| VANGUARD GROUP INC |
$64846119 |
2388439 |
15.74% |
股份
|
| FMR LLC |
$56487247 |
8162897 |
13.71% |
股份
|
| ORBIMED ADVISORS LLC |
$39399636 |
5693589 |
9.56% |
股份
|
| NORGES BANK |
$26078843 |
3768619 |
6.33% |
股份
|
| BlackRock, Inc. |
$25973237 |
3753358 |
6.30% |
股份
|
| Decheng Capital LLC |
$18856087 |
2724868 |
4.58% |
股份
|
| ENAVATE SCIENCES GP, LLC |
$17021145 |
2459703 |
4.13% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$12986999 |
1876734 |
3.15% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$7914923 |
1143775 |
1.92% |
股份
|
| D. E. Shaw & Co., Inc. |
$7169425 |
1036044 |
1.74% |
股份
|
| JPMORGAN CHASE & CO |
$7013464 |
1012044 |
1.70% |
股份
|
| Qube Research & Technologies Ltd |
$6771220 |
978500 |
1.64% |
股份
|
| Parkman Healthcare Partners LLC |
$6471909 |
935247 |
1.57% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$6445888 |
931261 |
1.56% |
股份
|
| SEB Asset Management AB |
$6079022 |
878473 |
1.48% |
股份
|
| Woodline Partners LP |
$5753849 |
831481 |
1.40% |
股份
|
| STATE STREET CORP |
$5302955 |
766323 |
1.29% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$4931656 |
712667 |
1.20% |
股份
|
| Y-Intercept (Hong Kong) Ltd |
$4799401 |
693555 |
1.16% |
股份
|
| Bain Capital Life Sciences Investors, LLC |
$4158567 |
600949 |
1.01% |
股份
|
| AQR CAPITAL MANAGEMENT LLC |
$3770493 |
544869 |
0.92% |
股份
|
| MORGAN STANLEY |
$3630453 |
524632 |
0.88% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$3539898 |
511546 |
0.86% |
股份
|
| Walleye Capital LLC |
$3449551 |
498490 |
0.84% |
股份
|
| Trexquant Investment LP |
$3227696 |
466430 |
0.78% |
股份
|
| Point72 Asset Management, L.P. |
$3134836 |
453011 |
0.76% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$2710993 |
391762 |
0.66% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$2640811 |
381613 |
0.64% |
股份
|
| Altshuler Shaham Ltd |
$2630022 |
380061 |
0.64% |
股份
|
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
$2475672 |
357756 |
0.60% |
股份
|
| SAMSARA BIOCAPITAL, LLC |
$2447722 |
353717 |
0.59% |
股份
|
| Propel Bio Management, LLC |
$2424692 |
350389 |
0.59% |
股份
|
| WELLINGTON MANAGEMENT GROUP LLP |
$2369083 |
342353 |
0.57% |
股份
|
| NORTHERN TRUST CORP |
$2057634 |
297346 |
0.50% |
股份
|
| Squarepoint Ops LLC |
$2013056 |
290904 |
0.49% |
股份
|
| Voleon Capital Management LP |
$1973819 |
285234 |
0.48% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$1816196 |
262456 |
0.44% |
股份
|
| JACOBS LEVY EQUITY MANAGEMENT, INC |
$1751397 |
253092 |
0.43% |
股份
|
| GOLDMAN SACHS GROUP INC |
$1708666 |
246917 |
0.41% |
股份
|
| XTX Topco Ltd |
$1677034 |
242346 |
0.41% |
股份
|
| DEUTSCHE BANK AG\ |
$1670814 |
241447 |
0.41% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$1658143 |
239616 |
0.40% |
股份
|
| UBS Group AG |
$1624221 |
234714 |
0.39% |
股份
|
| Schonfeld Strategic Advisors LLC |
$1562258 |
225760 |
0.38% |
股份
|
| Jump Financial, LLC |
$1544703 |
223223 |
0.37% |
股份
|
| SPHERA FUNDS MANAGEMENT LTD. |
$1520324 |
219700 |
0.37% |
股份
|
| Boxer Capital Management, LLC |
$1038000 |
150000 |
0.25% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$908596 |
131300 |
0.22% |
股份
|
| EntryPoint Capital, LLC |
$895766 |
129446 |
0.22% |
股份
|
| ALGERT GLOBAL LLC |
$820920 |
