| FMR LLC |
$298894493 |
7172894 |
13.99% |
股份
|
| TRV GP V, LLC |
$261709477 |
6280525 |
12.25% |
股份
|
| ARCH Venture Management, LLC |
$155376512 |
3728738 |
7.27% |
股份
|
| Capital International Investors |
$121757990 |
2921958 |
5.70% |
股份
|
| GOLDMAN SACHS GROUP INC |
$121278410 |
2910449 |
5.68% |
股份
|
| BlackRock, Inc. |
$112500083 |
2699786 |
5.27% |
股份
|
| Cormorant Asset Management, LP |
$110738900 |
2657521 |
5.18% |
股份
|
| Sofinnova Investments, Inc. |
$79356681 |
1904408 |
3.71% |
股份
|
| JOHNSON & JOHNSON |
$74360823 |
1784517 |
3.48% |
股份
|
| Polar Capital Holdings Plc |
$67026778 |
1608514 |
3.14% |
股份
|
| BAKER BROS. ADVISORS LP |
$64467240 |
1547090 |
3.02% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$56109155 |
1346512 |
2.63% |
股份
|
| VANGUARD GROUP INC |
$55150747 |
1817757 |
2.58% |
股份
|
| TRV GP VI, LLC |
$40387314 |
969218 |
1.89% |
股份
|
| STATE STREET CORP |
$34115729 |
818712 |
1.60% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$33068458 |
793453 |
1.55% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$32225161 |
773342 |
1.51% |
股份
|
| Vestal Point Capital, LP |
$30419100 |
730000 |
1.42% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$28751317 |
918866 |
1.35% |
股份
|
| Siren, L.L.C. |
$26730013 |
641469 |
1.25% |
股份
|
| Capital World Investors |
$22987547 |
551657 |
1.08% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$21695985 |
693384 |
1.02% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$15087064 |
362114 |
0.71% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$14998866 |
359944 |
0.70% |
股份
|
| Candriam S.C.A. |
$14472638 |
347650 |
0.68% |
股份
|
| Sio Capital Management, LLC |
$12820067 |
307657 |
0.60% |
股份
|
| MORGAN STANLEY |
$12401492 |
297612 |
0.58% |
股份
|
| NORTHERN TRUST CORP |
$11555299 |
277305 |
0.54% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$10450628 |
250795 |
0.49% |
股份
|
| Burkehill Global Management, LP |
$10417500 |
250000 |
0.49% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$10284781 |
246815 |
0.48% |
股份
|
| ALGERT GLOBAL LLC |
$9326663 |
223822 |
0.44% |
股份
|
| Invesco Ltd. |
$8968884 |
215236 |
0.42% |
股份
|
| D. E. Shaw & Co., Inc. |
$8952008 |
214831 |
0.42% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$8681236 |
208333 |
0.41% |
股份
|
| Ensign Peak Advisors, Inc |
$6898302 |
165546 |
0.32% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$6455016 |
154908 |
0.30% |
股份
|
| UBS Group AG |
$6299420 |
151174 |
0.29% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$6250500 |
150000 |
0.29% |
股份
|
| Artia Global Partners LP |
$5771628 |
138508 |
0.27% |
股份
|
| Swedbank AB |
$4892058 |
117400 |
0.23% |
股份
|
| Nuveen, LLC |
$4307053 |
103361 |
0.20% |
股份
|
| Walleye Capital LLC |
$4257132 |
102163 |
0.20% |
股份
|
| Woodline Partners LP |
$4064367 |
97537 |
0.19% |
股份
|
| TD Asset Management Inc |
$3828556 |
91878 |
0.18% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$3624790 |
86988 |
0.17% |
股份
|
| PRUDENTIAL FINANCIAL INC |
$3620498 |
86885 |
0.17% |
股份
|
| CITADEL ADVISORS LLC |
$3435358 |
82442 |
0.16% |
股份
|
| Bank of New York Mellon Corp |
$3426191 |
82222 |
0.16% |
股份
|
| ORBIMED ADVISORS LLC |
$3192589 |
76616 |
0.15% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$3170087 |
76076 |
0.15% |
股份
|
| DAFNA Capital Management LLC |
$3125250 |
75000 |
0.15% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$2903649 |
69682 |
0.14% |
股份
|
| STEMPOINT CAPITAL LP |
$2774472 |
66582 |
0.13% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$2740386 |
