ARVN Arvinas, Inc. - Common Stock

NASDAQ · Pharmaceuticals · View on SEC EDGAR ↗
$9.59
Price · Aug 19, 2026
Fundamentals as of Aug 4, 2026

About Arvinas, Inc. - Common Stock Company overview from Wikipedia

ARVN Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$9.59
Market Cap
$714M
P/E (TTM)
-9.9
EPS (TTM)
$-1.14
Revenue (TTM)
$263M
Div Yield
ROE
-15.5%
Debt/Equity
0.0
52W Range
$7 – $15

ARVN Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income $263M
9-point trend, +3364.9%
2017-12-31 2025-12-31
EPS $-1.14
7-point trend, +46.5%
2019-12-31 2025-12-31
Free Cash Flow $-276M
8-point trend, -1355.0%
2018-12-31 2025-12-31
Margins -30.8%

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
ARVN
Peer Median
P/E (TTM)
5-point trend, +51.6%
-9.9
11.7
P/S (TTM)
5-point trend, -96.5%
2.7
5.4
P/B
5-point trend, -68.8%
1.6
3.7
EV / EBITDA
5-point trend, +96.1%
-0.3
Price / FCF
5-point trend, -134.8%
-2.6

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
ARVN
Peer Median
Operating Margin
5-point trend, +89.2%
-45.1%
Net Profit Margin
5-point trend, +92.5%
-30.8%
-45.6%
ROA
5-point trend, +46.3%
-8.9%
-25.4%
ROE
5-point trend, +35.1%
-15.5%
-27.1%
ROIC
4-point trend, +45.7%
-27.4%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
ARVN
Peer Median
Debt / Equity
5-point trend, +7.7%
0.0
Current Ratio
5-point trend, -17.1%
4.9
4.6
Quick Ratio
5-point trend, -16.9%
4.8

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
ARVN
Peer Median
Revenue YoY
5-point trend, +389.9%
-0.30%
Revenue CAGR 3Y
5-point trend, +389.9%
26.0%
Revenue CAGR 5Y
5-point trend, +389.9%
58.9%

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
ARVN
Peer Median
EPS (Diluted)
5-point trend, +70.2%
$-1.14

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
ARVN
Peer Median

ARVN Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 23 analysts
  • Strong Buy 4 17.4%
  • Buy 10 43.5%
  • Hold 8 34.8%
  • Sell 1 4.3%
  • Strong Sell 0 0.0%

12-Month Price Target

14 analysts · 2026-08-19
Median target $13.00 +35.6%
Mean target $13.93 +45.2%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.85%
Period EPS Actual EPS Est Surprise
June 30, 2026 $2.58 $-0.38 3.0%
March 31, 2026 $-0.90 $-0.94 0.04%
Dec. 31, 2025 $-1.10 $-0.60 -0.50%
Sept. 30, 2025 $-0.48 $-0.81 0.33%
June 30, 2025 $-0.84 $-1.02 0.18%
March 31, 2025 $1.14 $-0.97 2.1%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
ARVN $753M -10.4 -0.30% -30.8% -15.5%
SGP 50.0%
ACRS $363M -5.7 -58.2% -829.6% -55.3%
PHAT $1.18B -5.5 216.9% -126.4% 52.4% 87.1%
CRMD $922M 5.7 617.0% 52.3% 52.1% 88.5%
ZVRA $509M 6.6 350.9% 78.2% 61.2%
CTNM -5.3 -27.7%
EOLS $432M -8.3 11.6% -17.4% 247.3% 66.3%
AQST $788M -8.3 -22.6% -188.1% 157.7%
RLMD $354M -3.3 93.7% -112.0%

