| RA CAPITAL MANAGEMENT, L.P. |
$389624083 |
12198625 |
17.79% |
股份
|
| FMR LLC |
$284921184 |
8920513 |
13.01% |
股份
|
| JANUS HENDERSON GROUP PLC |
$148867244 |
3890589 |
6.80% |
股份
|
| Alta Partners Management Company, L.P. |
$122120195 |
3823425 |
5.58% |
股份
|
| Nextech Invest Ltd. |
$113501505 |
3553585 |
5.18% |
股份
|
| TCG Crossover Management, LLC |
$103772421 |
3248980 |
4.74% |
股份
|
| BlackRock, Inc. |
$96841186 |
3031972 |
4.42% |
股份
|
| STATE STREET CORP |
$68363354 |
2140368 |
3.12% |
股份
|
| Commodore Capital LP |
$59887500 |
1875000 |
2.73% |
股份
|
| Paradigm Biocapital Advisors LP |
$58405708 |
1828607 |
2.67% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$48179797 |
1508447 |
2.20% |
股份
|
| BVF INC/IL |
$47149700 |
1476196 |
2.15% |
股份
|
| VANGUARD GROUP INC |
$41348518 |
1572785 |
1.89% |
股份
|
| 5AM Venture Management, LLC |
$32875778 |
1029298 |
1.50% |
股份
|
| DEERFIELD MANAGEMENT COMPANY, L.P. |
$32482980 |
1017000 |
1.48% |
股份
|
| Hood River Capital Management LLC |
$32475794 |
1016775 |
1.48% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$31010333 |
970734 |
1.42% |
股份
|
| Caligan Partners LP |
$25775133 |
806986 |
1.18% |
股份
|
| Canaan Partners XI LLC |
$23955000 |
750000 |
1.09% |
股份
|
| Siren, L.L.C. |
$23156500 |
725000 |
1.06% |
股份
|
| Sio Capital Management, LLC |
$22208361 |
695315 |
1.01% |
股份
|
| STEMPOINT CAPITAL LP |
$20210163 |
632754 |
0.92% |
股份
|
| MARSHALL WACE, LLP |
$18625268 |
583133 |
0.85% |
股份
|
| GOLDMAN SACHS GROUP INC |
$14803455 |
463477 |
0.68% |
股份
|
| JENNISON ASSOCIATES LLC |
$14403791 |
450964 |
0.66% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$14366868 |
449808 |
0.66% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$12872427 |
403019 |
0.59% |
股份
|
| Defilade Capital Management, L.P. |
$12037228 |
376870 |
0.55% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$11170440 |
349732 |
0.51% |
股份
|
| Walleye Capital LLC |
$11111862 |
347898 |
0.51% |
股份
|
| Woodline Partners LP |
$10222078 |
320040 |
0.47% |
股份
|
| NORTHERN TRUST CORP |
$9904084 |
310084 |
0.45% |
股份
|
| MORGAN STANLEY |
$9592284 |
300322 |
0.44% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$9086930 |
284500 |
0.41% |
买入期权
|
| CITADEL ADVISORS LLC |
$8889126 |
278307 |
0.41% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$8550306 |
267699 |
0.39% |
股份
|
| Qube Research & Technologies Ltd |
$8525872 |
266934 |
0.39% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$7672850 |
240227 |
0.35% |
股份
|
| ALGERT GLOBAL LLC |
$7637493 |
239120 |
0.35% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$7180272 |
224805 |
0.33% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$6933472 |
217078 |
0.32% |
股份
|
| Affinity Asset Advisors, LLC |
$6388383 |
200012 |
0.29% |
股份
|
| FRANKLIN RESOURCES INC |
$6143340 |
192340 |
0.28% |
股份
|
| HighVista Strategies LLC |
$5901681 |
184774 |
0.27% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$5777339 |
180881 |
0.26% |
股份
|
| JPMORGAN CHASE & CO |
$5743677 |
178263 |
0.26% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$5674844 |
177672 |
0.26% |
股份
|
| BOOTHBAY FUND MANAGEMENT, LLC |
$5543474 |
173559 |
0.25% |
股份
|
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
$5174280 |
162000 |
0.24% |
股份
|
| Jump Financial, LLC |
$5014580 |
157000 |
0.23% |
股份
|
| VICTORY CAPITAL MANAGEMENT INC |
$4873565 |
152585 |
0.22% |
股份
|
| Ensign Peak Advisors, Inc |
$4680392 |
146537 |
0.21% |
股份
|
| Trexquant Investment LP |
$4239716 |
132740 |
0.19% |
股份
|
| UBS Group AG |
$4150443 |
129945 |
0.19% |
股份
|
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. |
$3942035 |
123420 |
0.18% |
股份
|
| BARCLAYS PLC |
$3631578 |
113700 |
0.17% |
买入期权
|
| Bank of New York Mellon Corp |
$3312823 |
103720 |