65764 |
0.13% |
股份
|
| XTX Topco Ltd |
$2560246 |
61441 |
0.12% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$2439237 |
58537 |
0.11% |
股份
|
| Allspring Global Investments Holdings, LLC |
$2394692 |
57468 |
0.11% |
股份
|
| JANE STREET GROUP, LLC |
$2321228 |
55705 |
0.11% |
股份
|
| Russell Investments Group, Ltd. |
$2310936 |
55458 |
0.11% |
股份
|
| Swiss National Bank |
$2300184 |
55200 |
0.11% |
股份
|
| Trexquant Investment LP |
$2247555 |
53937 |
0.11% |
股份
|
| ALPS ADVISORS INC |
$2010286 |
48243 |
0.09% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$1665883 |
39978 |
0.08% |
股份
|
| RHUMBLINE ADVISERS |
$1550030 |
37198 |
0.07% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$1354233 |
32499 |
0.06% |
股份
|
| DEUTSCHE BANK AG\ |
$1342274 |
32212 |
0.06% |
股份
|
| WELLS FARGO & COMPANY/MN |
$1340566 |
32171 |
0.06% |
股份
|
| Integrated Quantitative Investments LLC |
$1266185 |
30386 |
0.06% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$1102338 |
26454 |
0.05% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$1019665 |
24470 |
0.05% |
股份
|
| CITIGROUP INC |
$1015623 |
24373 |
0.05% |
股份
|
| Ellsworth Advisors, LLC |
$979842 |
24539 |
0.05% |
股份
|
| Creative Planning |
$954993 |
22918 |
0.04% |
股份
|
| Legal & General Group Plc |
$939867 |
22555 |
0.04% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$920949 |
22101 |
0.04% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$919032 |
22055 |
0.04% |
股份
|
| Engineers Gate Manager LP |
$888154 |
21314 |
0.04% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$799606 |
19189 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$772228 |
18532 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$750435 |
18009 |
0.04% |
股份
|
| Vanguard Global Advisers, LLC |
$718391 |
17240 |
0.03% |
股份
|
| SEI INVESTMENTS CO |
$678971 |
16294 |
0.03% |
股份
|
| JPMORGAN CHASE & CO |
$669021 |
16564 |
0.03% |
股份
|
| BARCLAYS PLC |
$624800 |
14994 |
0.03% |
股份
|
| AMERIPRISE FINANCIAL INC |
$612382 |
14696 |
0.03% |
股份
|
| OPTIMIZE FINANCIAL INC. |
$608632 |
14606 |
0.03% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$594048 |
14256 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$587880 |
14108 |
0.03% |
股份
|
| PSP Research LLC |
$583380 |
14000 |
0.03% |
股份
|
| VARCOV Co. |
$537335 |
12895 |
0.03% |
股份
|
| China Universal Asset Management Co., Ltd. |
$450536 |
10812 |
0.02% |
股份
|
| Allianz Asset Management GmbH |
$445869 |
10700 |
0.02% |
股份
|
| JANUS HENDERSON GROUP PLC |
$432768 |
13800 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$429201 |
10300 |
0.02% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$424034 |
10176 |
0.02% |
股份
|
| CATALYST PRIVATE WEALTH, LLC |
$416700 |
10000 |
0.02% |
股份
|
| STIFEL FINANCIAL CORP |
$407243 |
9773 |
0.02% |
股份
|
| CLEAR WAVE WEALTH MANAGEMENT LLC |
$395865 |
9500 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$376447 |
9034 |
0.02% |
股份
|
| State of New Jersey Common Pension Fund D |
$370321 |
8887 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$362529 |
8700 |
0.02% |
买入期权
|
| Virtus Investment Advisers, LLC |
$355070 |
8521 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$348820 |
8371 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$343986 |
8255 |
0.02% |
股份
|
| ARIZONA STATE RETIREMENT SYSTEM |
$316025 |
7584 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$302483 |
7259 |
0.01% |
股份
|
| AlphaCentric Advisors LLC |
$272147 |
6531 |
0.01% |
股份
|
| Quadrature Capital Ltd |
$264980 |
6359 |
