ANNX — الملاك المؤسسيون (13F)
المؤسسات التي تبلغ عن حيازتها لهذا السهم في نموذج SEC 13F ربع السنوي الخاص بها. المراكز الطويلة فقط؛ قد يظهر مقدم واحد مرتين لأرجل خيارات منفصلة. الأرجل الكبيرة المتعاكسة من خيارات البيع/الشراء تعكس عادةً صناعة السوق أو المخزون المتحوط، وليس القناعة الاتجاهية.
| مؤسسة | القيمة | الأسهم | % من 13F المتتبعة | النوع |
|---|---|---|---|---|
| FMR LLC | $111450614 | 19518496 | 10,53% | الأسهم |
| BlackRock, Inc. | $77311938 | 13539744 | 7,31% | الأسهم |
| Redmile Group, LLC | $67776998 | 11869877 | 6,41% | الأسهم |
| STATE STREET CORP | $56096873 | 9824321 | 5,30% | الأسهم |
| BVF INC/IL | $49666568 | 8698173 | 4,69% | الأسهم |
| Woodline Partners LP | $39542133 | 6925067 | 3,74% | الأسهم |
| VANGUARD CAPITAL MANAGEMENT LLC | $39233496 | 6871015 | 3,71% | الأسهم |
| VANGUARD GROUP INC | $38922003 | 7753387 | 3,68% | الأسهم |
| MAK CAPITAL ONE LLC | $33473048 | 5862180 | 3,16% | الأسهم |
| GOLDMAN SACHS GROUP INC | $33264057 | 5825579 | 3,14% | الأسهم |
| Siren, L.L.C. | $25458869 | 4458646 | 2,41% | الأسهم |
| Bain Capital Life Sciences Investors, LLC | $25339444 | 4437731 | 2,39% | الأسهم |
| Bellevue Group AG | $23411091 | 4100016 | 2,21% | الأسهم |
| GEODE CAPITAL MANAGEMENT, LLC | $23056071 | 4037193 | 2,18% | الأسهم |
| MPM BIOIMPACT LLC | $20238261 | 3544354 | 1,91% | الأسهم |
| AMERIPRISE FINANCIAL INC | $20039948 | 3509623 | 1,89% | الأسهم |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $19985000 | 3500000 | 1,89% | الأسهم |
| GREAT POINT PARTNERS LLC | $19985000 | 3500000 | 1,89% | الأسهم |
| MORGAN STANLEY | $17954827 | 3144453 | 1,70% | الأسهم |
| Palo Alto Investors LP | $16833594 | 2948090 | 1,59% | الأسهم |
| Balyasny Asset Management L.P. | $16164873 | 2830976 | 1,53% | الأسهم |
| Nuveen, LLC | $15788607 | 2765080 | 1,49% | الأسهم |
| Qube Research & Technologies Ltd | $15702277 | 2749961 | 1,48% | الأسهم |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $12829228 | 2246800 | 1,21% | الأسهم |
| Opaleye Management Inc. | $9789515 | 1714451 | 0,93% | الأسهم |
| Logos Global Management LP | $8565000 | 1500000 | 0,81% | الأسهم |
| DIMENSIONAL FUND ADVISORS LP | $8550585 | 1497756 | 0,81% | الأسهم |
| Point72 Asset Management, L.P. | $7895211 | 1382699 | 0,75% | الأسهم |
| NORTHERN TRUST CORP | $7720182 | 1352046 | 0,73% | الأسهم |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $7182032 | 1257799 | 0,68% | الأسهم |
| Tetragon Partners GP Ltd | $7094418 | 1242455 | 0,67% | الأسهم |
| Candriam S.C.A. | $6817695 | 1195142 | 0,64% | الأسهم |
| MILLENNIUM MANAGEMENT LLC | $6765956 | 1184931 | 0,64% | الأسهم |
| VANGUARD FIDUCIARY TRUST CO | $6312120 | 1105450 | 0,60% | الأسهم |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $5923360 | 1037366 | 0,56% | الأسهم |
| JPMORGAN CHASE & CO | $5593995 | 1004308 | 0,53% | الأسهم |
| WELLS FARGO & COMPANY/MN | $5584694 | 978055 | 0,53% | الأسهم |
| PANAGORA ASSET MANAGEMENT INC | $5526857 | 967926 | 0,52% | الأسهم |
| KENNEDY CAPITAL MANAGEMENT LLC | $5129830 | 898394 | 0,48% | الأسهم |
| Ishara Investments LP | $4682200 | 820000 | 0,44% | الأسهم |
| Ensign Peak Advisors, Inc | $4570946 | 800516 | 0,43% | الأسهم |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | $4213609 | 737935 | 0,40% | الأسهم |
