236 |
14044943 |
16.23% |
股份
|
| ARK Investment Management LLC |
$110835941 |
8271339 |
9.56% |
股份
|
| BlackRock, Inc. |
$94905378 |
7082491 |
8.19% |
股份
|
| LIGHTSPEED MANAGEMENT COMPANY, L.L.C. |
$81764790 |
6101850 |
7.05% |
股份
|
| AMERIPRISE FINANCIAL INC |
$81556656 |
6086315 |
7.04% |
股份
|
| Deep Track Capital, LP |
$53600000 |
4000000 |
4.62% |
股份
|
| Aberdeen Group plc |
$50213686 |
3747290 |
4.33% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$40336010 |
3010150 |
3.48% |
股份
|
| Casdin Capital, LLC |
$34170000 |
2550000 |
2.95% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$31681379 |
2364282 |
2.73% |
股份
|
| VANGUARD GROUP INC |
$25900225 |
3253797 |
2.23% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$24425481 |
1822445 |
2.11% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$24395249 |
1820541 |
2.10% |
股份
|
| AIGH Capital Management LLC |
$22981000 |
1715000 |
1.98% |
股份
|
| Blue Water Life Science Advisors, LP |
$22462420 |
1676300 |
1.94% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$20062963 |
1496983 |
1.73% |
股份
|
| STATE STREET CORP |
$19926832 |
1487077 |
1.72% |
股份
|
| MORGAN STANLEY |
$17030682 |
1270946 |
1.47% |
股份
|
| GOLDMAN SACHS GROUP INC |
$12475815 |
931031 |
1.08% |
股份
|
| Nuveen, LLC |
$10090253 |
753004 |
0.87% |
股份
|
| JANE STREET GROUP, LLC |
$9892429 |
738241 |
0.85% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$8841776 |
659834 |
0.76% |
股份
|
| NORTHERN TRUST CORP |
$8479560 |
632803 |
0.73% |
股份
|
| Trexquant Investment LP |
$8042894 |
600216 |
0.69% |
股份
|
| HOWLAND CAPITAL MANAGEMENT LLC |
$7445590 |
555641 |
0.64% |
股份
|
| STATE OF MICHIGAN RETIREMENT SYSTEM |
$6616893 |
493798 |
0.57% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$6073644 |
453257 |
0.52% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$6032144 |
450160 |
0.52% |
股份
|
| Sumitomo Mitsui Trust Group, Inc. |
$5594339 |
417488 |
0.48% |
股份
|
| Amova Asset Management Americas, Inc. |
$5590164 |
417488 |
0.48% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$4887838 |
364764 |
0.42% |
股份
|
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd |
$4713329 |
351741 |
0.41% |
股份
|
| Wellington Shields Capital Management, LLC |
$4552427 |
339733 |
0.39% |
股份
|
| Wellington Shields & Co., LLC |
$3919353 |
292489 |
0.34% |
股份
|
| Militia Capital Management LLC |
$3911205 |
291881 |
0.34% |
股份
|
| GILDER GAGNON HOWE & CO LLC |
$3731766 |
278490 |
0.32% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$3675901 |
274321 |
0.32% |
股份
|
| STEMPOINT CAPITAL LP |
$3320292 |
247783 |
0.29% |
股份
|
| PERKINS CAPITAL MANAGEMENT INC |
$3202600 |
239000 |
0.28% |
股份
|
| GOLDMAN SACHS GROUP INC |
$3199920 |
238800 |
0.28% |
买入期权
|
| Bruce & Co., Inc. |
$3122200 |
233000 |
0.27% |
股份
|
| FIRST MANHATTAN CO. LLC. |
$3090040 |
230600 |
0.27% |
股份
|
| UDINE WEALTH MANAGEMENT, INC. |
$2898238 |
50030 |
0.25% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$2804888 |
209320 |
0.24% |
股份
|
| ORACLE INVESTMENT MANAGEMENT INC |
$2701170 |
339343 |
0.23% |
股份
|
| Bank of New York Mellon Corp |
$2533469 |
189065 |
0.22% |
股份
|
| FRED ALGER MANAGEMENT, LLC |
$2218759 |
165579 |
0.19% |
股份
|
| UBS Group AG |
$2207797 |
164761 |
0.19% |
股份
|
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
$2110500 |
157500 |
0.18% |
股份
|
| CITADEL ADVISORS LLC |
$1942973 |
144998 |
0.17% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1940320 |
144800 |
0.17% |
买入期权
|
| Swiss National Bank |
$1829100 |
136500 |
0.16% |
股份
|
| Williams Jones Wealth Management, LLC. |
$1796565 |
134072 |
0.15% |
股份
|
| LPL Financial LLC |