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 16
Annual Income Statement data for ARVN
Metric Trend 202520242023202220212020201920182017
Revenue 9-point trend, +3364.9% $263M $263M $78M $131M $54M $26M $43M $14M $8M
R&D Expense 9-point trend, +890.5% $285M $348M $380M $315M $180M $108M $67M $45M $29M
SG&A Expense 9-point trend, +2604.3% $96M $165M $100M $80M $62M $38M $27M $13M $4M
Operating Expenses 9-point trend, +1078.4% $381M $514M $480M $395M $242M $147M $94M $58M $32M
Operating Income 9-point trend, -378.6% $-118M $-250M $-402M $-263M $-188M $-121M $-52M $-44M $-25M
Interest Expense 8-point trend, -100.0% · $0 $0 $0 $0 $100.0K $100.0K $57.4K $50.4K
Interest Income 9-point trend, +18967.7% $38M $55M $39M $12M $2M $4M $5M $2M $201.4K
Other Non-op 9-point trend, -172.2% $-400.0K $-3M $-1M $200.0K $2M $2M $1M $102.7K $554.2K
Pretax Income 6-point trend, +30.1% $-80M $-198M $-364M $-251M $-184M $-115M · · ·
Income Tax 9-point trend, +300000.00 $300.0K $600.0K $900.0K $21M $0 $0 $0 $0 $0
Net Income 9-point trend, -236.0% $-81M $-199M $-367M $-282M $-191M $-119M $-70M $-41M $-24M
EPS (Basic) 7-point trend, +46.5% $-1.14 $-2.77 $-6.62 $-5.31 $-3.82 $-3.02 $-2.13 · ·
EPS (Diluted) 7-point trend, +46.5% $-1.14 $-2.77 $-6.62 $-5.31 $-3.82 $-3.02 $-2.13 · ·
Shares (Basic) 7-point trend, +115.5% 70,900,000 71,900,000 55,500,000 53,200,000 50,000,000 39,500,000 32,900,000 · ·
Shares (Diluted) 7-point trend, +115.5% 70,900,000 71,900,000 55,500,000 53,200,000 50,000,000 39,500,000 32,900,000 · ·
EBITDA 8-point trend, -170.5% $-118M $-250M $-402M $-263M $-195M $-125M $-52M $-44M ·
Balance Sheet 26
Annual Balance Sheet data for ARVN
Metric Trend 202520242023202220212020201920182017
Cash & Equivalents 9-point trend, +362.3% $143M $100M $312M $81M $108M $588M $9M $3M $31M
Short-term Investments 9-point trend, +6468.6% $542M $939M $949M $1.12B $1.39B $100M $272M $185M $8M
Receivables 8-point trend, -96.0% $1M $6M $0 $1M $15M $1M · $3M $25M
Prepaid Expense 9-point trend, +2708.4% $9M $14M $6M $21M $20M $6M $4M $3M $316.9K
Current Assets 9-point trend, +969.3% $701M $1.07B $1.28B $1.24B $1.55B $703M $291M $196M $66M
PP&E (Net) 9-point trend, +300.3% $5M $7M $12M $13M $13M $12M $8M $4M $1M
PP&E (Gross) 9-point trend, +1333.2% $33M $33M $33M $30M $23M $18M $12M $5M $2M
Accum. Depreciation 9-point trend, +2633.6% $28M $26M $21M $17M $11M $6M $3M $2M $1M
Other Non-current Assets 3-point trend, +38.6% · · · · · $28.8K $26.8K $20.8K ·
Total Assets 9-point trend, +973.9% $718M $1.09B $1.30B $1.27B $1.58B $717M $302M $199M $67M
Accounts Payable 9-point trend, +3990.3% $24M $13M $18M $6M $31M $7M $5M $3M $596.5K
Accrued Liabilities 5-point trend, +551.4% · · · · $23M $19M $8M $4M $4M
Current Liabilities 9-point trend, +698.1% $142M $230M $257M $295M $262M $49M $33M $23M $18M
Capital Leases 7-point trend, +296.7% $7M $7M $500.0K $3M $3M $1M $2M · ·
Other Non-current Liabilities · · · · · · · $150.0K ·
Total Liabilities 9-point trend, +326.4% $284M $530M $645M $704M $800M $75M $75M $63M $67M
Long-term Debt 9-point trend, +93.3% $600.0K $800.0K $1M $1M $1M $2M $2M $2M $310.4K
