COGT Cogent Biosciences, Inc. - Common Stock

NASDAQ · Biotechnology · View on SEC EDGAR ↗
$37.62
Price · Aug 19, 2026
Fundamentals as of Aug 10, 2026
52W Range
$12–$44
81% of range
Analyst Rating
STRONG BUY
19 analysts
Price Target
$54
+43% upside
P/E (TTM)
-17.4
ROE
-83.1%
Net Profit Margin
—

COGT Stock Snapshot Price, market cap, P/E, EPS, ROE, debt/equity, 52-week range

Price
$37.62
Market Cap
$6.06B
P/E (TTM)
-17.4
EPS (TTM)
$-2.16
Revenue (TTM)
—
Div Yield
—
ROE
-83.1%
Debt/Equity
—
52W Range
$12 – $44

COGT Stock Price Chart Daily OHLCV with technical indicators — pan, zoom, and customize your view

10-Year Performance Revenue, net income, margins and EPS trends

Revenue & Net Income —
4-point trend, -5.8%
2017-12-31 → 2020-12-31
EPS $-2.16
5-point trend, -15.5%
2021-12-31 → 2025-12-31
Free Cash Flow $-266M
7-point trend, -705.1%
2018-12-31 → 2025-12-31
Margins —

Valuation P/E, P/S, P/B, EV/EBITDA ratios — is the stock expensive or cheap?

Metric
5Y trend
COGT
Peer Median
P/E (TTM)
5-point trend, -258.4%
-17.4
16.0
P/S (TTM)
5-point trend, +1421.3%
261.5
47.5
P/B
5-point trend, +412.0%
9.5
8.5
Price / FCF
5-point trend, -245.9%
-22.8
—

Profitability Gross, operating and net margins; ROE, ROA, ROIC

Metric
5Y trend
COGT
Peer Median
ROA
5-point trend, -73.7%
-52.0%
-45.0%
ROE
5-point trend, -136.6%
-83.1%
-86.5%

Financial Health Debt, liquidity, solvency — balance sheet strength

Metric
5Y trend
COGT
Peer Median
Current Ratio
5-point trend, +9.2%
14.2
5.8
Quick Ratio
5-point trend, -62.1%
4.9
—

Growth Revenue, EPS and net income growth: YoY, 3Y CAGR, 5Y CAGR

Metric
5Y trend
COGT
Peer Median

Per Share Metrics EPS, book value per share, cash flow per share, dividend per share

Metric
5Y trend
COGT
Peer Median
EPS (Diluted)
5-point trend, -15.5%
$-2.16
—

Capital Efficiency Asset turnover, inventory turnover, receivables turnover

Metric
5Y trend
COGT
Peer Median

COGT Analyst Consensus Bullish and bearish analyst opinions, 12-month price target, upside

BUY 19 analysts
  • Strong Buy 8 42.1%
  • Buy 8 42.1%
  • Hold 3 15.8%
  • Sell 0 0.0%
  • Strong Sell 0 0.0%

12-Month Price Target

12 analysts · 2026-08-16
Median target $55.00 +46.2%
Mean target $53.83 +43.1%

Earnings History EPS actual vs estimate, surprise %, beat rate, next earnings date

Avg Surprise
0.01%
Period EPS Actual EPS Est Surprise
March 31, 2026 $-0.60 $-0.55 -0.05%
Dec. 31, 2025 $-0.64 $-0.53 -0.11%
Sept. 30, 2025 $-0.50 $-0.54 0.04%
June 30, 2025 $-0.53 $-0.60 0.07%
March 31, 2025 $-0.52 $-0.60 0.08%

Peer comparison (GICS sub-industry) Key metrics vs sector peers

Ticker Market Cap P/E Rev YoY Net Margin ROE Gross Margin
COGT $5.72B -16.4 — — -83.1% —
CGON $3.35B -20.0 254.7% -3985.0% -22.6% —
SRRK $4.78B -13.4 — — -157.9% —
MIRM $4.10B -168.1 54.7% -4.5% -8.2% —
CAI $7.62B -8.4 97.0% -8.4% -13.2% —
DNTH $1.78B -9.8 -67.3% -7973.3% -40.8% —
ERAS $1.06B -8.5 — — -35.7% —
TVTX $3.47B -131.8 110.5% -5.2% -34.6% —
PTCT $6.19B 9.8 114.5% 39.4% -331.5% —

