New Leaf Venture Partners, L.L.C.
CIK 1631614 · View on SEC EDGAR ↗
- Portfolio value
- $43.0M
- Positions
- 7
- As of
- Sept. 30, 2025 Data as of Q3 2025
Portfolio value QoQ: -18.7% 13F does not disclose cash
- Top 10 holdings weight
- 100.00%
- Top 25 holdings weight
- 100.00%
- Positions above 1%
- 7
- Effective number of positions
- 3.6
Based on 13F long-equity holdings only (cash, bonds, shorts not disclosed)
Turnover Q3 2025: 0.0% Est. buys $0 · sells $19,699,584
Median holding: 4.0 quarters Tracked Q4 2024–Q3 2025 · 77.8% still held
- New positions
- 0
- Increased
- 0
- Decreased
- 1
- Closed
- 1
On this page
- Performance vs S&P How this manager's 13F portfolio performed against the S&P 500.
- Sector breakdown How the portfolio splits across market sectors.
- Portfolio Every stock this institution reports holding, from its latest 13F.
- Top moves The biggest position increases and decreases this quarter.
- Exited positions Positions the manager fully sold out of last quarter.
Performance vs S&P 500
Annualized: -56.4% · S&P 500: +18.3%
Approximates a buy-and-hold portfolio built from quarterly SEC 13F snapshots. Excludes cash, short positions, options/derivatives, and non-13(f) securities — reflects the disclosed long-equity book only, not total fund AUM. SEC filing lag is up to 45 days; this is not a real-time-copyable timing.
Priceable coverage: 100.0% · Options excluded: 0.0%
Sector breakdown
Full portfolio 7 positions
| Type | Streak | 8Q trend | |||||
|---|---|---|---|---|---|---|---|
| EWTX Edgewise Therapeutics, Inc. - Common Stock | $16,709,211 | 38.82% | 1,030,161 | $3,203,800 | |||
| ARVN Arvinas, Inc. - Common Stock | $13,510,343 | 31.38% | 1,585,721 | $1,839,436 | |||
| CRNX Crinetics Pharmaceuticals, Inc. - Common Stock | $5,872,650 | 13.64% | 141,000 | $1,817,490 | |||
| COGT Cogent Biosciences, Inc. - Common Stock | $3,600,985 | 8.37% | 250,765 | $1,800,492 | |||
| RLYB Rallybio Corporation - Common Stock | $1,647,500 | 3.83% | 3,301,603 | $531,558 | |||
| ALEC Alector, Inc. - Common Stock | $1,005,124 | 2.33% | 339,569 | $529,727 | |||
| PASG Passage Bio, Inc. - Common Stock | $702,031 | 1.63% | 87,426 | $-19,281,345 | Down ×1 | ||
| No matches | |||||||
Top movers (QoQ)
| Security | Action | Shares Δ | Value Δ |
|---|---|---|---|
| EWTX | Price move only | +0 | +$3.2M |
| ARVN | Price move only | +0 | +$1.8M |
| CRNX | Price move only | +0 | +$1.8M |
| COGT | Price move only | +0 | +$1.8M |
| RLYB | Price move only | +0 | +$532K |
| ALEC | Price move only | +0 | +$530K |
1 position hidden (data completeness check)
Exited positions
Includes corporate events (mergers, delistings) — not all exits are sells
Closed positions reflect 13F reporting changes; for index managers these are often mechanical (delisting, M&A, index rebalancing), not active decisions.
| Security | Quarter | Shares before | Value before | Price since exit |
|---|---|---|---|---|
| RCKT | June 30, 2025 | 150,706 | $1,005,209 | 44.1% |
| ITRM | Sept. 30, 2025 | 345,020 | $343,295 | No longer tracked |