Total Debt 8-point trend, -72.2% $600.0K $800.0K $1M $1M $1M $2M $2M $2M ·
Common Stock 8-point trend, +220.1% $100.0K $100.0K $100.0K $100.0K $0 $0 $38.5K $31.2K ·
Paid-in Capital 8-point trend, +386.6% $2.14B $2.09B $2.00B $1.55B $1.47B $1.13B $599M $439M ·
Retained Earnings 9-point trend, -2483.3% $-1.61B $-1.53B $-1.33B $-965M $-683M $-492M $-373M $-302M $-62M
Treasury Stock 2-point trend, +91900000.00 $92M $0 · · · · · · ·
AOCI 9-point trend, +12406.4% $1M $1M $-3M $-19M $-5M $600.0K $107.6K $-217.7K $-9.8K
Stockholders' Equity 9-point trend, +808.6% $434M $562M $660M $565M $782M $642M $227M $137M $-61M
Liabilities + Equity 9-point trend, +973.9% $718M $1.09B $1.30B $1.27B $1.58B $717M $302M $199M $67M
Shares Outstanding 8-point trend, +103.5% 63,500,000 68,800,000 68,000,000 53,200,000 53,000,000 48,500,000 38,500,000 31,200,000 ·
Cash Flow 17
Annual Cash Flow data for ARVN
Metric Trend 202520242023202220212020201920182017
D&A 9-point trend, +763.6% $3M $5M $5M $6M $5M $3M $2M $706.0K $347.4K
Stock-based Comp 9-point trend, +17855.7% $44M $88M $72M $76M $57M $30M $20M $12M $245.0K
Deferred Tax Flat — no change across 6 periods $0 $0 $0 $0 $0 $0 · · ·
Restructuring 3-point trend, +3700000.00 $4M $0 $0 · · · · · ·
Operating Cash Flow 9-point trend, -5454.9% $-274M $-259M $-348M $-274M $559M $-90M $-41M $-16M $5M
CapEx 9-point trend, +87.7% $2M $2M $3M $7M $5M $6M $6M $3M $1M
Investing Cash Flow 9-point trend, +1852.8% $408M $35M $204M $243M $-1.31B $164M $-93M $-180M $21M
Debt Issued 4-point trend, +0.00 · · · · · $0 $0 $2M $0
Net Debt Issued 6-point trend, -111.0% $-200.0K $-400.0K · · $0 $0 $-169.6K $2M ·
Stock Issued 3-point trend, +137686006.00 · · · · · · $138M $115M $0
Stock Repurchased 3-point trend, +91900000.00 $92M $0 $0 · · · · · ·
Net Stock Activity 3-point trend, -180.2% $-92M · · · · · $138M $115M ·
Financing Cash Flow 9-point trend, -56542.5% $-91M $8M $375M $5M $279M $505M $140M $168M $-161.4K
Net Change in Cash 9-point trend, +64.2% $42M $-217M $230M $-26M $-476M $579M $6M $-28M $26M
Taxes Paid 6-point trend, -400000.00 $-400.0K $2M $11M $11M $0 $0 · · ·
Free Cash Flow 8-point trend, -1355.0% $-276M $-261M $-351M $-280M $555M $-96M $-47M $-19M ·
Levered FCF 2-point trend, +25.5% · $-261M $-351M · · · · · ·
Profitability 7
Annual Profitability data for ARVN
Metric Trend 202520242023202220212020201920182017
Operating Margin 8-point trend, +85.2% -45.1% -95.0% -511.5% -200.3% -418.2% -572.7% -119.9% -305.8% ·
Net Margin 8-point trend, +89.4% -30.8% -75.5% -467.9% -215.0% -409.0% -547.3% -163.6% -289.6% ·
Pretax Margin 4-point trend, +84.0% -30.6% -75.3% -463.6% -191.0% · · · · ·
EBITDA Margin 8-point trend, +85.2% -45.1% -95.0% -511.5% -200.3% -418.2% -572.7% -119.9% -305.8% ·
ROA 8-point trend, +71.4% -8.9% -16.6% -28.5% -19.8% -16.6% -23.4% -28.1% -31.2% ·
ROE 8-point trend, -126.5% -15.5% -34.7% -65.8% -47.6% -23.9% -28.2% -39.0% 58.4% ·
ROIC 4-point trend, +45.7% -27.4% -44.6% -60.9% -50.4% · · · · ·
Liquidity & Solvency 5
Annual Liquidity & Solvency data for ARVN
Metric Trend 202520242023202220212020201920182017