Full Fundamentals All metrics by year — income statement, balance sheet, cash flow

Income Statement 14
Annual Income Statement data for COGT
Metric Trend 202520242023202220212020201920182017
Revenue 4-point trend, -5.8% · · · · · $8M $22M $10M $8M
R&D Expense 9-point trend, +804.3% $270M $233M $174M $122M $56M $26M $44M $38M $30M
SG&A Expense 9-point trend, +1258.6% $64M $43M $34M $26M $20M $17M $11M $7M $5M
Operating Expenses 9-point trend, +865.9% $333M $276M $208M $148M $76M $90M $55M $46M $35M
Operating Income 9-point trend, -1174.7% $-333M $-276M $-208M $-148M $-76M $-82M $-32M $-36M $-26M
Interest Income 9-point trend, +3705.4% $15M $18M $13M $4M $467.0K $144.0K $267.0K $1M $386.0K
Other Non-op 9-point trend, -107.3% $-20.0K $2M $943.0K $2M $3M $7M $345.0K $320.0K $274.0K
Income Tax $0 · · · · · · · ·
Net Income 9-point trend, -1190.4% $-329M $-256M $-192M $-140M $-72M $-75M $-32M $-35M $-25M
EPS (Basic) 5-point trend, -15.5% $-2.16 $-1.94 $-1.94 $-1.73 $-1.87 · · · ·
EPS (Diluted) 5-point trend, -15.5% $-2.16 $-1.94 $-1.94 $-1.73 $-1.87 · · · ·
Shares (Basic) 5-point trend, +232.8% 128,899,408 103,856,611 79,657,942 58,739,713 38,730,813 · · · ·
Shares (Diluted) 5-point trend, +232.8% 128,899,408 103,856,611 79,657,942 58,739,713 38,730,813 · · · ·
EBITDA 8-point trend, -825.9% $-333M $-276M $-208M $-148M $-76M $-82M $-32M $-36M ·
Balance Sheet 22
Annual Balance Sheet data for COGT
Metric Trend 202520242023202220212020201920182017
Cash & Equivalents 9-point trend, +1003.7% $312M $98M $53M $140M $220M $242M $37M $56M $28M
Short-term Investments 2-point trend, +80.6% · · · · · · · $23M $13M
Receivables 3-point trend, +141.0% · · · · · · $2M $2M $830.0K
Prepaid Expense 9-point trend, +1769.4% $10M $9M $5M $4M $3M $3M $1M $740.0K $513.0K
Current Assets 9-point trend, +2048.1% $910M $296M $271M $265M $223M $245M $41M $81M $42M
PP&E (Net) 9-point trend, +32.8% $5M $6M $8M $8M $2M $134.0K $2M $3M $4M
PP&E (Gross) 9-point trend, +124.8% $14M $13M $12M $9M $2M $546.0K $6M $7M $6M
Accum. Depreciation 9-point trend, +298.1% $9M $6M $4M $1M $559.0K $412.0K $5M $3M $2M
Other Non-current Assets 7-point trend, +687.8% $3M $5M $5M $5M $4M · $427.0K $419.0K ·
Total Assets 9-point trend, +1809.0% $938M $328M $313M $301M $232M $251M $49M $86M $49M
Accounts Payable 9-point trend, +606.1% $10M $12M $11M $6M $3M $732.0K $3M $2M $1M
Current Liabilities 9-point trend, +471.5% $64M $56M $38M $27M $17M $13M $13M $25M $11M
Capital Leases 7-point trend, +225.3% $14M $16M $17M $18M $831.0K $3M $4M · ·
Other Non-current Liabilities 2-point trend, +33000.00 $33.0K $0 · · · · · · ·
Total Liabilities 9-point trend, +1347.6% $301M $72M $56M $45M $18M $16M $18M $26M $21M
Long-term Debt $223M · · · · · · · ·
Common Stock 9-point trend, +1510.0% $161.0K $110.0K $86.0K $70.0K $44.0K $32.0K $8.0K $30.0K $10.0K
Retained Earnings 9-point trend, -2214.8% $-1.19B $-859M $-604M $-411M $-271M $-199M $-124M $-92M $-51M
AOCI 6-point trend, +2318.8% $355.0K $447.0K $246.0K $-104.0K · · · $-12.0K $-16.0K
Stockholders' Equity 9-point trend, +1402.8% $636M $256M $258M $256M $214M $235M $32M $60M $-49M
Liabilities + Equity 9-point trend, +1809.0% $938M $328M $313M $301M $232M $251M $49M $86M $49M
Shares Outstanding 9-point trend, +1478.0% 160,980,024 110,461,729 86,124,249 69,893,434 43,805,922 32,347,905 7,665,763 30,057,970 10,201,690
Cash Flow 15
Annual Cash Flow data for COGT
