| Caligan Partners LP |
$31072107 |
7967207 |
11.30% |
股份
|
| Vivo Capital, LLC |
$28469645 |
7299909 |
10.35% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$25847254 |
6627501 |
9.40% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$24981657 |
6405553 |
9.09% |
股份
|
| RA CAPITAL MANAGEMENT, L.P. |
$17165850 |
4401500 |
6.24% |
股份
|
| Balyasny Asset Management L.P. |
$14665712 |
3760439 |
5.33% |
股份
|
| BlackRock, Inc. |
$11957462 |
3066016 |
4.35% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$11594423 |
2972929 |
4.22% |
股份
|
| Commodore Capital LP |
$11193000 |
2870000 |
4.07% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$10721439 |
2749087 |
3.90% |
股份
|
| Spruce Street Capital LP |
$8574158 |
2198502 |
3.12% |
股份
|
| Sessa Capital IM, L.P. |
$8573982 |
2198457 |
3.12% |
股份
|
| VANGUARD GROUP INC |
$6908288 |
1847136 |
2.51% |
股份
|
| Affinity Asset Advisors, LLC |
$5947500 |
1525000 |
2.16% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$5778474 |
1481660 |
2.10% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$4981704 |
1277185 |
1.81% |
股份
|
| Woodline Partners LP |
$4603385 |
1180355 |
1.67% |
股份
|
| Ensign Peak Advisors, Inc |
$4573300 |
1172641 |
1.66% |
股份
|
| Propel Bio Management, LLC |
$4198654 |
1076578 |
1.53% |
股份
|
| Soleus Capital Management, L.P. |
$3510000 |
900000 |
1.28% |
股份
|
| Seven Fleet Capital Management LP |
$2870700 |
736077 |
1.04% |
股份
|
| AMERIPRISE FINANCIAL INC |
$2382975 |
611019 |
0.87% |
股份
|
| STATE STREET CORP |
$2070241 |
530831 |
0.75% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1710209 |
438515 |
0.62% |
股份
|
| DV EQUITIES, LLC |
$1560000 |
400000 |
0.57% |
股份
|
| AWM Investment Company, Inc. |
$1462500 |
375000 |
0.53% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$1458522 |
373980 |
0.53% |
股份
|
| UBS Group AG |
$1426924 |
365878 |
0.52% |
股份
|
| NORTHERN TRUST CORP |
$1413707 |
362489 |
0.51% |
股份
|
| STEMPOINT CAPITAL LP |
$1336261 |
342631 |
0.49% |
股份
|
| HB Wealth Management, LLC |
$1199250 |
307500 |
0.44% |
股份
|
| Polymer Capital Management (HK) LTD |
$1195666 |
306581 |
0.43% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$1141639 |
292728 |
0.42% |
股份
|
| JANE STREET GROUP, LLC |
$883350 |
226500 |
0.32% |
卖出期权
|
| TWO SIGMA INVESTMENTS, LP |
$837065 |
214632 |
0.30% |
股份
|
| GOLDMAN SACHS GROUP INC |
$746089 |
191305 |
0.27% |
股份
|
| Bank of New York Mellon Corp |
$420604 |
107847 |
0.15% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$412160 |
105682 |
0.15% |
股份
|
| Simplify Asset Management Inc. |
$408911 |
104849 |
0.15% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$330271 |
84685 |
0.12% |
股份
|
| CITADEL ADVISORS LLC |
$315900 |
81000 |
0.11% |
买入期权
|
| ALPS ADVISORS INC |
$302640 |
77600 |
0.11% |
股份
|
| Stonepine Capital Management, LLC |
$285757 |
73271 |
0.10% |
股份
|
| CITADEL ADVISORS LLC |
$244908 |
62797 |
0.09% |
股份
|
| Nuveen, LLC |
$227752 |
58398 |
0.08% |
股份
|
| JANE STREET GROUP, LLC |
$209040 |
53600 |
0.08% |
买入期权
|
| Pathstone Holdings, LLC |
$197537 |
50650 |
0.07% |
股份
|
| Kestra Advisory Services, LLC |
$194263 |
49811 |
0.07% |
股份
|
| RHUMBLINE ADVISERS |
$176133 |
45164 |
0.06% |
股份
|
| WELLS FARGO & COMPANY/MN |
$171924 |
44083 |
0.06% |
股份
|
| DEUTSCHE BANK AG\ |
$165247 |
42371 |
0.06% |
股份
|
| IFP Advisors, Inc |
$150926 |
38699 |
0.05% |
股份
|
| BARCLAYS PLC |
$140019 |
35902 |
0.05% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$110760 |
28400 |
0.04% |
买入期权
|
| MetLife Investment Management, LLC |
$109259 |
28015 |
0.04% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$105183 |
26970 |
0.04% |
股份
|
| CITIGROUP INC |
$103677 |
26584 |
0.04% |
股份
|
| Persistent Asset Partners Ltd |
$99060 |
25400 |
0.04% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$97991 |
25126 |
0.04% |
股份
|
| Invesco Ltd. |
$88112 |
22593 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$77984 |
19996 |
0.03% |
股份
|
| JPMORGAN CHASE & CO |
$70547 |
18089 |
0.03% |
股份
|
| Scientech Research LLC |
$68039 |
17446 |
0.02% |
股份
|
| Quadrature Capital Ltd |
$59261 |
15195 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$57073 |
14634 |
0.02% |
股份
|
| MORGAN STANLEY |
$53624 |
13750 |
0.02% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$50493 |
12947 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$50310 |
12900 |
0.02% |
股份
|
| Miller Capital Partners, Inc. |
$50193 |
12870 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$49947 |
12807 |
0.02% |
股份
|
| Vanguard Global Advisers, LLC |
$46223 |
11852 |
0.02% |
股份
|
| PNC Financial Services Group, Inc. |
$40053 |
10270 |
0.01% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$33669 |
8633 |
0.01% |
股份
|
| STRS OHIO |
$33150 |
8500 |
0.01% |
股份
|
| OSAIC HOLDINGS, INC. |
$31534 |
8086 |
0.01% |
股份
|
| Plante Moran Financial Advisors, LLC |
$23108 |
5925 |
0.01% |
股份
|
| Legal & General Group Plc |
$16470 |
4223 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$15370 |
3941 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$13540 |
3472 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$9828 |
2520 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$7800 |
2000 |
0.00% |
股份
|
| GROUP ONE TRADING LLC |
$7223 |
1852 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$7000 |
1687 |
0.00% |
股份
|
| Truvestments Capital LLC |
$4290 |
1100 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$3413 |
875 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$2894 |
742 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$2332 |
598 |
0.00% |
股份
|
| GS Investments, Inc. |
$780 |
200 |
0.00% |
股份
|
| FMR LLC |
$452 |
116 |
0.00% |
股份
|
| HARBOUR INVESTMENTS, INC. |
$195 |
50 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$139 |
35620 |
0.00% |
股份
|
| First PREMIER Bank |
$74 |
18986 |
0.00% |
股份
|