Current Ratio 8-point trend, -42.3% 4.9 4.6 5.0 4.2 5.9 14.3 8.9 8.5 ·
Quick Ratio 8-point trend, -41.9% 4.8 4.5 4.9 4.1 5.8 14.0 8.6 8.3 ·
Debt / Equity 8-point trend, -91.1% 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ·
LT Debt / Equity 8-point trend, -93.8% 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ·
Interest Coverage 4-point trend, -156.1% · · · · -1953.0 -1920.9 -602.1 -762.6 ·
Efficiency 2
Annual Efficiency data for ARVN
Metric Trend 202520242023202220212020201920182017
Asset Turnover 8-point trend, +169.8% 0.3 0.2 0.1 0.1 0.0 0.0 0.2 0.1 ·
Receivables Turnover 7-point trend, +7500.2% 78.4 40.5 10.0 131.4 5.5 11.5 · 1.0 ·
Per Share 5
Annual Per Share data for ARVN
Metric Trend 202520242023202220212020201920182017
Book Value / Share 8-point trend, +56.2% $6.83 $8.16 $9.71 $10.62 $14.75 $13.25 $5.89 $4.38 ·
Revenue / Share 5-point trend, +296.6% $3.70 $3.66 $1.41 $2.47 $0.93 · · · ·
Cash Flow / Share 5-point trend, -134.5% $-3.86 $-3.61 $-6.27 $-5.14 $11.19 · · · ·
Cash / Share 8-point trend, +2104.1% $2.25 $1.46 $4.58 $1.53 $2.04 $12.14 $0.24 $0.10 ·
EPS (TTM) 7-point trend, +46.5% $-1.14 $-2.77 $-6.62 $-5.31 $-3.82 $-3.02 $-2.13 · ·
Growth Rates 3
Annual Growth Rates data for ARVN
Metric Trend 202520242023202220212020201920182017
Revenue YoY 5-point trend, -100.3% -0.30% 235.5% -40.3% 145.2% 106.9% · · · ·
Revenue CAGR 3Y 3-point trend, -41.9% 26.0% 70.0% 44.7% · · · · · ·
Revenue CAGR 5Y 58.9% · · · · · · · ·
Valuation (TTM) 14
Annual Valuation (TTM) data for ARVN
Metric Trend 202520242023202220212020201920182017
Revenue TTM 8-point trend, +1733.3% $263M $263M $78M $131M $54M $26M $43M $14M ·
Net Income TTM 8-point trend, -94.8% $-81M $-199M $-367M $-282M $-191M $-119M $-70M $-41M ·
Market Cap 8-point trend, +87.6% $753M $1.32B $2.80B $1.82B $4.35B $4.12B $1.58B $401M ·
Enterprise Value 8-point trend, -68.3% $68M $280M $1.54B $616M $2.85B $3.43B $1.30B $216M ·
P/E 7-point trend, +46.1% -10.4 -6.9 -6.2 -6.4 -21.5 -28.1 -19.3 · ·
P/S 8-point trend, -89.8% 2.9 5.0 35.7 13.9 81.2 158.9 36.8 28.0 ·
P/B 8-point trend, -40.9% 1.7 2.3 4.2 3.2 5.6 6.4 7.0 2.9 ·
P / Tangible Book 6-point trend, -72.9% 1.7 2.3 4.2 3.2 5.6 6.4 · · ·
P / Cash Flow 8-point trend, +89.0% -2.8 -5.1 -8.0 -6.7 7.8 -45.8 -38.9 -24.9 ·
P / FCF 8-point trend, +87.1% -2.7 -5.1 -8.0 -6.5 7.8 -42.8 -33.7 -21.2 ·
EV / EBITDA 8-point trend, +88.3% -0.6 -1.1 -3.8 -2.3 -14.6 -27.5 -25.3 -4.9 ·
EV / FCF 8-point trend, +97.8% -0.2 -1.1 -4.4 -2.2 5.1 -35.6 -27.8 -11.4 ·
EV / Revenue 8-point trend, -98.3% 0.3 1.1 19.6 4.7 53.2 132.4 30.3 15.1 ·
Earnings Yield 7-point trend, -85.5% -9.6% -14.4% -16.1% -15.5% -4.7% -3.6% -5.2% · ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Revenue $263M$263M$78M$131M$54M
Operating Margin % -45.1%-95.0%-511.5%-200.3%-418.2%
Net Income $-81M$-199M$-367M$-282M$-191M
Diluted EPS $-1.14$-2.77$-6.62$-5.31$-3.82
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Debt / Equity 0.00.00.00.00.0
Current Ratio 4.94.65.04.25.9
Quick Ratio 4.84.54.94.15.8
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-276M$-261M$-351M$-280M$555M

