UPB Upstream Bio, Inc. - Common Stock
$6.55
价格 · 八月 24, 2026
截至...的财报数据 八月 11, 2026
52周区间
$6–$34
3% of range
分析师评级
BUY
13 analysts
目标价
$34
+411% upside
P/E (TTM)
-2.5
ROE
-38.3%
净利润率
-5026.0%
UPB 股票快照 价格、市值、P/E、EPS、ROE、负债/权益、52周范围
价格
$6.55
市值
$355M
P/E (TTM)
-2.5
每股收益 (TTM)
$-2.66
营收 (TTM)
$3M
股息收益率
—
ROE
-38.3%
负债/权益
—
52周区间
$6 – $34
UPB 股价图表 包含技术指标的日 OHLCV — 平移、缩放和自定义您的视图
Configure
10年表现 收入、净利润、利润率和每股收益趋势
营收与净利润
$3M
2023-12-31
→
2025-12-31
EPS
$-2.66
2023-12-31
→
2025-12-31
自由现金流
$-133M
2024-12-31
→
2025-12-31
利润率
-5026.0%
估值 P/E、P/S、P/B、EV/EBITDA 比率 — 该股票是昂贵还是便宜？
指标
5年趋势
UPB
同行中位数
P/E (TTM)
-2.5
4.6
P/S (TTM) (市销率 (TTM))
124.5
9.4
P/B (市净率)
1.0
3.7
Price / FCF (股价/自由现金流)
-2.7
—
盈利能力 毛利率、营业利润率和净利率；股本回报率 (ROE)、资产回报率 (ROA)、投入资本回报率 (ROIC)
指标
5年趋势
UPB
同行中位数
Operating Margin (营业利润率)
-5618.8%
—
Net Profit Margin (净利润率)
-5026.0%
-186.4%
ROA
-34.3%
-48.0%
ROE
-38.3%
-67.6%
财务健康 债务、流动性、偿付能力 — 资产负债表强度
指标
5年趋势
UPB
同行中位数
Current Ratio (流动比率)
26.2
5.2
Quick Ratio (速动比率)
25.4
—
成长 营收、每股收益 (EPS) 和净利润增长：同比、3年复合年增长率 (CAGR)、5年复合年增长率 (CAGR)
指标
5年趋势
UPB
同行中位数
Revenue YoY (营收同比增长)
20.4%
—
资本效率 资产周转率、库存周转率、应收账款周转率
指标
5年趋势
UPB
同行中位数
UPB 分析师共识 看涨和看跌分析师观点、12个月价格目标、上涨空间
买入
13 位分析师
- 强烈买入 2 15.4%
- 买入 8 61.5%
- 持有 3 23.1%
- 卖出 0 0.0%
- 强烈卖出 0 0.0%
12个月价格目标
8 位分析师 · 2026-08-20
中位数
$30.50
← 低于所有目标
$6.55
最低
$9.00
最高
$75.00
中位数目标
$30.50
+365.6%
平均目标
$33.50
+411.5%
收益历史 每股收益实际值 vs 预估值，惊喜%，达标率，下次财报日期
平均惊喜
-0.18%
| 期间 | EPS Actual | EPS 预期 | 惊喜 |
|---|---|---|---|
| 2026年3月31日 | $-0.75 | $-0.78 | 0.03% |
| 2025年12月31日 | $-0.79 | $-0.71 | -0.08% |
| 2025年9月30日 | $-0.63 | $-0.79 | 0.16% |
| 2025年6月30日 | $-0.74 | $-0.62 | -0.12% |
| 2025年3月31日 | $-0.51 | $-0.49 | -0.02% |
| 2024年12月31日 | $-1.59 | $-0.57 | -1.0% |
同行比较（GICS 子行业） 关键指标与行业同行对比
| 股票代码 | 市值 | P/E | 营收同比增长 | 净利润率 | ROE | 毛利率 |
|---|---|---|---|---|---|---|
| UPB | $1.47B | -10.2 | 20.4% | -5026.0% | -38.3% | — |
| RCKT | — | — | — | — | — | — |
| ENTA | $256M | -3.1 | -3.4% | -125.4% | -103.5% | — |
| LYEL | $654M | -1.9 | -41.0% | -762355.6% | -100.3% | — |
| CAPR | $1.66B | -12.8 | -11.6% | — | -51.1% | — |
| XFOR | $364M | -2.1 | 150.0% | -1218.5% | -83.2% | — |
| ARCT | $174M | -2.6 | -46.1% | -80.2% | -29.6% | — |
| GALT | $271M | -8.7 | — | — | 25.0% | — |
完整基本面 所有年度指标 — 损益表、资产负债表、现金流量表
损益表 14
| 指标 | 趋势 | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue | $3M | $2M | $2M | |
| R&D Expense | $137M | $63M | $32M | |
| SG&A Expense | $26M | $17M | $11M | |
| Operating Expenses | $163M | $80M | $42M | |
| Operating Income | $-160M | $-78M | $-40M | |
| Interest Income | $17M | $12M | $4M | |
| Other Non-op | $17M | $15M | $20M | |
| Income Tax | $0 | $0 | $0 | |
| Net Income | $-143M | $-63M | $-21M | |
| EPS (Basic) | $-2.66 | $-5.58 | $-12.95 | |
| EPS (Diluted) | $-2.66 | $-5.58 | $-12.95 | |
| Shares (Basic) | 53,852,752 | 13,682,326 | 2,953,756 | |
| Shares (Diluted) | 53,852,752 | 13,682,326 | 2,953,756 | |
| EBITDA | $-160M | $-78M | · |
资产负债表 22