| Y-Intercept (Hong Kong) Ltd | $4194480 | 734585 | 0,40% | الأسهم |
| Russell Investments Group, Ltd. | $4027213 | 705291 | 0,38% | الأسهم |
| AQR CAPITAL MANAGEMENT LLC | $3950245 | 691812 | 0,37% | الأسهم |
| Parkman Healthcare Partners LLC | $3660276 | 641029 | 0,35% | الأسهم |
| UBS Group AG | $3557866 | 623094 | 0,34% | الأسهم |
| DEUTSCHE BANK AG\ | $3520153 | 616489 | 0,33% | الأسهم |
| BANK OF AMERICA CORP /DE/ | $3507002 | 614186 | 0,33% | الأسهم |
| CITADEL ADVISORS LLC | $3406483 | 596582 | 0,32% | الأسهم |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $3334143 | 583913 | 0,32% | الأسهم |
| SIRIOS CAPITAL MANAGEMENT L P | $3250566 | 569276 | 0,31% | الأسهم |
| Schonfeld Strategic Advisors LLC | $3046666 | 533567 | 0,29% | الأسهم |
| TWO SIGMA INVESTMENTS, LP | $2928065 | 512796 | 0,28% | الأسهم |
| Bank of New York Mellon Corp | $2863235 | 501442 | 0,27% | الأسهم |
| Board of Trustees of The Leland Stanford Junior University | $2755360 | 482550 | 0,26% | الأسهم |
| RENAISSANCE TECHNOLOGIES LLC | $2620890 | 459000 | 0,25% | الأسهم |
| Ikarian Capital, LLC | $2456693 | 430244 | 0,23% | الأسهم |
| MOORE CAPITAL MANAGEMENT, LP | $2428646 | 425332 | 0,23% | الأسهم |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $2352520 | 412000 | 0,22% | عقد خيار الشراء |
| Trexquant Investment LP | $2339199 | 409667 | 0,22% | الأسهم |
| WELLINGTON MANAGEMENT GROUP LLP | $2322799 | 406795 | 0,22% | الأسهم |
| Susquehanna Portfolio Strategies, LLC | $2256763 | 395230 | 0,21% | الأسهم |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $2253166 | 394600 | 0,21% | الأسهم |
| DIADEMA PARTNERS LP | $2016772 | 353200 | 0,19% | عقد خيار الشراء |
| Invesco Ltd. | $1888463 | 330729 | 0,18% | الأسهم |
| Engineers Gate Manager LP | $1821815 | 319057 | 0,17% | الأسهم |
| DAFNA Capital Management LLC | $1700507 | 297812 | 0,16% | الأسهم |
| Jump Financial, LLC | $1700438 | 297800 | 0,16% | الأسهم |
| STATE OF WISCONSIN INVESTMENT BOARD | $1635201 | 286375 | 0,15% | الأسهم |
| D. E. Shaw & Co., Inc. | $1514772 | 265284 | 0,14% | الأسهم |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $1427643 | 250025 | 0,13% | الأسهم |
| Swiss National Bank | $1396666 | 244600 | 0,13% | الأسهم |
| CITIGROUP INC | $1347502 | 235990 | 0,13% | الأسهم |
| CITADEL ADVISORS LLC | $1340137 | 234700 | 0,13% | عقد خيار الشراء |
| Cinctive Capital Management LP | $1231921 | 215748 | 0,12% | الأسهم |
| MARSHALL WACE, LLP | $1202566 | 210607 | 0,11% | الأسهم |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1086042 | 190200 | 0,10% | عقد خيار البيع |
| RHUMBLINE ADVISERS | $1082480 | 189578 | 0,10% | الأسهم |
| SEI INVESTMENTS CO | $1049635 | 183817 | 0,10% | الأسهم |
| Squarepoint Ops LLC | $989457 | 173285 | 0,09% | الأسهم |
| Rafferty Asset Management, LLC | $989423 | 173279 | 0,09% | الأسهم |
| Point72 Europe (London) LLP | $923726 | 302861 | 0,09% | الأسهم |
| OSAIC HOLDINGS, INC. | $842933 | 147624 | 0,08% | الأسهم |
| ALLIANCEBERNSTEIN L.P. | $815710 | 147240 | 0,08% | الأسهم |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $766619 | 134259 | 0,07% | الأسهم |