118630 |
0.20% |
股份
|
| Bank of New York Mellon Corp |
$593369 |
85747 |
0.14% |
股份
|
| Nuveen, LLC |
$586608 |
84770 |
0.14% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$541102 |
78194 |
0.13% |
股份
|
| Man Group plc |
$510855 |
73823 |
0.12% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$465120 |
51680 |
0.11% |
股份
|
| Simplify Asset Management Inc. |
$429822 |
62113 |
0.10% |
股份
|
| ALPS ADVISORS INC |
$382178 |
55228 |
0.09% |
股份
|
| Quantinno Capital Management LP |
$379479 |
54838 |
0.09% |
股份
|
| Virtus Investment Advisers, LLC |
$371175 |
53638 |
0.09% |
股份
|
| Invesco Ltd. |
$369508 |
53397 |
0.09% |
股份
|
| Brevan Howard Capital Management LP |
$348553 |
50369 |
0.08% |
股份
|
| Swiss National Bank |
$332852 |
48100 |
0.08% |
股份
|
| Russell Investments Group, Ltd. |
$329000 |
47543 |
0.08% |
股份
|
| Allspring Global Investments Holdings, LLC |
$298819 |
43182 |
0.07% |
股份
|
| RHUMBLINE ADVISERS |
$293288 |
42384 |
0.07% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$292889 |
42325 |
0.07% |
股份
|
| ExodusPoint Capital Management, LP |
$284031 |
41045 |
0.07% |
股份
|
| CITIGROUP INC |
$279145 |
40339 |
0.07% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$267347 |
38634 |
0.06% |
股份
|
| Stonepine Capital Management, LLC |
$231349 |
33432 |
0.06% |
股份
|
| Mariner, LLC |
$229337 |
33141 |
0.06% |
股份
|
| WELLS FARGO & COMPANY/MN |
$204119 |
29497 |
0.05% |
股份
|
| BARCLAYS PLC |
$202120 |
29208 |
0.05% |
股份
|
| Creative Planning |
$197102 |
28483 |
0.05% |
股份
|
| Quantbot Technologies LP |
$194992 |
28178 |
0.05% |
股份
|
| AXQ CAPITAL, LP |
$187311 |
27068 |
0.05% |
股份
|
| nVerses Capital, LLC |
$166280 |
24029 |
0.04% |
股份
|
| DNB Asset Management AS |
$163312 |
23600 |
0.04% |
股份
|
| VANGUARD ASSET MANAGEMENT, Ltd |
$157250 |
22724 |
0.04% |
股份
|
| Graham Capital Management, L.P. |
$155755 |
22508 |
0.04% |
股份
|
| LOS ANGELES CAPITAL MANAGEMENT LLC |
$154904 |
22385 |
0.04% |
股份
|
| Verdad Advisers, LP |
$150925 |
21810 |
0.04% |
股份
|
| MetLife Investment Management, LLC |
$144296 |
20852 |
0.04% |
股份
|
| SEI INVESTMENTS CO |
$138580 |
20026 |
0.03% |
股份
|
| WINTON GROUP Ltd |
$137016 |
19800 |
0.03% |
股份
|
| IEQ CAPITAL, LLC |
$135182 |
19535 |
0.03% |
股份
|
| DIADEMA PARTNERS LP |
$132124 |
19093 |
0.03% |
股份
|
| Shay Capital LLC |
$124560 |
18000 |
0.03% |
股份
|
| Quadrature Capital Ltd |
$124477 |
17988 |
0.03% |
股份
|
| Entropy Technologies, LP |
$121391 |
17542 |
0.03% |
股份
|
| STATE OF WISCONSIN INVESTMENT BOARD |
$118090 |
17065 |
0.03% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$112222 |
16217 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$108886 |
15735 |
0.03% |
股份
|
| JANE STREET GROUP, LLC |
$107910 |
15594 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$103800 |
15000 |
0.03% |
买入期权
|
| MERCER GLOBAL ADVISORS INC /ADV |
$92396 |
13352 |
0.02% |
股份
|
| Vanguard Global Advisers, LLC |
$90368 |
13059 |
0.02% |
股份
|
| Legal & General Group Plc |
$86922 |
12561 |
0.02% |
股份
|
| Engineers Gate Manager LP |
$86438 |
12491 |
0.02% |
股份
|
| STRS OHIO |
$83040 |
12000 |
0.02% |
股份
|
| JANE STREET GROUP, LLC |
$82348 |
11900 |
0.02% |
买入期权
|
| CANADA PENSION PLAN INVESTMENT BOARD |
$79580 |
11500 |
0.02% |
股份
|