| 指标 | 趋势 | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Cash & Equivalents | $102M | $326M | $26M | |
| Short-term Investments | $240M | $145M | $84M | |
| Receivables | $668.0K | $613.0K | $98.0K | |
| Prepaid Expense | $10M | $8M | $7M | |
| Other Current Assets | $727.0K | · | · | |
| Current Assets | $352M | $479M | $117M | |
| PP&E (Net) | $559.0K | $582.0K | $159.0K | |
| PP&E (Gross) | $903.0K | $738.0K | $226.0K | |
| Accum. Depreciation | $344.0K | $156.0K | $67.0K | |
| Goodwill | · | $0 | · | |
| Total Assets | $354M | $482M | $117M | |
| Accounts Payable | $3M | $4M | $2M | |
| Current Liabilities | $13M | $11M | $7M | |
| Capital Leases | $549.0K | $1M | · | |
| Total Liabilities | $14M | $12M | $9M | |
| Common Stock | $54.0K | $53.0K | $3.0K | |
| Paid-in Capital | $673M | $661M | $5M | |
| Retained Earnings | $-334M | $-191M | $-128M | |
| AOCI | $530.0K | $-25.0K | $21.0K | |
| Stockholders' Equity | $340M | $470M | $-123M | |
| Liabilities + Equity | $354M | $482M | $117M | |
| Shares Outstanding | 54,237,750 | 53,603,398 | 2,992,479 |
现金流 9
| 指标 | 趋势 | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| D&A | $188.0K | $89.0K | $60.0K | |
| Stock-based Comp | $10M | $6M | $3M | |
| Other Non-cash | $-352.0K | $-2M | · | |
| Operating Cash Flow | $-133M | $-59M | $-38M | |
| CapEx | $165.0K | $511.0K | $144.0K | |
| Investing Cash Flow | $-93M | $-59M | $-83M | |
| Financing Cash Flow | $2M | $419M | $130M | |
| Net Change in Cash | $-224M | $300M | $9M | |
| Free Cash Flow | $-133M | $-60M | · |
盈利能力 5
| 指标 | 趋势 | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Operating Margin | -5618.8% | -3281.2% | · | |
| Net Margin | -5026.0% | -2650.0% | · | |
| EBITDA Margin | -5612.2% | -3277.4% | · | |
| ROA | -34.3% | -21.0% | · | |
| ROE | -38.3% | -40.6% | · |
流动性与偿付能力 2
| 指标 | 趋势 | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Current Ratio | 26.2 | 44.6 | · | |
| Quick Ratio | 25.4 | 43.9 | · |
效率 2
| 指标 | 趋势 | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Asset Turnover | 0.0 | 0.0 | · | |
| Receivables Turnover | 4.5 | 6.7 | · |
增长率 1
| 指标 | 趋势 | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue YoY | 20.4% | -0.42% | · |
估值 (TTM) 10
| 指标 | 趋势 | 2025 | 2024 | 2023 |
|---|---|---|---|---|
| Revenue TTM | $3M | $2M | · | |
| Net Income TTM | $-143M | $-63M | · | |
| Market Cap | $1.47B | $881M | · | |
| P/E | -10.2 | -2.9 | · | |
| P/S | 516.0 | 371.8 | · | |
| P/B | 4.3 | 1.9 | · | |
| P / Tangible Book | 4.3 | 1.9 | · | |
| P / Cash Flow | -11.0 | -14.9 | · | |
| P / FCF | -11.0 | -14.8 | · | |
| Earnings Yield | -9.8% | -33.9% | · |
损益表 14
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue | $773.0K | $1M | $668.0K | $683.0K | $937.0K | $566.0K | $613.0K | $607.0K | $510.0K | $640.0K | $450.0K | |
| R&D Expense | $36M | $37M | $40M | $33M | $38M | $26M | $22M | $15M | $14M | $12M | $12M | |
| SG&A Expense | $7M | $8M | $7M | $6M | $7M | $7M | $5M | $4M | $4M | $4M | $3M | |