Latest News Recent headlines mentioning this company

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Institutional owners (13F) 222 filers · $383.7M total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
43 (+14 vs prior Q) 37 (+7 vs prior Q) 66 (+10 vs prior Q) 53 (-19 vs prior Q) +7.1M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
VANGUARD PORTFOLIO MANAGEMENT LLC $34,265,446 4,123,399 8.93% Shares
Pfizer Inc $27,662,520 3,457,815 7.21% Shares
Nextech Invest Ltd. $26,998,913 1,408,394 7.04% Shares
D. E. Shaw & Co., Inc. $25,317,977 3,046,688 6.60% Shares
ARMISTICE CAPITAL, LLC $23,234,760 2,796,000 6.05% Shares
VANGUARD CAPITAL MANAGEMENT LLC $22,554,695 2,714,163 5.88% Shares
TWO SIGMA INVESTMENTS, LP $21,385,345 2,573,447 5.57% Shares
STATE STREET CORP $18,256,006 2,196,872 4.76% Shares
New Leaf Venture Partners, L.L.C. $13,510,343 1,585,721 3.52% Shares
Qube Research & Technologies Ltd $13,231,814 1,592,276 3.45% Shares
GEODE CAPITAL MANAGEMENT, LLC $11,919,953 1,434,021 3.11% Shares
JACOBS LEVY EQUITY MANAGEMENT, INC $11,739,063 1,412,643 3.06% Shares
TWO SIGMA ADVISERS, LP $7,352,014 619,900 1.92% Shares
Hillsdale Investment Management Inc. $6,239,979 750,900 1.63% Shares
TCG Crossover Management, LLC $5,875,984 707,098 1.53% Shares
CITADEL ADVISORS LLC $5,106,570 614,509 1.33% Shares
DIMENSIONAL FUND ADVISORS LP $5,004,523 602,229 1.30% Shares
KENNEDY CAPITAL MANAGEMENT LLC $4,896,568 589,238 1.28% Shares
MILLENNIUM MANAGEMENT LLC $4,770,031 574,011 1.24% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $4,505,466 542,174 1.17% Shares
VANGUARD FIDUCIARY TRUST CO $3,550,231 427,224 0.93% Shares
ALGERT GLOBAL LLC $3,543,509 426,415 0.92% Shares
BlackRock, Inc. $3,394,701 408,508 0.88% Shares
FMR LLC $3,032,776 364,955 0.79% Shares
WASATCH ADVISORS LP $2,987,684 281,857 0.78% Shares
Ikarian Capital, LLC $2,977,115 358,257 0.78% Shares
Nextech Invest Ltd. $2,964,285 356,713 0.77% Shares
GOLDMAN SACHS GROUP INC $2,563,992 308,543 0.67% Shares
Aquilo Capital Management, LLC $2,532,577 360,766 0.66% Shares
Nantahala Capital Management, LLC $2,493,000 300,000 0.65% Shares
Arbiter Partners Capital Management LLC $2,448,076 294,594 0.64% Shares
Man Group plc $2,128,224 256,104 0.55% Shares
BANK OF AMERICA CORP /DE/ $1,988,782 239,324 0.52% Shares
MORGAN STANLEY $1,871,063 225,158 0.49% Shares
RENAISSANCE TECHNOLOGIES LLC $1,789,517 215,345 0.47% Shares
Squarepoint Ops LLC $1,677,141 201,822 0.44% Shares
Cubist Systematic Strategies, LLC $1,598,724 187,643 0.42% Shares
AMERIPRISE FINANCIAL INC $1,536,910 184,947 0.40% Shares
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $1,496,000 180,000 0.39% Shares
Rangeley Capital, LLC $1,459,153 175,590 0.38% Shares
Connor, Clark & Lunn Investment Management Ltd. $1,332,367 160,333 0.35% Shares
Susquehanna Portfolio Strategies, LLC $1,315,348 158,285 0.34% Shares
Point72 Asset Management, L.P. $1,173,920 141,266 0.31% Shares
Bank of New York Mellon Corp $1,159,760 139,562 0.30% Shares
OCCUDO QUANTITATIVE STRATEGIES LP $1,035,825 124,648 0.27% Shares
LPL Financial LLC $944,548 113,664 0.25% Shares