Metric Trend 202520242023202220212020201920182017
D&A 9-point trend, +122.0% $3M $2M $2M $800.0K $147.0K $720.0K $1M $1M $1M
Stock-based Comp 9-point trend, +3336.2% $46M $40M $31M $18M $12M $6M $3M $3M $1M
Deferred Tax Flat — no change across 9 periods $0 $0 $0 $0 $0 $0 $0 $0 $0
Restructuring · · · · · $4M · · ·
Operating Cash Flow 9-point trend, -923.6% $-264M $-208M $-154M $-119M $-59M $-36M $-42M $-32M $-26M
CapEx 8-point trend, +70.4% $2M $573.0K $3M $7M $2M · $33.0K $549.0K $912.0K
Investing Cash Flow 9-point trend, -3040.3% $-400M $38M $-98M $-125M $-2M $8M $23M $-11M $14M
Debt Issued 3-point trend, +49291000.00 $49M $0 $0 · · · · · ·
Net Debt Issued $49M · · · · · · · ·
Stock Issued 8-point trend, -100.0% · $0 $162M $0 $0 $25M $108.0K $609.0K $60.0K
Net Stock Activity 5-point trend, -100.0% · $0 $162M · · $25M $108.0K $609.0K ·
Financing Cash Flow 9-point trend, +120570.9% $878M $214M $164M $164M $38M $232M $108.0K $70M $-729.0K
Net Change in Cash 9-point trend, +1751.2% $214M $45M $-88M $-80M $-23M $205M $-18M $27M $-13M
Taxes Paid $0 · · · · · · · ·
Free Cash Flow 7-point trend, -705.1% $-266M $-208M $-156M $-126M $-60M · $-42M $-33M ·
Profitability 5
Annual Profitability data for COGT
Metric Trend 202520242023202220212020201920182017
Operating Margin 3-point trend, -182.3% · · · · · -1044.3% -143.0% -369.9% ·
Net Margin 3-point trend, -167.9% · · · · · -950.4% -141.5% -354.8% ·
EBITDA Margin 3-point trend, -182.3% · · · · · -1044.3% -143.0% -369.9% ·
ROA 8-point trend, -1.7% -52.0% -79.8% -62.6% -52.6% -29.9% -49.8% -47.0% -51.1% ·
ROE 8-point trend, -53.8% -83.1% -89.6% -68.6% -51.4% -35.1% -70.4% -105.4% -54.1% ·
Liquidity & Solvency 2
Annual Liquidity & Solvency data for COGT
Metric Trend 202520242023202220212020201920182017
Current Ratio 8-point trend, +338.4% 14.2 5.3 7.1 9.9 13.0 18.7 3.1 3.2 ·
Quick Ratio 8-point trend, +51.6% 4.9 1.8 1.4 5.2 12.9 18.5 3.0 3.2 ·
Efficiency 2
Annual Efficiency data for COGT
Metric Trend 202520242023202220212020201920182017
Asset Turnover 3-point trend, -63.7% · · · · · 0.1 0.3 0.1 ·
Receivables Turnover 2-point trend, +57.4% · · · · · · 12.3 7.8 ·
Per Share 4
Annual Per Share data for COGT
Metric Trend 202520242023202220212020201920182017
Book Value / Share 8-point trend, +97.3% $3.95 $2.32 $2.99 $3.66 $4.89 $7.25 $1.04 $2.00 ·
Cash Flow / Share 4-point trend, -1.6% $-2.05 $-2.00 $-1.93 $-2.02 · · · · ·
Cash / Share 8-point trend, +4.6% $1.94 $0.89 $0.62 $2.00 $5.01 $7.49 $1.22 $1.85 ·
EPS (TTM) 8-point trend, -35.0% $-2.16 $-1.94 $-1.94 $-1.73 $-1.87 $-1.05 $-1.05 $-1.60 ·
Valuation (TTM) 10
Annual Valuation (TTM) data for COGT
Metric Trend 202520242023202220212020201920182017
Revenue TTM 8-point trend, +137.9% $23M $23M $23M $23M $23M $8M $22M $10M ·
Net Income TTM 8-point trend, -852.6% $-329M $-256M $-192M $-140M $-72M $-75M $-32M $-35M ·
Market Cap 8-point trend, +980.9% $5.72B $862M $506M $808M $376M $363M $88M $529M ·
P/E 8-point trend, -49.5% -16.4 -4.0 -3.0 -6.7 -4.6 -10.7 -2.7 -11.0 ·
P/S 8-point trend, +354.3% 246.9 37.2 21.9 34.9 16.2 46.2 3.9 54.3 ·
P/B 8-point trend, +2.3% 9.0 3.4 2.0 3.2 1.8 1.5 2.8 8.8 ·
P / Tangible Book 6-point trend, +480.4% 9.0 3.4 2.0 3.2 1.8 1.5 · · ·
P / Cash Flow 8-point trend, -32.8% -21.6 -4.1 -3.3 -6.8 -6.4 -10.1 -2.1 -16.3 ·
P / FCF 7-point trend, -34.2% -21.5 -4.1 -3.2 -6.4 -6.2 · -2.1 -16.0 ·
Earnings Yield 8-point trend, +33.1% -6.1% -24.9% -33.0% -15.0% -21.8% -9.3% -36.5% -9.1% ·

