| RA CAPITAL MANAGEMENT, L.P. |
$435722930 |
9905045 |
20.30% |
股份
|
| TPG GP A, LLC |
$285713378 |
6494962 |
13.31% |
股份
|
| VIKING GLOBAL INVESTORS LP |
$140556012 |
3195181 |
6.55% |
股份
|
| Atlas Venture Life Science Advisors, LLC |
$131776532 |
2995602 |
6.14% |
股份
|
| ORBIMED ADVISORS LLC |
$112433029 |
2555877 |
5.24% |
股份
|
| ENAVATE SCIENCES GP, LLC |
$109008540 |
2478030 |
5.08% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$70384000 |
1600000 |
3.28% |
股份
|
| BlackRock, Inc. |
$64875089 |
1474769 |
3.02% |
股份
|
| JPMORGAN CHASE & CO |
$64085673 |
1490508 |
2.99% |
股份
|
| JENNISON ASSOCIATES LLC |
$51562131 |
1172133 |
2.40% |
股份
|
| CITADEL ADVISORS LLC |
$50484507 |
1147636 |
2.35% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$49796724 |
1132001 |
2.32% |
股份
|
| VANGUARD GROUP INC |
$48748883 |
1184951 |
2.27% |
股份
|
| STATE STREET CORP |
$44937281 |
1021534 |
2.09% |
股份
|
| PERCEPTIVE ADVISORS LLC |
$39810950 |
905000 |
1.85% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$29953495 |
680916 |
1.40% |
股份
|
| Siren, L.L.C. |
$26856555 |
610515 |
1.25% |
股份
|
| EVENTIDE ASSET MANAGEMENT, LLC |
$20894402 |
474981 |
0.97% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$20113984 |
457145 |
0.94% |
股份
|
| Casdin Capital, LLC |
$17596000 |
400000 |
0.82% |
股份
|
| BAKER BROS. ADVISORS LP |
$17596000 |
400000 |
0.82% |
股份
|
| GOLDMAN SACHS GROUP INC |
$17103752 |
388810 |
0.80% |
股份
|
| Driehaus Capital Management LLC |
$16955814 |
385447 |
0.79% |
股份
|
| FRANKLIN RESOURCES INC |
$12762071 |
290113 |
0.59% |
股份
|
| Aberdeen Group plc |
$12499231 |
284138 |
0.58% |
股份
|
| FMR LLC |
$12242065 |
278292 |
0.57% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$12173485 |
276733 |
0.57% |
股份
|
| Candriam S.C.A. |
$10248950 |
233208 |
0.48% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$9807527 |
222949 |
0.46% |
股份
|
| Kalehua Capital Management LLC |
$8669197 |
197072 |
0.40% |
股份
|
| Longaeva Partners L.P. |
$8637524 |
196352 |
0.40% |
股份
|
| Artisan Partners Limited Partnership |
$8336017 |
189498 |
0.39% |
股份
|
| Ensign Peak Advisors, Inc |
$8117563 |
184532 |
0.38% |
股份
|
| Soleus Capital Management, L.P. |
$7816451 |
177687 |
0.36% |
股份
|
| NORTHERN TRUST CORP |
$6795399 |
154476 |
0.32% |
股份
|
| MORGAN STANLEY |
$6644558 |
151047 |
0.31% |
股份
|
| Sofinnova Investments, Inc. |
$6353564 |
144432 |
0.30% |
股份
|
| Qube Research & Technologies Ltd |
$6172193 |
140309 |
0.29% |
股份
|
| Alyeska Investment Group, L.P. |
$5992406 |
136222 |
0.28% |
股份
|
| GordonMD Global Investments LP |
$5982640 |
136000 |
0.28% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$5707834 |
129753 |
0.27% |
股份
|
| Sio Capital Management, LLC |
$5622274 |
127808 |
0.26% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$5342234 |
121442 |
0.25% |
股份
|
| Artia Global Partners LP |
$5267407 |
119741 |
0.25% |
股份
|
| UBS Group AG |
$5111902 |
116206 |
0.24% |
股份
|
| First Turn Management, LLC |
$4860587 |
110493 |
0.23% |
股份
|
| CITIGROUP INC |
$4846070 |
110163 |
0.23% |
股份
|
| Ikarian Capital, LLC |
$4728925 |
107500 |
0.22% |
卖出期权
|
| D. E. Shaw & Co., Inc. |
$4471320 |
101644 |
0.21% |
股份
|
| Rock Springs Capital Management LP |
$4373882 |
99429 |
0.20% |
股份
|
| Walleye Capital LLC |
$4282295 |
97347 |
0.20% |
股份
|