0.15% |
股份
|
| Russell Investments Group, Ltd. |
$3280346 |
102703 |
0.15% |
股份
|
| ORBIMED ADVISORS LLC |
$3257880 |
102000 |
0.15% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$2849208 |
89205 |
0.13% |
股份
|
| OPPENHEIMER & CO INC |
$2676029 |
83783 |
0.12% |
股份
|
| XTX Topco Ltd |
$2597361 |
81320 |
0.12% |
股份
|
| Nuveen, LLC |
$2517798 |
78829 |
0.11% |
股份
|
| Kalehua Capital Management LLC |
$2378412 |
74465 |
0.11% |
股份
|
| SEI INVESTMENTS CO |
$2127428 |
66607 |
0.10% |
股份
|
| Squarepoint Ops LLC |
$2037932 |
63805 |
0.09% |
股份
|
| CITIGROUP INC |
$1989192 |
62279 |
0.09% |
股份
|
| Fisher Asset Management, LLC |
$1923745 |
60230 |
0.09% |
股份
|
| ALPS ADVISORS INC |
$1921478 |
60159 |
0.09% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$1903655 |
59601 |
0.09% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$1854486 |
48420 |
0.08% |
股份
|
| AXA Investment Managers S.A. |
$1801758 |
128789 |
0.08% |
股份
|
| RHUMBLINE ADVISERS |
$1662114 |
52039 |
0.08% |
股份
|
| TD Asset Management Inc |
$1597000 |
50000 |
0.07% |
股份
|
| Arkadios Wealth Advisors |
$1575792 |
49336 |
0.07% |
股份
|
| TWO SIGMA ADVISERS, LP |
$1548481 |
58900 |
0.07% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$1491502 |
46697 |
0.07% |
股份
|
| JANE STREET GROUP, LLC |
$1437300 |
45000 |
0.07% |
卖出期权
|
| Susquehanna Portfolio Strategies, LLC |
$1433403 |
44878 |
0.07% |
股份
|
| Swiss National Bank |
$1427718 |
44700 |
0.07% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$1415804 |
44327 |
0.06% |
股份
|
| ExodusPoint Capital Management, LP |
$1310370 |
41026 |
0.06% |
股份
|
| Rafferty Asset Management, LLC |
$1236142 |
38702 |
0.06% |
股份
|
| DEUTSCHE BANK AG\ |
$1179704 |
36935 |
0.05% |
股份
|
| Verdad Advisers, LP |
$1149936 |
36003 |
0.05% |
股份
|
| WELLS FARGO & COMPANY/MN |
$1071938 |
33561 |
0.05% |
股份
|
| Sofinnova Investments, Inc. |
$1030608 |
32267 |
0.05% |
股份
|
| Engineers Gate Manager LP |
$1020739 |
31958 |
0.05% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$953505 |
29853 |
0.04% |
股份
|
| PDT Partners, LLC |
$820347 |
25684 |
0.04% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$798500 |
25000 |
0.04% |
买入期权
|
| Invesco Ltd. |
$795083 |
24893 |
0.04% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$783935 |
24544 |
0.04% |
股份
|
| STRS OHIO |
$705874 |
22100 |
0.03% |
股份
|
| Creative Planning |
$696387 |
21803 |
0.03% |
股份
|
| MetLife Investment Management, LLC |
$693833 |
21723 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$683131 |
21364 |
0.03% |
股份
|
| LMR Partners LLP |
$675563 |
21151 |
0.03% |
股份
|
| Auour Investments LLC |
$671379 |
21020 |
0.03% |
股份
|
| VOYA INVESTMENT MANAGEMENT LLC |
$647807 |
20282 |
0.03% |
股份
|
| BARCLAYS PLC |
$647585 |
20275 |
0.03% |
股份
|
| D. E. Shaw & Co., Inc. |
$644837 |
20189 |
0.03% |
股份
|
| Vanguard Global Advisers, LLC |
$643719 |
20154 |
0.03% |
股份
|
| Elmind Capital, LP |
$638800 |
20000 |
0.03% |
股份
|
| PROFUND ADVISORS LLC |
$625641 |
19588 |
0.03% |
股份
|
| Legal & General Group Plc |
$575463 |
18017 |
0.03% |
股份
|
| Cubist Systematic Strategies, LLC |
$549946 |
39310 |
0.03% |
股份
|
| AMERIPRISE FINANCIAL INC |
$540425 |
16920 |
0.02% |
股份
|
| WINTON GROUP Ltd |
$536592 |
16800 |
0.02% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$494399 |
15479 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$479100 |
15000 |
0.02% |
卖出期权
|
| FOX RUN MANAGEMENT, L.L.C. |
$461533 |
14450 |
0.02% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$412761 |
12923 |
0.02% |
股份
|
| Virtus Investment Advisers, LLC |
$387209 |
12123 |
0.02% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$346549 |
10850 |
0.02% |
股份
|
| BAKER BROS. ADVISORS LP |
$338788 |
10607 |
0.02% |
股份
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$334060 |