Financial Statements Income statement, balance sheet, cash flow — annual, last 5 years

Income Statement
2025-12-312024-12-312023-12-312022-12-312021-12-31
Net Income $-329M$-256M$-192M$-140M$-72M
Diluted EPS $-2.16$-1.94$-1.94$-1.73$-1.87
Balance Sheet
2025-12-312024-12-312023-12-312022-12-312021-12-31
Current Ratio 14.25.37.19.913.0
Quick Ratio 4.91.81.45.212.9
Cash Flow
2025-12-312024-12-312023-12-312022-12-312021-12-31
Free Cash Flow $-266M$-208M$-156M$-126M$-60M

Latest News Recent headlines mentioning this company

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Institutional owners (13F) 342 filers · $5.5B total · As of June 30, 2026

Institutions that report holding this stock in their quarterly SEC Form 13F. Long positions only; a single filer may appear twice for separate option legs. Large offsetting put/call legs typically reflect market-making or hedged inventory, not directional conviction.

Institutional activity — Q2 2026 vs prior quarter
New positions Exited positions Increased Decreased Net shares change
71 (-4 vs prior Q) 40 (+6 vs prior Q) 119 (+7 vs prior Q) 93 (+10 vs prior Q) +18.6M

Compared to Q1 2026. SEC Form 13F filings are due within 45 days of quarter-end plus a short buffer for late filers — quarters still inside that window are skipped in favor of the most recent fully-reported pair.