AMERICAN CENTURY COMPANIES INC $920,507 110,771 0.24% Shares
NORDEA INVESTMENT MANAGEMENT AB $912,146 108,978 0.24% Shares
Swiss National Bank $897,480 108,000 0.23% Shares
HSBC HOLDINGS PLC $868,736 102,809 0.23% Shares
VIRGINIA RETIREMENT SYSTEMS ET Al $837,909 70,650 0.22% Shares
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO $811,147 97,611 0.21% Shares
LOS ANGELES CAPITAL MANAGEMENT LLC $787,929 94,817 0.21% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $739,590 89,000 0.19% Call option
FEDERATED HERMES, INC. $739,042 88,934 0.19% Shares
Verition Fund Management LLC $702,004 84,477 0.18% Shares
BOOTHBAY FUND MANAGEMENT, LLC $685,425 82,482 0.18% Shares
CAXTON ASSOCIATES LLP $684,021 82,313 0.18% Shares
BARCLAYS PLC $679,907 81,818 0.18% Shares
ALLIANCEBERNSTEIN L.P. $676,492 63,820 0.18% Shares
Graham Capital Management, L.P. $676,135 81,364 0.18% Shares
RHUMBLINE ADVISERS $649,391 78,147 0.17% Shares
WOLVERINE TRADING, LLC $645,721 75,700 0.17% Call option
MANGROVE PARTNERS IM, LLC $633,388 76,220 0.17% Shares
Engineers Gate Manager LP $600,988 72,321 0.16% Shares
TEMA ETFS LLC $578,780 48,801 0.15% Shares
Assenagon Asset Management S.A. $568,869 68,456 0.15% Shares
Nebula Research & Development LLC $564,858 76,747 0.15% Shares
Quantinno Capital Management LP $555,075 66,796 0.14% Shares
Headlands Technologies LLC $502,223 60,436 0.13% Shares
Stonepine Capital Management, LLC $498,600 60,000 0.13% Shares
GLOBEFLEX CAPITAL L P $493,041 59,331 0.13% Shares
AlphaQuest LLC $491,668 41,456 0.13% Shares
ADAR1 Capital Management, LLC $478,581 57,591 0.12% Shares
Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group $477,825 57,500 0.12% Shares
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM $459,415 43,341 0.12% Shares
CITIGROUP INC $452,696 54,476 0.12% Shares
Longaeva Partners L.P. $439,923 52,939 0.11% Shares
ExodusPoint Capital Management, LP $423,253 50,933 0.11% Shares
STRS OHIO $409,683 49,300 0.11% Shares
EntryPoint Capital, LLC $399,894 48,122 0.10% Shares
FOX RUN MANAGEMENT, L.L.C. $398,182 47,916 0.10% Shares
Yelin Lapidot Holdings Management Ltd. $387,786 46,665 0.10% Shares
Virtus Investment Advisers, LLC $358,709 43,166 0.09% Shares
Schonfeld Strategic Advisors LLC $357,703 43,045 0.09% Shares
IEQ CAPITAL, LLC $344,408 41,445 0.09% Shares
Quinn Opportunity Partners LLC $342,896 41,263 0.09% Shares
CITADEL ADVISORS LLC $324,921 39,100 0.08% Call option
VOYA INVESTMENT MANAGEMENT LLC $319,943 38,501 0.08% Shares
RAYMOND JAMES FINANCIAL INC $299,135 35,997 0.08% Shares
MetLife Investment Management, LLC $295,271 35,532 0.08% Shares
Jain Global LLC $283,437 34,108 0.07% Shares
VANGUARD ASSET MANAGEMENT, Ltd $278,684 33,536 0.07% Shares
AlphaCentric Advisors LLC $254,469 30,622 0.07% Shares
Brevan Howard Capital Management LP $254,278 30,599 0.07% Shares
JANUS HENDERSON GROUP PLC $247,319 23,365 0.06% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $241,314 29,039 0.06% Shares
Dynamic Technology Lab Private Ltd $228,000 27,450 0.06% Shares
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. $227,561 27,384 0.06% Shares
Entropy Technologies, LP $227,021 27,319 0.06% Shares

