ORIC — Détenteurs institutionnels (13F)
Institutions qui déclarent détenir cette action dans leur Formulaire SEC 13F trimestriel. Uniquement les positions longues ; un même déclarant peut apparaître deux fois pour des jambes d'options distinctes. Les jambes put/call compensatoires importantes reflètent généralement la tenue de marché ou un inventaire couvert, pas une conviction directionnelle.
| Institution | Valeur | Actions | % de 13F suivies | Type |
|---|---|---|---|---|
| Nextech Invest Ltd. | $77 571 359 | 7 162 637 | 5,94% | Actions |
| BlackRock, Inc. | $73 903 628 | 6 823 973 | 5,66% | Actions |
| EcoR1 Capital, LLC | $72 865 496 | 6 728 116 | 5,58% | Actions |
| VIKING GLOBAL INVESTORS LP | $55 522 832 | 5 126 762 | 4,25% | Actions |
| STATE STREET CORP | $53 002 020 | 4 894 000 | 4,06% | Actions |
| SR One Capital Management, LP | $49 984 609 | 4 615 384 | 3,83% | Actions |
| Venrock Adviser, LLC | $46 783 055 | 4 319 765 | 3,58% | Actions |
| NEA Management Company, LLC | $44 604 665 | 4 118 621 | 3,42% | Actions |
| VANGUARD CAPITAL MANAGEMENT LLC | $42 791 160 | 3 951 169 | 3,28% | Actions |
| AIHC Capital Management Ltd | $41 462 222 | 3 828 460 | 3,18% | Actions |
| ALKEON CAPITAL MANAGEMENT LLC | $40 494 410 | 3 739 096 | 3,10% | Actions |
| Column Group LLC | $38 346 615 | 3 540 777 | 2,94% | Actions |
| VANGUARD GROUP INC | $37 153 347 | 4 541 974 | 2,85% | Actions |
| Siren, L.L.C. | $32 470 419 | 2 998 192 | 2,49% | Actions |
| FMR LLC | $28 542 194 | 2 635 475 | 2,19% | Actions |
| CITADEL ADVISORS LLC | $28 107 088 | 2 595 299 | 2,15% | Actions |
| GOLDMAN SACHS GROUP INC | $26 552 951 | 2 451 796 | 2,03% | Actions |
| GEODE CAPITAL MANAGEMENT, LLC | $22 639 952 | 2 090 089 | 1,73% | Actions |
| First Turn Management, LLC | $21 847 186 | 2 017 284 | 1,67% | Actions |
| ORBIMED ADVISORS LLC | $21 822 450 | 2 015 000 | 1,67% | Actions |
| Integral Health Asset Management, LLC | $20 577 000 | 1 900 000 | 1,58% | Actions |
| MPM BIOIMPACT LLC | $20 383 814 | 1 882 162 | 1,56% | Actions |
| Vivo Capital, LLC | $20 022 352 | 1 848 786 | 1,53% | Actions |
| DIMENSIONAL FUND ADVISORS LP | $19 503 242 | 1 801 399 | 1,49% | Actions |
| FRANKLIN RESOURCES INC | $19 465 593 | 1 797 377 | 1,49% | Actions |
| MORGAN STANLEY | $19 429 237 | 1 794 020 | 1,49% | Actions |
| D. E. Shaw & Co., Inc. | $17 113 739 | 1 580 216 | 1,31% | Actions |
| Woodline Partners LP | $13 510 587 | 1 247 515 | 1,03% | Actions |
| ALGERT GLOBAL LLC | $13 161 623 | 1 215 293 | 1,01% | Actions |
| BRAIDWELL LP | $13 153 468 | 1 214 540 | 1,01% | Actions |
| Candriam S.C.A. | $12 764 594 | 1 179 768 | 0,98% | Actions |
| BANK OF AMERICA CORP /DE/ | $11 675 336 | 1 078 055 | 0,89% | Actions |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $11 392 109 | 1 051 903 | 0,87% | Actions |
| Defilade Capital Management, L.P. | $11 346 483 | 1 047 690 | 0,87% | Actions |
| Euclidean Capital LLC | $10 715 310 | 989 410 | 0,82% | Actions |
| ROYCE & ASSOCIATES LP | $10 609 761 | 979 664 | 0,81% | Actions |
| EVENTIDE ASSET MANAGEMENT, LLC | $10 337 886 | 954 768 | 0,79% | Actions |
| NORTHERN TRUST CORP | $8 732 272 | 806 304 | 0,67% | Actions |
| Qube Research & Technologies Ltd | $8 604 890 | 794 542 | 0,66% | Actions |
| SPHERA FUNDS MANAGEMENT LTD. | $8 154 806 | 752 983 | 0,62% | Actions |
| Jones Hill Capital LP | $8 093 400 | 747 313 | 0,62% | Actions |