Institution Value Shares % of tracked 13F Type
FMR LLC $868,722,546 22,447,611 15.68% Shares
VANGUARD PORTFOLIO MANAGEMENT LLC $312,402,306 8,072,411 5.64% Shares
VANGUARD CAPITAL MANAGEMENT LLC $286,857,171 7,412,330 5.18% Shares
STATE STREET CORP $269,542,365 6,964,919 4.87% Shares
Fairmount Funds Management LLC $212,982,277 5,503,418 3.84% Shares
DEERFIELD MANAGEMENT COMPANY, L.P. $193,736,225 5,006,104 3.50% Shares
TCG Crossover Management, LLC $187,866,673 4,854,436 3.39% Shares
GEODE CAPITAL MANAGEMENT, LLC $150,424,045 3,885,979 2.72% Shares
Kynam Capital Management, LP $141,916,654 3,667,097 2.56% Shares
Polar Capital Holdings Plc $125,113,424 3,232,905 2.26% Shares
Commodore Capital LP $118,035,000 3,050,000 2.13% Shares
WELLINGTON MANAGEMENT GROUP LLP $108,741,040 2,809,846 1.96% Shares
Woodline Partners LP $100,742,369 2,603,162 1.82% Shares
Pictet Asset Management Holding SA $92,634,023 2,393,515 1.67% Shares
Octagon Capital Advisors LP $90,945,000 2,350,000 1.64% Shares
RTW INVESTMENTS, LP $89,359,113 2,309,021 1.61% Shares
Candriam S.C.A. $80,742,121 2,088,369 1.46% Shares
Deep Track Capital, LP $77,400,000 2,000,000 1.40% Shares
Siren, L.L.C. $71,954,097 1,859,279 1.30% Shares
ORBIMED ADVISORS LLC $65,066,310 1,681,300 1.17% Shares
Venrock Adviser, LLC $63,551,824 1,642,166 1.15% Shares
GOLDMAN SACHS GROUP INC $63,052,788 1,629,271 1.14% Shares
EMERALD ADVISERS, LLC $62,048,445 1,603,319 1.12% Shares
CHARLES SCHWAB INVESTMENT MANAGEMENT INC $56,087,910 1,449,300 1.01% Shares
Assenagon Asset Management S.A. $55,795,957 1,441,756 1.01% Shares
AMERICAN CENTURY COMPANIES INC $55,455,537 1,432,957 1.00% Shares
SILVERARC CAPITAL MANAGEMENT, LLC $49,563,361 1,280,707 0.89% Shares
VANGUARD FIDUCIARY TRUST CO $46,962,837 1,213,510 0.85% Shares
Elmind Capital, LP $45,307,638 1,170,740 0.82% Shares
FRED ALGER MANAGEMENT, LLC $41,518,521 1,072,830 0.75% Shares
Sofinnova Investments, Inc. $40,060,228 1,035,148 0.72% Shares
EMERALD MUTUAL FUND ADVISERS TRUST $39,914,329 1,031,378 0.72% Shares
BANK OF AMERICA CORP /DE/ $38,680,534 999,497 0.70% Shares
RENAISSANCE TECHNOLOGIES LLC $38,551,702 996,168 0.70% Shares
Balyasny Asset Management L.P. $36,952,424 954,843 0.67% Shares
MILLENNIUM MANAGEMENT LLC $35,128,454 907,712 0.63% Shares
Logos Global Management LP $34,830,000 900,000 0.63% Shares
Squadron Capital Management LLC $33,475,500 865,000 0.60% Shares
CITADEL ADVISORS LLC $32,883,158 849,694 0.59% Shares
D. E. Shaw & Co., Inc. $29,941,106 773,672 0.54% Shares
Point72 Asset Management, L.P. $28,800,347 744,195 0.52% Shares
MARSHALL WACE, LLP $27,328,122 706,153 0.49% Shares
BOOTHBAY FUND MANAGEMENT, LLC $26,812,328 692,825 0.48% Shares
J. Goldman & Co LP $24,690,368 637,994 0.45% Shares
First Turn Management, LLC $23,308,275 602,281 0.42% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $23,119,380 597,400 0.42% Call option
ALLIANCEBERNSTEIN L.P. $22,042,992 572,694 0.40% Shares
Rock Springs Capital Management LP $19,965,988 515,917 0.36% Shares
Redmile Group, LLC $19,478,523 503,321 0.35% Shares