Company insiders 20 insiders · 7 officers · 13 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
John G Houston President and CEO March 4, 2022 M 843,820 0 0 $0
Andrew Saik Chief Financial Officer June 24, 2026 S 187,432 0 1 $-46,479
Sean A Cassidy Chief Financial Officer March 11, 2022 M 161,447 0 0 $0
Angela M Cacace Chief Scientific Officer June 17, 2026 S 180,390 0 1 $-19,578
Ian Taylor Chief Scientific Officer March 31, 2022 G 80,962 0 0 $0
Ronald Peck Chief Medical Officer Feb. 23, 2022 A 5,402 0 0 $0
Andrew Crew Senior Vice President, Chemistry March 1, 2019 A 0 0 $0
Edward Moore Kennedy Jr. Director June 24, 2026 A 54,957 0 0 $0
Briggs Morrison Director June 24, 2026 A 111,548 0 0 $0
Alsup Laurie Smaldone Director June 24, 2026 A 41,572 0 0 $0
Linda Bain Director June 24, 2026 A 41,572 0 0 $0
Everett Cunningham Director June 24, 2026 A 41,572 0 0 $0
Leslie V Norwalk Director June 24, 2026 A 41,572 0 0 $0
Bradley Albert Margus Director June 16, 2022 A 2,000 0 0 $0
Liam Ratcliffe Director June 16, 2022 A 185,686 0 0 $0
Timothy M Shannon Director June 16, 2022 A 1,653,128 0 0 $0
Wendy L Dixon Director June 16, 2022 A 0 0 $0
Jakob Loven Director June 3, 2020 A 1,694,351 0 0 $0
Kush Parmar Director Sept. 24, 2019 G 1,775 0 0 $0
Craig Martin Crews 10% owner Sept. 26, 2018 J 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 1 position