| VICTORY CAPITAL MANAGEMENT INC | $727100 | 127338 | 0,07% | الأسهم |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $723784 | 130647 | 0,07% | الأسهم |
| BOOTHBAY FUND MANAGEMENT, LLC | $685937 | 120129 | 0,06% | الأسهم |
| IEQ CAPITAL, LLC | $685257 | 120010 | 0,06% | الأسهم |
| J. Goldman & Co LP | $662623 | 116046 | 0,06% | الأسهم |
| XTX Topco Ltd | $640359 | 112147 | 0,06% | الأسهم |
| Vanguard Global Advisers, LLC | $582803 | 102067 | 0,06% | الأسهم |
| Quarry LP | $571000 | 100000 | 0,05% | الأسهم |
| SCS Capital Management LLC | $565290 | 99000 | 0,05% | الأسهم |
| Legal & General Group Plc | $560254 | 98118 | 0,05% | الأسهم |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $520567 | 91661 | 0,05% | الأسهم |
| MetLife Investment Management, LLC | $519639 | 91005 | 0,05% | الأسهم |
| JANE STREET GROUP, LLC | $516755 | 90500 | 0,05% | عقد خيار الشراء |
| J. Safra Sarasin Holding AG | $516681 | 90487 | 0,05% | الأسهم |
| CITADEL ADVISORS LLC | $507619 | 88900 | 0,05% | عقد خيار البيع |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $505438 | 88518 | 0,05% | الأسهم |
| CAPTRUST FINANCIAL ADVISORS | $501960 | 87909 | 0,05% | الأسهم |
| PROFUND ADVISORS LLC | $499676 | 87509 | 0,05% | الأسهم |
| VANGUARD ASSET MANAGEMENT, Ltd | $453865 | 79486 | 0,04% | الأسهم |
| DNB Asset Management AS | $417669 | 73147 | 0,04% | الأسهم |
| Virtus Investment Advisers, LLC | $396662 | 69468 | 0,04% | الأسهم |
| Jain Global LLC | $369545 | 64719 | 0,03% | الأسهم |
| China Universal Asset Management Co., Ltd. | $354454 | 62076 | 0,03% | الأسهم |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $354437 | 62073 | 0,03% | الأسهم |
| DIVERSIFIED TRUST CO | $352860 | 61797 | 0,03% | الأسهم |
| DLD Asset Management, LP | $343200 | 60000 | 0,03% | عقد خيار الشراء |
| JANUS HENDERSON GROUP PLC | $327710 | 59100 | 0,03% | الأسهم |
| VIRGINIA RETIREMENT SYSTEMS ET Al | $310053 | 54300 | 0,03% | الأسهم |
| WINTON GROUP Ltd | $272938 | 47800 | 0,03% | الأسهم |
| JUPITER ASSET MANAGEMENT LTD | $263083 | 46074 | 0,02% | الأسهم |
| Creative Planning | $262374 | 45950 | 0,02% | الأسهم |
| Police & Firemen's Retirement System of New Jersey | $261592 | 45813 | 0,02% | الأسهم |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $255272 | 44706 | 0,02% | الأسهم |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $254009 | 44485 | 0,02% | الأسهم |
| Allegheny Financial Group | $244959 | 42900 | 0,02% | الأسهم |
| BARCLAYS PLC | $238193 | 41715 | 0,02% | الأسهم |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $237062 | 41517 | 0,02% | الأسهم |
| State of New Jersey Common Pension Fund D | $225025 | 39409 | 0,02% | الأسهم |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $224940 | 39394 | 0,02% | الأسهم |
| BNP PARIBAS FINANCIAL MARKETS | $224146 | 39255 | 0,02% | الأسهم |
| FIFTH THIRD BANCORP | $220634 | 38640 | 0,02% | الأسهم |
| CANADA PENSION PLAN INVESTMENT BOARD | $220406 | 38600 | 0,02% | الأسهم |
| CWM, LLC | $219672 | 39652 | 0,02% | الأسهم |
| NEW YORK STATE COMMON RETIREMENT FUND | $208803 | 36568 | 0,02% | الأسهم |
| Persistent Asset Partners Ltd | $206640 | 897 | 0,02% | عقد خيار الشراء |
| Vanguard Investments Australia, Ltd. | $200044 | 35034 | 0,02% | الأسهم |