DIADEMA PARTNERS LP $19,104,797 493,664 0.34% Shares
Eversept Partners, LP $18,972,094 490,235 0.34% Shares
SPHERA FUNDS MANAGEMENT LTD. $17,776,458 459,340 0.32% Shares
Ensign Peak Advisors, Inc $17,697,587 457,302 0.32% Shares
Affinity Asset Advisors, LLC $17,415,000 450,000 0.31% Shares
BlackRock, Inc. $16,916,738 437,125 0.31% Shares
Patient Square Capital LP $16,447,500 425,000 0.30% Shares
SEGALL BRYANT & HAMILL, LLC $16,300,711 421,207 0.29% Shares
AMERIPRISE FINANCIAL INC $16,177,723 418,029 0.29% Shares
Defilade Capital Management, L.P. $15,226,167 393,441 0.27% Shares
Aberdeen Group plc $15,218,156 393,234 0.27% Shares
NOMURA ASSET MANAGEMENT INTERNATIONAL INC. $15,189,000 392,484 0.27% Shares
Ikarian Capital, LLC $14,322,251 370,084 0.26% Shares
KENNEDY CAPITAL MANAGEMENT LLC $13,691,673 353,790 0.25% Shares
SUPERSTRING CAPITAL MANAGEMENT LP $13,285,091 343,284 0.24% Shares
BNP PARIBAS FINANCIAL MARKETS $12,861,326 332,334 0.23% Shares
Burkehill Global Management, LP $12,577,500 325,000 0.23% Shares
FEDERATED HERMES, INC. $10,951,287 282,979 0.20% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $10,799,854 279,066 0.19% Shares
Alyeska Investment Group, L.P. $10,636,656 274,849 0.19% Shares
NEUBERGER BERMAN GROUP LLC $9,918,346 256,288 0.18% Shares
Parkman Healthcare Partners LLC $9,805,226 253,365 0.18% Shares
Evergreen Quality Fund GP, Ltd. $9,675,000 250,000 0.17% Shares
Swiss National Bank $9,535,680 246,400 0.17% Shares
Russell Investments Group, Ltd. $8,936,487 230,917 0.16% Shares
Susquehanna Portfolio Strategies, LLC $8,891,519 229,755 0.16% Shares
F/m Investments LLC $8,850,226 228,688 0.16% Shares
SEB Asset Management AB $8,827,182 228,093 0.16% Shares
PEREGRINE CAPITAL MANAGEMENT LLC $8,759,745 226,350 0.16% Shares
Boxer Capital Management, LLC $8,707,500 225,000 0.16% Shares
NEW YORK STATE COMMON RETIREMENT FUND $8,673,289 224,116 0.16% Shares
Exome Asset Management LLC $8,147,240 210,523 0.15% Shares
RHUMBLINE ADVISERS $8,034,456 207,609 0.15% Shares
Integral Health Asset Management, LLC $7,740,000 200,000 0.14% Shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP $7,472,970 193,100 0.13% Put option
Pier Capital, LLC $7,312,404 188,951 0.13% Shares
HighVista Strategies LLC $7,305,786 188,780 0.13% Shares
Jefferies Financial Group Inc. $7,281,753 188,159 0.13% Shares
Fisher Asset Management, LLC $7,154,661 184,875 0.13% Shares
Caption Management, LLC $7,124,670 184,100 0.13% Call option
SummitTX Capital, L.P. $6,955,706 179,734 0.13% Shares
OSTERWEIS CAPITAL MANAGEMENT INC $6,659,690 172,085 0.12% Shares
CITIGROUP INC $6,611,315 170,835 0.12% Shares
Qube Research & Technologies Ltd $6,547,963 169,198 0.12% Shares
Schonfeld Strategic Advisors LLC $6,544,672 169,113 0.12% Shares
Man Group plc $6,496,105 167,858 0.12% Shares
VOYA INVESTMENT MANAGEMENT LLC $6,491,112 167,729 0.12% Shares
SILVERCREST ASSET MANAGEMENT GROUP LLC $6,174,392 159,545 0.11% Shares
Nuveen, LLC $6,140,258 158,663 0.11% Shares
Atika Capital Management LLC $6,130,970 158,423 0.11% Shares
WELLS FARGO & COMPANY/MN $6,096,256 157,526 0.11% Shares