$1776867 |
132602 |
0.15% |
股份
|
| Jump Financial, LLC |
$1745940 |
130294 |
0.15% |
股份
|
| Russell Investments Group, Ltd. |
$1697377 |
126670 |
0.15% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$1625407 |
121299 |
0.14% |
股份
|
| Engineers Gate Manager LP |
$1552283 |
115842 |
0.13% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$1410015 |
105225 |
0.12% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$1341260 |
100094 |
0.12% |
股份
|
| Brevan Howard Capital Management LP |
$1333863 |
99542 |
0.12% |
股份
|
| Kercheville Advisors, LLC |
$1256920 |
93800 |
0.11% |
股份
|
| CITIGROUP INC |
$1242287 |
92708 |
0.11% |
股份
|
| JANE STREET GROUP, LLC |
$1165800 |
87000 |
0.10% |
买入期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1165559 |
86982 |
0.10% |
股份
|
| RHUMBLINE ADVISERS |
$1156696 |
86321 |
0.10% |
股份
|
| Invesco Ltd. |
$1117131 |
83368 |
0.10% |
股份
|
| AlphaCentric Advisors LLC |
$1057582 |
78924 |
0.09% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1008564 |
75266 |
0.09% |
股份
|
| Green Alpha Advisors, LLC |
$904058 |
67467 |
0.08% |
股份
|
| WELLS FARGO & COMPANY/MN |
$894784 |
66775 |
0.08% |
股份
|
| DEUTSCHE BANK AG\ |
$886919 |
66188 |
0.08% |
股份
|
| ROYAL BANK OF CANADA |
$857000 |
63947 |
0.07% |
股份
|
| STEMPOINT CAPITAL LP |
$810750 |
470000 |
0.07% |
买入期权
|
| CITADEL ADVISORS LLC |
$795960 |
59400 |
0.07% |
买入期权
|
| XTX Topco Ltd |
$792516 |
59143 |
0.07% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$767257 |
57258 |
0.07% |
股份
|
| CITADEL ADVISORS LLC |
$766480 |
57200 |
0.07% |
卖出期权
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$756122 |
56427 |
0.07% |
股份
|
| BARCLAYS PLC |
$716055 |
53437 |
0.06% |
股份
|
| SEI INVESTMENTS CO |
$697242 |
52033 |
0.06% |
股份
|
| Cerity Partners LLC |
$660138 |
49264 |
0.06% |
股份
|
| ExodusPoint Capital Management, LP |
$660030 |
49256 |
0.06% |
股份
|
| Schonfeld Strategic Advisors LLC |
$656452 |
48989 |
0.06% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$635160 |
47400 |
0.05% |
卖出期权
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$630095 |
47022 |
0.05% |
股份
|
| JPMORGAN CHASE & CO |
$585324 |
42569 |
0.05% |
股份
|
| Qube Research & Technologies Ltd |
$547283 |
40842 |
0.05% |
股份
|
| Atom Investors LP |
$546224 |
40763 |
0.05% |
股份
|
| JANE STREET GROUP, LLC |
$542700 |
40500 |
0.05% |
卖出期权
|
| MetLife Investment Management, LLC |
$532905 |
39769 |
0.05% |
股份
|
| Pathstone Holdings, LLC |
$519835 |
39015 |
0.04% |
股份
|
| Dynamic Technology Lab Private Ltd |
$514000 |
38394 |
0.04% |
股份
|
| AlpInvest Partners B.V. |
$505220 |
37703 |
0.04% |
股份
|
| WINTON GROUP Ltd |
$495974 |
37013 |
0.04% |
股份
|
| Legal & General Group Plc |
$488015 |
36419 |
0.04% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$469469 |
73700 |
0.04% |
股份
|
| Entropy Technologies, LP |
$407628 |
30420 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$375401 |
28015 |
0.03% |
股份
|
| IEQ CAPITAL, LLC |
$366182 |
27327 |
0.03% |
股份
|
| MARSHALL WACE, LLP |
$358182 |
26730 |
0.03% |
股份
|
| Voleon Capital Management LP |
$355127 |
26502 |
0.03% |
股份
|
| CAPTRUST FINANCIAL ADVISORS |
$342919 |
25591 |
0.03% |
股份
|
| Squarepoint Ops LLC |
$319027 |
23808 |
0.03% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$318920 |
23800 |
0.03% |
股份
|
| STRS OHIO |
$317580 |
23700 |
0.03% |
股份
|
| KLP KAPITALFORVALTNING AS |
$313560 |
23400 |
0.03% |
股份
|
| Alamea Verwaltungs GmbH |
$311885 |
23275 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$268134 |
20010 |
0.02% |
股份
|
| Caitong International Asset Management Co., Ltd |
$262774 |
19610 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$251464 |