| Operating Expenses | $43M | $45M | $47M | $39M | $45M | $33M | $27M | $20M | $18M | $16M | $15M | |
| Operating Income | $-42M | $-44M | $-46M | $-38M | $-44M | $-32M | $-26M | $-19M | $-18M | $-15M | $-14M | |
| Interest Income | $3M | $3M | $4M | $4M | $4M | $5M | $5M | $3M | $3M | $1M | $2M | |
| Other Non-op | $3M | $3M | $4M | $4M | $4M | $5M | $5M | $3M | $3M | $4M | $2M | |
| Income Tax | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | $0 | |
| Net Income | $-40M | $-41M | $-42M | $-34M | $-40M | $-27M | $-21M | $-16M | $-15M | $-11M | $-12M | |
| EPS (Basic) | $-0.73 | $-0.75 | $-0.78 | $-0.63 | $-0.74 | $-0.51 | $12.56 | $-6.96 | $-6.50 | $-4.68 | $-5.05 | |
| EPS (Diluted) | $-0.73 | $-0.75 | $-0.78 | $-0.63 | $-0.74 | $-0.51 | $12.56 | $-6.96 | $-6.50 | $-4.68 | $-5.05 | |
| Shares (Basic) | 54,567,976 | 54,332,319 | -107,466,785 | 53,930,946 | 53,770,868 | 53,617,723 | 4,654,757 | 3,023,155 | 3,008,807 | 2,995,607 | 8,952 | |
| Shares (Diluted) | 54,567,976 | 54,332,319 | -107,466,785 | 53,930,946 | 53,770,868 | 53,617,723 | 4,654,757 | 3,023,155 | 3,008,807 | 2,995,607 | 8,952 | |
| EBITDA | $-42M | $-44M | · | $-38M | $-44M | $-32M | · | $-19M | · | · | · |
资产负债表 21
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cash & Equivalents | $79M | $97M | $102M | $72M | $45M | $71M | $326M | $33M | · | · | $26M | |
| Short-term Investments | $182M | $198M | $240M | $300M | $348M | $360M | $145M | $188M | · | · | $84M | |
| Receivables | $772.0K | $1M | $668.0K | $683.0K | $937.0K | $566.0K | $613.0K | $607.0K | · | · | $98.0K | |
| Prepaid Expense | $18M | $21M | $10M | $16M | $24M | $22M | $8M | $6M | · | · | $7M | |
| Other Current Assets | $1M | · | · | · | · | · | · | · | · | · | · | |
| Current Assets | $280M | $316M | $352M | $389M | $418M | $454M | $479M | $227M | · | · | $117M | |
| PP&E (Net) | $460.0K | $510.0K | $559.0K | $616.0K | $544.0K | $539.0K | $582.0K | $578.0K | · | · | $159.0K | |
| PP&E (Gross) | $903.0K | $903.0K | $903.0K | $903.0K | $785.0K | $738.0K | $738.0K | $685.0K | · | · | $226.0K | |
| Accum. Depreciation | $443.0K | $393.0K | $344.0K | $287.0K | $241.0K | $199.0K | $156.0K | $107.0K | · | · | $67.0K | |
| Total Assets | $281M | $318M | $354M | $391M | $421M | $456M | $482M | $233M | · | · | $117M | |
| Accounts Payable | $2M | $2M | $3M | $4M | $3M | $5M | $4M | $5M | · | · | $2M | |
| Current Liabilities | $10M | $14M | $13M | $12M | $11M | $10M | $11M | $11M | · | · | $7M | |
| Capital Leases | $226.0K | $390.0K | $549.0K | $703.0K | $849.0K | $992.0K | $1M | $1M | · | · | · | |
| Total Liabilities | $10M | $14M | $14M | $13M | $12M | $11M | $12M | $12M | · | · | $9M | |
| Common Stock | $54.0K | $54.0K | $54.0K | $56.0K | $54.0K | $53.0K | $53.0K | $3.0K | · | · | $3.0K | |
| Paid-in Capital | $686M | $679M | $673M | $670M | $666M | $663M | $661M | $9M | · | · | $5M | |
| Retained Earnings | $-415M | $-375M | $-334M | $-292M | $-258M | $-218M | $-191M | $-170M | · | · | $-128M | |
