| 5AM Venture Management, LLC |
$19147378 |
3947913 |
8.51% |
股份
|
| BlackRock, Inc. |
$18204597 |
3753525 |
8.09% |
股份
|
| Squadron Capital Management LLC |
$17945000 |
3700000 |
7.98% |
股份
|
| TWO SIGMA INVESTMENTS, LP |
$14670940 |
3024936 |
6.52% |
股份
|
| VANGUARD CAPITAL MANAGEMENT LLC |
$13752995 |
2835669 |
6.11% |
股份
|
| CITADEL ADVISORS LLC |
$11147254 |
2298403 |
4.95% |
股份
|
| RENAISSANCE TECHNOLOGIES LLC |
$7804028 |
1609078 |
3.47% |
股份
|
| Opaleye Management Inc. |
$6851382 |
1412656 |
3.05% |
股份
|
| ORBIMED ADVISORS LLC |
$6744294 |
1390576 |
3.00% |
股份
|
| Decheng Capital LLC |
$6418136 |
1323327 |
2.85% |
股份
|
| GEODE CAPITAL MANAGEMENT, LLC |
$6229699 |
1284117 |
2.77% |
股份
|
| BANK OF AMERICA CORP /DE/ |
$5406053 |
1114650 |
2.40% |
股份
|
| Ishara Investments LP |
$4971250 |
1025000 |
2.21% |
股份
|
| PRIMECAP MANAGEMENT CO/CA/ |
$4643487 |
957420 |
2.06% |
股份
|
| Soleus Capital Management, L.P. |
$4607500 |
950000 |
2.05% |
股份
|
| STATE STREET CORP |
$4303968 |
887416 |
1.91% |
股份
|
| VANGUARD PORTFOLIO MANAGEMENT LLC |
$3921458 |
808548 |
1.74% |
股份
|
| VANGUARD GROUP INC |
$3855047 |
2855590 |
1.71% |
股份
|
| Pfizer Inc |
$3853489 |
953834 |
1.71% |
股份
|
| Connor, Clark & Lunn Investment Management Ltd. |
$3676460 |
758033 |
1.63% |
股份
|
| MILLENNIUM MANAGEMENT LLC |
$3221763 |
664281 |
1.43% |
股份
|
| ADAR1 Capital Management, LLC |
$3165838 |
652750 |
1.41% |
股份
|
| MARSHALL WACE, LLP |
$2868644 |
591473 |
1.28% |
股份
|
| Qube Research & Technologies Ltd |
$2787809 |
574806 |
1.24% |
股份
|
| D. E. Shaw & Co., Inc. |
$2650845 |
546566 |
1.18% |
股份
|
| DIMENSIONAL FUND ADVISORS LP |
$2630116 |
542852 |
1.17% |
股份
|
| MORGAN STANLEY |
$2285563 |
471250 |
1.02% |
股份
|
| Squadron Capital Management LLC |
$2066100 |
426000 |
0.92% |
买入期权
|
| TWO SIGMA ADVISERS, LP |
$2002725 |
1483500 |
0.89% |
股份
|
| NORTHERN TRUST CORP |
$1883251 |
388299 |
0.84% |
股份
|
| GOLDMAN SACHS GROUP INC |
$1806936 |
372564 |
0.80% |
股份
|
| VANGUARD FIDUCIARY TRUST CO |
$1634159 |
336940 |
0.73% |
股份
|
| FMR LLC |
$1504780 |
310264 |
0.67% |
股份
|
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD |
$1451844 |
961486 |
0.65% |
股份
|
| Seven Fleet Capital Management LP |
$1451432 |
317600 |
0.65% |
股份
|
| UBS Group AG |
$1442283 |
297378 |
0.64% |
股份
|
| XTX Topco Ltd |
$1405011 |
289693 |
0.62% |
股份
|
| Creative Planning |
$1382250 |
285000 |
0.61% |
股份
|
| SEI INVESTMENTS CO |
$1241983 |
256079 |
0.55% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$1043298 |
215113 |
0.46% |
股份
|
| Peapod Lane Capital LLC |
$983890 |
202864 |
0.44% |
股份
|
| CDC Financial, Inc. |
$862146 |
177762 |
0.38% |
股份
|
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