| SILVERARC CAPITAL MANAGEMENT, LLC | $8 001 995 | 738 873 | 0,61% | Actions |
| NEXTBio Capital Management LP | $7 647 323 | 706 124 | 0,59% | Actions |
| MILLENNIUM MANAGEMENT LLC | $7 556 026 | 697 694 | 0,58% | Actions |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $7 340 823 | 677 823 | 0,56% | Actions |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $6 808 626 | 628 682 | 0,52% | Actions |
| TWO SIGMA INVESTMENTS, LP | $6 537 681 | 603 664 | 0,50% | Actions |
| ArrowMark Colorado Holdings LLC | $6 312 536 | 582 875 | 0,48% | Actions |
| VANGUARD FIDUCIARY TRUST CO | $6 130 192 | 566 038 | 0,47% | Actions |
| Connor, Clark & Lunn Investment Management Ltd. | $5 614 922 | 518 460 | 0,43% | Actions |
| SUPERSTRING CAPITAL MANAGEMENT LP | $4 397 814 | 406 077 | 0,34% | Actions |
| Blue Owl Capital Holdings LP | $4 332 000 | 400 000 | 0,33% | Actions |
| VICTORY CAPITAL MANAGEMENT INC | $4 256 948 | 393 070 | 0,33% | Actions |
| Redmile Group, LLC | $3 920 568 | 362 010 | 0,30% | Actions |
| AQR CAPITAL MANAGEMENT LLC | $3 885 273 | 358 751 | 0,30% | Actions |
| Boxer Capital Management, LLC | $3 790 500 | 350 000 | 0,29% | Actions |
| BNP PARIBAS FINANCIAL MARKETS | $3 736 762 | 345 038 | 0,29% | Actions |
| Squarepoint Ops LLC | $3 729 235 | 344 343 | 0,29% | Actions |
| Pfizer Inc | $3 553 775 | 372 904 | 0,27% | Actions |
| JPMORGAN CHASE & CO | $3 130 462 | 308 268 | 0,24% | Actions |
| CITIGROUP INC | $2 694 038 | 248 757 | 0,21% | Actions |
| TD Asset Management Inc | $2 664 202 | 246 002 | 0,20% | Actions |
| UBS Group AG | $2 414 256 | 222 923 | 0,18% | Actions |
| Trexquant Investment LP | $2 402 300 | 221 819 | 0,18% | Actions |
| Bank of New York Mellon Corp | $2 383 466 | 220 080 | 0,18% | Actions |
| XTX Topco Ltd | $2 359 066 | 217 827 | 0,18% | Actions |
| WELLINGTON MANAGEMENT GROUP LLP | $2 310 830 | 213 373 | 0,18% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1 935 321 | 178 700 | 0,15% | Option d'achat |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $1 886 824 | 174 222 | 0,14% | Actions |
| Nuveen, LLC | $1 864 569 | 172 167 | 0,14% | Actions |
| AMERICAN CENTURY COMPANIES INC | $1 826 241 | 168 628 | 0,14% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1 508 251 | 139 266 | 0,12% | Actions |
| Jump Financial, LLC | $1 423 062 | 131 400 | 0,11% | Actions |
| Atom Investors LP | $1 408 756 | 130 079 | 0,11% | Actions |
| Ishara Investments LP | $1 332 090 | 123 000 | 0,10% | Actions |
| Caption Management, LLC | $1 191 300 | 110 000 | 0,09% | Option d'achat |
| Invesco Ltd. | $1 167 182 | 107 773 | 0,09% | Actions |
| SPHERA FUNDS MANAGEMENT LTD. | $1 083 000 | 100 000 | 0,08% | Option d'achat |
| Caption Management, LLC | $1 083 000 | 100 000 | 0,08% | Option de vente |
| Russell Investments Group, Ltd. | $1 080 205 | 99 742 | 0,08% | Actions |
| RHUMBLINE ADVISERS | $1 017 131 | 93 919 | 0,08% | Actions |
| Rafferty Asset Management, LLC | $982 963 | 90 763 | 0,08% | Actions |
| Abu Dhabi Investment Council Co P.J.S.C | $968 646 | 89 441 | 0,07% | Actions |
| WELLS FARGO & COMPANY/MN | $942 307 | 87 009 | 0,07% | Actions |
| Swiss National Bank | $933 546 | 86 200 | 0,07% | Actions |
| WINTON GROUP Ltd | $898 890 | 83 000 | 0,07% | Actions |
| ALLIANCEBERNSTEIN L.P. | $808 473 | 63 810 | 0,06% | Actions |
| DEUTSCHE BANK AG\ | $800 098 | 73 878 | 0,06% | Actions |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $780 410 | 72 060 | 0,06% | Actions |