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Logos Global Management LP, Logos Global Management GP LLC, Logos Global Master Fund LP, Logos GP LLC, Logos Opportunities Fund IV GP LLC, Logos Opportunities Fund IV LP, Arsani William, Graham Walmsley ×3 filings Oct. 15, 2025 3.40% Amendment Passive investment SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 46 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
PILL · Direxion Shares ETF Trust 0.81% 10,582 NS April 30, 2026 N-PORT
BBC · ETFis Series Trust I 0.58% 21,940 NS April 30, 2026 N-PORT
QQQS · Invesco Exchange-Traded Fund Trust … 0.48% 12,452 SH Aug. 8, 2026 Daily
CANC · Tema ETF Trust 0.43% 84,124 NS May 31, 2026 N-PORT
FSCC · Federated Hermes ETF Trust 0.27% 83,660 NS May 31, 2026 N-PORT
OASC · Unified Series Trust 0.18% 16,936 NS May 31, 2026 N-PORT
IHE · iShares Trust 0.12% 231,021 SH Aug. 8, 2026 Daily
ESSC · Strategy Shares 0.12% 3,026 NS April 30, 2026 N-PORT
PRFZ · Invesco Exchange-Traded Fund Trust 0.06% 202,038 SH Aug. 8, 2026 Daily
IBBQ · Invesco Exchange-Traded Fund Trust … 0.04% 3,479 SH Aug. 8, 2026 Daily
IBB · iShares Trust 0.04% 396,447 SH Aug. 8, 2026 Daily
VTWV · VANGUARD SCOTTSDALE FUNDS 0.03% 46,763 SH Aug. 8, 2026 Daily
IWN · iShares Trust 0.03% 502,091 SH Aug. 8, 2026 Daily
BIB · ProShares Trust 0.03% 2,363 NS May 31, 2026 N-PORT
AVSC · AMERICAN CENTURY ETF TRUST 0.03% 89,341 NS May 31, 2026 N-PORT
PKW · Invesco Exchange-Traded Fund Trust 0.02% 34,025 SH Aug. 8, 2026 Daily
RSSL · Global X Funds 0.02% 24,118 NS April 30, 2026 N-PORT
IWM · iShares Trust 0.02% 1,518,892 SH Aug. 8, 2026 Daily
DFAS · Dimensional ETF Trust 0.02% 212,759 NS April 30, 2026 N-PORT
GSSC · Goldman Sachs ETF Trust 0.01% 14,334 NS May 31, 2026 N-PORT
ITWO · ProShares Trust 0.01% 2,618 NS May 31, 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0.01% 305,573 NS May 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.01% 727,130 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.01% 341,952 SH Aug. 8, 2026 Daily
VHT · VANGUARD WORLD FUND 0.01% 163,348 SH Aug. 8, 2026 Daily
FHLC · FIDELITY COVINGTON TRUST 0.01% 25,043 NS April 30, 2026 N-PORT
TILT · FlexShares Trust 0.01% 16,551 NS April 30, 2026 N-PORT
UWM · ProShares Trust 0.01% 2,046 NS May 31, 2026 N-PORT
DXUV · Dimensional ETF Trust 0.01% 2,431 NS April 30, 2026 N-PORT
URTY · ProShares Trust 0.01% 2,073 NS May 31, 2026 N-PORT
WSML · iShares Trust 0.01% 3,938 SH Aug. 8, 2026 Daily
ONEQ · Fidelity Commonwealth Trust 0.00% 40,807 NS May 31, 2026 N-PORT
AVSU · AMERICAN CENTURY ETF TRUST 0.00% 1,599 NS May 31, 2026 N-PORT
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.00% 2,283 NS May 31, 2026 N-PORT
IWO · iShares Trust 0.00% 46,084 SH Aug. 8, 2026 Daily
HDG · ProShares Trust 0.00% 52 NS May 31, 2026 N-PORT
SCHB · SCHWAB STRATEGIC TRUST 0.00% 47,280 NS May 31, 2026 N-PORT
ITOT · iShares Trust 0.00% 95,479 SH Aug. 8, 2026 Daily
IWV · iShares Trust 0.00% 14,773 SH Aug. 8, 2026 Daily
DCOR · Dimensional ETF Trust 0.00% 1,710 NS April 30, 2026 N-PORT
DFUS · Dimensional ETF Trust 0.00% 10,043 NS April 30, 2026 N-PORT
AVUS · AMERICAN CENTURY ETF TRUST 0.00% 4,550 NS May 31, 2026 N-PORT
DFAC · Dimensional ETF Trust 0.00% 11,109 NS April 30, 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0.00% 1,920,682 SH Aug. 8, 2026 Daily
VTWG · VANGUARD SCOTTSDALE FUNDS 0.00% 6,113 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.00% 4,186 SH Aug. 8, 2026 Daily