$833768 |
171911 |
0.37% |
股份
|
| Invesco Ltd. |
$784037 |
161657 |
0.35% |
股份
|
| Stonepine Capital Management, LLC |
$783678 |
161583 |
0.35% |
股份
|
| BARCLAYS PLC |
$770452 |
158856 |
0.34% |
股份
|
| Anfield Capital Management, LLC |
$642367 |
274516 |
0.29% |
股份
|
| Informed Momentum Co LLC |
$615286 |
126863 |
0.27% |
股份
|
| Quarry LP |
$606803 |
125114 |
0.27% |
股份
|
| Bank of New York Mellon Corp |
$592030 |
122068 |
0.26% |
股份
|
| Susquehanna Portfolio Strategies, LLC |
$543792 |
112122 |
0.24% |
股份
|
| BARR E S & CO |
$533500 |
110000 |
0.24% |
股份
|
| JANE STREET GROUP, LLC |
$481120 |
99200 |
0.21% |
买入期权
|
| FEDERATED HERMES, INC. |
$478292 |
98617 |
0.21% |
股份
|
| AMERICAN CENTURY COMPANIES INC |
$474121 |
97757 |
0.21% |
股份
|
| SIMPLEX TRADING, LLC |
$382684 |
78904 |
0.17% |
股份
|
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
$374905 |
77300 |
0.17% |
股份
|
| ExodusPoint Capital Management, LP |
$363585 |
74966 |
0.16% |
股份
|
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC |
$335824 |
68816 |
0.15% |
股份
|
| Nuveen, LLC |
$323369 |
66674 |
0.14% |
股份
|
| COMMONWEALTH EQUITY SERVICES, LLC |
$297850 |
61412 |
0.13% |
股份
|
| RHUMBLINE ADVISERS |
$270430 |
55760 |
0.12% |
股份
|
| DEUTSCHE BANK AG\ |
$236709 |
48806 |
0.11% |
股份
|
| WELLS FARGO & COMPANY/MN |
$203202 |
41898 |
0.09% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$200305 |
41300 |
0.09% |
买入期权
|
| Verdad Advisers, LP |
$192099 |
39608 |
0.09% |
股份
|
| Quadrature Capital Ltd |
$182423 |
37613 |
0.08% |
股份
|
| Private Advisor Group, LLC |
$176889 |
36472 |
0.08% |
股份
|
| MetLife Investment Management, LLC |
$145961 |
30095 |
0.06% |
股份
|
| RBF Capital, LLC |
$145500 |
30000 |
0.06% |
股份
|
| Regency Capital Management Inc.\DE |
$143075 |
29500 |
0.06% |
股份
|
| Marquette Asset Management, LLC |
$140520 |
28973 |
0.06% |
股份
|
| CITADEL ADVISORS LLC |
$128525 |
26500 |
0.06% |
买入期权
|
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC |
$125916 |
25962 |
0.06% |
股份
|
| TORONTO DOMINION BANK |
$114295 |
23566 |
0.05% |
股份
|
| CITIGROUP INC |
$112093 |
23112 |
0.05% |
股份
|
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
$111729 |
23037 |
0.05% |
股份
|
| RAYMOND JAMES FINANCIAL INC |
$110507 |
22785 |
0.05% |
股份
|
| Graham Capital Management, L.P. |
$108436 |
22358 |
0.05% |
股份
|
| Cubist Systematic Strategies, LLC |
$106619 |
70609 |
0.05% |
股份
|
| Vanguard Global Advisers, LLC |
$105366 |
21725 |
0.05% |
股份
|
| JPMORGAN CHASE & CO |
$103443 |
22439 |
0.05% |
股份
|
| Carson Advisory Inc. |
$102675 |
21170 |
0.05% |
股份
|
| Sivia Capital Partners, LLC |
$97000 |
20000 |
0.04% |
股份
|
| State of Wyoming |
$90967 |
18756 |
0.04% |