| Rhenman & Partners Asset Management AB |
$4271429 |
97100 |
0.20% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$3911063 |
88908 |
0.18% |
股份
|
| AMERIPRISE FINANCIAL INC |
$3617386 |
82232 |
0.17% |
股份
|
| Integral Health Asset Management, LLC |
$3299250 |
75000 |
0.15% |
股份
|
| SUPERSTRING CAPITAL MANAGEMENT LP |
$2778232 |
63156 |
0.13% |
股份
|
| STEMPOINT CAPITAL LP |
$2614150 |
59426 |
0.12% |
股份
|
| DEUTSCHE BANK AG\ |
$2346998 |
53353 |
0.11% |
股份
|
| SEVEN GRAND MANAGERS, LLC |
$2199500 |
50000 |
0.10% |
股份
|
| Point72 Asset Management, L.P. |
$2169939 |
49328 |
0.10% |
股份
|
| TD Asset Management Inc |
$2084950 |
47396 |
0.10% |
股份
|
| ALPS ADVISORS INC |
$2002645 |
45525 |
0.09% |
股份
|
| SILVERARC CAPITAL MANAGEMENT, LLC |
$1868607 |
42478 |
0.09% |
股份
|
| Russell Investments Group, Ltd. |
$1858960 |
42258 |
0.09% |
股份
|
| Bank of New York Mellon Corp |
$1829361 |
41586 |
0.09% |
股份
|
| Nuveen, LLC |
$1814984 |
41259 |
0.08% |
股份
|
| XTX Topco Ltd |
$1675843 |
38096 |
0.08% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1643686 |
37365 |
0.08% |
股份
|
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC |
$1582232 |
35968 |
0.07% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$1558126 |
35420 |
0.07% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$1429675 |
32500 |
0.07% |
卖出期权
|
| BNP PARIBAS FINANCIAL MARKETS |
$1399014 |
31803 |
0.07% |
股份
|
| Ishara Investments LP |
$1350540 |
123000 |
0.06% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$1258114 |
28600 |
0.06% |
卖出期权
|
| Swiss National Bank |
$1187730 |
27000 |
0.06% |
股份
|
| Quadrature Capital Ltd |
$1144752 |
26023 |
0.05% |
股份
|
| Trexquant Investment LP |
$1047402 |
23810 |
0.05% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$1037548 |
23586 |
0.05% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$1020291 |
25450 |
0.05% |
股份
|
| TUDOR INVESTMENT CORP ET AL |
$993074 |
22575 |
0.05% |
股份
|
| RHUMBLINE ADVISERS |
$981362 |
22309 |
0.05% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$879800 |
20000 |
0.04% |
买入期权
|
| Maven Securities LTD |
$879800 |
20000 |
0.04% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$820193 |
18645 |
0.04% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$793316 |
18034 |
0.04% |
股份
|
| Rafferty Asset Management, LLC |
$791996 |
18004 |
0.04% |
股份
|
| Shay Capital LLC |
$791820 |
18000 |
0.04% |
股份
|
| WELLS FARGO & COMPANY/MN |
$739955 |
16821 |
0.03% |
股份
|
| Engineers Gate Manager LP |
$686376 |
15603 |
0.03% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$653339 |
14852 |
0.03% |
股份
|
| KENNEDY CAPITAL MANAGEMENT LLC |
$555198 |
12621 |
0.03% |
股份
|
| MARSHALL WACE, LLP |
$554230 |
12599 |
0.03% |
股份
|
| Invesco Ltd. |
$546267 |
12418 |
0.03% |
股份
|
| MetLife Investment Management, LLC |
$482658 |
10972 |
0.02% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$463369 |
10582 |
0.02% |
股份
|
| Jump Financial, LLC |
$460708 |
10473 |
0.02% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$419445 |
9535 |
0.02% |
股份
|
| PROFUND ADVISORS LLC |
$402069 |
9140 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$400705 |
9109 |
0.02% |
股份
|
| Legal & General Group Plc |
$397846 |
9044 |
0.02% |
股份
|
| CITADEL ADVISORS LLC |
$369516 |
8400 |
0.02% |
卖出期权
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$356319 |