18766 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$247766 |
18490 |
0.02% |
股份
|
| Quadrature Capital Ltd |
$243867 |
18199 |
0.02% |
股份
|
| Focus Partners Wealth |
$240825 |
17972 |
0.02% |
股份
|
| GUGGENHEIM CAPITAL LLC |
$235130 |
17547 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$223324 |
16666 |
0.02% |
股份
|
| Vanguard Investments Australia, Ltd. |
$215914 |
16113 |
0.02% |
股份
|
| Creative Planning |
$201925 |
15069 |
0.02% |
股份
|
| ADAR1 Capital Management, LLC |
$201000 |
15000 |
0.02% |
股份
|
| Jasper Ridge Partners, L.P. |
$193161 |
14415 |
0.02% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$192022 |
14330 |
0.02% |
股份
|
| JANUS HENDERSON GROUP PLC |
$191921 |
30200 |
0.02% |
股份
|
| FOX RUN MANAGEMENT, L.L.C. |
$191432 |
14286 |
0.02% |
股份
|
| OSAIC HOLDINGS, INC. |
$179493 |
13395 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$177255 |
13228 |
0.02% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$176746 |
13190 |
0.02% |
股份
|
| ProShare Advisors LLC |
$165035 |
12316 |
0.01% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$158402 |
11821 |
0.01% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$149946 |
11190 |
0.01% |
股份
|
| US BANCORP \DE\ |
$146837 |
10958 |
0.01% |
股份
|
| J. Safra Sarasin Holding AG |
$134670 |
10047 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$82504 |
6157 |
0.01% |
股份
|
| Quantbot Technologies LP |
$69157 |
5161 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$62766 |
4684 |
0.01% |
股份
|
| Steward Partners Investment Advisory, LLC |
$58866 |
4393 |
0.01% |
股份
|
| FMR LLC |
$54672 |
4080 |
0.00% |
股份
|
| AlphaQuest LLC |
$39856 |
5007 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$37949 |
2832 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$29668 |
2214 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$28140 |
2100 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$18318 |
1367 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$18318 |
1367 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$17420 |
1300 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$12472 |
930816 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$10626 |
793 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$7001 |
1099 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$5856 |
437 |
0.00% |
股份
|
| GAMMA Investing LLC |
$4971 |
371 |
0.00% |
股份
|
| JONES FINANCIAL COMPANIES LLLP |
$3763 |
289 |
0.00% |
股份
|
| Allworth Financial LP |
$2587 |
193 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$2278 |
170 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$2130 |
158838 |
0.00% |
股份
|
| HUNTINGTON NATIONAL BANK |
$1930 |
144 |
0.00% |
股份
|
| CWM, LLC |
$1497 |
235 |
0.00% |
股份
|
| Janney Montgomery Scott LLC |
$1407 |
105001 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$1353 |
101 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$1138 |
85 |
0.00% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$975 |
73 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$938 |
70 |
0.00% |
股份
|
| C M BIDWELL & ASSOCIATES LTD |
$764 |
57 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$713 |
203 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$579 |
43244 |
0.00% |
股份
|
| Arax Advisory Partners |
$362 |
27 |
0.00% |
股份
|
| Quarry LP |
$255 |
19 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$174 |
13 |
0.00% |
股份
|
| CANADA LIFE ASSURANCE Co |
$120 |
8987 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$118 |
8800 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$94 |
7 |
0.00% |
股份
|