| AOCI | $-123.0K | $100.0K | $530.0K | $493.0K | $258.0K | $368.0K | $-25.0K | $351.0K | · | · | $21.0K | |
| Stockholders' Equity | $271M | $304M | $340M | $379M | $409M | $446M | $470M | $-160M | · | · | $-123M | |
| Liabilities + Equity | $281M | $318M | $354M | $391M | $421M | $456M | $482M | $233M | · | · | $117M | |
| Shares Outstanding | 54,771,041 | 54,419,986 | 54,237,750 | 53,999,522 | 53,798,151 | 53,640,895 | 53,603,398 | 3,025,452 | · | · | 2,992,479 |
现金流 8
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| D&A | $50.0K | $49.0K | $57.0K | $46.0K | $42.0K | $43.0K | $49.0K | $14.0K | $13.0K | $13.0K | $14.0K | |
| Stock-based Comp | $4M | $5M | $3M | $3M | $3M | $3M | $2M | $2M | $1M | $643.0K | $711.0K | |
| Other Non-cash | · | $-12M | · | · | · | $-17M | · | · | · | · | · | |
| Operating Cash Flow | $-36M | $-48M | $-31M | $-22M | $-39M | $-41M | $-20M | $-14M | $-8M | $-18M | $-16M | |
| CapEx | · | · | $54.0K | $64.0K | · | · | $185.0K | · | · | · | $0 | |
| Investing Cash Flow | $16M | $42M | $59M | $48M | $13M | $-213M | $42M | $1M | $-117M | $14M | $-5M | |
| Financing Cash Flow | $3M | $598.0K | $1M | $760.0K | $612.0K | $-34.0K | $271M | $-2M | $141M | $9M | $-133.0K | |
| Net Change in Cash | $-17M | $-5M | $29M | $27M | $-26M | $-255M | $293M | $-14M | $16M | $6M | $-21M |
盈利能力 5
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Operating Margin | -5481.0% | -4218.1% | · | -5539.4% | -4732.9% | -5656.0% | · | -3112.5% | · | · | · | |
| Net Margin | -5136.1% | -3925.6% | · | -4941.1% | -4265.3% | -4818.0% | · | -2634.6% | · | · | · | |
| EBITDA Margin | -5481.0% | -4213.3% | · | -5539.4% | -4732.9% | -5648.4% | · | -3112.5% | · | · | · | |
| ROA | -11.3% | -10.5% | · | -10.8% | -19.0% | -12.0% | · | -13.7% | · | · | · | |
| ROE | -11.7% | -10.8% | · | -30.9% | -19.6% | -12.2% | · | 20.0% | · | · | · |
流动性与偿付能力 2
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current Ratio | 28.0 | 23.1 | · | 32.7 | 38.3 | 47.4 | · | 20.9 | · | · | · | |
| Quick Ratio | 26.2 | 21.6 | · | 31.3 | 36.1 | 45.1 | · | 20.3 | · | · | · |
效率 2
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Asset Turnover | 0.0 | 0.0 | · | 0.0 | 0.0 | 0.0 | · | 0.0 | · | · | · | |
| Receivables Turnover | 0.9 | 1.3 | · | 1.1 | 2.0 | 2.0 | · | 2.0 | · | · | · |
估值 (TTM) 9
| 指标 | 趋势 | Q2 2026 | Q1 2026 | Q4 2025 | Q3 2025 | Q2 2025 | Q1 2025 | Q4 2024 | Q3 2024 | Q2 2024 | Q1 2024 | Q4 2023 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Revenue TTM | $3M | $3M | · | $3M | $3M | $2M | · | $2M | · | · | · | |
| Net Income TTM | $-154M | $-142M | · | $-117M | $-98M | $-69M | · | $-45M | · | · | · | |
| Market Cap | $379M | $490M | · | $1.02B | $591M | $328M | · | · | · | · | · | |
| P/E | -2.4 | -3.4 | · | -2.1 | -0.7 | -0.3 | · | · | · | · | · | |
| P/S | 110.6 | 152.1 | · | 363.7 | 225.5 | 141.3 | · | · | · | · | · | |
| P/B | 1.4 | 1.6 | · | 2.7 | 1.4 | 0.7 | · | · | · | · | · | |
| P / Tangible Book | 1.4 | 1.6 | · | 2.7 | 1.4 | 0.7 | · | · | · | · | · | |