8100 |
0.02% |
买入期权
|
| Vanguard Global Advisers, LLC |
$345409 |
7852 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$338723 |
7700 |
0.02% |
卖出期权
|
| China Universal Asset Management Co., Ltd. |
$316112 |
7186 |
0.01% |
股份
|
| Quarry LP |
$296933 |
6750 |
0.01% |
股份
|
| BARCLAYS PLC |
$285715 |
6495 |
0.01% |
股份
|
| VARCOV Co. |
$282328 |
6418 |
0.01% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$239218 |
5438 |
0.01% |
股份
|
| Squarepoint Ops LLC |
$238206 |
5415 |
0.01% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$229540 |
5218 |
0.01% |
股份
|
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
$229408 |
5215 |
0.01% |
股份
|
| SEI INVESTMENTS CO |
$226900 |
5158 |
0.01% |
股份
|
| Verition Fund Management LLC |
$219950 |
5000 |
0.01% |
买入期权
|
| AlphaCentric Advisors LLC |
$213923 |
4863 |
0.01% |
股份
|
| Jain Global LLC |
$210272 |
4780 |
0.01% |
股份
|
| AXQ CAPITAL, LP |
$202222 |
4597 |
0.01% |
股份
|
| STRS OHIO |
$153965 |
3500 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$153525 |
3490 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$136369 |
3100 |
0.01% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$88816 |
2019 |
0.00% |
股份
|
| Quantbot Technologies LP |
$80062 |
1820 |
0.00% |
股份
|
| Ameritas Investment Partners, Inc. |
$73595 |
1673 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$56263 |
1279 |
0.00% |
股份
|
| Mitsubishi UFJ Asset Management Co., Ltd. |
$43990 |
1000 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$41615 |
946 |
0.00% |
股份
|
| State of Wyoming |
$35368 |
804 |
0.00% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$31189 |
709 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$25000 |
568 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$21029 |
478016 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$16936 |
385 |
0.00% |
股份
|
| GAMMA Investing LLC |
$10734 |
244 |
0.00% |
股份
|
| Federation des caisses Desjardins du Quebec |
$9238 |
210 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$8622 |
196 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$5015 |
114 |
0.00% |
股份
|
| Hurley Capital, LLC |
$4971 |
113 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$4650 |
116 |
0.00% |
股份
|
| US BANCORP \DE\ |
$4575 |
104 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$2859 |
65 |
0.00% |
股份
|
| CWM, LLC |
$2686 |
67 |
0.00% |
股份
|
| Arax Advisory Partners |
$1804 |
41 |
0.00% |
股份
|
| Bare Financial Services, Inc |
$1628 |
37 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$1364 |
31 |
0.00% |
股份
|
| Hughes Financial Services, LLC |
$1100 |
25 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$880 |
20 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$660 |
15 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$396 |
9 |
0.00% |
股份
|
| CONTRAVISORY INVESTMENT MANAGEMENT, INC. |
$264 |
6 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$220 |
5 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$176 |
4 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$88 |
2 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$44 |
1 |
0.00% |
股份
|
| Allworth Financial LP |
$44 |
1 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$13 |
301 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
12 |
0.00% |
股份
|