| ARIZONA STATE RETIREMENT SYSTEM | $192027 | 33630 | 0,02% | الأسهم |
| Blueshift Asset Management, LLC | $190360 | 33338 | 0,02% | الأسهم |
| PRELUDE CAPITAL MANAGEMENT, LLC | $180676 | 31642 | 0,02% | الأسهم |
| VOYA INVESTMENT MANAGEMENT LLC | $176268 | 30870 | 0,02% | الأسهم |
| Lido Advisors, LLC | $176114 | 30843 | 0,02% | الأسهم |
| EntryPoint Capital, LLC | $175794 | 30787 | 0,02% | الأسهم |
| INTECH INVESTMENT MANAGEMENT LLC | $170895 | 29929 | 0,02% | الأسهم |
| Bridgefront Capital, LLC | $162895 | 28528 | 0,02% | الأسهم |
| COMERICA BANK | $162432 | 32357 | 0,02% | الأسهم |
| Quadrature Capital Ltd | $159098 | 27863 | 0,02% | الأسهم |
| DIADEMA PARTNERS LP | $157116 | 27516 | 0,01% | الأسهم |
| KLP KAPITALFORVALTNING AS | $150173 | 26300 | 0,01% | الأسهم |
| ProShare Advisors LLC | $146810 | 25711 | 0,01% | الأسهم |
| Verdad Advisers, LP | $144463 | 25300 | 0,01% | الأسهم |
| Brevan Howard Capital Management LP | $144389 | 25287 | 0,01% | الأسهم |
| AlphaCentric Advisors LLC | $142019 | 24872 | 0,01% | الأسهم |
| PRUDENTIAL FINANCIAL INC | $141894 | 24850 | 0,01% | الأسهم |
| E Fund Management Co., Ltd. | $139512 | 24433 | 0,01% | الأسهم |
| Crown Wealth Group, LLC | $135687 | 23763 | 0,01% | الأسهم |
| SBI Securities Co., Ltd. | $132615 | 23225 | 0,01% | الأسهم |
| RAYMOND JAMES FINANCIAL INC | $130582 | 22869 | 0,01% | الأسهم |
| STRS OHIO | $121052 | 21200 | 0,01% | الأسهم |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | $119967 | 21010 | 0,01% | الأسهم |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | $118843 | 20813 | 0,01% | الأسهم |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $117467 | 20253 | 0,01% | الأسهم |
| Corient Private Wealth LP | $112510 | 19704 | 0,01% | الأسهم |
| State of Wyoming | $111225 | 19479 | 0,01% | الأسهم |
| MERCER GLOBAL ADVISORS INC /ADV | $97510 | 17077 | 0,01% | الأسهم |
| Coastal Bridge Advisors, LLC | $97070 | 17000 | 0,01% | الأسهم |
| Pictet Asset Management Holding SA | $95363 | 16701 | 0,01% | الأسهم |
| Mariner, LLC | $94053 | 16469 | 0,01% | الأسهم |
| LPL Financial LLC | $90269 | 15809 | 0,01% | الأسهم |
| Balefire, LLC | $85713 | 15011 | 0,01% | الأسهم |
| DLD Asset Management, LP | $85650 | 15000 | 0,01% | الأسهم |
| XPONANCE LLC | $84879 | 14865 | 0,01% | الأسهم |
| Forefront Analytics, LLC | $81310 | 14240 | 0,01% | الأسهم |
| TEACHER RETIREMENT SYSTEM OF TEXAS | $81270 | 14233 | 0,01% | الأسهم |
| Ameritas Investment Partners, Inc. | $80494 | 14097 | 0,01% | الأسهم |
| Private Advisor Group, LLC | $80054 | 14020 | 0,01% | الأسهم |
| Cerity Partners LLC | $79182 | 13867 | 0,01% | الأسهم |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $73088 | 12800 | 0,01% | الأسهم |
| Tower Research Capital LLC (TRC) | $73008 | 12786 | 0,01% | الأسهم |
| Vanguard Personalized Indexing Management, LLC | $71306 | 12488 | 0,01% | الأسهم |
| Quantinno Capital Management LP | $70022 | 12263 | 0,01% | الأسهم |
| Cubist Systematic Strategies, LLC | $69451 | 22771 | 0,01% | الأسهم |
| PRINCIPAL FINANCIAL GROUP INC | $67812 | 11876 | 0,01% | الأسهم |
| Merit Financial Group, LLC | $63398 | 11103 | 0,01% | الأسهم |
| FOX RUN MANAGEMENT, L.L.C. | $62353 | 10920 | 0,01% | الأسهم |