| P / Cash Flow | · | -10.2 | · | · | · | -8.0 | · | · | · | · | · | |
| Earnings Yield | -41.2% | -29.2% | · | -47.0% | -134.0% | -304.7% | · | · | · | · | · |
财务报表 损益表、资产负债表、现金流量表 — 年度，近5年
损益表
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| 收入 | $3M | $2M | $2M |
| 营业利润率 % | -5618.8% | -3281.2% | — |
| 净收入 | $-143M | $-63M | $-21M |
| 稀释后每股收益 (EPS) | $-2.66 | $-5.58 | $-12.95 |
资产负债表
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| 流动比率 | 26.2 | 44.6 | — |
| 速动比率 | 25.4 | 43.9 | — |
现金流
| 2025-12-31 | 2024-12-31 | 2023-12-31 | |
|---|---|---|---|
| 自由现金流 | $-133M | $-60M | — |
我的指标 您的个人关注列表 — 来自完整基本面的选定行
📊
选择对您重要的指标 — 点击上方完整基本面中任意行的 ➕。
您的选择已保存，并会跟随您浏览所有股票。
机构持有人 (13F) 157 家申报者 · $351.5M 总计 · 截至 2026年6月30日
在其季度SEC表格13F中报告持有此股票的机构。仅限多头头寸；单个申报人可能因单独的期权腿而出现两次。 大的抵消性看跌/看涨腿通常反映做市或对冲库存，而非方向性判断。
机构活动 — Q2 2026 与上一季度对比
| 新仓位 | 已退出持仓 | 增加 | 减少 | 净股数变动 |
|---|---|---|---|---|
| 38 (-13 与上一季度对比) | 25 (-11 与上一季度对比) | 62 (+17 与上一季度对比) | 32 (-2 与上一季度对比) | +3.9M |
与Q1 2026对比。 SEC 13F表格的提交截止日期是季度末后45天，外加少量延迟提交的缓冲期——在此窗口期内的季度将被跳过，优先显示最近一个已完整报告的季度对。
| 机构 | 价值 | 股份 | % 已追踪的13F | 类型 |
|---|---|---|---|---|
| VANGUARD GROUP INC | $57916706 | 2133212 | 16.48% | 股份 |
| FMR LLC | $50318247 | 7271423 | 14.31% | 股份 |
| ORBIMED ADVISORS LLC | $39399636 | 5693589 | 11.21% | 股份 |
| NORGES BANK | $26078843 | 3768619 | 7.42% | 股份 |
| Decheng Capital LLC | $18856087 | 2724868 | 5.36% | 股份 |
| ENAVATE SCIENCES GP, LLC | $17021145 | 2459703 | 4.84% | 股份 |
| VANGUARD CAPITAL MANAGEMENT LLC | $12986999 | 1876734 | 3.69% | 股份 |
| MILLENNIUM MANAGEMENT LLC | $7914923 | 1143775 | 2.25% | 股份 |
| Qube Research & Technologies Ltd | $6771220 | 978500 | 1.93% | 股份 |
| Parkman Healthcare Partners LLC | $6471909 | 935247 | 1.84% | 股份 |
| SEB Asset Management AB | $6079022 | 878473 | 1.73% | 股份 |
| D. E. Shaw & Co., Inc. | $5795971 | 837568 | 1.65% | 股份 |
| Woodline Partners LP | $5753849 | 831481 | 1.64% | 股份 |
| GEODE CAPITAL MANAGEMENT, LLC | $5539562 | 800289 | 1.58% | 股份 |
| STATE STREET CORP | $5302955 | 766323 | 1.51% | 股份 |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $4931656 | 712667 | 1.40% | 股份 |
| Y-Intercept (Hong Kong) Ltd | $4799401 | 693555 | 1.37% | 股份 |
| Bain Capital Life Sciences Investors, LLC | $4158567 | 600949 | 1.18% | 股份 |
| BNP PARIBAS FINANCIAL MARKETS | $3539898 | 511546 | 1.01% | 股份 |
| Walleye Capital LLC | $3449551 | 498490 | 0.98% | 股份 |
| Trexquant Investment LP | $3227696 | 466430 | 0.92% | 股份 |
| Point72 Asset Management, L.P. | $3134836 | 453011 | 0.89% | 股份 |
| BANK OF AMERICA CORP /DE/ | $2710993 | 391762 | 0.77% | 股份 |
| Altshuler Shaham Ltd | $2630022 | 380061 | 0.75% | 股份 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $2475672 | 357756 | 0.70% | 股份 |
| SAMSARA BIOCAPITAL, LLC | $2447722 | 353717 | 0.70% | 股份 |
| Propel Bio Management, LLC | $2424692 | 350389 | 0.69% | 股份 |
| WELLINGTON MANAGEMENT GROUP LLP | $2369083 | 342353 | 0.67% | 股份 |
| DIMENSIONAL FUND ADVISORS LP | $2363464 | 341541 | 0.67% | 股份 |