股份
|
| Jump Financial, LLC |
$86374 |
17809 |
0.04% |
股份
|
| EVERGREEN CAPITAL MANAGEMENT LLC |
$84533 |
17429 |
0.04% |
股份
|
| NEW YORK STATE COMMON RETIREMENT FUND |
$75175 |
15500 |
0.03% |
股份
|
| Police & Firemen's Retirement System of New Jersey |
$71562 |
14755 |
0.03% |
股份
|
| JANE STREET GROUP, LLC |
$69816 |
14395 |
0.03% |
股份
|
| MANUFACTURERS LIFE INSURANCE COMPANY, THE |
$69302 |
14289 |
0.03% |
股份
|
| PRELUDE CAPITAL MANAGEMENT, LLC |
$67139 |
13843 |
0.03% |
股份
|
| Scientech Research LLC |
$66023 |
13613 |
0.03% |
股份
|
| Squarepoint Ops LLC |
$65412 |
13487 |
0.03% |
股份
|
| CITADEL ADVISORS LLC |
$62565 |
12900 |
0.03% |
卖出期权
|
| OPPENHEIMER & CO INC |
$61382 |
12656 |
0.03% |
股份
|
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
$61110 |
12600 |
0.03% |
卖出期权
|
| Spark Investment Management LLC |
$60625 |
12500 |
0.03% |
股份
|
| BNP PARIBAS FINANCIAL MARKETS |
$60523 |
12479 |
0.03% |
股份
|
| nVerses Capital, LLC |
$53146 |
10958 |
0.02% |
股份
|
| INTECH INVESTMENT MANAGEMENT LLC |
$50731 |
10460 |
0.02% |
股份
|
| Cornerstone Wealth Management, LLC |
$49402 |
10186 |
0.02% |
股份
|
| Universal- Beteiligungs- und Servicegesellschaft mbH |
$48966 |
10096 |
0.02% |
股份
|
| ALLIANCEBERNSTEIN L.P. |
$40014 |
17100 |
0.02% |
股份
|
| Point72 Asia (Singapore) Pte. Ltd. |
$36050 |
23874 |
0.02% |
股份
|
| Legal & General Group Plc |
$23513 |
4848 |
0.01% |
股份
|
| Ameritas Investment Partners, Inc. |
$22019 |
4540 |
0.01% |
股份
|
| Russell Investments Group, Ltd. |
$19400 |
4000 |
0.01% |
股份
|
| Tower Research Capital LLC (TRC) |
$15108 |
3115 |
0.01% |
股份
|
| ACADIAN ASSET MANAGEMENT LLC |
$12995 |
2681900 |
0.01% |
股份
|
| CWM, LLC |
$12582 |
5377 |
0.01% |
股份
|
| EverSource Wealth Advisors, LLC |
$9428 |
1944 |
0.00% |
股份
|
| ROYAL BANK OF CANADA |
$8000 |
1636 |
0.00% |
股份
|
| Sterling Capital Management LLC |
$4889 |
1008 |
0.00% |
股份
|
| Wilmington Savings Fund Society, FSB |
$4850 |
1000 |
0.00% |
股份
|
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
$3342 |
689 |
0.00% |
股份
|
| SUMMIT SECURITIES GROUP LLC |
$2493 |
514 |
0.00% |
股份
|
| NISA INVESTMENT ADVISORS, LLC |
$1877 |
387 |
0.00% |
股份
|
| GSA CAPITAL PARTNERS LLP |
$1815 |
374260 |
0.00% |
股份
|
| Fortitude Family Office, LLC |
$1014 |
209 |
0.00% |
股份
|
| HighMark Wealth Management LLC |
$630 |
130 |
0.00% |
股份
|
| Silicon Valley Capital Partners |
$407 |
84 |
0.00% |
股份
|
| PRICE T ROWE ASSOCIATES INC /MD/ |
$200 |
41049 |
0.00% |
股份
|
| Caitong International Asset Management Co., Ltd |
$150 |
31 |
0.00% |
股份
|
| SBI Securities Co., Ltd. |
$131 |
27 |
0.00% |
股份
|
| Inspire Investing, LLC |
$50 |
21 |
0.00% |
股份
|
| Optiver Holding B.V. |
$19 |
4 |
0.00% |
股份
|