| Engineers Gate Manager LP | $693 683 | 64 052 | 0,05% | Actions |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $687 208 | 54 239 | 0,05% | Actions |
| Caption Management, LLC | $521 248 | 48 130 | 0,04% | Actions |
| PROFUND ADVISORS LLC | $494 931 | 45 700 | 0,04% | Actions |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $479 703 | 44 951 | 0,04% | Actions |
| MetLife Investment Management, LLC | $474 787 | 43 840 | 0,04% | Actions |
| TUDOR INVESTMENT CORP ET AL | $459 289 | 42 409 | 0,04% | Actions |
| Virtus Investment Advisers, LLC | $428 489 | 39 565 | 0,03% | Actions |
| AXQ CAPITAL, LP | $395 501 | 36 519 | 0,03% | Actions |
| Quadrature Capital Ltd | $393 086 | 36 296 | 0,03% | Actions |
| LMR Partners LLP | $381 942 | 35 267 | 0,03% | Actions |
| AlphaQuest LLC | $363 086 | 44 387 | 0,03% | Actions |
| OPTIMIZE FINANCIAL INC. | $348 899 | 32 216 | 0,03% | Actions |
| Legal & General Group Plc | $332 276 | 30 667 | 0,03% | Actions |
| Brevan Howard Capital Management LP | $331 983 | 30 654 | 0,03% | Actions |
| Creative Planning | $323 850 | 29 903 | 0,02% | Actions |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $310 626 | 28 682 | 0,02% | Actions |
| Vanguard Global Advisers, LLC | $306 457 | 28 297 | 0,02% | Actions |
| CITADEL ADVISORS LLC | $281 580 | 26 000 | 0,02% | Option d'achat |
| VANGUARD ASSET MANAGEMENT, Ltd | $272 797 | 25 189 | 0,02% | Actions |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | $270 750 | 25 000 | 0,02% | Actions |
| Balyasny Asset Management L.P. | $262 097 | 24 201 | 0,02% | Actions |
| GROUP ONE TRADING LLC | $261 674 | 24 162 | 0,02% | Actions |
| Police & Firemen's Retirement System of New Jersey | $260 819 | 24 083 | 0,02% | Actions |
| SECTORAL ASSET MANAGEMENT INC | $254 505 | 23 500 | 0,02% | Actions |
| China Universal Asset Management Co., Ltd. | $239 917 | 22 153 | 0,02% | Actions |
| Quantinno Capital Management LP | $234 892 | 21 689 | 0,02% | Actions |
| TEMA ETFS LLC | $227 846 | 27 854 | 0,02% | Actions |
| Jasper Ridge Partners, L.P. | $226 022 | 20 870 | 0,02% | Actions |
| INTECH INVESTMENT MANAGEMENT LLC | $218 149 | 20 143 | 0,02% | Actions |
| BARCLAYS PLC | $214 509 | 19 807 | 0,02% | Actions |
| PRUDENTIAL FINANCIAL INC | $204 958 | 18 925 | 0,02% | Actions |
| NEW YORK STATE COMMON RETIREMENT FUND | $199 586 | 18 429 | 0,02% | Actions |
| Jain Global LLC | $191 009 | 17 637 | 0,01% | Actions |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $183 902 | 16 949 | 0,01% | Actions |
| Quarry LP | $182 269 | 16 830 | 0,01% | Actions |
| JANUS HENDERSON GROUP PLC | $182 232 | 14 400 | 0,01% | Actions |
| ALLSTATE CORP | $175 197 | 16 177 | 0,01% | Actions |
| Blueshift Asset Management, LLC | $166 468 | 15 371 | 0,01% | Actions |
| VOYA INVESTMENT MANAGEMENT LLC | $160 566 | 14 826 | 0,01% | Actions |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $154 869 | 14 300 | 0,01% | Option de vente |
| CWM, LLC | $153 244 | 12 095 | 0,01% | Actions |
| State of New Jersey Common Pension Fund D | $149 357 | 13 791 | 0,01% | Actions |
| IEQ CAPITAL, LLC | $145 599 | 13 444 | 0,01% | Actions |
| ProShare Advisors LLC | $142 717 | 13 178 | 0,01% | Actions |
| PSP Research LLC | $140 790 | 13 000 | 0,01% | Actions |
| E Fund Management Co., Ltd. | $138 602 | 12 798 | 0,01% | Actions |