| Squarepoint Ops LLC | $2013056 | 290904 | 0.57% | 股份 |
| Voleon Capital Management LP | $1973819 | 285234 | 0.56% | 股份 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $1816196 | 262456 | 0.52% | 股份 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $1751397 | 253092 | 0.50% | 股份 |
| GOLDMAN SACHS GROUP INC | $1708666 | 246917 | 0.49% | 股份 |
| XTX Topco Ltd | $1677034 | 242346 | 0.48% | 股份 |
| VANGUARD FIDUCIARY TRUST CO | $1658143 | 239616 | 0.47% | 股份 |
| UBS Group AG | $1624200 | 234711 | 0.46% | 股份 |
| Schonfeld Strategic Advisors LLC | $1562258 | 225760 | 0.44% | 股份 |
| SPHERA FUNDS MANAGEMENT LTD. | $1520324 | 219700 | 0.43% | 股份 |
| BlackRock, Inc. | $1054823 | 152431 | 0.30% | 股份 |
| Boxer Capital Management, LLC | $1038000 | 150000 | 0.30% | 股份 |
| RENAISSANCE TECHNOLOGIES LLC | $908596 | 131300 | 0.26% | 股份 |
| EntryPoint Capital, LLC | $895766 | 129446 | 0.25% | 股份 |
| ALGERT GLOBAL LLC | $820920 | 118630 | 0.23% | 股份 |
| AMERICAN CENTURY COMPANIES INC | $541102 | 78194 | 0.15% | 股份 |
| Man Group plc | $510855 | 73823 | 0.15% | 股份 |
| JPMORGAN CHASE & CO | $505093 | 72885 | 0.14% | 股份 |
| ALLIANCEBERNSTEIN L.P. | $465120 | 51680 | 0.13% | 股份 |
| Simplify Asset Management Inc. | $429822 | 62113 | 0.12% | 股份 |
| ALPS ADVISORS INC | $382178 | 55228 | 0.11% | 股份 |
| Quantinno Capital Management LP | $379479 | 54838 | 0.11% | 股份 |
| Nuveen Asset Management, LLC | $371314 | 22586 | 0.11% | 股份 |
| Virtus Investment Advisers, LLC | $371175 | 53638 | 0.11% | 股份 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $356949 | 39661 | 0.10% | 股份 |
| Brevan Howard Capital Management LP | $348553 | 50369 | 0.10% | 股份 |
| Swiss National Bank | $332852 | 48100 | 0.09% | 股份 |
| MORGAN STANLEY | $311220 | 44974 | 0.09% | 股份 |
| Allspring Global Investments Holdings, LLC | $298819 | 43182 | 0.09% | 股份 |
| RHUMBLINE ADVISERS | $293288 | 42384 | 0.08% | 股份 |
| TWO SIGMA INVESTMENTS, LP | $292889 | 42325 | 0.08% | 股份 |
| ExodusPoint Capital Management, LP | $284031 | 41045 | 0.08% | 股份 |
| CITIGROUP INC | $265084 | 38307 | 0.08% | 股份 |
| Stonepine Capital Management, LLC | $231349 | 33432 | 0.07% | 股份 |
| Mariner, LLC | $229337 | 33141 | 0.07% | 股份 |
| DEUTSCHE BANK AG\ | $228561 | 33029 | 0.07% | 股份 |
| WELLS FARGO & COMPANY/MN | $204119 | 29497 | 0.06% | 股份 |
| Bank of New York Mellon Corp | $197711 | 28571 | 0.06% | 股份 |
| Quantbot Technologies LP | $194992 | 28178 | 0.06% | 股份 |
| BARCLAYS PLC | $193608 | 27978 | 0.06% | 股份 |
| AXQ CAPITAL, LP | $187311 | 27068 | 0.05% | 股份 |
| nVerses Capital, LLC | $166280 | 24029 | 0.05% | 股份 |
| DNB Asset Management AS | $163312 | 23600 | 0.05% | 股份 |
| VANGUARD ASSET MANAGEMENT, Ltd | $157250 | 22724 | 0.04% | 股份 |
| Graham Capital Management, L.P. | $155755 | 22508 | 0.04% | 股份 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $154904 | 22385 | 0.04% | 股份 |
| Verdad Advisers, LP | $150925 | 21810 | 0.04% | 股份 |
| MetLife Investment Management, LLC | $144296 | 20852 | 0.04% | 股份 |