Company insiders 25 insiders · 11 officers · 13 directors

Insider Role Last activity Shares owned Buys 12m Sells 12m Net 12m
Andrew R Robbins President and CEO May 19, 2026 G 160,000 0 0 $0
Charles Wilson Chief Executive Officer March 1, 2019 A — 0 0 $0
John L. Green Chief Financial Officer Dec. 26, 2025 S 131,834 0 1 $-2,978,360
Matthew Scott Osborne Chief Financial Officer Feb. 11, 2020 A — 0 0 $0
John Edward Robinson Chief Scientific Officer Dec. 26, 2025 S 140,002 0 1 $-3,486,600
Jessica Sachs Chief Medical Officer Dec. 26, 2025 S 133,938 0 1 $-3,198,245
Evan Kearns Chief Legal Officer Dec. 26, 2025 S 109,398 0 1 $-2,515,500
Cole Pinnow Chief Commercial Officer Dec. 17, 2025 A 216,650 0 0 $0
Geoffrey Hodge Chief Technical Officer Feb. 11, 2020 A — 0 0 $0
Seth Ettenberg Chief Scientific Officer Feb. 11, 2020 A 0 0 0 $0
Michael Vasconcelles Chief Medical Officer March 1, 2019 A — 0 0 $0
Karen Jean Ferrante Director July 1, 2026 A — 0 0 $0
Christopher W. Cain Director June 9, 2026 A — 0 0 $0
Todd Shegog Director June 9, 2026 A — 0 0 $0
Matthew Ros Director June 9, 2026 A — 0 0 $0
Peter Harwin Director June 9, 2026 A — 0 0 $0
Arlene Morris Director June 9, 2026 A — 0 0 $0
Fairmount Funds Management LLC Director March 31, 2026 C 5,503,418 0 2 $-370,020,000
Jorn Aldag Director July 1, 2020 A — 0 0 $0
Bruce Booth Director July 1, 2020 A 3,361,535 0 0 $0
Liam Ratcliffe Director June 14, 2019 A 897,773 0 0 $0
Robert J Perez Director June 14, 2019 A — 0 0 $0
Dario Campana 10% owner May 12, 2020 S 3,095,114 0 0 $0
FIL Ltd — April 3, 2018 C 1,138,274 0 0 $0
FMR LLC — April 3, 2018 C 23,240 0 0 $0

Insiders from SEC Form 3/4/5 filings; net = open-market P/S only

Activists & 5%+ owners 1 position

Investors who filed SEC Schedule 13D — beneficial ownership above 5% with an intent to influence the issuer (activist stakes, board campaigns, M&A). Each row shows the most recent known state of that filer's position.

Filer Filed Stake Status Purpose Filing
Fairmount Funds Management LLC, Fairmount Healthcare Fund II GP LLC ×11 filings March 31, 2026 8.60% Amendment — SEC

Purpose is an automated classification of the filer's own stated purpose (SEC Item 4) — not investment advice. "—" means no clear purpose was stated or the text could not be classified.

ETF ownership Held by 46 ETFs

Weight reflects direct equity holdings (N-PORT) only; leveraged or derivative-based funds may hold additional swap exposure not shown.