| HSBC HOLDINGS PLC |
$77602 |
10793 |
0.02% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$75428 |
10017 |
0.02% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$73006 |
10550 |
0.02% |
股份
|
| AMERIPRISE FINANCIAL INC |
$72570 |
10487 |
0.02% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$69892 |
10100 |
0.02% |
买入期权
|
| Police & Firemen's Retirement System of New Jersey |
$65436 |
9456 |
0.02% |
股份
|
| China Universal Asset Management Co., Ltd. |
$59934 |
8661 |
0.01% |
股份
|
| KLP KAPITALFORVALTNING AS |
$40828 |
5900 |
0.01% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$35984 |
5200 |
0.01% |
股份
|
| CWM, LLC |
$34947 |
3883 |
0.01% |
股份
|
| Persistent Asset Partners Ltd |
$33597 |
4855 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$33133 |
4788 |
0.01% |
股份
|
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO |
$32524 |
4700 |
0.01% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$29604 |
4278 |
0.01% |
股份
|
| Vanguard Investments Australia, Ltd. |
$28344 |
4096 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$18968 |
2741 |
0.00% |
股份
|
| Mirae Asset Global Investments Co., Ltd. |
$16843 |
2434 |
0.00% |
股份
|
| Global Retirement Partners, LLC |
$12940 |
1870 |
0.00% |
股份
|
| Arax Advisory Partners |
$12255 |
1771 |
0.00% |
股份
|
| GAMMA Investing LLC |
$8055 |
1164 |
0.00% |
股份
|
| GF FUND MANAGEMENT CO. LTD. |
$7923 |
1145 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$7000 |
1091 |
0.00% |
股份
|
| Zurcher Kantonalbank (Zurich Cantonalbank) |
$6678 |
965 |
0.00% |
股份
|
| Quarry LP |
$6180 |
893 |
0.00% |
股份
|
| Allworth Financial LP |
$5384 |
778 |
0.00% |
股份
|
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
$5292 |
588 |
0.00% |
股份
|
| Rockefeller Capital Management L.P. |
$5107 |
738 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$4913 |
710 |
0.00% |
股份
|
| PNC Financial Services Group, Inc. |
$2678 |
387 |
0.00% |
股份
|
| Farther Finance Advisors, LLC |
$2443 |
353 |
0.00% |
股份
|
| ROTHSCHILD INVESTMENT LLC |
$1986 |
287 |
0.00% |
股份
|
| EverSource Wealth Advisors, LLC |
$1882 |
272 |
0.00% |
股份
|
| US BANCORP \DE\ |
$1827 |
264 |
0.00% |
股份
|
| IFP Advisors, Inc |
$1675 |
242 |
0.00% |
股份
|
| Torren Management, LLC |
$1458 |
162 |
0.00% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$1208 |
175110 |
0.00% |
股份
|
| HRT FINANCIAL LP |
$1180 |
170590 |
0.00% |
股份
|
| Physician Wealth Advisors, Inc. |
$1108 |
160 |
0.00% |
股份
|
| Essential Partners LLC |
$1010 |
146 |
0.00% |
股份
|
| N.E.W. Advisory Services LLC |
$830 |
120 |
0.00% |
股份
|
| SJS Investment Consulting Inc. |
$526 |
76 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$480 |
69348 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$195 |
28058 |
0.00% |
股份
|
| Silver Grove Financial Group, Inc. |
$194 |
28 |
0.00% |
股份
|
| SG Americas Securities, LLC |
$141 |
20338 |
0.00% |
股份
|
| SIMPLEX TRADING, LLC |
$138 |
20 |
0.00% |
股份
|
| OSAIC HOLDINGS, INC. |
$131 |
19 |
0.00% |
股份
|
| Clearstead Advisors, LLC |
$105 |
15 |
0.00% |
股份
|
| JPL Wealth Management, LLC |
$97 |
14 |
0.00% |
股份
|
| Freestone Grove Partners LP |
$7 |
1 |
0.00% |
股份
|
| NATIONAL BANK OF CANADA /FI/ |
$7 |
1 |
0.00% |
股份
|
| Covestor Ltd |
$0 |
39 |
0.00% |
股份
|