| SEI INVESTMENTS CO | $138580 | 20026 | 0.04% | 股份 |
| WINTON GROUP Ltd | $137016 | 19800 | 0.04% | 股份 |
| IEQ CAPITAL, LLC | $135182 | 19535 | 0.04% | 股份 |
| DIADEMA PARTNERS LP | $132124 | 19093 | 0.04% | 股份 |
| Shay Capital LLC | $124560 | 18000 | 0.04% | 股份 |
| Quadrature Capital Ltd | $124477 | 17988 | 0.04% | 股份 |
| Entropy Technologies, LP | $121391 | 17542 | 0.03% | 股份 |
| STATE OF WISCONSIN INVESTMENT BOARD | $118090 | 17065 | 0.03% | 股份 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $112222 | 16217 | 0.03% | 股份 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $108886 | 15735 | 0.03% | 股份 |
| CITADEL ADVISORS LLC | $103800 | 15000 | 0.03% | 买入期权 |
| MERCER GLOBAL ADVISORS INC /ADV | $92396 | 13352 | 0.03% | 股份 |
| Vanguard Global Advisers, LLC | $90368 | 13059 | 0.03% | 股份 |
| Engineers Gate Manager LP | $86438 | 12491 | 0.02% | 股份 |
| Invesco Ltd. | $84611 | 12227 | 0.02% | 股份 |
| STRS OHIO | $83040 | 12000 | 0.02% | 股份 |
| JANE STREET GROUP, LLC | $82348 | 11900 | 0.02% | 买入期权 |
| CANADA PENSION PLAN INVESTMENT BOARD | $79580 | 11500 | 0.02% | 股份 |
| HSBC HOLDINGS PLC | $77602 | 10793 | 0.02% | 股份 |
| JANE STREET GROUP, LLC | $77324 | 11174 | 0.02% | 股份 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $75428 | 10017 | 0.02% | 股份 |
| PRELUDE CAPITAL MANAGEMENT, LLC | $73006 | 10550 | 0.02% | 股份 |
| AMERIPRISE FINANCIAL INC | $72570 | 10487 | 0.02% | 股份 |
公司内部人士 12 位内幕人士 · 5 位高管 · 7 位董事
| 内部人士 | 角色 | 上次活动 | 持股数量 | 买入 12个月 | 卖出 12个月 | 净额 12个月 |
|---|---|---|---|---|---|---|
| Everett Rand Sutherland | Chief Executive Officer | 2026年6月16日 S | 70812 | 0 | 2 | $-32224 |
| Michael Gray | CFO and COO | 2026年6月16日 S | 28795 | 0 | 2 | $-13118 |
| Allison Ambrose | General Counsel | 2026年6月16日 S | 16048 | 0 | 2 | $-7323 |
| Aaron Deykin | Chief Medical Officer | 2026年6月16日 S | 33197 | 0 | 2 | $-13765 |
| Adam Houghton | Chief Business Officer | 2026年6月16日 S | 23601 | 0 | 2 | $-10764 |
| Marcella K. Ruddy | 董事 | 2026年6月9日 A | — | 0 | 0 | $0 |
| Harold Edward Fleming | 董事 | 2026年6月9日 A | — | 0 | 0 | $0 |
| CHIMOVITS EREZ | 董事 | 2026年6月9日 A | 4554873 | 0 | 0 | $0 |
| Liam Ratcliffe | 董事 | 2026年6月9日 A | — | 0 | 0 | $0 |
| Daniella Beckman | 董事 | 2026年6月9日 A | — | 0 | 0 | $0 |
| Ronald C Renaud JR | 董事 | 2026年6月9日 A | — | 0 | 0 | $0 |
| Wellington Biomedical Innovation Master Investors (Cayman) II L.P. | 10% 所有者 | 2024年10月15日 C | 894733 | 0 | 0 | $0 |
来自SEC表格3/4/5申报的内部人士；净额=仅公开市场买卖
激进投资者及 5%+ 股东 2 持仓
提交了 SEC Schedule 13D 的投资者 — 持有超过 5% 的受益所有权，意图影响发行人（激进股东持股、董事会活动、并购）。每一行显示该申报人持仓的最新已知状态。
| 申报人 | 已申报 | 持股 | 状态 | 目的 | 申报 |
|---|---|---|---|---|---|
| AI Upstream LLC, Access Industries Holdings LLC, AI Biotechnology LLC, Access Industries Management, LLC, Len Blavatnik | 2024年10月22日 | — | 初始申报 | 被动投资 | SEC |
| OrbiMed Advisors LLC, OrbiMed Capital GP VIII LLC, OrbiMed Advisors Israel II Limited, OrbiMed Israel GP II, L.P. | 2024年10月17日 | — | 初始申报 | — | SEC |
Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.