Fund Weight Units As of Source
LFSC · RBB Fund, Inc. 7.53% 226,142 NS May 31, 2026 N-PORT
CANC · Tema ETF Trust 4.10% 206,419 NS May 31, 2026 N-PORT
FMED · Fidelity Covington Trust 2.85% 33,428 NS May 31, 2026 N-PORT
LABU · Direxion Shares ETF Trust 0.93% 134,554 NS April 30, 2026 N-PORT
BBC · ETFis Series Trust I 0.63% 6,554 NS April 30, 2026 N-PORT
IBBQ · Invesco Exchange-Traded Fund Trust … 0.49% 9,297 SH Aug. 8, 2026 Daily
IBB · iShares Trust 0.47% 1,079,378 SH Aug. 8, 2026 Daily
IWO · iShares Trust 0.43% 1,511,513 SH Aug. 8, 2026 Daily
ESSC · Strategy Shares 0.42% 3,026 NS April 30, 2026 N-PORT
VTWG · VANGUARD SCOTTSDALE FUNDS 0.38% 178,467 SH Aug. 8, 2026 Daily
BIB · ProShares Trust 0.28% 6,002 NS May 31, 2026 N-PORT
FFSM · FIDELITY COVINGTON TRUST 0.25% 89,450 NS April 30, 2026 N-PORT
BBSC · J.P. Morgan Exchange-Traded Fund Tr… 0.22% 45,155 NS April 30, 2026 N-PORT
IWM · iShares Trust 0.22% 4,223,751 SH Aug. 8, 2026 Daily
ISCG · iShares Trust 0.20% 48,762 SH Aug. 8, 2026 Daily
VTWO · VANGUARD SCOTTSDALE FUNDS 0.20% 959,613 SH Aug. 8, 2026 Daily
BKSE · BNY Mellon ETF Trust 0.18% 4,161 NS April 30, 2026 N-PORT
VFMO · VANGUARD WELLINGTON FUND 0.17% 85,339 SH Aug. 8, 2026 Daily
RSSL · Global X Funds 0.16% 62,036 NS April 30, 2026 N-PORT
VBR · VANGUARD INDEX FUNDS 0.13% 2,363,019 SH Aug. 8, 2026 Daily
ITWO · ProShares Trust 0.13% 6,734 NS May 31, 2026 N-PORT
SCHA · SCHWAB STRATEGIC TRUST 0.11% 738,864 NS May 31, 2026 N-PORT
ISCB · iShares Trust 0.10% 6,956 SH Aug. 8, 2026 Daily
ESML · iShares Trust 0.08% 57,512 SH Aug. 8, 2026 Daily
VB · VANGUARD INDEX FUNDS 0.08% 3,722,357 SH Aug. 8, 2026 Daily
UWM · ProShares Trust 0.07% 5,268 NS May 31, 2026 N-PORT
VXF · VANGUARD INDEX FUNDS 0.07% 1,958,933 SH Aug. 8, 2026 Daily
VHT · VANGUARD WORLD FUND 0.07% 368,585 SH Aug. 8, 2026 Daily
PRFZ · Invesco Exchange-Traded Fund Trust 0.06% 43,571 SH Aug. 8, 2026 Daily
GSSC · Goldman Sachs ETF Trust 0.06% 17,403 NS May 31, 2026 N-PORT
URTY · ProShares Trust 0.05% 5,326 NS May 31, 2026 N-PORT
AVIE · AMERICAN CENTURY ETF TRUST 0.05% 147 NS May 31, 2026 N-PORT
FHLC · FIDELITY COVINGTON TRUST 0.05% 38,351 NS April 30, 2026 N-PORT
WSML · iShares Trust 0.05% 7,228 SH Aug. 8, 2026 Daily
MSSM · MORGAN STANLEY PATHWAY FUNDS 0.03% 5,488 NS May 31, 2026 N-PORT
HDG · ProShares Trust 0.02% 134 NS May 31, 2026 N-PORT
SMLF · iShares Trust 0.02% 18,861 SH Aug. 8, 2026 Daily
ONEQ · Fidelity Commonwealth Trust 0.01% 42,596 NS May 31, 2026 N-PORT
VTI · VANGUARD INDEX FUNDS 0.01% 5,158,077 SH Aug. 8, 2026 Daily
VT · VANGUARD INTERNATIONAL EQUITY INDEX… 0.01% 133,924 SH Aug. 8, 2026 Daily
VTHR · VANGUARD SCOTTSDALE FUNDS 0.01% 13,697 SH Aug. 8, 2026 Daily
ESGV · VANGUARD WORLD FUND 0.01% 36,815 SH Aug. 8, 2026 Daily
ITOT · iShares Trust 0.01% 228,068 SH Aug. 8, 2026 Daily
TILT · FlexShares Trust 0.01% 5,513 NS April 30, 2026 N-PORT
IWV · iShares Trust 0.01% 44,292 SH Aug. 8, 2026 Daily
SCHB · SCHWAB STRATEGIC TRUST 0.01% 92,899 NS May 31, 2026 N-PORT