10459 |
0.02% |
股份
|
| Cinctive Capital Management LP |
$325277 |
10184 |
0.01% |
股份
|
| CAPSTONE INVESTMENT ADVISORS, LLC |
$321029 |
10051 |
0.01% |
股份
|
| China Universal Asset Management Co., Ltd. |
$302312 |
9465 |
0.01% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$299966 |
7832 |
0.01% |
股份
|
| Jain Global LLC |
$274844 |
8605 |
0.01% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$272225 |
8523 |
0.01% |
股份
|
| Savant Capital, LLC |
$251375 |
7141 |
0.01% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
$237059 |
7422 |
0.01% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$236963 |
7419 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$234727 |
7349 |
0.01% |
股份
|
| State of New Jersey Common Pension Fund D |
$230383 |
7213 |
0.01% |
股份
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$229968 |
7200 |
0.01% |
股份
|
| ProShare Advisors LLC |
$216074 |
6765 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$162894 |
5100 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$106648 |
3339 |
0.00% |
股份
|
| Tower Research Capital LLC (TRC) |
$93584 |
2930 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$88876 |
2782567 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$84960 |
2660 |
0.00% |
股份
|
| State of Wyoming |
$76305 |
2389 |
0.00% |
股份
|
| Hilton Head Capital Partners, LLC |
$64647 |
2024 |
0.00% |
股份
|
| Chung Wu Investment Group, LLC |
$63880 |
2000 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$61261 |
1918 |
0.00% |
股份
|
| CWM, LLC |
$59978 |
1566 |
0.00% |
股份
|
| AlphaQuest LLC |
$56234 |
2139 |
0.00% |
股份
|
| Steward Partners Investment Advisory, LLC |
$39190 |
1227 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$38007 |
1190 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$36124 |
1131 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$36000 |
1126 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$24626 |
771 |
0.00% |
股份
|
| Versant Capital Management, Inc |
$17912 |
819 |
0.00% |
股份
|
| GAMMA Investing LLC |
$16130 |
505 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$13447 |
421 |
0.00% |
股份
|
| FEDERATED HERMES, INC. |
$11786 |
369 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$6645 |
208 |
0.00% |
股份
|
| Larson Financial Group LLC |
$4791 |
150 |
0.00% |
股份
|
| True Wealth Design, LLC |
$4536 |
142 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$4120 |
129 |
0.00% |
股份
|
| Smartleaf Asset Management LLC |
$4078 |
127 |
0.00% |
股份
|
| LORD, ABBETT & CO. LLC |
$3891 |
121833 |
0.00% |
股份
|
| Allworth Financial LP |
$3194 |
100 |
0.00% |
股份
|
| Atlantic Union Bankshares Corp |
$3194 |
100 |
0.00% |
股份
|
| Optiver Holding B.V. |
$3130 |
98 |
0.00% |
股份
|
| Arax Advisory Partners |
$2779 |
87 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$1919 |
60 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1757 |
55 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$1406 |
44 |
0.00% |
股份
|
| SIGNATUREFD, LLC |
$1373 |
43 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$940 |
29444 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$921 |
29 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$543 |
17 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$480 |
15 |
0.00% |
股份
|
| Quarry LP |
$383 |
12 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$224 |
7 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$92 |
2906 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$64 |
2 |
0.00% |
股份
|
| Keating Financial Advisory Services, Inc. |
$32 |
1 |
0.00% |
股份
|
| TFC Financial Management, Inc. |
$32 |
1 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$32 |
1 |
0.00% |
股份
|
| Pacer Advisors, Inc. |
$21 |
646 |
0.00% |
股份
|
| Covestor Ltd |
$1 |
16 |
0.00% |
股份
|