0.01% |
股份
|
| PROFUND ADVISORS LLC |
$264938 |
6358 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$245853 |
5900 |
0.01% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$241686 |
5800 |
0.01% |
卖出期权
|
| ProShare Advisors LLC |
$232519 |
5580 |
0.01% |
股份
|
| Pictet Asset Management Holding SA |
$216601 |
5198 |
0.01% |
股份
|
| JANE STREET GROUP, LLC |
$208350 |
5000 |
0.01% |
卖出期权
|
| Sandia Investment Management LP |
$182040 |
6000 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$124010 |
2976 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$115843 |
2780 |
0.01% |
股份
|
| MEEDER ASSET MANAGEMENT INC |
$115593 |
2774 |
0.01% |
股份
|
| AlphaQuest LLC |
$113896 |
3754 |
0.01% |
股份
|
| STRS OHIO |
$108342 |
2600 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$89132 |
2139 |
0.00% |
股份
|
| Aquatic Capital Management LLC |
$88007 |
2112 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$79923 |
1918 |
0.00% |
股份
|
| State of Wyoming |
$65005 |
1560 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$47000 |
1147 |
0.00% |
股份
|
| CWM, LLC |
$46153 |
1475 |
0.00% |
股份
|
| Tidemark, LLC |
$45337 |
1088 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$42128 |
1011 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$32814 |
787446 |
0.00% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$32128 |
771 |
0.00% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$20710 |
497 |
0.00% |
股份
|
| GAMMA Investing LLC |
$17001 |
408 |
0.00% |
股份
|
| T. Rowe Price Investment Management, Inc. |
$16385 |
393200 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$15668 |
376 |
0.00% |
股份
|
| FEDERATED HERMES, INC. |
$10001 |
240 |
0.00% |
股份
|
| Stone House Investment Management, LLC |
$8792 |
211 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$8542 |
205 |
0.00% |
股份
|
| MassMutual Private Wealth & Trust, FSB |
$6792 |
163 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$6125 |
147 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$5875 |
141 |
0.00% |
股份
|
| Larson Financial Group LLC |
$5459 |
131 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$5167 |
124 |
0.00% |
股份
|
| TD Waterhouse Canada Inc. |
$4845 |
123 |
0.00% |
股份
|
| Aster Capital Management (DIFC) Ltd |
$4500 |
108 |
0.00% |
股份
|
| Arax Advisory Partners |
$2251 |
54 |
0.00% |
股份
|
| Optiver Holding B.V. |
$2250 |
54 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$2209 |
53 |
0.00% |
股份
|
| Cornerstone Financial Management LLC |
$2042 |
49 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$2000 |
48 |
0.00% |
股份
|
| True Wealth Design, LLC |
$1709 |
41 |
0.00% |
股份
|
| Essential Partners LLC |
$1667 |
40 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$1625 |
39 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$1125 |
27 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$875 |
21 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$833 |
20 |
0.00% |
股份
|
| US BANCORP \DE\ |
$583 |
14 |
0.00% |
股份
|
| Sunbelt Securities, Inc. |
$344 |
11 |
0.00% |
股份
|
| Allworth Financial LP |
$292 |
7 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$291 |
7 |
0.00% |
股份
|
| Ameritas Advisory Services, LLC |
$208 |
5 |
0.00% |
股份
|
| Lindbrook Capital, LLC |
$150 |
15 |
0.00% |
股份
|
| IFP Advisors, Inc |
$125 |
3 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$83 |
2 |
0.00% |
股份
|
| KBC Group NV |
$40 |
962 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$39 |
957 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
17 |
0.00% |
股份
|