| NISA INVESTMENT ADVISORS, LLC | $61548 | 10779 | 0,01% | الأسهم |
| GROUP ONE TRADING LLC | $57597 | 10087 | 0,01% | الأسهم |
| Harbor Advisors LLC | $57100 | 10000 | 0,01% | الأسهم |
| Shay Capital LLC | $57100 | 10000 | 0,01% | الأسهم |
| JANE STREET GROUP, LLC | $57100 | 10000 | 0,01% | عقد خيار البيع |
| Fulcrum Asset Management LLP | $56090 | 10070 | 0,01% | الأسهم |
| Arax Advisory Partners | $43876 | 7684 | 0,00% | الأسهم |
| Mirae Asset Global Investments Co., Ltd. | $41843 | 7328 | 0,00% | الأسهم |
| Persistent Asset Partners Ltd | $38971 | 6825 | 0,00% | الأسهم |
| Geneos Wealth Management Inc. | $34260 | 6000 | 0,00% | الأسهم |
| ROYAL BANK OF CANADA | $31000 | 5395 | 0,00% | الأسهم |
| JONES FINANCIAL COMPANIES LLLP | $19536 | 3565 | 0,00% | الأسهم |
| GF FUND MANAGEMENT CO. LTD. | $17501 | 3065 | 0,00% | الأسهم |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $11557 | 2024 | 0,00% | الأسهم |
| BARCLAYS PLC | $11420 | 2000 | 0,00% | عقد خيار الشراء |
| Larson Financial Group LLC | $11420 | 2000 | 0,00% | الأسهم |
| Quantbot Technologies LP | $8919 | 1562 | 0,00% | الأسهم |
| PNC Financial Services Group, Inc. | $7114 | 1246 | 0,00% | الأسهم |
| Trask Adam Roland | $5540 | 1000 | 0,00% | الأسهم |
| Allworth Financial LP | $4774 | 836 | 0,00% | الأسهم |
| Rockefeller Capital Management L.P. | $4488 | 786 | 0,00% | الأسهم |
| Farther Finance Advisors, LLC | $4185 | 738 | 0,00% | الأسهم |
| Essential Partners LLC | $3849 | 674 | 0,00% | الأسهم |
| ACADIAN ASSET MANAGEMENT LLC | $3588 | 629127 | 0,00% | الأسهم |
| GAMMA Investing LLC | $3255 | 570 | 0,00% | الأسهم |
| IFP Advisors, Inc | $3249 | 569 | 0,00% | الأسهم |
| EverSource Wealth Advisors, LLC | $3191 | 559 | 0,00% | الأسهم |
| Sterling Capital Management LLC | $3112 | 545 | 0,00% | الأسهم |
| Caitong International Asset Management Co., Ltd | $2838 | 497 | 0,00% | الأسهم |
| Fortitude Family Office, LLC | $2758 | 483 | 0,00% | الأسهم |
| Optiver Holding B.V. | $2318 | 406 | 0,00% | الأسهم |
| HighMark Wealth Management LLC | $1713 | 300 | 0,00% | الأسهم |
| True Wealth Design, LLC | $1616 | 283 | 0,00% | الأسهم |
| Physician Wealth Advisors, Inc. | $1536 | 269 | 0,00% | الأسهم |
| ROTHSCHILD INVESTMENT LLC | $1422 | 249 | 0,00% | الأسهم |
| Global Retirement Partners, LLC | $1034 | 181 | 0,00% | الأسهم |
| PRICE T ROWE ASSOCIATES INC /MD/ | $738 | 129243 | 0,00% | الأسهم |
| Sunbelt Securities, Inc. | $609 | 110 | 0,00% | الأسهم |
| GSA CAPITAL PARTNERS LLP | $596 | 104378 | 0,00% | الأسهم |
| NATIONAL BANK OF CANADA /FI/ | $383 | 67 | 0,00% | الأسهم |
| SG Americas Securities, LLC | $245 | 42823 | 0,00% | الأسهم |
| CANADA LIFE ASSURANCE Co | $124 | 21646 | 0,00% | الأسهم |
| Cygnus Capital Advisors, LLC | $123 | 21549 | 0,00% | الأسهم |
| SJS Investment Consulting Inc. | $115 | 20 | 0,00% | الأسهم |
| Stone House Investment Management, LLC | $91 | 16 | 0,00% | الأسهم |
| Clearstead Advisors, LLC | $86 | 15 | 0,00% | الأسهم |
| MOUNT VERNON ASSOCIATES INC /MD/ | $60 | 10500 | 0,00% | الأسهم |
| Cambridge Investment Research Advisors, Inc. | $58 | 10110 | 0,00% | الأسهم |
| Pacer Advisors, Inc. | $17 | 2894 | 0,00% | الأسهم |
| Silver Grove Financial Group, Inc. | $6 | 1 | 0,00% | الأسهم |