| CANADA PENSION PLAN INVESTMENT BOARD | $127 794 | 11 800 | 0,01% | Actions |
| ARIZONA STATE RETIREMENT SYSTEM | $127 458 | 11 769 | 0,01% | Actions |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $122 487 | 11 310 | 0,01% | Actions |
| PRELUDE CAPITAL MANAGEMENT, LLC | $122 379 | 11 300 | 0,01% | Actions |
| STIFEL FINANCIAL CORP | $121 665 | 11 234 | 0,01% | Actions |
| Cerity Partners LLC | $120 278 | 11 106 | 0,01% | Actions |
| Vanguard Investments Australia, Ltd. | $115 664 | 10 680 | 0,01% | Actions |
| KLP KAPITALFORVALTNING AS | $100 719 | 9 300 | 0,01% | Actions |
| ROYAL BANK OF CANADA | $89 000 | 8 237 | 0,01% | Actions |
| SIMPLEX TRADING, LLC | $76 957 | 7 106 | 0,01% | Actions |
| Ameritas Investment Partners, Inc. | $73 438 | 6 781 | 0,01% | Actions |
| PRICE T ROWE ASSOCIATES INC /MD/ | $71 670 | 6 617 554 | 0,01% | Actions |
| Federation des caisses Desjardins du Quebec | $64 980 | 6 000 | 0,00% | Actions |
| Arax Advisory Partners | $56 847 | 5 249 | 0,00% | Actions |
| Mirae Asset Global Investments Co., Ltd. | $50 143 | 4 630 | 0,00% | Actions |
| Quantbot Technologies LP | $46 352 | 4 280 | 0,00% | Actions |
| Steward Partners Investment Advisory, LLC | $34 039 | 3 143 | 0,00% | Actions |
| ASSETMARK, INC | $31 894 | 2 945 | 0,00% | Actions |
| Tower Research Capital LLC (TRC) | $31 624 | 2 920 | 0,00% | Actions |
| NISA INVESTMENT ADVISORS, LLC | $27 465 | 2 536 | 0,00% | Actions |
| GF FUND MANAGEMENT CO. LTD. | $23 025 | 2 126 | 0,00% | Actions |
| Versant Capital Management, Inc | $14 925 | 1 108 | 0,00% | Actions |
| Caitong International Asset Management Co., Ltd | $13 559 | 1 252 | 0,00% | Actions |
| Sterling Capital Management LLC | $12 195 | 1 126 | 0,00% | Actions |
| IFP Advisors, Inc | $11 133 | 1 028 | 0,00% | Actions |
| EverSource Wealth Advisors, LLC | $9 996 | 923 | 0,00% | Actions |
| OSAIC HOLDINGS, INC. | $6 606 | 610 | 0,00% | Actions |
| Essential Partners LLC | $5 567 | 514 | 0,00% | Actions |
| GAMMA Investing LLC | $3 617 | 334 | 0,00% | Actions |
| Fortitude Family Office, LLC | $3 401 | 314 | 0,00% | Actions |
| Allworth Financial LP | $3 022 | 279 | 0,00% | Actions |
| Optiver Holding B.V. | $2 686 | 248 | 0,00% | Actions |
| Lindbrook Capital, LLC | $1 780 | 319 | 0,00% | Actions |
| HRT FINANCIAL LP | $1 659 | 153 245 | 0,00% | Actions |
| SJS Investment Consulting Inc. | $1 517 | 140 | 0,00% | Actions |
| Silver Grove Financial Group, Inc. | $1 375 | 127 | 0,00% | Actions |
| ROTHSCHILD INVESTMENT LLC | $1 365 | 126 | 0,00% | Actions |
| Point72 Europe (London) LLP | $1 356 | 113 | 0,00% | Actions |
| Farther Finance Advisors, LLC | $1 268 | 122 | 0,00% | Actions |
| JPL Wealth Management, LLC | $1 051 | 97 | 0,00% | Actions |
| State of Wyoming | $964 | 89 | 0,00% | Actions |
| Parallel Advisors, LLC | $899 | 83 | 0,00% | Actions |
| SIGNATUREFD, LLC | $899 | 83 | 0,00% | Actions |
| Larson Financial Group LLC | $877 | 81 | 0,00% | Actions |
| SG Americas Securities, LLC | $564 | 52 089 | 0,00% | Actions |
| Ameritas Advisory Services, LLC | $498 | 46 | 0,00% | Actions |
| Stone House Investment Management, LLC | $195 | 18 | 0,00% | Actions |
| Clearstead Advisors, LLC | $98 | 9 | 0,00% | Actions |
| CANADA LIFE ASSURANCE Co | $60 | 5 593 | 0,00% | Actions |
| SBI Securities Co., Ltd. | $22 | 2 | 0,00% | Actions |
| Pacer Advisors, Inc. | $16 | 1 516 | 0,00% | Actions |
| Covestor Ltd | $1 | 48 | 0,00% | Actions |