ETF持仓 由 33 只交易所交易基金持有
权重仅反映直接股权持仓（N-PORT）；杠杆基金或基于衍生品的基金可能持有未显示的额外掉期敞口。
| 基金 | 权重 | 单位 | 截至 | 来源 |
|---|---|---|---|---|
| FMED · Fidelity Covington Trust | 0.51% | 24900 NS | 2026年5月31日 | N-PORT |
| SBIO · ALPS ETF Trust | 0.29% | 55699 NS | 2026年5月31日 | N-PORT |
| BBC · ETFis Series Trust I | 0.25% | 10169 NS | 2026年4月30日 | N-PORT |
| FFSM · FIDELITY COVINGTON TRUST | 0.07% | 92201 NS | 2026年4月30日 | N-PORT |
| IBBQ · Invesco Exchange-Traded Fund Trus... | 0.02% | 3155 SH | 2026年8月21日 | 每日 |
| BIB · ProShares Trust | 0.02% | 1997 NS | 2026年5月31日 | N-PORT |
| VTWV · VANGUARD SCOTTSDALE FUNDS | 0.02% | 31318 SH | 2026年8月19日 | 每日 |
| AVSC · AMERICAN CENTURY ETF TRUST | 0.02% | 62606 NS | 2026年5月31日 | N-PORT |
| IBB · iShares Trust | 0.02% | 269530 SH | 2026年8月21日 | 每日 |
| IWN · iShares Trust | 0.02% | 335939 SH | 2026年8月21日 | 每日 |
| VTWO · VANGUARD SCOTTSDALE FUNDS | 0.01% | 202528 SH | 2026年8月19日 | 每日 |
| RSSL · Global X Funds | 0.01% | 14420 NS | 2026年4月30日 | N-PORT |
| PRFZ · Invesco Exchange-Traded Fund Trust | 0.01% | 33614 SH | 2026年8月21日 | 每日 |
| IWM · iShares Trust | 0.01% | 906868 SH | 2026年8月21日 | 每日 |
| DFAS · Dimensional ETF Trust | 0.01% | 108557 NS | 2026年4月30日 | N-PORT |
| ITWO · ProShares Trust | 0.01% | 1544 NS | 2026年5月31日 | N-PORT |
| RB · ProShares Trust | 0.01% | 9 NS | 2026年5月31日 | N-PORT |
| SCHA · SCHWAB STRATEGIC TRUST | 0.01% | 161663 NS | 2026年5月31日 | N-PORT |
| UWM · ProShares Trust | 0.00% | 1208 NS | 2026年5月31日 | N-PORT |
| FHLC · FIDELITY COVINGTON TRUST | 0.00% | 11160 NS | 2026年4月30日 | N-PORT |
| URTY · ProShares Trust | 0.00% | 1224 NS | 2026年5月31日 | N-PORT |
| MSSM · MORGAN STANLEY PATHWAY FUNDS | 0.00% | 1388 NS | 2026年5月31日 | N-PORT |
| HDG · ProShares Trust | 0.00% | 31 NS | 2026年5月31日 | N-PORT |
| DFAU · Dimensional ETF Trust | 0.00% | 10145 NS | 2026年4月30日 | N-PORT |
| DCOR · Dimensional ETF Trust | 0.00% | 2366 NS | 2026年4月30日 | N-PORT |
| ITOT · iShares Trust | 0.00% | 50111 SH | 2026年8月21日 | 每日 |
| SCHB · SCHWAB STRATEGIC TRUST | 0.00% | 20416 NS | 2026年5月31日 | N-PORT |
| IWV · iShares Trust | 0.00% | 9589 SH | 2026年8月21日 | 每日 |
| AVSU · AMERICAN CENTURY ETF TRUST | 0.00% | 34 NS | 2026年5月31日 | N-PORT |
| VXF · VANGUARD INDEX FUNDS | 0.00% | 386877 SH | 2026年8月19日 | 每日 |
| VTI · VANGUARD INDEX FUNDS | 0.00% | 1443025 SH | 2026年8月19日 | 每日 |
| VTHR · VANGUARD SCOTTSDALE FUNDS | 0.00% | 2529 SH | 2026年8月19日 | 每日 |
| VHT · VANGUARD WORLD FUND | 0.00% | 72742 SH | 2026年8月19日 | 每日 |